WO2011048589A3 - Ion exchangers and methods of use thereof - Google Patents

Ion exchangers and methods of use thereof Download PDF

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Publication number
WO2011048589A3
WO2011048589A3 PCT/IL2010/000855 IL2010000855W WO2011048589A3 WO 2011048589 A3 WO2011048589 A3 WO 2011048589A3 IL 2010000855 W IL2010000855 W IL 2010000855W WO 2011048589 A3 WO2011048589 A3 WO 2011048589A3
Authority
WO
WIPO (PCT)
Prior art keywords
nclx
exchanger
mitochondrial
stimulating
treating
Prior art date
Application number
PCT/IL2010/000855
Other languages
French (fr)
Other versions
WO2011048589A2 (en
Inventor
Israel Sekler
Michal Hershfinkel
Yoram Yagil
Raz Palty
Original Assignee
Ben Gurion University Of The Negev Research And Development Authority
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ben Gurion University Of The Negev Research And Development Authority filed Critical Ben Gurion University Of The Negev Research And Development Authority
Publication of WO2011048589A2 publication Critical patent/WO2011048589A2/en
Publication of WO2011048589A3 publication Critical patent/WO2011048589A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

This invention provides a method of treating a disease by stimulating or accelerating calcium flux via a mitochondrial Na+/Ca2+ NCLX exchanger. This invention further provides a method of treating a disease by diminishing or abrogating calcium flux via a mitochondrial Na+/Ca2+ NCLX exchanger. This invention also provides compounds and compositions comprising the same for diminishing or abrogating mitochondrial Na+/Ca2+-Li+ exchanger (NCLX) expression or activity, thereby inhibiting apoptosis, or for stimulating or increasing mitochondrial Na+/Ca2+ NCLX exchanger expression or activity, thereby stimulating or accelerating apoptosis. This invention further provides compounds and compositions comprising the same for modulating apoptosis and treating diseases, disorders and/or conditions related thereto.
PCT/IL2010/000855 2009-10-23 2010-10-19 Ion exchangers and methods of use thereof WO2011048589A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27270109P 2009-10-23 2009-10-23
US61/272,701 2009-10-23

Publications (2)

Publication Number Publication Date
WO2011048589A2 WO2011048589A2 (en) 2011-04-28
WO2011048589A3 true WO2011048589A3 (en) 2011-12-01

Family

ID=43900753

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2010/000855 WO2011048589A2 (en) 2009-10-23 2010-10-19 Ion exchangers and methods of use thereof

Country Status (1)

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WO (1) WO2011048589A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4588221B2 (en) 1999-04-05 2010-11-24 エミスフェアー・テクノロジーズ・インク Disodium salts, monohydrates, and ethanol solvates for delivering active agents
US20210330744A1 (en) * 2017-02-10 2021-10-28 Temple University-Of The Commonwealth System Of Higher Education Methods and Compositions for Treating Neurodegeneration and Fibrosis
WO2024156726A1 (en) 2023-01-24 2024-08-02 Vib Vzw MAINTAINING REGULATORY T CELL (Treg) FUNCTIONALITY UNDER CONDITIONS TRIGGERING Treg DYSFUNCTIONALITY

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030077748A1 (en) * 2001-10-03 2003-04-24 Millennium Pharmaceuticals, Inc. 96829, a human transporter family member and uses therefor
US20080166736A1 (en) * 2001-02-16 2008-07-10 Arbor Vita Corporation Pdz domain interactions and lipid rafts
US20080241839A1 (en) * 2006-10-12 2008-10-02 The Regents Of The University Of California Method for correlating differential brain images and genotypes; genes that correlate with differential brain images
US20090010917A1 (en) * 2001-07-17 2009-01-08 Rosenblum Michael G Therapeutic Agents Comprising Pro-Apoptotic Proteins
US20090258794A1 (en) * 2006-02-15 2009-10-15 Bhabatosh Chaudhuri Apoptosis methods, genes and proteins

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080166736A1 (en) * 2001-02-16 2008-07-10 Arbor Vita Corporation Pdz domain interactions and lipid rafts
US20090010917A1 (en) * 2001-07-17 2009-01-08 Rosenblum Michael G Therapeutic Agents Comprising Pro-Apoptotic Proteins
US20030077748A1 (en) * 2001-10-03 2003-04-24 Millennium Pharmaceuticals, Inc. 96829, a human transporter family member and uses therefor
US20090258794A1 (en) * 2006-02-15 2009-10-15 Bhabatosh Chaudhuri Apoptosis methods, genes and proteins
US20080241839A1 (en) * 2006-10-12 2008-10-02 The Regents Of The University Of California Method for correlating differential brain images and genotypes; genes that correlate with differential brain images

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] 10 June 2004 (2004-06-10), "Homo sapiens Na+/Ca2+ K+ independent exchanger (NCLX) mRNA, complete cds, alternatively spliced.", retrieved from http://www.ncbi.nlm.nih.gov/nuccore/AY601759 Database accession no. AY601759. *
PALTY ET AL.: "Lithium-Calcium Exchange Is Mediated by a Distinct Potassium-independent Sodium-Calcium Exchanger.", J BIOL CHEM., vol. 279, no. 24, 2004, pages 25234 - 25240 *
PALTY ET AL.: "NCLX is an essential component of mitochondrial Na+/Ca2+ exchange.", PROC NATL ACAD SCI USA, vol. 107, no. 1, 2009, pages 436 - 441 *
PINTON ET AL.: "Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis.", ONCOGENE, vol. 27, no. 50, 2008, pages 6407 - 6418 *

Also Published As

Publication number Publication date
WO2011048589A2 (en) 2011-04-28

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