WO2011038149A3 - Méthodes de traitement d'une inflammation - Google Patents

Méthodes de traitement d'une inflammation Download PDF

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Publication number
WO2011038149A3
WO2011038149A3 PCT/US2010/050047 US2010050047W WO2011038149A3 WO 2011038149 A3 WO2011038149 A3 WO 2011038149A3 US 2010050047 W US2010050047 W US 2010050047W WO 2011038149 A3 WO2011038149 A3 WO 2011038149A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
mif
treating inflammation
cxcr2
cxcr4
Prior art date
Application number
PCT/US2010/050047
Other languages
English (en)
Other versions
WO2011038149A2 (fr
Inventor
Jurgen Bernhagen
Christian Weber
Benedikt Vollrath
Court Turner
Joshua Robert Schults
Alma Zernecke
Sergio Duron
Original Assignee
Carolus Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carolus Therapeutics, Inc. filed Critical Carolus Therapeutics, Inc.
Priority to BR112012006468A priority Critical patent/BR112012006468A2/pt
Priority to CN2010800526286A priority patent/CN102725311A/zh
Priority to AU2010298249A priority patent/AU2010298249A1/en
Priority to MX2012003514A priority patent/MX2012003514A/es
Priority to IN2423DEN2012 priority patent/IN2012DN02423A/en
Priority to EP10819481.2A priority patent/EP2480579A4/fr
Priority to CA2773978A priority patent/CA2773978A1/fr
Publication of WO2011038149A2 publication Critical patent/WO2011038149A2/fr
Publication of WO2011038149A3 publication Critical patent/WO2011038149A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne, dans certains modes de réalisation, des méthodes pour traiter un trouble à médiation assurée par le facteur d'inhibition de la migration (MIF). Dans certains modes de réalisation, la méthode consiste à administrer un agent qui inhibe (i) la liaison du MIF à CXCR2 et CXCR4 et/ou (ii) l'activation par le MIFde CXCR2 et CXCR4; (iii) la capacité du MIF à former un homomultimère; ou une combinaison de celles-ci.
PCT/US2010/050047 2009-09-23 2010-09-23 Méthodes de traitement d'une inflammation WO2011038149A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
BR112012006468A BR112012006468A2 (pt) 2009-09-23 2010-09-23 métodos de tratamento de inflamação
CN2010800526286A CN102725311A (zh) 2009-09-23 2010-09-23 治疗发炎的方法
AU2010298249A AU2010298249A1 (en) 2009-09-23 2010-09-23 Methods of treating inflammation
MX2012003514A MX2012003514A (es) 2009-09-23 2010-09-23 Metodos para tratamiento de inflamaciones.
IN2423DEN2012 IN2012DN02423A (fr) 2009-09-23 2010-09-23
EP10819481.2A EP2480579A4 (fr) 2009-09-23 2010-09-23 Méthodes de traitement d'une inflammation
CA2773978A CA2773978A1 (fr) 2009-09-23 2010-09-23 Methodes de traitement d'une inflammation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24521409P 2009-09-23 2009-09-23
US61/245,214 2009-09-23
US31903910P 2010-03-30 2010-03-30
US61/319,039 2010-03-30

Publications (2)

Publication Number Publication Date
WO2011038149A2 WO2011038149A2 (fr) 2011-03-31
WO2011038149A3 true WO2011038149A3 (fr) 2011-10-27

Family

ID=43796491

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/050047 WO2011038149A2 (fr) 2009-09-23 2010-09-23 Méthodes de traitement d'une inflammation

Country Status (9)

