WO2011095277A1 - Phosphinyl hydrazides - Google Patents
Phosphinyl hydrazides Download PDFInfo
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- WO2011095277A1 WO2011095277A1 PCT/EP2011/000189 EP2011000189W WO2011095277A1 WO 2011095277 A1 WO2011095277 A1 WO 2011095277A1 EP 2011000189 W EP2011000189 W EP 2011000189W WO 2011095277 A1 WO2011095277 A1 WO 2011095277A1
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- WIPO (PCT)
- Prior art keywords
- fluorinated
- independently
- linear
- another
- perfluorinated
- Prior art date
Links
- 229940042795 hydrazides for tuberculosis treatment Drugs 0.000 title abstract description 14
- 125000005328 phosphinyl group Chemical group [PH2](=O)* 0.000 title abstract description 13
- 150000001875 compounds Chemical class 0.000 claims abstract description 30
- 238000000034 method Methods 0.000 claims abstract description 12
- 238000003786 synthesis reaction Methods 0.000 claims abstract description 8
- 238000002360 preparation method Methods 0.000 claims abstract description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- 230000015572 biosynthetic process Effects 0.000 claims description 12
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 11
- -1 flames retardants Substances 0.000 claims description 9
- 125000005037 alkyl phenyl group Chemical group 0.000 claims description 8
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims description 4
- 239000007983 Tris buffer Substances 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 125000001153 fluoro group Chemical group F* 0.000 claims description 4
- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
- 150000002429 hydrazines Chemical class 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical class O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 claims description 4
- 125000004434 sulfur atom Chemical group 0.000 claims description 4
- 239000007858 starting material Substances 0.000 claims description 3
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000000306 component Substances 0.000 claims description 2
- 239000003792 electrolyte Substances 0.000 claims description 2
- 239000006260 foam Substances 0.000 claims description 2
- 230000003993 interaction Effects 0.000 claims description 2
- 239000000314 lubricant Substances 0.000 claims description 2
- 239000000696 magnetic material Substances 0.000 claims description 2
- 150000002894 organic compounds Chemical class 0.000 claims description 2
- 238000010422 painting Methods 0.000 claims description 2
- 239000003444 phase transfer catalyst Substances 0.000 claims description 2
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims description 2
- 239000004014 plasticizer Substances 0.000 claims description 2
- 238000004611 spectroscopical analysis Methods 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 21
- WEVYAHXRMPXWCK-FIBGUPNXSA-N acetonitrile-d3 Chemical compound [2H]C([2H])([2H])C#N WEVYAHXRMPXWCK-FIBGUPNXSA-N 0.000 description 18
- 239000013558 reference substance Substances 0.000 description 12
- 239000002904 solvent Substances 0.000 description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 10
- 238000005481 NMR spectroscopy Methods 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 9
- YRMAQKVAROMHCP-UHFFFAOYSA-N tris(1,1,2,2,2-pentafluoroethyl)phosphane Chemical compound FC(F)(F)C(F)(F)P(C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)F YRMAQKVAROMHCP-UHFFFAOYSA-N 0.000 description 7
- RHUYHJGZWVXEHW-UHFFFAOYSA-N 1,1-Dimethyhydrazine Chemical compound CN(C)N RHUYHJGZWVXEHW-UHFFFAOYSA-N 0.000 description 6
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 6
- 239000011541 reaction mixture Substances 0.000 description 6
- GFEQDHMENQAHKI-UHFFFAOYSA-N 1-[bis(1,1,2,2,2-pentafluoroethyl)phosphoryl]-1,1,2,2,2-pentafluoroethane Chemical compound FC(F)(F)C(F)(F)P(=O)(C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)F GFEQDHMENQAHKI-UHFFFAOYSA-N 0.000 description 5
- HKOOXMFOFWEVGF-UHFFFAOYSA-N phenylhydrazine Chemical compound NNC1=CC=CC=C1 HKOOXMFOFWEVGF-UHFFFAOYSA-N 0.000 description 5
- 229940067157 phenylhydrazine Drugs 0.000 description 5
- 239000004810 polytetrafluoroethylene Substances 0.000 description 5
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 238000004293 19F NMR spectroscopy Methods 0.000 description 4
- 238000005160 1H NMR spectroscopy Methods 0.000 description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 150000003254 radicals Chemical class 0.000 description 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 150000002367 halogens Chemical group 0.000 description 3
- HDZGCSFEDULWCS-UHFFFAOYSA-N monomethylhydrazine Chemical compound CNN HDZGCSFEDULWCS-UHFFFAOYSA-N 0.000 description 3
- MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical class [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 description 3
- GTLACDSXYULKMZ-UHFFFAOYSA-N pentafluoroethane Chemical compound FC(F)C(F)(F)F GTLACDSXYULKMZ-UHFFFAOYSA-N 0.000 description 3
- 239000012265 solid product Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- ICIJWVXTJKISHG-UHFFFAOYSA-N 1-[chloro(1,1,2,2,2-pentafluoroethyl)phosphoryl]-1,1,2,2,2-pentafluoroethane Chemical compound FC(F)(F)C(F)(F)P(Cl)(=O)C(F)(F)C(F)(F)F ICIJWVXTJKISHG-UHFFFAOYSA-N 0.000 description 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 150000002222 fluorine compounds Chemical class 0.000 description 2
- 150000002391 heterocyclic compounds Chemical class 0.000 description 2
