WO2011049400A3 - N,n-디메틸 이미도디카르본이미딕 디아미드의 산 부가염을 포함하는 항암용 약제학적 조성물 - Google Patents

N,n-디메틸 이미도디카르본이미딕 디아미드의 산 부가염을 포함하는 항암용 약제학적 조성물 Download PDF

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Publication number
WO2011049400A3
WO2011049400A3 PCT/KR2010/007273 KR2010007273W WO2011049400A3 WO 2011049400 A3 WO2011049400 A3 WO 2011049400A3 KR 2010007273 W KR2010007273 W KR 2010007273W WO 2011049400 A3 WO2011049400 A3 WO 2011049400A3
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WO
WIPO (PCT)
Prior art keywords
salt
acid addition
addition salt
metformin
dimethyl
Prior art date
Application number
PCT/KR2010/007273
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English (en)
French (fr)
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WO2011049400A2 (ko
Inventor
김성욱
전성수
김영웅
오병규
이승호
Original Assignee
한올바이오파마주식회사
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Application filed by 한올바이오파마주식회사 filed Critical 한올바이오파마주식회사
Publication of WO2011049400A2 publication Critical patent/WO2011049400A2/ko
Publication of WO2011049400A3 publication Critical patent/WO2011049400A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

N,N-디메틸 이미도디카르본이미딕 디아미드(메트포르민)의 디클로로아세트산염 또는 아미노옥시아세트산염의 항암 용도가 제공된다. 본 발명에 따른 메트포르민의 산 부가염은 메트포르민의 AMPK 효소 활성화에 따른 항암 효과와 염으로 사용된 유기산들의 항암 효과가 상승적으로 작용하여 항암 효과가 현저히 우수해진다. 또한, 메트포르민 염산염에 비해 용해도, 안정성, 비흡습성, 정제 제형으로서의 가공성 등의 물리화학적 성질이 우수하고, 독성이 낮아, 메트포르민의 약제학적으로 허용되는 염으로써 유용하게 이용될 수 있다.
PCT/KR2010/007273 2009-10-23 2010-10-22 N,n-디메틸 이미도디카르본이미딕 디아미드의 산 부가염을 포함하는 항암용 약제학적 조성물 WO2011049400A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20090101413 2009-10-23
KR10-2009-0101413 2009-10-23

Publications (2)

Publication Number Publication Date
WO2011049400A2 WO2011049400A2 (ko) 2011-04-28
WO2011049400A3 true WO2011049400A3 (ko) 2011-11-03

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Application Number Title Priority Date Filing Date
PCT/KR2010/007273 WO2011049400A2 (ko) 2009-10-23 2010-10-22 N,n-디메틸 이미도디카르본이미딕 디아미드의 산 부가염을 포함하는 항암용 약제학적 조성물

Country Status (1)

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WO (1) WO2011049400A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015183956A1 (en) * 2014-05-27 2015-12-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of abl1 inhibitors with ampk activators for treating fumarate hydratase-deficient cancer

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957853A (en) * 1973-09-19 1976-05-18 Societe D'etudes Et D'exploitation De Marques Et Brevets S.E.M.S. Metformine salt of acetylsalicylic acid
US4028402A (en) * 1974-10-11 1977-06-07 Hoffmann-La Roche Inc. Biguanide salts
US4080472A (en) * 1974-03-22 1978-03-21 Societe D'etudes Et D'exploitation De Marques Et Brevets S.E.M.S. Metformin 2-(p-chlorophenoxy)-2-methylpropionate
US4835184A (en) * 1985-07-31 1989-05-30 Albert Rolland Sa Novel pharmaceutical compositions intended to the treatment of neuropathies and promoting the nervous regeneration
US6031004A (en) * 1997-12-08 2000-02-29 Bristol-Myers Squibb Company Salts of metformin and method
KR20080071095A (ko) * 2007-01-29 2008-08-01 한올제약주식회사 Ｎ,ｎ―디메틸 이미도디카르본이미딕 디아미드의 초산염,그의 제조방법 및 그를 포함하는 약제학적 조성물

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957853A (en) * 1973-09-19 1976-05-18 Societe D'etudes Et D'exploitation De Marques Et Brevets S.E.M.S. Metformine salt of acetylsalicylic acid
US4080472A (en) * 1974-03-22 1978-03-21 Societe D'etudes Et D'exploitation De Marques Et Brevets S.E.M.S. Metformin 2-(p-chlorophenoxy)-2-methylpropionate
US4028402A (en) * 1974-10-11 1977-06-07 Hoffmann-La Roche Inc. Biguanide salts
US4835184A (en) * 1985-07-31 1989-05-30 Albert Rolland Sa Novel pharmaceutical compositions intended to the treatment of neuropathies and promoting the nervous regeneration
US6031004A (en) * 1997-12-08 2000-02-29 Bristol-Myers Squibb Company Salts of metformin and method
KR20080071095A (ko) * 2007-01-29 2008-08-01 한올제약주식회사 Ｎ,ｎ―디메틸 이미도디카르본이미딕 디아미드의 초산염,그의 제조방법 및 그를 포함하는 약제학적 조성물

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WO2011049400A2 (ko) 2011-04-28

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