WO2011073905A8 - Novel tumor markers - Google Patents

Novel tumor markers Download PDF

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Publication number
WO2011073905A8
WO2011073905A8 PCT/IB2010/055805 IB2010055805W WO2011073905A8 WO 2011073905 A8 WO2011073905 A8 WO 2011073905A8 IB 2010055805 W IB2010055805 W IB 2010055805W WO 2011073905 A8 WO2011073905 A8 WO 2011073905A8
Authority
WO
WIPO (PCT)
Prior art keywords
stage
progressed
cancer
tumor markers
progression
Prior art date
Application number
PCT/IB2010/055805
Other languages
French (fr)
Other versions
WO2011073905A1 (en
Inventor
Ralf Hoffmann
Original Assignee
Koninklijke Philips Electronics N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP09179125A external-priority patent/EP2295977A1/en
Application filed by Koninklijke Philips Electronics N.V. filed Critical Koninklijke Philips Electronics N.V.
Priority claimed from PCT/IB2010/055796 external-priority patent/WO2011073896A1/en
Publication of WO2011073905A1 publication Critical patent/WO2011073905A1/en
Publication of WO2011073905A8 publication Critical patent/WO2011073905A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to a tumor marker or group of tumor markers associated with the progression of a cancer disease from a less progressed stage to a more progressed stage, wherein the expression of the tumor markers is modified when comparing the expression in the less progressed stage and in the more progressed stage. The present invention further relates to a composition for diagnosing, detecting, graduating, monitoring or prognosticating a cancer disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage comprising affinity ligands for the expression products of the tumor markers, to corresponding methods, and to the use of said tumor markers for detecting, diagnosing,graduating, monitoring or prognosticating a cancer disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage. The present invention further relates to a corresponding immunoassay, to a method of identifying an individual for eligibility for a cancer disease therapy, as well as to a pharmaceutical composition based on the inhibition of the expression of said tumor markers. The present invention further relates to a corresponding immunoassay for stratifying a patient or cohort of patients with a cancer disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage to a therapeutic treatment for monitoring a therapeutic treatment of the stratified patient(s) during the progression from a less progressed cancer stage to a more progressed cancer stage.
PCT/IB2010/055805 2009-12-14 2010-12-14 Novel tumor markers WO2011073905A1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
EP09179125.1 2009-12-14
EP09179125A EP2295977A1 (en) 2009-09-03 2009-12-14 Novel tumor markers
EP10155369 2010-03-03
EP10155369.1 2010-03-03
EP10165039.8 2010-06-07
EP10165039 2010-06-07
PCT/IB2010/055796 WO2011073896A1 (en) 2009-12-14 2010-12-14 Novel tumor markers
IBPCT/IB2010/055796 2010-12-14

Publications (2)

Publication Number Publication Date
WO2011073905A1 WO2011073905A1 (en) 2011-06-23
WO2011073905A8 true WO2011073905A8 (en) 2011-12-08

Family

ID=44246840

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2010/055805 WO2011073905A1 (en) 2009-12-14 2010-12-14 Novel tumor markers

Country Status (1)

Country Link
WO (1) WO2011073905A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013182537A1 (en) 2012-06-07 2013-12-12 F. Hoffmann-La Roche Ag Autoimmune antibodies
EP3102944B1 (en) * 2014-02-04 2018-10-10 CellTrend GmbH Diagnosis of cancer by detecting auto-antibodies against egf-receptor
GB201521746D0 (en) * 2015-12-10 2016-01-27 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against CLL and other cancers
WO2019139754A2 (en) * 2017-12-19 2019-07-18 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions and methods for fetal growth

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002090580A1 (en) * 2001-05-03 2002-11-14 National Cancer Centre Of Singapore Pte Ltd Identifying liver cancer by detecting aberrant expression of insulin like growth factor binding protein
AU2003298689A1 (en) * 2002-11-21 2004-06-18 Wyeth Methods for diagnosing rcc and other solid tumors
AU2003298786A1 (en) * 2002-11-26 2004-06-18 Protein Design Labs, Inc. Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators

Also Published As

Publication number Publication date
WO2011073905A1 (en) 2011-06-23

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