- 239000012456 homogeneous solution Substances 0.000 description 2
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 description 2
- 239000011343 solid material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000002211 ultraviolet spectrum Methods 0.000 description 2
- 0 *c1cc(O)c(*)c(N)c1 Chemical compound *c1cc(O)c(*)c(N)c1 0.000 description 1
- 125000006539 C12 alkyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- KIAWNCIDEJNMPR-UHFFFAOYSA-N Cc(cc1N)cc(N)c1O Chemical compound Cc(cc1N)cc(N)c1O KIAWNCIDEJNMPR-UHFFFAOYSA-N 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- QPQGTZMAQRXCJW-UHFFFAOYSA-N [chloro(phenyl)phosphoryl]benzene Chemical class C=1C=CC=CC=1P(=O)(Cl)C1=CC=CC=C1 QPQGTZMAQRXCJW-UHFFFAOYSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000007810 chemical reaction solvent Substances 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 229910052805 deuterium Inorganic materials 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- YADSGOSSYOOKMP-UHFFFAOYSA-N lead dioxide Inorganic materials O=[Pb]=O YADSGOSSYOOKMP-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 239000003880 polar aprotic solvent Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- MMCXETIAXNXKPE-UHFFFAOYSA-J tetraiodotungsten Chemical compound I[W](I)(I)I MMCXETIAXNXKPE-UHFFFAOYSA-J 0.000 description 1
- FIQMHBFVRAXMOP-UHFFFAOYSA-N triphenylphosphane oxide Chemical class C=1C=CC=CC=1P(C=1C=CC=CC=1)(=O)C1=CC=CC=C1 FIQMHBFVRAXMOP-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/36—Amides thereof
Definitions
- This invention relates to fluorinated phosphinyl hydrazides, a process for their preparation, and the use of these compounds, especially in organic synthesis.
- Acylhydrazides are common reagents in the synthesis of heterocyclic compounds and are well know buildings blocks in organic chemistry (The Chemistry of Heterocyclic Compounds, E.C. Teylor, P. Wipf (Eds.), John Wiley and Sons: New. Jersey, 2004). Only few phosphinyl hydrazides are described in the literature, namely: Ph 2 P(O)NHNH 2 , Ph 2 P(O)NHN(CH 3 ) 2 (D.E.C. Corbridge, Phosphorus. An Outline of its Chemistry, Biochemistry and Technology (Second Edition), Elsvier, Amsterdam-Oxford-N.Y., 1980, p.
- the present invention provides phosphinyl hydrazides of formula (I)
- RF independently of one another are fluorinated linear or fluorinated branched alkyl, optionally comprising one or more oxygen atoms, or fluorinated phenyl or fluorinated alkylphenyl
- R 1 , R 2 and R 3 independently of one another are H, phenyl, substituted phenyl, alkylphenyl, linear or branched alkyi optionally comprising one or more aromatic rings, heteroaromatic ring, oxygen atoms, sulfur atoms, double bonds and/or triple bonds, whereby one or more H atoms may be
- halogen especially CI and/or F atoms.
- RF independently of one another are perfluorinated linear or perfluorinated branched alkyi or perfluorinated phenyl.
- Preferred alkyi derivatives are compounds wherein R F independently of one another are perfluorinated linear or perfluorinated branched Ci bis C 2 o alkyi, especially 0,2 bis Ci 2 alkyi.
- R F independently of one another are perfluorinated linear or perfluorinated branched Ci bis C 2 o alkyi, especially 0,2 bis Ci 2 alkyi.
- R F independently of one another are perfluorinated linear or perfluorinated branched Ci bis C 2 o alkyi, especially 0,2 bis Ci 2 alkyi.
- R F independently of one another are perfluorinated linear or perfluorinated branched Ci bis C 2 o alkyi, especially 0,2 bis Ci 2 alkyi.
- R F independently of one another are perfluorinated linear or perfluorinated branched Ci bis C 2 o al
- perfluorinated linear or perfluorinated branched C 2 bis C 6 alkyi or perfluorinated phenyl independently of one another are perfluorinated linear or perfluorinated branched C 2 bis C 6 alkyi or perfluorinated phenyl.
- R 1 , R 2 and R 3 are preferably independently of one another linear or branched Ci bis C 20 alkyi, especially Ci bis Ci 2 alkyi, or substituted or unsubstituted phenyl or benzyl.
- phenyl and/or benzyl are substituted with one or more Ci bis C 6 alkyi, especially with C-i bis C 4 alkyi.
- R F and R 1 , R 2 and R 3 have the preferred meanings.
- a second subject matter of this invention is the use of fluorinated
- fluorinated phosphinyl hydrazides of formula (I) can be used as phase-transfer catalysts, surfactants, lubricants, plasticizers, flames retardants, foams forming agents, starting material for generating of stable radicals and synthesis of molecular magnetic materials for molecular recognition by spectroscopic methods, antioxidants, components or additives to polymeric or painting compositions, or as additives to
- a further subject matter of this invention is a process for the preparation of fluorinated phosphiny! hydrazides of formula (I) via reaction of hydrazines of formula (II)
- RF independently of one another are fluorinated linear or
- fluorinated branched alkyl optionally comprising one or more oxygen atoms, or fluorinated phenyl or fluorinated alkylphenyl, R 1 , R 2 and R 3 independently of one another are H, phenyl, substituted phenyl,
- alkylphenyl linear or branched alkyl optionally comprising one or more aromatic rings, heteroaromatic ring, oxygen atoms, sulfur atoms, double bonds and/or triple bonds, whereby one or more H atoms may be
- halogen especially CI and/or F atoms
- X is halogen, especially CI or F.
