WO2011104555A3 - Nouveau procédé - Google Patents

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Publication number
WO2011104555A3
WO2011104555A3 PCT/GB2011/050369 GB2011050369W WO2011104555A3 WO 2011104555 A3 WO2011104555 A3 WO 2011104555A3 GB 2011050369 W GB2011050369 W GB 2011050369W WO 2011104555 A3 WO2011104555 A3 WO 2011104555A3
Authority
WO
WIPO (PCT)
Prior art keywords
sunitinib
preparation
sunitinib malate
malate form
hydroxybutanedioate
Prior art date
Application number
PCT/GB2011/050369
Other languages
English (en)
Other versions
WO2011104555A2 (fr
Inventor
Vinayak Govind Gore
Laxmikant Narahari Patkar
Kiran Shivaji Pokharkar
Mahesh Gorakhnath Hublikar
Prakash Vishnu Bansode
Original Assignee
Generics [Uk] Limited
Mylan India Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Generics [Uk] Limited, Mylan India Private Limited filed Critical Generics [Uk] Limited
Publication of WO2011104555A2 publication Critical patent/WO2011104555A2/fr
Publication of WO2011104555A3 publication Critical patent/WO2011104555A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne un procédé amélioré de préparation des sels d'addition acide du sunitinib, en particulier du (2S)-2-hydroxybutanedioate de sunitinib (I). La présente invention concerne également des compositions comprenant des sels d'addition acide du sunitinib comme le (2S)-2-hydroxybutanedioate (I) de sunitinib et l'emploi desdites compositions dans le traitement de pathologies.
PCT/GB2011/050369 2010-02-25 2011-02-24 Nouveau procédé WO2011104555A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN184/KOL/2010 2010-02-25
IN184KO2010 2010-02-25

Publications (2)

Publication Number Publication Date
WO2011104555A2 WO2011104555A2 (fr) 2011-09-01
WO2011104555A3 true WO2011104555A3 (fr) 2012-02-02

Family

ID=43748595

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2011/050369 WO2011104555A2 (fr) 2010-02-25 2011-02-24 Nouveau procédé

Country Status (1)

Country Link
WO (1) WO2011104555A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2761826B1 (fr) 2011-09-30 2015-06-24 British Telecommunications PLC Attribution de contributions à un encombrement
WO2013190569A2 (fr) * 2012-06-22 2013-12-27 Shilpa Medicare Limited Nouveaux sels de sunitinib et leur préparation
WO2015031604A1 (fr) 2013-08-28 2015-03-05 Crown Bioscience, Inc. Signatures d'expression génique permettant de prédire la réponse d'un sujet à un inhibiteur multikinase et leurs procédés d'utilisation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001060814A2 (fr) * 2000-02-15 2001-08-23 Sugen, Inc. Inhibiteurs de la proteine kinase 2-indolinone a substitution pyrrole
WO2009150523A1 (fr) * 2008-06-13 2009-12-17 Medichem, S.A. Procédé de préparation d’un sel 2-indolinone malate à substitution 3‑pyrrole
WO2009157011A1 (fr) * 2008-06-23 2009-12-30 Natco Pharma Limited Procédé de préparation de sunitinib de haute pureté et de ses sels pharmaceutiquement acceptables

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2455050C (fr) 2001-08-15 2007-02-20 Pharmacia & Upjohn Company Cristaux comprenant un sel d'acide malique de n-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide, procedes de preparation associes et compositions correspondantes
KR100657110B1 (ko) 2002-02-15 2006-12-12 파마시아 앤드 업존 캄파니 엘엘씨 인돌리논 유도체의 제조방법
US20060009510A1 (en) 2004-07-09 2006-01-12 Pharmacia & Upjohn Company Llc Method of synthesizing indolinone compounds
EP2318364A2 (fr) 2008-07-02 2011-05-11 Generics [UK] Limited Preparation des derives de 2-indolinone substitue par 3-pyrrole

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001060814A2 (fr) * 2000-02-15 2001-08-23 Sugen, Inc. Inhibiteurs de la proteine kinase 2-indolinone a substitution pyrrole
WO2009150523A1 (fr) * 2008-06-13 2009-12-17 Medichem, S.A. Procédé de préparation d’un sel 2-indolinone malate à substitution 3‑pyrrole
WO2009157011A1 (fr) * 2008-06-23 2009-12-30 Natco Pharma Limited Procédé de préparation de sunitinib de haute pureté et de ses sels pharmaceutiquement acceptables

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. H. VAN 'T HOFF, H. M. DAWSON: "Die racemische Umwandlung des Ammoniumbimalats", CHEMISCHE BERICHTE, vol. 31, no. 1, 1898, pages 528 - 534, XP002630290 *
KAY SCHWARZKOPF ET AL: "Synthesis of Novel Optically Active Tin Hydrides Containing Chiral Ligands", CHEMISCHE BERICHTE, vol. 130, 1997, pages 1539 - 1546, XP002630291 *
TADASHI SHIRAIWA ET AL: "Racemic Structure and Optical Resolution by Preferential Crystalization of (+/-)-Organic Ammonium Hydrogen Malates", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 61, 1988, pages 899 - 903, XP002630292 *

Also Published As

Publication number Publication date
WO2011104555A2 (fr) 2011-09-01

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