WO2009142968A3 - Valproic acid salts - Google Patents

Valproic acid salts Download PDF

Info

Publication number
WO2009142968A3
WO2009142968A3 PCT/US2009/043701 US2009043701W WO2009142968A3 WO 2009142968 A3 WO2009142968 A3 WO 2009142968A3 US 2009043701 W US2009043701 W US 2009043701W WO 2009142968 A3 WO2009142968 A3 WO 2009142968A3
Authority
WO
WIPO (PCT)
Prior art keywords
valproic acid
acid salts
salts
compositions
methods
Prior art date
Application number
PCT/US2009/043701
Other languages
French (fr)
Other versions
WO2009142968A2 (en
Inventor
Cyrus Harmon
David Myles
Original Assignee
Olema Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olema Pharmaceuticals, Inc. filed Critical Olema Pharmaceuticals, Inc.
Publication of WO2009142968A2 publication Critical patent/WO2009142968A2/en
Publication of WO2009142968A3 publication Critical patent/WO2009142968A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to therapeutically acceptable salts of valproic acid, such as tamoxifen valproic acid salt, compositions comprising salts of valproic acid, and methods of treating cancer with valproic acid salts. Compositions according to the invention include pharmaceutical formulations of valproic acid salts. The invention therefore provides methods of treatment and pharmaceutical compositions.
PCT/US2009/043701 2008-05-20 2009-05-13 Valproic acid salts WO2009142968A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5469108P 2008-05-20 2008-05-20
US61/054,691 2008-05-20

Publications (2)

Publication Number Publication Date
WO2009142968A2 WO2009142968A2 (en) 2009-11-26
WO2009142968A3 true WO2009142968A3 (en) 2010-01-14

Family

ID=41340785

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/043701 WO2009142968A2 (en) 2008-05-20 2009-05-13 Valproic acid salts

Country Status (1)

Country Link
WO (1) WO2009142968A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3846789A4 (en) * 2018-09-05 2022-05-25 National Centre For Cell Science A novel anti-cancer combination and a method of therapy using the combination

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4788063A (en) * 1984-08-14 1988-11-29 State Of Israel, Represented By Prime Minister's Office Israel Institute For Biological Research Drug delivery system
US5558877A (en) * 1993-12-23 1996-09-24 Roussel Uclaf Method and device for treatment of cancer
US20080085874A1 (en) * 2006-08-28 2008-04-10 The Regents Of The University Of California Small molecule potentiator of hormonal therapy for breast cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4788063A (en) * 1984-08-14 1988-11-29 State Of Israel, Represented By Prime Minister's Office Israel Institute For Biological Research Drug delivery system
US5558877A (en) * 1993-12-23 1996-09-24 Roussel Uclaf Method and device for treatment of cancer
US20080085874A1 (en) * 2006-08-28 2008-04-10 The Regents Of The University Of California Small molecule potentiator of hormonal therapy for breast cancer

Also Published As

Publication number Publication date
WO2009142968A2 (en) 2009-11-26

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