- RF independently of one another are perfluorinated linear or perfluorinated branched alkyl or perfluorinated phenyl.
- Preferred alkyl derivatives are compounds wherein R F independently of one another are perfluorinated linear or perfluorinated branched Ci bis C 20 alkyi, especially C 2 bis C 12 alkyi. Especially preferred are compounds wherein R F
- perfluorinated linear or perfluorinated branched C 2 bis C-6 alkyi or perfluorinated phenyl independently of one another are perfluorinated linear or perfluorinated branched C 2 bis C-6 alkyi or perfluorinated phenyl.
- R , R 2 and R 3 are preferably independently of one another linear or branched C-i bis C2 0 alkyi, especially Ci bis C 12 alkyi, or substituted or unsubstituted phenyl or benzyl.
- phenyl and/or benzyl are substituted with one or more d bis C 6 alkyi, especially with Ci bis C 4 alkyi.
- phosphinic acid derivatives especially chlorides, or fluorides, but also from less reactive corresponding phosphine oxides.
- fluorinated bis(alkyl)- or fluorinated bis(phenyl)-phosphinic acid chlorides or fluorides may be used.
- the preferred processes are:
- RF independently of one another are perfluorinated linear or perfluorinated branched alkyl or perfluorinated phenyl.
- R F independently of one another are perfluorinated linear or perfluorinated branched C 2 bis C 12 alkyl, optionally comprising one or more oxygen atoms are preferred.
- R 1 , R 2 and R 3 are preferably independently of one another linear or branched Ci bis C 2 0 alkyl- Especially preferred are the compounds in which R F are identical.
- R F and R 1 , R 2 and R 3 have the preferred meanings.
- phosphinyl hydrazides of formula (I) are prepared via reaction of fluorinated tris(alkyl)- or fluorinated tris(phenyl)-phosphine oxides with corresponding hydrazines.
- preferred starting materials for the application in the synthesis of bis(perfluoroalkyl)phosphinyl hydrazides are: tris(pentafluoroethyl)phosphine oxide, or bis(pentafluoroethyl)phosphinyl chloride in combination with methylhydrazine, phenylhydrazine, 1 ,1- dimethylhydrazine, or 3,5-di-f-butyl-4-hydroxy-benzyl hydrazine.
- Tris(perfluoroalkyl)phosphine oxides can be easily prepared (V.Ya.
- the process of the invention for the preparation of fluorinated phosphinyl hydrazides of formula (I) is preferably conducted at a temperature range of from -60°C up to 120°C, depending from the compounds used.
- the reaction is carried out at a temperature range of from -40°C up to room temperature (approximately 25°C), wherein the reaction temperature is in a range of from -40°C up to -10°C, when phosphinic acid derivatives are used and in a range of from -10°C up to room temperature (approximately 25°C), when phosphine oxides are used.
- the reaction time depends from the compounds used and it is usually between 10 minutes and 24 hours. The skilled man in the art can easily adapt the reaction temperature and time to the reactivity of the compounds used.
- Preferred reaction solvents are organic solvents, preferably polar-aprotic solvents.
- the reaction can be conducted in acetonitrile, N,N- dimethylformamide, ⁇ , ⁇ -dimethylacetamide, N-methylpyrrolidone and/or other amides of secondary amines.
- acetonitrile is especially preferred.
- the compounds of formula (I) are purified by usual methods, e.g. by destination, crystallization, extraction, filtration, etc.
- NMR spectra were measured in CD 3 CN solution at room temperature on a Bruker Avance DRX-400 ( 1 H, 400.13 MHz; 19 F, 376.49 MHz; 31 P, 161.97 MHz) spectrometer. The chemical shifts were referenced to external TMS ( H), CFCI 3 ( 19 F) and H 3 P0 4 ( 31 P). UV-spectra were recorded on Lambda EZ210 Spectrophotometer with Deuterium (D2) lamp (UV) and Tungsten Iodide lamp (Vis).
- D2 Deuterium
- Vis Tungsten Iodide lamp
- a dry 25 ml flask, equipped with PTFE Young valve, is charged with 0.47 g (4.3 mmol) of phenylhydrazine, 1 ml of dry acetonitrile and 1.9 g (4.7 mmol) of tris(pentafluoroethyl)phosphine oxide, (C 2 F 5 ) 3 P O. After one hour at room temperature the homogeneous solution is formed. To complete the reaction, the mixture is left stirred at room temperature for 20 hours and then all volatile products are removed under high vacuum (10 "3 mbar).
- NMR spectra are recorded in the dry acetonitrile-D 3 and confirm the formation of bis(pentafluoroethyl)phosphinyl- N(3,5-di-i-butyl-4-hydroxy-benzyl)hydrazide, (C 2 F 5 ) 2 P(O)NHNHCH 2 [3,5-(f- C 4 H9) 2 -C 6 H 2 -4-OH].
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Abstract
This invention relates to fluorinated phosphinyl hydrazides, a process for their preparation, and the use of these compounds, especially in organic synthesis.
