WO2011046522A2 - Novel uses of reconstituted free testosterone - Google Patents

Novel uses of reconstituted free testosterone Download PDF

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Publication number
WO2011046522A2
WO2011046522A2 PCT/TN2010/000006 TN2010000006W WO2011046522A2 WO 2011046522 A2 WO2011046522 A2 WO 2011046522A2 TN 2010000006 W TN2010000006 W TN 2010000006W WO 2011046522 A2 WO2011046522 A2 WO 2011046522A2
Authority
WO
WIPO (PCT)
Prior art keywords
lowering
product
free testosterone
product allows
insulin
Prior art date
Application number
PCT/TN2010/000006
Other languages
French (fr)
Other versions
WO2011046522A3 (en
Inventor
Rached Smida
Original Assignee
Rached Smida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rached Smida filed Critical Rached Smida
Publication of WO2011046522A2 publication Critical patent/WO2011046522A2/en
Publication of WO2011046522A3 publication Critical patent/WO2011046522A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives

Definitions

  • the essential role of free testosterone is to lower the level of bad cholesterol or LDL cholesterol and the level of triglycerides.
  • I increase the level of free insulin which helps to improve diabetes with lowering of blood sugar.
  • the proposed product is a food supplement that is a mixture of oils that can be produced industrially:
  • This blend of oils is composed of:
  • free testosterone contains choline, chromium and alphalinolenic acid or omega 3
  • arginine which produces nitric oxide (NO which performs multiple functions on the vessels). Also NO is considered as a kind of physiological antagonist of the sympathetic and the renin system
  • angiotensin in the regulation of vascular tone thus lowering blood pressure.

Abstract

The invention relates to novel uses of free testosterone reconstituted from a mixture of food oils comprising olive oil, wheat germ, flax and sunflower, which have enabled: R1 lower blood pressure; R2 lower blood sugar levels; R3 lower triglycerides; R4 lower LDL cholesterol; R5 lower urea and creatinine levels in blood; R6 lower rates of uricaemia; R7 lower overall insulin levels and an increase in free insulin. The ingredients required for the production thereof are: 1 olive oil, 2 wheat germ, flax, and sunflower.

Description

DESCRIPTION  DESCRIPTION
La testosterone libre a pour rôle essentiel d'abaisser le taux du mauvais cholestérol ou LDL cholestérol et le taux des triglycérides. The essential role of free testosterone is to lower the level of bad cholesterol or LDL cholesterol and the level of triglycerides.
Jusqu'à ce jour, la recherche internationale n'a pas permis de produire la testostérone libre. To date, international research has not produced free testosterone.
Les nouvelles applications de la testostérone libre a permis de mettre à jour de nouvelles propriétés : The new applications of free testosterone allowed to update new properties:
_ l'abaissement du taux de l'urée et de la créatinine sanguines. lowering the level of blood urea and creatinine.
_ l'abaissement du taux de l'uricémie. _ the lowering of the rate of uricemia.
_ l'abaissement du taux de l'insuline totale. lowering the level of total insulin.
J'accroissement du taux de l'insuline libre ce qui contribue à améliorer le diabète avec abaissement de la glycémie. I increase the level of free insulin which helps to improve diabetes with lowering of blood sugar.
_ l'abaissement de la tension artérielle _ lowering of blood pressure
_ l'abaissement des triglycérides _ lowering triglycerides
Le produit proposé est un complément alimentaire qui est un mélange d'huiles qu'on peut produire industriellement : The proposed product is a food supplement that is a mixture of oils that can be produced industrially:
Ce mélange d'huiles est composé de : This blend of oils is composed of:
_ 50% huile d'olive _ 50% olive oil
_ 35% huile de germe de blé _ 35% wheat germ oil
_ 10% huile de lin _ 10% linseed oil
_ 5%huile de tournesol _ 5% sunflower oil
On note que la testostérone libre contient de la choline, du chrome et de l'acide alphalinolénique ou oméga 3 It is noted that free testosterone contains choline, chromium and alphalinolenic acid or omega 3
Concernant la partie protéique, elle est constituée de 4 acides aminés : a _ cystéine b_ aspartate c_ glutamate : il joue un rôle essentiel dans les fonctions cérébrales d'apprentissage et de mémorisation. d_ arginine : qui produit le monoxyde d'azote ( NO qui effectue de multiples fonctions sur les vaisseaux) .Aussi le NO est considéré comme une sorte d'antagoniste physiologique du sympathique et du système rénine Concerning the protein part, it consists of 4 amino acids: Cystine aspartate and glutamate play an essential role in the brain functions of learning and memorization. arginine: which produces nitric oxide (NO which performs multiple functions on the vessels). Also NO is considered as a kind of physiological antagonist of the sympathetic and the renin system
angiotensine au niveau de la régulation du tonus vasculaire abaissant ainsi la tension artérielle. angiotensin in the regulation of vascular tone thus lowering blood pressure.

