WO2011070436A3 - In situ cross linked biodegradable gel with hydrophobic pockets - Google Patents

In situ cross linked biodegradable gel with hydrophobic pockets Download PDF

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Publication number
WO2011070436A3
WO2011070436A3 PCT/IB2010/003190 IB2010003190W WO2011070436A3 WO 2011070436 A3 WO2011070436 A3 WO 2011070436A3 IB 2010003190 W IB2010003190 W IB 2010003190W WO 2011070436 A3 WO2011070436 A3 WO 2011070436A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrophobic
cross linked
biodegradable gel
situ cross
hydrophobic pockets
Prior art date
Application number
PCT/IB2010/003190
Other languages
French (fr)
Other versions
WO2011070436A2 (en
Inventor
Jitendra Jaikumar Gangwal
Mohan Gopalkrishna Kulkarni
Original Assignee
Council Of Scientific & Industrial Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council Of Scientific & Industrial Research filed Critical Council Of Scientific & Industrial Research
Publication of WO2011070436A2 publication Critical patent/WO2011070436A2/en
Publication of WO2011070436A3 publication Critical patent/WO2011070436A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
    • C08G73/1092—Polysuccinimides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2379/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen, or carbon only, not provided for in groups C08J2361/00 - C08J2377/00
    • C08J2379/04—Polycondensates having nitrogen-containing heterocyclic rings in the main chain; Polyhydrazides; Polyamide acids or similar polyimide precursors
    • C08J2379/08—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

Hydrophilic biodegradable gel incorporating hydrophobic pocket/cavity immobilized by a cross linker where the gel comprises a polymer backbone of polyaspartic acid substituted with a hydrophobic and a hydrophilic amine is disclosed. The pocket/cavity comprises at least one hydrophobic moiety, and is useful for drug delivery and tissue reconstruction.
PCT/IB2010/003190 2009-12-11 2010-12-10 In situ cross linked biodegradable gel with hydrophobic pockets WO2011070436A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2575DE2009 2009-12-11
IN2575/DEL/2009 2009-12-11

Publications (2)

Publication Number Publication Date
WO2011070436A2 WO2011070436A2 (en) 2011-06-16
WO2011070436A3 true WO2011070436A3 (en) 2011-08-11

Family

ID=44022885

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2010/003190 WO2011070436A2 (en) 2009-12-11 2010-12-10 In situ cross linked biodegradable gel with hydrophobic pockets

Country Status (1)

Country Link
WO (1) WO2011070436A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2890804A4 (en) * 2013-05-17 2016-10-05 Xyleco Inc Processing biomass
WO2015130877A1 (en) 2014-02-26 2015-09-03 University Of Massachusetts Medical School Amphiphilic degradable polymers for immobilization and sustained delivery of biomolecules

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10292044A (en) * 1997-02-07 1998-11-04 Mitsui Chem Inc Water-absorbent film and sheet, and production of them
WO1999037624A1 (en) * 1998-01-27 1999-07-29 Donlar Corporation Super-absorbing polymeric networks
US5998492A (en) * 1994-09-13 1999-12-07 Donlar Corporation Super-absorbing polymeric networks
JP2003012801A (en) * 2001-07-03 2003-01-15 Mitsui Chemicals Inc Continuous method for producing crosslinked polysuccinimide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
KR100360827B1 (en) 1999-08-14 2002-11-18 주식회사 삼양사 Polymeric composition for solubilizing poorly water soluble drugs and process for the preparation thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998492A (en) * 1994-09-13 1999-12-07 Donlar Corporation Super-absorbing polymeric networks
JPH10292044A (en) * 1997-02-07 1998-11-04 Mitsui Chem Inc Water-absorbent film and sheet, and production of them
WO1999037624A1 (en) * 1998-01-27 1999-07-29 Donlar Corporation Super-absorbing polymeric networks
JP2003012801A (en) * 2001-07-03 2003-01-15 Mitsui Chemicals Inc Continuous method for producing crosslinked polysuccinimide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 200359, Derwent World Patents Index; AN 2003-620818, XP002639831 *

Also Published As

Publication number Publication date
WO2011070436A2 (en) 2011-06-16

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