Description
Phosphinyl Hydrazides
This invention relates to fluorinated phosphinyl hydrazides, a process for their preparation, and the use of these compounds, especially in organic synthesis.
Acylhydrazides are common reagents in the synthesis of heterocyclic compounds and are well know buildings blocks in organic chemistry (The Chemistry of Heterocyclic Compounds, E.C. Teylor, P. Wipf (Eds.), John Wiley and Sons: New. Jersey, 2004). Only few phosphinyl hydrazides are described in the literature, namely: Ph2P(O)NHNH2, Ph2P(O)NHN(CH3)2 (D.E.C. Corbridge, Phosphorus. An Outline of its Chemistry, Biochemistry and Technology (Second Edition), Elsvier, Amsterdam-Oxford-N.Y., 1980, p. 282), (CH3)2P(0)NHNHPh, Ph2P(O)NHNHPh (H. Bock and E. Baltin, Chemische Berichte, 98 (1965), S. 2844-2854), (CH3)2P(O)NHNH2 (E. Steininger et. al., Monatshefte fur Chemie, 97 (1966), S. 383-390),
(C2H5)2P(O)NHN(CH3)2, (C2H5)2P(O)NHNH(C4H9-t) (M. Negareche et. al., J of Organic Chemistry, 51 (1986), p. 342-346). All these phosphinyl hydrazides were obtained by the interaction of phosphinyl chlorides with corresponding hydrazines.
The present invention provides phosphinyl hydrazides of formula (I)
wherein RF independently of one another are fluorinated linear or fluorinated branched alkyl, optionally comprising one or more oxygen atoms, or fluorinated phenyl or fluorinated alkylphenyl, and R1 , R2 and R3 independently of one another are H, phenyl, substituted phenyl,
alkylphenyl, linear or branched alkyi optionally comprising one or more aromatic rings, heteroaromatic ring, oxygen atoms, sulfur atoms, double bonds and/or triple bonds, whereby one or more H atoms may be
substituted by halogen, especially CI and/or F atoms.
Preferably, RF independently of one another are perfluorinated linear or perfluorinated branched alkyi or perfluorinated phenyl. Preferred alkyi derivatives are compounds wherein RF independently of one another are perfluorinated linear or perfluorinated branched Ci bis C2o alkyi, especially 0,2 bis Ci2 alkyi. Especially preferred are compounds wherein RF
independently of one another are perfluorinated linear or perfluorinated branched C2 bis C6 alkyi or perfluorinated phenyl.
R1 , R2 and R3 are preferably independently of one another linear or branched Ci bis C20 alkyi, especially Ci bis Ci2 alkyi, or substituted or unsubstituted phenyl or benzyl. Preferably phenyl and/or benzyl are substituted with one or more Ci bis C6 alkyi, especially with C-i bis C4 alkyi. Especially preferred are compounds with R1 = methyl, phenyl or 3,5-di-i- butyl-4-hydroxy-benzyl and R2 and R3 = H or compounds with R1 and R2 = linear Ci bis C4 alkyi, especially methyl or ethyl and R3 = H. Also preferred are compounds wherein R and R2 are the same and R3 = H.
Especially advantageous are combinations wherein RF and R1 , R2 and R3 have the preferred meanings. Particularly preferred are compounds with RF = perfluorinated C2 bis C6 alkyi, preferably C2F5, R and R3 = H, and R2 = linear Ci bis C4 alkyi, prefereably CH3, phenyl or 3,5-di-f-butyl-4-hydroxy- benzyl. Also prefereed are compounds with R3 = H and R1 and R2 = alkyi, preferably CH3. A second subject matter of this invention is the use of fluorinated
phosphinyl hydrazides of formula (I) for the synthesis of organic compounds
comprising (Rf)2 (0) groups, wherein Rf has the meaning described in the foregoing.
Furthermore, fluorinated phosphinyl hydrazides of formula (I) can be used as phase-transfer catalysts, surfactants, lubricants, plasticizers, flames retardants, foams forming agents, starting material for generating of stable radicals and synthesis of molecular magnetic materials for molecular recognition by spectroscopic methods, antioxidants, components or additives to polymeric or painting compositions, or as additives to
electrolytes in electrochemical cells.
A further subject matter of this invention is a process for the preparation of fluorinated phosphiny! hydrazides of formula (I) via reaction of hydrazines of formula (II)
R R2N-NHR3 (II)
with fluorinated phosphine oxides of formula (III) or fluorinated phosphinic acid derivatives of formula (IV)
(RF)3P=0 (RF)2P(0)X
(III) (IV)
wherein RF independently of one another are fluorinated linear or
fluorinated branched alkyl, optionally comprising one or more oxygen atoms, or fluorinated phenyl or fluorinated alkylphenyl, R1 , R2 and R3 independently of one another are H, phenyl, substituted phenyl,
alkylphenyl, linear or branched alkyl optionally comprising one or more aromatic rings, heteroaromatic ring, oxygen atoms, sulfur atoms, double bonds and/or triple bonds, whereby one or more H atoms may be
substituted by halogen, especially CI and/or F atoms, and X is halogen, especially CI or F.
