WO2011083495A8 - Process for the preparation of dihydroxy protected derivatives and novel intermediate compounds - Google Patents

Process for the preparation of dihydroxy protected derivatives and novel intermediate compounds Download PDF

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Publication number
WO2011083495A8
WO2011083495A8 PCT/IN2011/000011 IN2011000011W WO2011083495A8 WO 2011083495 A8 WO2011083495 A8 WO 2011083495A8 IN 2011000011 W IN2011000011 W IN 2011000011W WO 2011083495 A8 WO2011083495 A8 WO 2011083495A8
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
protected derivatives
intermediate compounds
novel intermediate
dihydroxy
Prior art date
Application number
PCT/IN2011/000011
Other languages
French (fr)
Other versions
WO2011083495A2 (en
WO2011083495A3 (en
Inventor
Manne Satyanarayana Reddy
Srinivasan Thirumalai Rajan
Maramreddy Sahadeva Reddy
Original Assignee
Msn Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Limited filed Critical Msn Laboratories Limited
Publication of WO2011083495A2 publication Critical patent/WO2011083495A2/en
Publication of WO2011083495A8 publication Critical patent/WO2011083495A8/en
Publication of WO2011083495A3 publication Critical patent/WO2011083495A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The present invention relates to an improved process for the preparation of dihydroxy protected derivatives, which are important intermediates in the preparation of HMG-CoA reductase inhibitors.
PCT/IN2011/000011 2010-01-07 2011-01-07 Process for the preparation of dihydroxy protected derivatives and novel intermediate compounds WO2011083495A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN41CH2010 2010-01-07
IN41/CHE/2010 2010-01-07
IN471/CHE/2010 2010-02-24
IN471CH2010 2010-02-24

Publications (3)

Publication Number Publication Date
WO2011083495A2 WO2011083495A2 (en) 2011-07-14
WO2011083495A8 true WO2011083495A8 (en) 2011-08-25
WO2011083495A3 WO2011083495A3 (en) 2011-10-13

Family

ID=44305898

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000011 WO2011083495A2 (en) 2010-01-07 2011-01-07 Process for the preparation of dihydroxy protected derivatives and novel intermediate compounds

Country Status (1)

Country Link
WO (1) WO2011083495A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8987444B2 (en) * 2010-01-18 2015-03-24 Msn Laboratories Private Limited Process for the preparation of amide intermediates and their use thereof
CN104513232A (en) * 2015-01-08 2015-04-15 苏州莱克施德药业有限公司 Preparation process for rosuvastatin ethyl ester
CN109574938B (en) * 2017-09-28 2022-04-22 安徽省庆云医药股份有限公司 Method for synthesizing rosuvastatin sodium
CN113956243A (en) * 2020-12-31 2022-01-21 宣城美诺华药业有限公司 Rosuvastatin intermediate and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6151555A (en) * 1999-03-09 2000-11-21 Schlumberger Technology Corporation Seismic signal processing method and apparatus for generating a cube of variance values
US8455640B2 (en) * 2006-05-03 2013-06-04 Msn Laboratories Limited Process for statins and its pharmaceutically acceptable salts thereof
WO2010023678A1 (en) * 2008-08-27 2010-03-04 Biocon Limited A process for preparation of rosuvastatin intermediate

Also Published As

Publication number Publication date
WO2011083495A2 (en) 2011-07-14
WO2011083495A3 (en) 2011-10-13

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