WO2011035308A1 - Système de dispositif de commande implanté câblé - Google Patents
Système de dispositif de commande implanté câblé Download PDFInfo
- Publication number
- WO2011035308A1 WO2011035308A1 PCT/US2010/049666 US2010049666W WO2011035308A1 WO 2011035308 A1 WO2011035308 A1 WO 2011035308A1 US 2010049666 W US2010049666 W US 2010049666W WO 2011035308 A1 WO2011035308 A1 WO 2011035308A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- implantable
- controller
- power source
- electrical device
- percutaneous connector
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
- A61M60/871—Energy supply devices; Converters therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/165—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart
- A61M60/178—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/50—Details relating to control
- A61M60/508—Electronic control means, e.g. for feedback regulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
- A61M60/871—Energy supply devices; Converters therefor
- A61M60/873—Energy supply devices; Converters therefor specially adapted for wireless or transcutaneous energy transfer [TET], e.g. inductive charging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
- A61M60/871—Energy supply devices; Converters therefor
- A61M60/876—Implantable batteries
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/10—General characteristics of the apparatus with powered movement mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/18—General characteristics of the apparatus with alarm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3507—Communication with implanted devices, e.g. external control
- A61M2205/3523—Communication with implanted devices, e.g. external control using telemetric means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
- A61M2205/3592—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using telemetric means, e.g. radio or optical transmission
Definitions
- This invention relates to implantable medical devices. Specifically, the invention relates to a system for controlling implantable medical devices .
- Implantable medical devices such as ventricular assist devices are being developed for long term treatment of chronic heart failure. Such devices require a pumping mechanism to move blood. Due to the nature of the application, the pumping mechanism must be highly reliable. Patient comfort is also a significant consideration.
- Transcutaneous energy transfer (“TET”) systems are used to supply power to devices such as heart pumps implanted internally within a human body.
- An electromagnetic field generated by a transmitting coil outside the body can transmit power across a cutaneous (skin) barrier to a magnetic receiving coil implanted within the body.
- the receiving coil can then transfer the received power to the implanted heart pump or other internal device and to one or more batteries implanted within the body to charge the battery.
- the implanted battery may be required to supply the implanted device's entire power demand for one to several hours at a time, such as when the patient does activities that preclude wearing the external TET power unit, such as showering or swimming.
- the battery capacity is large and can meet the power demand for the required amount of time.
- the implanted battery's capacity decreases. ith decreased battery capacity, the patient cannot spend as much time without the external TET power unit .
- the battery may need to be replaced so that the patient can go without the external TET power unit for long enough periods of time again.
- an implantable controller and implantable power source attach to an implantable electrical device, such as a VAD, for powering the implantable electrical device when tether-free operation is desired, for example.
- a second power source which may be referred to herein as an external power source in embodiments where implantable elements are actually implanted, supplies power to the implanted system and recharges the implantable power source by direct contact through a percutaneous connector .
- a backup controller is provided and it may have a hard wire communication link, through a percutaneous connector, to directly communicate with the implanted controller and serve as a programming/monitoring/diagnostic device) .
- a back-up controller which may be referred to herein as an external backup controller in embodiments where implantable elements are actually implanted, may also be plugged into the percutaneous connector to control the implantable electrical device.
- a monitoring circuit of the implantable power unit can be used to monitor a condition of the implantable power source.
- the monitoring circuit can transmit a transcutaneous telemetry signal which represents the monitored condition to transfer control of the implantable electrical device to the backup controller or to trigger an alarm to alert a patient that an external power source should be connected to the percutaneous connector.
- the transcutaneous telemetry signal represents the monitored condition of the implantable controller for use by a control circuit to activate the backup controller.
- the backup controller transmits signals to the implantable controller through the percutaneous connector to disable the implantable controller and override the pump drive signals that are normally outputted by the implantable controller.
- a logic signal used to switch between implantable controller and backup controller may be CMOS compatible ( 3 . 3 or 5 Volts , for example) , depending on the internal logic design.
- One object of the invention is to provide VAD technology that improves a patient's lifestyle during tether free operation. Another object of the invention is to reduce the external hardware required during normal operation.
- FIG. 1 illustrates components and operation of an implantable therapeutic electrical system in accordance with one embodiment of the invention
- FIG. 2 illustrates a backup controller and a power source connected to an implantable therapeutic electrical system in accordance with one embodiment of the invention
- FIG. 3 illustrates a power source connected to an implantable therapeutic electrical system in accordance with one embodiment of the invention
- FIG , 4 illustrates an implantable therapeutic electrical system in accordance with one embodiment of the invention
- FIG. 5 illustrates a backup controller and a power source connected to an implanted therapeutic electrical system in accordance with one embodiment of the invention.