Preferably, RF independently of one another are perfluorinated linear or perfluorinated branched alkyl or perfluorinated phenyl. Preferred alkyl derivatives are compounds wherein RF independently of one another are
perfluorinated linear or perfluorinated branched Ci bis C20 alkyi, especially C2 bis C12 alkyi. Especially preferred are compounds wherein RF
independently of one another are perfluorinated linear or perfluorinated branched C2 bis C-6 alkyi or perfluorinated phenyl.
R , R2 and R3 are preferably independently of one another linear or branched C-i bis C20 alkyi, especially Ci bis C12 alkyi, or substituted or unsubstituted phenyl or benzyl. Preferably phenyl and/or benzyl are substituted with one or more d bis C6 alkyi, especially with Ci bis C4 alkyi. Especially preferred are compounds with R1 = methyl, phenyl or 3,5-di-i- butyl-4-hydroxy-benzyl and R2 and R3 = H or compounds with R1 and R2 = linear Ci bis C4 alkyi, especially methyl or ethyl and R3 = H. Also preferred are compounds wherein R and R2 are the same and R3 = H. Surprisingly, it has been found that fluorinated phosphinyl hydrazides of formula (I) can be easily synthesized not only from corresponding
phosphinic acid derivatives, especially chlorides, or fluorides, but also from less reactive corresponding phosphine oxides. Especially fluorinated bis(alkyl)- or fluorinated bis(phenyl)-phosphinic acid chlorides or fluorides may be used.
The preferred processes are:
(RF)3P=0 + R1R2N- NHR3 (RF)2P(0)N- NR1 R2 + RFH
( in ) ( >· )
(RF)2P(0)CI + R1 R2N- N(H)R3 (RF)2P(0)N- NR1R2 + HCI
(trapped with CaH2,
( V ) ( II ) ^3 or other base)
(RF)2P(0)F + R1 R2N- N(H)R3 - (RF)2P(0)N- NR-,R2 + HF
! j L (trapped with CaH2,
■^3 or other base)
wherein RF independently of one another are perfluorinated linear or perfluorinated branched alkyl or perfluorinated phenyl. Especially, compounds wherein RF independently of one another are perfluorinated linear or perfluorinated branched C2 bis C12 alkyl, optionally comprising one or more oxygen atoms are preferred. R1 , R2 and R3 are preferably independently of one another linear or branched Ci bis C20 alkyl- Especially preferred are the compounds in which RF are identical.
Especially advantageous are combinations wherein RF and R1 , R2 and R3 have the preferred meanings.
Preferably phosphinyl hydrazides of formula (I) are prepared via reaction of fluorinated tris(alkyl)- or fluorinated tris(phenyl)-phosphine oxides with corresponding hydrazines. Especialy, preferred starting materials for the application in the synthesis of bis(perfluoroalkyl)phosphinyl hydrazides are: tris(pentafluoroethyl)phosphine oxide, or bis(pentafluoroethyl)phosphinyl chloride in combination with methylhydrazine, phenylhydrazine, 1 ,1- dimethylhydrazine, or 3,5-di-f-butyl-4-hydroxy-benzyl hydrazine.
Tris(perfluoroalkyl)phosphine oxides can be easily prepared (V.Ya.
Semenii, V.A. Stepanov, N.V. Ignatyev, G.G. Furin, L.M. Yagupolskii, Zh. Obshch. Khim., 55 (1985), S. 2716-2720) from industrially available tris(perfluoroalkyl)difluorophosphoranes (N. Ignatyev und P. Sartori, J.
Fluorine Chem., 103 (2000), S. 57-61 ; and WO 2000/21969).
The process of the invention for the preparation of fluorinated phosphinyl hydrazides of formula (I) is preferably conducted at a temperature range of from -60°C up to 120°C, depending from the compounds used. Preferably the reaction is carried out at a temperature range of from -40°C up to room temperature (approximately 25°C), wherein the reaction temperature is in a range of from -40°C up to -10°C, when phosphinic acid derivatives are used and in a range of from -10°C up to room temperature (approximately 25°C),
when phosphine oxides are used. The reaction time depends from the compounds used and it is usually between 10 minutes and 24 hours. The skilled man in the art can easily adapt the reaction temperature and time to the reactivity of the compounds used.
Preferred reaction solvents are organic solvents, preferably polar-aprotic solvents. The reaction can be conducted in acetonitrile, N,N- dimethylformamide, Ν,Ν-dimethylacetamide, N-methylpyrrolidone and/or other amides of secondary amines. Especially preferred is acetonitrile.
The compounds of formula (I) are purified by usual methods, e.g. by destination, crystallization, extraction, filtration, etc.
Apart from the preferred compounds, methods, compositions and processes mentioned in the description, the claims disclose further preferred combinations of the subject-matters according to the invention. The disclosures in the cited references are explicitly part of the content of the present application. The following examples explain the present invention in greater detail without restricting the scope of protection. In particular, the features, properties and advantages, described in the examples, of the compounds on which the relevant examples are based can also be applied to other substances and compounds which are not described in detail, but fall within the scope of protection, unless stated otherwise elsewhere. In addition, the invention can be carried out throughout the range claimed and is not restricted to the examples mentioned here.
NMR spectra were measured in CD3CN solution at room temperature on a Bruker Avance DRX-400 (1H, 400.13 MHz; 19F, 376.49 MHz; 31P, 161.97 MHz) spectrometer. The chemical shifts were referenced to external TMS ( H), CFCI3 (19F) and H3P04 (31P).
