WO2011070152A3 - Analogues de la 3 - deazauridine phenyles en position c3 en tant que composes antiviraux - Google Patents

Analogues de la 3 - deazauridine phenyles en position c3 en tant que composes antiviraux Download PDF

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Publication number
WO2011070152A3
WO2011070152A3 PCT/EP2010/069375 EP2010069375W WO2011070152A3 WO 2011070152 A3 WO2011070152 A3 WO 2011070152A3 EP 2010069375 W EP2010069375 W EP 2010069375W WO 2011070152 A3 WO2011070152 A3 WO 2011070152A3
Authority
WO
WIPO (PCT)
Prior art keywords
deazauridine
analogues
compounds
phenylated
hydrogen atom
Prior art date
Application number
PCT/EP2010/069375
Other languages
English (en)
Other versions
WO2011070152A2 (fr
Inventor
François Xavier FELPIN
Nathalie Bourgougnon
Marion Zanese
Original Assignee
Universite De Bordeaux 1
Universite De Bretagne Sud
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite De Bordeaux 1, Universite De Bretagne Sud filed Critical Universite De Bordeaux 1
Publication of WO2011070152A2 publication Critical patent/WO2011070152A2/fr
Publication of WO2011070152A3 publication Critical patent/WO2011070152A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux composés antiviraux, analogues de la 3-deazauridine arylés en position C3, un procédé de synthèse de ces composés, ainsi que leurs applications antivirales. Les composés sont de formule générale (I): dans laquelle R1 représente un atome d'hydrogène ou un acyle en C2-C6, R2, R3, R4, R5 et R6 sont indépendamment choisis parmi un atome d'hydrogène, un alkyle en C1-C6, un alcoxy en C1-C6, un atome d'halogène, un groupement nitro ou un groupement cyano, sous réserve qu'au moins un de R2, R3, R4, R5 et R6 n'est pas l'atome d'hydrogène, ainsi que leurs sels pharmaceutiquement acceptables, leurs énantiomères ou diastéréoisomères ou des mélanges de ceux-ci.
PCT/EP2010/069375 2009-12-10 2010-12-10 Nouveaux composés antiviraux, analogues de la 3-deazauridine aryles en position c3 WO2011070152A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0958842 2009-12-10
FR0958842A FR2953835B1 (fr) 2009-12-10 2009-12-10 Nouveaux composes antiviraux, analogues de la 3-deazauridine aryles en position c3

Publications (2)

Publication Number Publication Date
WO2011070152A2 WO2011070152A2 (fr) 2011-06-16
WO2011070152A3 true WO2011070152A3 (fr) 2012-03-15

Family

ID=42937485

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/069375 WO2011070152A2 (fr) 2009-12-10 2010-12-10 Nouveaux composés antiviraux, analogues de la 3-deazauridine aryles en position c3

Country Status (2)

Country Link
FR (1) FR2953835B1 (fr)
WO (1) WO2011070152A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014186435A2 (fr) 2013-05-14 2014-11-20 University Of Georgia Research Foundation, Inc. Compositions et procédés de réduction de la formation de néo-intima

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3836645A (en) * 1972-06-23 1974-09-17 Icn Pharmaceuticals Anti-viral compositions containing 3-deaza nucleosides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3836645A (en) * 1972-06-23 1974-09-17 Icn Pharmaceuticals Anti-viral compositions containing 3-deaza nucleosides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LEGRAVEREND M ET AL: "SYNTHESIS AND BIOLOGICAL EVALUATION OF 3 DEAZACYTIDINE AND 3 DEAZAURIDINE DERIVATIVES", NUCLEOSIDES & NUCLEOTIDES, MARCEL DEKKER, INC, US, vol. 5, no. 2, 1 January 1986 (1986-01-01), pages 125 - 134, XP009140114, ISSN: 0732-8311 *
MCNAMARA D J ET AL: "Synthesis, antitumor activity, and antiviral activity of 3-substituted 3-deazacytidines and 3-substituted 3-deazauridines", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US LNKD- DOI:10.1021/JM00169A032, vol. 33, no. 7, 1 July 1990 (1990-07-01), pages 2006 - 2011, XP002548340, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
FR2953835B1 (fr) 2012-07-27
WO2011070152A2 (fr) 2011-06-16
FR2953835A1 (fr) 2011-06-17

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