Claims

REVENDICATIONS
RI : le produit proposé est un complément alimentaire sous forme d'huile destinée à produire la testostérone libre. RI: the proposed product is a food supplement in the form of an oil intended to produce free testosterone.
R2 : le complément alimentaire selon la revendication 1 caractérisé en ce qu'il est obtenu à partir d'un mélange d'huiles. R2: the food supplement according to claim 1 characterized in that it is obtained from a mixture of oils.
- Olive 50% - Olive 50%
- Germes de blé 35%  - Wheat germs 35%
- Lin 10%  - Linen 10%
- Tournesol 5%  - Sunflower 5%
R3 : ce produit permet l'abaissement des chiffres tentionnels. R3: this product allows the lowering of the numbers.
R4 : ce produit permet la diminution des taux de cholestérol total, du taux de LDL cholestérol, du taux des triglycérides. R4: this product reduces total cholesterol, LDL cholesterol, triglyceride levels.
R5 : ce produit permet l'abaissement de la glycémie . R5: this product allows the lowering of blood sugar.
R6 : ce produit permet un meilleur fonctionnement rénal par la diminution des taux de l'urée et de la créatinine sanguine. R6: this product allows better renal function by lowering urea and blood creatinine levels.
R7 : ce produit permet la diminution du taux de l'uricémie. R7: this product makes it possible to reduce the level of serum uric acid.
R8 : ce produit permet l'augmentation des taux de l'insuline libre et l'abaissement du taux de l'insuline totale. R8: this product allows increase of rates of free insulin and lowering of rate of the general insulin.
R9 : ce produit permet l'amélioration des lésions du vitiligo avec disparition des taches blanches sous la peau. R9: this product allows the improvement of vitiligo lesions with disappearance of white spots under the skin.
PCT/TN2010/000006 2009-10-16 2010-10-11 Novel uses of reconstituted free testosterone WO2011046522A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TNTN2009/0426 2009-10-16
TN09426 2009-10-16

Publications (2)

Publication Number Publication Date
WO2011046522A2 true WO2011046522A2 (en) 2011-04-21
WO2011046522A3 WO2011046522A3 (en) 2011-09-09

Family

ID=43743456

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TN2010/000006 WO2011046522A2 (en) 2009-10-16 2010-10-11 Novel uses of reconstituted free testosterone

Country Status (1)

Country Link
WO (1) WO2011046522A2 (en)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB487493A (en) * 1935-11-16 1938-06-21 Naamlooze Vennootschap Organon Production of biological preparations
FR2698785A1 (en) * 1992-12-04 1994-06-10 Thorel Jean Noel Compsn. to stimulate melanogenesis contg. arachidonic acid or a deriv. - and a non-saponifiable vegetable fraction as a potentiator, for treating vitiligo and to tan skin and treat grey hair.
WO2000040095A1 (en) * 1999-01-04 2000-07-13 Ehrlich, Menachem Food spreads
WO2002055020A2 (en) * 2000-12-11 2002-07-18 Testocreme Llc Topical testosterone formulations and associated methods
CN1382482A (en) * 2002-05-23 2002-12-04 熊德功 Medicinal oil for treating leukoderma
EP1634583A1 (en) * 2004-09-09 2006-03-15 Laboratoires Besins International Testosterone gels comprising propylene glycol as penetration enhancer
US20070243307A1 (en) * 2006-04-11 2007-10-18 Martek Biosciences Corporation Food Products Comprising Long Chain Polyunsaturated Fatty Acids and Methods for Preparing the Same
CN101401929A (en) * 2008-10-30 2009-04-08 林赫 Traditional Chinese medicine liniment for treating leukoderma
KR20090076536A (en) * 2008-01-09 2009-07-13 동국대학교 산학협력단 Essential oil of lotus flower extract for treating dermatological diseases and method for preparing the same