UV-spectra were recorded on Lambda EZ210 Spectrophotometer with Deuterium (D2) lamp (UV) and Tungsten Iodide lamp (Vis).
Examples
Example 1 : Bis(pentafluoroethyl)phosphinyl-N-(methyl)hydrazide,
(C2F5)2P(0)NHNHCH3
(C2F5)3P=O + NH2-NHCH3 (C2F5)2P(0)NH-NHCH3 + C2F5H t
A dry 25 ml flask, equipped with PTFE Young valve, is charged with 0.10 g (2.1 mmol) of methylhydrazine, 1 ml of dry acetonitrile and 1.3 g (3.2 mmol) of tris(pentafluoroethyl)phosphine oxide, (C2F5)3P=0. The reaction mixture is left stirred at room temperature for 16 hours and then all volatile products are removed under high vacuum (10"3 mbar). The white solid product (0.58 g; yield is 84 % calculating on methylhydrazine) is moved into the glove-box to take the NMR probe and to measure the melting point (M.p. = 72° C). NMR spectra are recorded in the dry acetonitrile-D3 and confirm the formation of bis(pentafluoroethyl)-phosphinyl N-(methyl)hydrazide,
(C2F5)2P(0)NHNHCH3.
19F NMR (Solvent: CD3CN; Reference substance: CCI3F), δ, ppm: -81.4 m (CF3), 122.4 (centre of A,B doublet) d.d.m (FA, CF2), 124.6 (centre of A,B doublet) d.d.m (Fb> CF2), 2JP,F(A) = 73 Hz, 2JP,F(B) = 80 Hz, JF(A),F(B) = 322 Hz.
31 P NMR (Solvent: CD3CN; Reference substance: 85 % Η3Ρ04), δ, ppm: 9.0 m.
1H NMR (Solvent: CD3CN; Reference substance: TMS), δ, ppm
(CH3), 4.12 br.s (NH). 6.75 br.d (NH); 2 P,H = 40 Hz.
Example 2: Bis(pentafluoroethyl)phosphinyl-N-(phenyl)hydrazide, (C2F5)2P(0)NHNHC6H5
(C2F5)3P=0 + NH2-NHC6H5 - (C2F5)2P(0)NH-NHC6H5 + C2F5H |
A dry 25 ml flask, equipped with PTFE Young valve, is charged with 0.47 g (4.3 mmol) of phenylhydrazine, 1 ml of dry acetonitrile and 1.9 g (4.7 mmol) of tris(pentafluoroethyl)phosphine oxide, (C2F5)3P=O. After one hour at room temperature the homogeneous solution is formed. To complete the reaction, the mixture is left stirred at room temperature for 20 hours and then all volatile products are removed under high vacuum (10"3 mbar). The resulting slightly yellow crystalline solid material (1.37 g; yield is 81 % calculating on phenylhydrazine) is purified by sublimation in a high vacuum at 82° C and moved into the glove-box to take the NMR probe and to measure the melting point (M.p. = 88° C). NMR spectra are recorded in the dry acetonitrile-D3 and confirm the formation of
bis(pentafluoroethyl)phosphinyl N-(phenyl)hydrazide,
(C2F5)2P(O)NHNHC6H5.
19F NMR (Solvent: CD3CN; Reference substance: CCI3F), δ, ppm: -81.2 m (CF3), 121.9 (centre of A,B doublet) d,d,m (FA, CF2), 124.6 (centre of A,B doublet) d.d.rn (Fb, CF2), 2JP,F(A) = 74 Hz, 2 P,F(B) = 83 Hz, JF(A),F(B) = 340 Hz.
31 P NMR (Solvent: CD3CN; Reference substance: 85 % H3PO4), δ, ppm: 8.9 t.t.d.d, 2JP,H = 44 Hz, 3JP,H = 4 Hz, 2JP,F(A) = 78 Hz, 2JP,F(B) = 82 Hz.
1H NMR (Solvent: CD3CN; Reference substance: TMS), δ, ppm: 6.47 d (NH), 6.92 - 7.00 m (3H), 7.24 - 7.31 m (2H). 7.46 br.d (NH); 2JP,H = 44 Hz, 3JP,H = 4 Hz.