- the embodiments described below provide an alternate configuration to the prior art implantable systems .
- power is provided by an external power source, including a battery, cigarette lighter adapter, AC adaptor or DC power source, through a percutaneous connector.
- This configuration may be used as an alternative to the TET power transfer disclosed in U.S. Provisional Application No. 61/191,595, assigned to the same assignee of the present application.
- the percutaneous connector includes extra pin connections to allow a backup controller to be connected in case the implantable controller were to fail.
- signals are transmitted by the backup controller to inhibit or block the implantable controller's drive circuits so that the backup controller's drive circuits tap into pump drive connections.
- the internal circuitry may sink the signal from the external motor drive and not properly drive the pump.
- Fig. 1 illustrates an embodiment of the present invention, including an implantable therapeutic electrical device 101, such as a VAD device, implantable power sources including a rechargeable power source 103, a controller 105, and a skin button 107.
- the power source 103 supplies power to the controller 105.
- the controller 105 sends driving signals to a motor in the electrical device 101.
- the skin button 107 may be implemented as a percutaneous connector that allows external modules to connect to the implantable controller 105 , as well as to the implantable power source 103 and implantable device 101 (through wire lines inside the controller) .
- controller 105, power source 103 and device 101 are all implanted inside a patient's body.
- DC power may be supplied through the skin button 107 to the controller 105, the power source 103 and the device 101. If the implantable device 101 is a VAD, its power demands may not be supplied by the implantable power source 103 for long periods of time. In such case, the implantable power source 103 may act as a supplemental power source, the primary power being supplied externally through skin button 107, but the implanted power source 103 may still be used to supply power for short periods of time.
- FIG. 2 illustrates another embodiment of the present invention.
- the figure illustrates implantable therapeutic electrical device 201, implantable power source 203, implantable controller 205, and wires 233, 255, 265 and 223. Also illustrated are external power source 213, external backup controller 235, external telemetry transceiver 227, as well as external wired connections 245 and 243 and wireless connection 217.
- the controller 205 may include Drive MOSFETs 225 connected to a motor controller 215.
- the motor controller 215 may produce control signals for controlling a pump in the illustrated VAD 201. These control signals may be relayed to the VAD 201 by the Drive MOSFETs 225. The signals may also be conditioned by the Drive MOSFETs 225.
- the Drive MOSFETs 225 operate as switches that interrupt the signal from the motor controller 215.
- the backup controller 235 sends the signal through wired connection 265 to command the interruption of the control signal from motor control 215.
- the backup controller may supply a backup motor control signal 255 to drive the VAD 201.
- this mode of operation is triggered after the remote telemetry transceiver 225 detects a signal sent over the wireless connection 217 indicative of a malfunction of motor controller 215.
- the backup controller may receive the signal indicative of a malfunction through a wired connection.
- the VAD's motor may be a permanent magnet brushless, sensorless DC motor.
- the motor is desirably highly reliable and maintenance free.
- the drive signals that are input to the stators(s) may be multiphase and biphasic to create a requisite rotating magnetic field excitation for normal operation of the motor.
- the stator drive signals may range from nearly zero volts to 16 volts, and from zero to three (3) amps. Typical power dissipation may be between 1 to 45 Watts, depending upon selected RPM and resultant flow rate.
- the backup controller may have a hard wire communication link to directly communicate with the implanted controller and serve as a programming/monitoring/diagnostic device.
- the transceiver 225 may also detect other signals representative of measurements of operational parameters of the implanted module. These can be routed to the external controller 235 for remedial or corrective action. Examples of these parameters include low battery, excessive voltage applied to implanted electrical device (e.g., VAD), high temperature of implanted module, etc.
- VAD excessive voltage applied to implanted electrical device
- power may be supplied externally by power source 3131, the power signal being routed through backup controller.
- the external rechargeable battery 213 is connected to the skin button 207 (instead of backup controller) and may supply power to the controller 205 through wired connections 223 and 243.
- the cable 223 may be of a lesser width and composition from the cable 243, as cable 223 is implantable .
- the skin button 207 serves not only as the percutaneous physical interface between external and internal modules, it also serves as the electrical interface.
