WO2011061561A3 - Method of obtaining regenerative molecular matrices and regenerative molecular matrices thus obtained - Google Patents

Method of obtaining regenerative molecular matrices and regenerative molecular matrices thus obtained Download PDF

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Publication number
WO2011061561A3
WO2011061561A3 PCT/IB2009/055180 IB2009055180W WO2011061561A3 WO 2011061561 A3 WO2011061561 A3 WO 2011061561A3 IB 2009055180 W IB2009055180 W IB 2009055180W WO 2011061561 A3 WO2011061561 A3 WO 2011061561A3
Authority
WO
WIPO (PCT)
Prior art keywords
regeneration
tissue
matrices
guided
hard
Prior art date
Application number
PCT/IB2009/055180
Other languages
Spanish (es)
French (fr)
Other versions
WO2011061561A2 (en
Inventor
Elda Restrepo
Original Assignee
Elda Restrepo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elda Restrepo filed Critical Elda Restrepo
Priority to PCT/IB2009/055180 priority Critical patent/WO2011061561A2/en
Publication of WO2011061561A2 publication Critical patent/WO2011061561A2/en
Publication of WO2011061561A3 publication Critical patent/WO2011061561A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/363—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

Abstract

The present application relates to a method for obtaining regenerative molecular matrices which induce, through cell signalling, selective differentiation of the mesenchymal stem cells present in all connective tissues. Furthermore, there is claimed the matrix which is obtained by means of said method and which possesses properties of regeneration of hard and soft connective tissues, having uses for both humans and animals. The matrix disclosed is relevant for multiple applications, inter alia, for the regeneration of soft tissue, such as mucus and skin; regeneration of hard tissue, including bone and cartilage; epithelial regeneration and keratinisation; tissue adhesion, cicatrisation, conservation and autologous or cultivated cell implantation, reduction or elimination of postsurgical paresthesia, local haemostasis, release and local transfer of molecules and medicaments, bioabsorbable matrices with barrier effect (guided osseoregeneration or guided periodontal regeneration), tissue neovascularisation and revascularisation, optimisation of reimplantation of structures or tissues lost through trauma, prosthetic osseointegration, etc.
PCT/IB2009/055180 2009-11-19 2009-11-19 Method of obtaining regenerative molecular matrices and regenerative molecular matrices thus obtained WO2011061561A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IB2009/055180 WO2011061561A2 (en) 2009-11-19 2009-11-19 Method of obtaining regenerative molecular matrices and regenerative molecular matrices thus obtained

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2009/055180 WO2011061561A2 (en) 2009-11-19 2009-11-19 Method of obtaining regenerative molecular matrices and regenerative molecular matrices thus obtained

Publications (2)

Publication Number Publication Date
WO2011061561A2 WO2011061561A2 (en) 2011-05-26
WO2011061561A3 true WO2011061561A3 (en) 2012-08-23

Family

ID=44060120

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/055180 WO2011061561A2 (en) 2009-11-19 2009-11-19 Method of obtaining regenerative molecular matrices and regenerative molecular matrices thus obtained

Country Status (1)

Country Link
WO (1) WO2011061561A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5570111A1 (en) * 2005-04-13 2005-10-31 Elda Restrepo NEW TECHNIQUE TO OBTAIN IN A SINGLE PHASE AUTOMOTIVE GROWTH, THROMBIN AND FIBRINE FACTORS, TO BE APPLIED IN GELIFIED FORM
US20080199513A1 (en) * 1997-06-24 2008-08-21 Cascade Medical Enterprises, Llc Systems and methods for preparing autologous fibrin glue
ES2306655T3 (en) * 1999-01-26 2008-11-16 Eduardo Anitua Aldecoa COMPOSITION FOR THE REGENERATION OF OSEO FABRIC.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080199513A1 (en) * 1997-06-24 2008-08-21 Cascade Medical Enterprises, Llc Systems and methods for preparing autologous fibrin glue
ES2306655T3 (en) * 1999-01-26 2008-11-16 Eduardo Anitua Aldecoa COMPOSITION FOR THE REGENERATION OF OSEO FABRIC.
CO5570111A1 (en) * 2005-04-13 2005-10-31 Elda Restrepo NEW TECHNIQUE TO OBTAIN IN A SINGLE PHASE AUTOMOTIVE GROWTH, THROMBIN AND FIBRINE FACTORS, TO BE APPLIED IN GELIFIED FORM

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DOHAN M. D. ET AL.: "Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF).", TRENDS IN BIOTECHNOLOGY., vol. 27, no. 3, 31 January 2009 (2009-01-31), pages 158 - 167, XP025958233, DOI: doi:10.1016/j.tibtech.2008.11.009 *
EPPLEY, B. ET AL.: "Platelet Quantification and Growth Factor Analysis from Platelet-Rich Plasma: Implications for Wound Healing.", PLASTIC AND RECONSTRUCTION SURGERY., vol. 114, November 2004 (2004-11-01), pages 1502 - 1508 *

Also Published As

Publication number Publication date
WO2011061561A2 (en) 2011-05-26

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