Example 3: Bis(pentafluoroethyl)phosphinyl-N-(phenyl)hydrazide,
(C2F5)2P(0)NH HC6H5
(C2F5)2P(0)CI + NH2-NHC6H5 » (C2F5)2P(0)NH-NHC6H5 + HCI
2 HCI + CaH2 — - CaCI2 + H2 1
A dry 25 ml flask, equipped with PTFE Young valve, is charged with 0.15 g CaH2, 0.34 g (3.1 mmol) of phenylhydrazine, 1 ml of dry acetonitrile and cooled down to -30° C. 1.5 g (4.6 mmol) of bis(pentafluoroethyl)phosphinyl chloride, (C2F5)2P(0)CI are condensed to the reaction mixture. After
warming up to the room temperature, the reaction mixture is left stirred for 20 hours and filtered. All volatile products are removed then under high vacuum (10~3 mbar). The resulting yellow crystalline solid material (0.94 g; yield is 77 % calculating on phenylhydrazine) is moved into the glove-box to take the NMR probe. NMR spectra, which are recorded in the dry
acetonitrile-D3, coincides with the spectra of
bis(pentafluoroethyl)phosphinyl-N-(phenyl)hydrazide,
(C2F5)2P(O)NHNHC6H5, obtained in the Example 2
Example 4: Bis(pentafluoroethyl)phosphinyl N,N-di(methyl)hydrazide,
(C2F5)3P=0 + NH2-N(CH3)2 - (C2F5)2P(0)NH-N(CH3)2 + C2F5H |
A dry 25 ml flask, equipped with PTFE Young valve, is charged with 0.23 g (3.8 mmol) of 1 ,1-dimethylhydrazine, 1 ml of dry acetonitrile and 1.78 g (4.4 mmol) of tris(pentafluoroethyl)phosphine oxide, (C2F5)3P=O at 0° C. After 5-10 min of exothermic reaction at room temperature, the reaction mixture becomes homogeneous. The reaction mixture is left stirred at room
temperature for 15 hours and then all volatile products are removed under
high vacuum (10"3 mbar). The white solid product (1.45 g; yield is 82 % calculating on 1 ,1-dimethylhydrazine) is moved into the glove-box to take the NMR probe and to measure the melting point (M.p. = 71° C). NMR spectra are recorded in the dry acetonitrile-D3 and confirm the formation of bis(pentafluoroethyl)phosphinyl N,N-di(methyl)hydrazide,
(C2F5)2P(O)NHN(CH3)2.
19F NMR (Solvent: CD3CN; Reference substance: CCI3F), δ, ppm: -81.2 m (CF3), 121.4 (centre of A,B doublet) d,d (FA, CF2), 124.9 (centre of A,B doublet) d,d (Fb, CF2), 2JP,F(A) = 72 Hz, 2JP,F(B) = 82 Hz, JF(A),F(B) = 338 Hz.
3 P NMR (Solvent: CD3CN; Reference substance: 85 % Η3Ρ04), δ, ppm: 6.5 t,t,d, 2JP,H = 42 Hz, 3JP,H = 4 Hz, 2JP,F(A) = 74 Hz, 2JP,F(B) = 82 Hz.
1H NMR (Solvent: CD3CN; Reference substance: TMS), δ, ppm: 2.61 s (CH3), 6.90 br.d (NH); 2JP,H = 42 Hz.
Example 5: Bis(pentafluoroethyl)phosphinyl-N(3,5-di-f-butyl-4- hydroxy-benzyl)hydrazide,
(C2F5)2P(0)NHNHCH2[3,5-(i-C4H9)2-C6H2-4-OH]
A dry 25 ml flask, equipped with PTFE Young valve, is charged with 0.80 g (3.2 mmol) of 3,5-di-f-butyl-4-hydroxy-benzyl hydrazine, 1 ml of dry acetonitrile and 1.5 g (3.7 mmol) of tris(pentafluoroethyl)phosphine oxide, (C2F5)3P=0 at 0° C. After stirring for 30 min at room temperature the homogeneous solution is formed. To complete the reaction, the mixture is left stirred at room temperature for 21 hours and then all volatile products
are removed under high vacuum (10"3 mbar). The white solid product (1.5 g; yield is 88 % calculating on3,5-di-f-butyl-4-hydroxy-benzyl hydrazine) is moved into the glove-box to take the NMR probe and to measure the melting point (M.p. = 106 - 108° C). NMR spectra are recorded in the dry acetonitrile-D3 and confirm the formation of bis(pentafluoroethyl)phosphinyl- N(3,5-di-i-butyl-4-hydroxy-benzyl)hydrazide, (C2F5)2P(O)NHNHCH2[3,5-(f- C4H9)2-C6H2-4-OH].
19F NMR (Solvent: CD3CN; Reference substance: CCI3F), δ, ppm: -81 .2 m (CF3), 122.0 (centre of A,B doublet) d,d,m (FA, CF2), 124.3 (centre of A,B doublet) d,d,m (Fb, CF2), 2JP,F(A) = 72 Hz, 2JP,F(B) = 81 Hz, JF(A).F<B) = 335 Hz.
3 P NMR (Solvent: CD3CN; Reference substance: 85 % H3PO4), δ, ppm: 9.2 quin.d, 2JP,H = 37 Hz, 2JP,F = 76 Hz.
1H NMR (Solvent: CD3CN; Reference substance: TMS), δ, ppm: 1.38 br.s (18H, 6CH3), 3,82 s (2H, CH2), 4.38 br.s (OH), 5.41 s (NH), 6.69 br.d (NH), 7.10 s (2H, ArH); 2JP,H = 39 Hz. Example 6: Oxidation of Bis(pentafluoroethyl)phosphinyl-N(3,5-di-f- butyl-4-hydroxy-benzyl)hydrazide to stable radical, (C2F5)2P(O)NHNHCH2[3,5-(f-C4H9)2-C6H2-4-O ]
0.084 g (0.16 mmol) of bis(pentafluoroethyl)phosphinyl-N(3,5-di-i-butyl-4- hydroxy-benzyl)hydrazide, (C2F5)2P(0)NHNHCH2[3,5-(f-C4H9)2-C6H2- -OH] is dissolved in 1.5 ml of dry toluene and 0.10 g (0.46 mmol) of PbO2 is added in inert atmosphere. The reaction mixture is stirred for 30 min at room temperature. The colouring of the solution changes to yellow that
indicates the formation of radical species. The UV-spectra (see Figure 1) also confirmes the formation of stable radical. The colour of the solution in closed flask remains unchanged for several weeks.
