WO2011087802A3 - Illumination methods and systems for improving image resolution of imaging systems - Google Patents

Illumination methods and systems for improving image resolution of imaging systems Download PDF

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Publication number
WO2011087802A3
WO2011087802A3 PCT/US2010/061653 US2010061653W WO2011087802A3 WO 2011087802 A3 WO2011087802 A3 WO 2011087802A3 US 2010061653 W US2010061653 W US 2010061653W WO 2011087802 A3 WO2011087802 A3 WO 2011087802A3
Authority
WO
WIPO (PCT)
Prior art keywords
systems
illumination
microscope
light
illumination beam
Prior art date
Application number
PCT/US2010/061653
Other languages
French (fr)
Other versions
WO2011087802A2 (en
Inventor
Miao Zhang
Hui Hu
Original Assignee
Miao Zhang
Hui Hu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miao Zhang, Hui Hu filed Critical Miao Zhang
Priority to EP10843550A priority Critical patent/EP2517064A2/en
Priority to US13/517,960 priority patent/US20120289832A1/en
Priority to CN201080064871XA priority patent/CN103038691A/en
Publication of WO2011087802A2 publication Critical patent/WO2011087802A2/en
Publication of WO2011087802A3 publication Critical patent/WO2011087802A3/en

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/10—Condensers affording dark-field illumination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microscoopes, Condenser (AREA)

Abstract

Method and systems for improving resolution of imaging systems, such as a microscope or a medical ultrasonic scanner, are provided. The resolution of the microscope is improved by reducing direct illumination of unrelated regions of an object under examination. According to an aspect of the present invention, a method is provided to reduce the direct illumination of the unrelated regions in a detectable region such as a cone of light that otherwise could generate substantial noises. In another aspect of the invention, a method is provided that focuses the illumination beams such that the width of the projected beam spot is narrowed, preventing the generation of a large amount of noise. In particular, the width of the illumination beam is narrowed such that the size of the projected illumination beam is smaller than the field of view of the microscope. In another aspect of the invention, a system according to the principles of the present invention is provided, wherein the illumination beam of light is such arranged that the overlap of the path of the illumination beam of light and the detectable region is reduced.
PCT/US2010/061653 2009-12-22 2010-12-21 Illumination methods and systems for improving image resolution of imaging systems WO2011087802A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP10843550A EP2517064A2 (en) 2009-12-22 2010-12-21 Illumination methods and systems for improving image resolution of imaging systems
US13/517,960 US20120289832A1 (en) 2009-12-22 2010-12-21 Illumination Methods And Systems For Improving Image Resolution Of Imaging Systems
CN201080064871XA CN103038691A (en) 2009-12-22 2010-12-21 Methods and systems for improving image resolution of imaging systems

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28932709P 2009-12-22 2009-12-22
US61/289,327 2009-12-22
US95909410A 2010-12-02 2010-12-02
US12/959,094 2010-12-02

Publications (2)

Publication Number Publication Date
WO2011087802A2 WO2011087802A2 (en) 2011-07-21
WO2011087802A3 true WO2011087802A3 (en) 2011-10-20

Family

ID=44304892

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/061653 WO2011087802A2 (en) 2009-12-22 2010-12-21 Illumination methods and systems for improving image resolution of imaging systems

Country Status (3)

Country Link
EP (1) EP2517064A2 (en)
CN (1) CN103038691A (en)
WO (1) WO2011087802A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9176054B2 (en) * 2012-06-07 2015-11-03 Canon Kabushiki Kaisha System for tomographic imaging using coherent light that has a random phase distribution
CN105300887B (en) * 2015-10-10 2018-06-29 中国航空工业集团公司北京航空材料研究院 A kind of method of laser-ultrasound non-destructive testing material texture
CN107101942B (en) * 2017-05-17 2019-04-23 大连理工大学 A kind of probe being used to polarize micro-imaging based on bimetal nano particles
CN107918576B (en) * 2017-10-31 2023-03-28 深圳市鸿合创新信息技术有限责任公司 OPS module plug protection device and electronic equipment
CN113613544B (en) * 2019-03-22 2024-05-28 奥林巴斯株式会社 Endoscope with a lens
CN111722392B (en) * 2020-07-22 2021-06-08 南京大学 Large-view-field integrated microscopic imaging device based on super-structured lens array
CN112162395A (en) * 2020-10-27 2021-01-01 江苏三米科思半导体设备有限公司 Deep ultraviolet oblique incidence high-resolution dark field illumination optical system
CN116067880B (en) * 2023-01-05 2024-03-05 睿励科学仪器（上海）有限公司 Method and device for determining parameters of objective lens hood and objective lens hood

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020185615A1 (en) * 2001-06-08 2002-12-12 Thomas Giering Apparatus and method for examining documents
US20080100839A1 (en) * 2006-10-31 2008-05-01 Fouquet Julie E Method and system for measuring light propagating at multiple wavelengths
US20080265175A1 (en) * 2005-07-21 2008-10-30 Koninklijke Philips Electronics, N.V. Device for Detection of Excitation Using a Multiple Spot Arrangement

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6663560B2 (en) * 1999-12-17 2003-12-16 Digital Optical Imaging Corporation Methods and apparatus for imaging using a light guide bundle and a spatial light modulator
CN1170183C (en) * 2002-03-19 2004-10-06 天津大学 High-speed laser-confocal scanning microscopic imaging apparatus
EP1699349A1 (en) * 2003-12-22 2006-09-13 Koninklijke Philips Electronics N.V. Apparatus and method for performing orthogonal polarized spectral imaging (opsi)
CN100460922C (en) * 2007-05-29 2009-02-11 华中科技大学同济医学院附属同济医院 Stereomicroscope side-irradiation type lighting method and its dark view stereomicroscope

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020185615A1 (en) * 2001-06-08 2002-12-12 Thomas Giering Apparatus and method for examining documents
US20080265175A1 (en) * 2005-07-21 2008-10-30 Koninklijke Philips Electronics, N.V. Device for Detection of Excitation Using a Multiple Spot Arrangement
US20080100839A1 (en) * 2006-10-31 2008-05-01 Fouquet Julie E Method and system for measuring light propagating at multiple wavelengths

Also Published As

Publication number Publication date
CN103038691A (en) 2013-04-10
EP2517064A2 (en) 2012-10-31
WO2011087802A2 (en) 2011-07-21

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