Country Link
EP (1) EP2480579A4 (fr)
KR (1) KR20120105429A (fr)
CN (1) CN102725311A (fr)
AU (1) AU2010298249A1 (fr)
BR (1) BR112012006468A2 (fr)
CA (1) CA2773978A1 (fr)
IN (1) IN2012DN02423A (fr)
MX (1) MX2012003514A (fr)
WO (1) WO2011038149A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013010955A1 (fr) 2011-07-15 2013-01-24 Morphosys Ag Anticorps à réactions croisées anti-facteur inhibiteur de la migration des macrophages (mif) et anti-d-dopachrome tautomérase (d-dt)
US9328174B2 (en) * 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
AU2013262397B2 (en) * 2012-05-17 2017-07-27 Anji Pharmaceuticals Inc. Methods and uses for proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors
TW201605886A (zh) * 2013-11-14 2016-02-16 巴克斯特保健公司 作爲治療標靶的ｍｉｆ
CA3017345A1 (fr) 2016-03-11 2017-09-14 Ardea Biosciences, Inc. Inhibiteurs du cxcr-2 permettant de traiter des troubles associes a une arthropathie cristalline
AU2019282132A1 (en) 2018-06-05 2020-12-17 Anji Pharmaceuticals Inc. Compositions and methods for treating pancreatitis
US11573228B2 (en) * 2018-12-26 2023-02-07 Colgate-Palmolive Company Biomarkers of neutrophil deregulation as diagnostic for gingivitis
JP2023517616A (ja) * 2020-03-11 2023-04-26 バイオラインアールエックス・リミテッド 急性呼吸窮迫症候群およびウイルス感染の治療用のｃｘｃｒ４阻害剤
WO2021219495A1 (fr) * 2020-04-28 2021-11-04 Dalcor Pharma Uk Ltd., Leatherhead, Zug Branch Méthodes de traitement ou de prévention d'une infection virale ou d'inhibition de la réplication virale
CN112656934A (zh) * 2021-01-22 2021-04-16 深圳市图微安创科技开发有限公司 多肽at03在治疗原发性胆汁性胆管炎药物中的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040009149A1 (en) * 2002-02-27 2004-01-15 Altman John D. Multimeric binding complexes
US20040115193A1 (en) * 2002-03-01 2004-06-17 Immunomedics, Inc. Internalizing anti-CD-74 antibodies and methods of use
US20050176039A1 (en) * 2003-12-30 2005-08-11 Siegler Katherine M. Macrophage migration inhibitory factor (MIF) as marker for urological inflammatory disease
EP1724286A1 (fr) * 2005-05-17 2006-11-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Variante du polypeptide CD44, polynucléotides les codant, anticorps le liant, et procédé d'utilisation pour le diagnostic et le traitement des maladies inflammatoires
US20070071675A1 (en) * 2005-08-19 2007-03-29 Chengbin Wu Dual variable domain immunoglobulin and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0910259A2 (pt) * 2008-03-20 2015-12-01 Carolus Therapeutics Inc métodos de tratamento de inflamação
WO2010056910A2 (fr) * 2008-11-12 2010-05-20 Carolus Therapeutics, Inc. Procedes de traitement de troubles cardio-vasculaires

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040009149A1 (en) * 2002-02-27 2004-01-15 Altman John D. Multimeric binding complexes
US20040115193A1 (en) * 2002-03-01 2004-06-17 Immunomedics, Inc. Internalizing anti-CD-74 antibodies and methods of use
US20050176039A1 (en) * 2003-12-30 2005-08-11 Siegler Katherine M. Macrophage migration inhibitory factor (MIF) as marker for urological inflammatory disease
EP1724286A1 (fr) * 2005-05-17 2006-11-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Variante du polypeptide CD44, polynucléotides les codant, anticorps le liant, et procédé d'utilisation pour le diagnostic et le traitement des maladies inflammatoires
US20070071675A1 (en) * 2005-08-19 2007-03-29 Chengbin Wu Dual variable domain immunoglobulin and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of EP2480579A4 *
VENKATA ET AL.: "Chemically programmed antibodies: Endothelin receptor targeting CovX-bodies", BIOORGANIC AND MEDICAL CHEMISTRY LETTERS, vol. 17, 2007, pages 501 - 506, XP008154000 *

Also Published As

Publication number Publication date
EP2480579A2 (fr) 2012-08-01
CA2773978A1 (fr) 2011-03-31
MX2012003514A (es) 2012-04-19
IN2012DN02423A (fr) 2015-08-21
EP2480579A4 (fr) 2013-07-31
KR20120105429A (ko) 2012-09-25
WO2011038149A2 (fr) 2011-03-31
CN102725311A (zh) 2012-10-10
BR112012006468A2 (pt) 2016-08-09
AU2010298249A1 (en) 2012-04-19

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