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB487493A (en) * 1935-11-16 1938-06-21 Naamlooze Vennootschap Organon Production of biological preparations
FR2698785A1 (en) * 1992-12-04 1994-06-10 Thorel Jean Noel Compsn. to stimulate melanogenesis contg. arachidonic acid or a deriv. - and a non-saponifiable vegetable fraction as a potentiator, for treating vitiligo and to tan skin and treat grey hair.
WO2000040095A1 (en) * 1999-01-04 2000-07-13 Ehrlich, Menachem Food spreads
WO2002055020A2 (en) * 2000-12-11 2002-07-18 Testocreme Llc Topical testosterone formulations and associated methods
CN1382482A (en) * 2002-05-23 2002-12-04 熊德功 Medicinal oil for treating leukoderma
EP1634583A1 (en) * 2004-09-09 2006-03-15 Laboratoires Besins International Testosterone gels comprising propylene glycol as penetration enhancer
US20070243307A1 (en) * 2006-04-11 2007-10-18 Martek Biosciences Corporation Food Products Comprising Long Chain Polyunsaturated Fatty Acids and Methods for Preparing the Same
KR20090076536A (en) * 2008-01-09 2009-07-13 동국대학교 산학협력단 Essential oil of lotus flower extract for treating dermatological diseases and method for preparing the same
CN101401929A (en) * 2008-10-30 2009-04-08 林赫 Traditional Chinese medicine liniment for treating leukoderma

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CARVALHO A A: "A few observations on leucoderma and a new method of treatment", JOURNAL OF THE INDIAN MEDICAL ASSOCIATION, INDIAN MEDICAL ASSOCIATION, CALCUTTA, IN, vol. 26, no. 3, 1 février 1956 (1956-02-01), pages 93-96, XP008138310, ISSN: 0019-5847 *
GROMADZKA-OSTROWSKA JOANNA: "Effects of dietary fat on androgen secretion and metabolism", REPRODUCTIVE BIOLOGY, TOWARZYSTWO BIOLOGII ROZRODU, POLAND, [Online] vol. 6, no. Suppl. 2, 1 novembre 2006 (2006-11-01), pages 13-20, XP008134746, ISSN: 1642-431X Extrait de l'Internet: URL:http://repbiol.pan.olsztyn.pl/2010/06/ 11/effects-of-dietary-fat-on-an drogen-secretion-and-metabolism/> *
HURTADO DE CATALFO GRACIELA E ET AL: "Influence of Commercial Dietary Oils on Lipid Composition and Testosterone Production in Interstitial Cells Isolated from Rat Testis", LIPIDS, SPRINGER, US, vol. 44, no. 4, 1 avril 2009 (2009-04-01), pages 345-357, XP008134712, ISSN: 0024-4201, DOI: DOI:10.1007/S11745-008-3277-Z *
MONDAL M ET AL: "DEPRESSION OF ASCORBIC-ACID BY DRUG AND HORMONES IN WHITE AND BLACK SKINS OF GUINEA-PIG", INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH, IN, vol. 18, no. 12, 1 janvier 1980 (1980-01-01), pages 1499-1501, XP008138325, ISSN: 0019-5189 *
PUNSHI S K: "TOPICAL USE OF ANACARCIN FORTE OIL IN VITILIGO", INDIAN JOURNAL OF DERMATOLOGY, VENEREOLOGY AND LEPROLOGY, MEDKNOW PUBLICATIONS ON BEHALF OF THE INDIAN ASSOCIATION OF DERMATOLOGISTS, VENEREOLOGISTS AND LEPROLOGISTS (IADVL), INDIA, vol. 46, no. 2, 1 mars 1980 (1980-03-01), pages 102-103, XP008138324, ISSN: 0378-6323 *
SEBOKOVA E ET AL: "Alteration of the lipid composition of rat testicular plasma membranes by dietary (n-3) fatty acids changes the responsiveness of Leydig cells and testosterone synthesis", JOURNAL OF NUTRITION, WISTAR INSTITUTE OF ANATOMY AND BIOLOGY, PHILADELPHIA, PA, US, vol. 120, no. 6, 1 juin 1990 (1990-06-01), pages 610-618, XP008134727, ISSN: 0022-3166 *

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