WO2011102626A3 - 폴리아자마크로사이클릭 화합물, 그 제조 방법 및 생의학적 적용 - Google Patents

폴리아자마크로사이클릭 화합물, 그 제조 방법 및 생의학적 적용 Download PDF

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Publication number
WO2011102626A3
WO2011102626A3 PCT/KR2011/000977 KR2011000977W WO2011102626A3 WO 2011102626 A3 WO2011102626 A3 WO 2011102626A3 KR 2011000977 W KR2011000977 W KR 2011000977W WO 2011102626 A3 WO2011102626 A3 WO 2011102626A3
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WO
WIPO (PCT)
Prior art keywords
production method
polyazamacrocyclic compound
use therefor
biomedical use
polyazamacrocyclic
Prior art date
Application number
PCT/KR2011/000977
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English (en)
French (fr)
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WO2011102626A2 (ko
Inventor
유정수
판댜달판
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경북대학교 산학협력단
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Application filed by 경북대학교 산학협력단 filed Critical 경북대학교 산학협력단
Priority to EP11744868.8A priority Critical patent/EP2537834B1/en
Priority to US13/521,177 priority patent/US9079867B2/en
Publication of WO2011102626A2 publication Critical patent/WO2011102626A2/ko
Publication of WO2011102626A3 publication Critical patent/WO2011102626A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1051—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from breast, e.g. the antibody being herceptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

본 발명에 따라 이작용기성 킬레이트제(BFC)로서 유용한 신규의 폴리아자마크로사이클릭 화합물을 선택적이며 높은 수율로 합성할 수 있다. 합성된 신규의 폴리아자마크로사이클릭 화합물은 금속에 킬레이트되어 펩티드 등의 생활성(bioactive) 분자와 컨쥬게이션될 수 있으며, 질환의 치료 및 진단에 응용될 수 있다.
PCT/KR2011/000977 2010-02-16 2011-02-14 폴리아자마크로사이클릭 화합물, 그 제조 방법 및 생의학적 적용 WO2011102626A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP11744868.8A EP2537834B1 (en) 2010-02-16 2011-02-14 Polyazamacrocyclic compound, and a production method and a biomedical use therefor
US13/521,177 US9079867B2 (en) 2010-02-16 2011-02-14 Polyazamacrocyclic compound, and a production method and a biomedical use therefor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2010-0013781 2010-02-16
KR20100013781 2010-02-16
KR1020110010062A KR101253100B1 (ko) 2010-02-16 2011-02-01 폴리아자마크로사이클릭 화합물, 그 제조 방법 및 생의학적 적용
KR10-2011-0010062 2011-02-01

Publications (2)

Publication Number Publication Date
WO2011102626A2 WO2011102626A2 (ko) 2011-08-25
WO2011102626A3 true WO2011102626A3 (ko) 2012-01-19

Family

ID=44931020

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/000977 WO2011102626A2 (ko) 2010-02-16 2011-02-14 폴리아자마크로사이클릭 화합물, 그 제조 방법 및 생의학적 적용

Country Status (4)

Country Link
US (1) US9079867B2 (ko)
EP (1) EP2537834B1 (ko)
KR (1) KR101253100B1 (ko)
WO (1) WO2011102626A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023500377A (ja) * 2019-11-08 2023-01-05 ザ・ユニバーシティ・オブ・クイーンズランド 放射性標識された標的化リガンド
WO2023178313A2 (en) * 2022-03-18 2023-09-21 The Research Foundation For The State University Of New York Radiopharmaceutical compositions, synthetic methods, and methods of treatment

Citations (2)

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Also Published As

Publication number Publication date
KR101253100B1 (ko) 2013-04-10
EP2537834B1 (en) 2018-09-05
KR20110095143A (ko) 2011-08-24
US9079867B2 (en) 2015-07-14
WO2011102626A2 (ko) 2011-08-25
US20130004423A1 (en) 2013-01-03
EP2537834A4 (en) 2013-09-11
EP2537834A2 (en) 2012-12-26

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