Claims
1. Compounds of formula (I)
RF independently of one another are fluorinated linear or fluorinated branched alkyl or fluorinated phenyl, optionally comprising one or more oxygen atoms, or fluorinated alkylphenyl, and
R1, R2 and R3 independently of one another are H, phenyl, substituted phenyl, alkylphenyl, linear or branched alkyl optionally comprising one or more aromatic rings, heteroaromatic ring, oxygen atoms, sulfur atoms, double bonds and/or triple bonds, whereby one or more H atoms may be substituted by halogen, especially CI and/or fluorine atoms.
2. Compounds according to claim 1 , wherein RF independently of one another are perfluorinated linear or perfluorinated branched alkyl or perfluorinated phenyl.
3. Compounds according to any of claims 1 or 2, wherein RF
independently of one another are perfluorinated linear or
perfluorinated branched C2 bis Ci2 alkyl, optionally comprising one or more oxygen atoms.
4. Compounds according to any of claims 1 to 3, wherein R , R2 and R3 independently of one another are linear or branched Ci bis C20 alkyl.
5. Use of compounds according to any of claim 1 to 4 for synthesis of organic compounds comprising (Rf)2P(O) groups, wherein Rf has the meaning according to claims 1 to 4.
6. Use of compounds according to any of claim 1 to 4 as phase-transfer catalysts, surfactants, lubricants, plasticizers, flames retardants, foams forming agents, starting material for generating of stable radicals and synthesis of molecular magnetic materials for molecular recognition by spectroscopic methods, antioxidants, components or additives to polymeric or painting compositions, or as additives to electrolytes in electrochemical cells.
7. Process for preparation of compounds to any of claims 1 to 4 via interaction of hydrazines of formula (II)
R1R2N-NHR3 (II)
with fluorinated tris(alkyl)phosphine oxides of formula (III) or fluorinated phosphinic acid derivatives of formula (IV)
wherein RF independently of one another are fluorinated linear or fluorinated branched alkyl, optionally comprising one or more oxygen atoms, or fluorinated phenyl or fluorinated alkylphenyl,
R1, R2 and R3 independently of one another are H, phenyl, substituted phenyl, alkylphenyl, linear or branched alkyl optionally comprising one or more aromatic rings, heteroaromatic ring, oxygen atoms, sulfur atoms, double bonds and/or triple bonds, whereby one or more H atoms may be substituted by halogen, especially CI and/or F atoms, and X is halogen, especially CI or F.
8. Process according to claim 7, wherein RF independently of one
another are perfluorinated linear or perfluorinated branched alkyl or perfluorinated phenyl.
9. Process according to any of claims 7 or 8, wherein RF independently of one another are perfluonnated linear or perfluonnated branched C2 bis C12 a'kyl, optionally comprising one or more oxygen atoms.
10. Process according to any of claims 7 to 9, wherein R1 , R2 and R3 independently of one another are linear or branched Ci bis C20 alkyl.
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2451178A1 (en) * | 1973-10-31 | 1975-05-07 | Ciba Geigy Ag | BENZYLATED PHOSPHORIC ACID HYDRACIDES |
WO2000021969A1 (en) | 1998-10-09 | 2000-04-20 | Merck Patent Gmbh | Electrochemical synthesis of perfluoroalkylfluorophosphoranes |
-
2011
- 2011-01-18 WO PCT/EP2011/000189 patent/WO2011095277A1/en active Application Filing
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Patent Citations (2)
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DE2451178A1 (en) * | 1973-10-31 | 1975-05-07 | Ciba Geigy Ag | BENZYLATED PHOSPHORIC ACID HYDRACIDES |
WO2000021969A1 (en) | 1998-10-09 | 2000-04-20 | Merck Patent Gmbh | Electrochemical synthesis of perfluoroalkylfluorophosphoranes |
Non-Patent Citations (10)
Title |
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"Chemistry, Biochemistry and Technology", 1980, ELSVIER |
BAGROV ET AL, RUSS. J. GEN. CHEM., vol. 63, no. 7, 1993, pages 1109 - 1111, XP008135036 * |
BEJAN ET AL, J. FLUOR. CHEM., vol. 131, 14 November 2009 (2009-11-14), pages 325 - 332, XP002630528 * |
H. BOCK; E. BALTIN, CHEMISCHE BERICHTE, vol. 98, 1965, pages 2844 - 2854 |
JOHN. A. GLADYSZ, DENNIS P. CURRAN, ISTVÁN T. HORVÁTH: "Handbook of Fluorous Chemistry", 30 June 2005 (2005-06-30), pages I - xxix, XP002630708, ISBN: 9783527603909, Retrieved from the Internet <URL:http://onlinelibrary.wiley.com/doi/10.1002/3527603905.fmatter/pdf> [retrieved on 20110331], DOI: 10.1002/3527603905 * |
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MOSKALEV ET AL, RUSS. J. ORG. CHEM., vol. 30, no. 5, 1994, pages 785 - 789, XP008135035 * |
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STEININGER, MONATSHEFTE FUR CHEMIE, vol. 97, 1966, pages 383 - 390 |
V.YA. SEMENII; V.A. STEPANOV; N.V. IGNATYEV; G.G. FURIN; L.M. YAGUPOLSKII, ZH. OBSHCH. KHIM., vol. 55, 1985, pages 2716 - 2720 |
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