- the mode of operation where the external power source 213 supplies power to the controller 205 may be triggered by receipt by the transceiver 227 of a signal over wireless connection 217 which is indicative of implanted battery 203 having low power.
- the "low power" signal may be generated by monitoring the signal fed to the controller 205 over cable 233.
- the signal indicative of a malfunction (e.g., low power) may trigger a visual or audible alarm to alert the patient to connect external power source to the skin button.
- FIG. 3 illustrates another configuration of the system of the present invention.
- the backup controller 213 is not connected to the skin button 207.
- the skin button may mechanically ground the input MOSFET disable signal 265 to avoid accidental disabling of controller 205
- the telemetry transceiver 227 may still detect whether the controller 205 functions properly and may activate a visual and/or audible alarm to alert the patient of any malfunctioning of the implanted controller 205.
- the alarm may be inserted in a wristwatch for use by the patient.
- FIG. 4 illustrates the system components that may be used in one mode of operation.
- neither the external battery (or power sources) 213 nor the backup controller is connected to the skin button 207 , allowing the patient to move freely without any external physical connections .
- the external transceiver 227 is still able to detect anomalies in the operation of the implanted controller 205 or in the supply of power through cable 233 and alert the patient of these.
- the patient may plug in either the battery 213 or the backup controller 235 as illustrated in FIG. 3.
- the power source 213 and the controller 235 may be connected in series as illustrated in FIG. 5, with the signal for providing power being routed through the controller 235.
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2010295272A AU2010295272B2 (en) | 2009-09-21 | 2010-09-21 | Hard-wired implanted controller system |
EP10818025.8A EP2480284B1 (fr) | 2009-09-21 | 2010-09-21 | Système de dispositif de commande implanté câblé |
CA2774222A CA2774222A1 (fr) | 2009-09-21 | 2010-09-21 | Systeme de dispositif de commande implante cable |
KR1020127009884A KR101686888B1 (ko) | 2009-09-21 | 2010-09-21 | 하드-와이어드 이식된 컨트롤러 시스템 |
CN201080041999.4A CN102497910B (zh) | 2009-09-21 | 2010-09-21 | 硬连线植入式控制器系统 |
IL218620A IL218620A (en) | 2009-09-21 | 2012-03-14 | A modified implanted control system |
IL243715A IL243715A0 (en) | 2009-09-21 | 2016-01-21 | Multi-unit drug delivery devices and methods |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27713509P | 2009-09-21 | 2009-09-21 | |
US61/277,135 | 2009-09-21 | ||
US39931510P | 2010-07-09 | 2010-07-09 | |
US61/399,315 | 2010-07-09 |
Publications (1)
Publication Number | Publication Date |
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WO2011035308A1 true WO2011035308A1 (fr) | 2011-03-24 |
Family
ID=43757192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/049666 WO2011035308A1 (fr) | 2009-09-21 | 2010-09-21 | Système de dispositif de commande implanté câblé |
Country Status (8)
Country | Link |
---|---|
US (4) | US8628460B2 (fr) |
EP (1) | EP2480284B1 (fr) |
KR (1) | KR101686888B1 (fr) |
CN (1) | CN102497910B (fr) |
AU (1) | AU2010295272B2 (fr) |
CA (1) | CA2774222A1 (fr) |
IL (2) | IL218620A (fr) |
WO (1) | WO2011035308A1 (fr) |
Cited By (3)
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DE102012020260A1 (de) | 2011-10-14 | 2013-07-18 | Biomet Manufacturing Corp. | Implantierbare subkutane elektrische Steckdose und perkutaner Stecker |
WO2016053688A1 (fr) * | 2014-10-01 | 2016-04-07 | Heartware, Inc. | Système d'organe de commande de secours avec mise à jour |
WO2019089367A1 (fr) * | 2017-11-03 | 2019-05-09 | Heartware, Inc. | Mise à jour d'un système de dav sans arrêter la pompe |
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US8628460B2 (en) | 2009-09-21 | 2014-01-14 | Heartware, Inc. | Hard-wired implanted controller system |
US8562508B2 (en) | 2009-12-30 | 2013-10-22 | Thoratec Corporation | Mobility-enhancing blood pump system |
US10383990B2 (en) | 2012-07-27 | 2019-08-20 | Tc1 Llc | Variable capacitor for resonant power transfer systems |
US9592397B2 (en) | 2012-07-27 | 2017-03-14 | Thoratec Corporation | Thermal management for implantable wireless power transfer systems |
WO2014018967A1 (fr) | 2012-07-27 | 2014-01-30 | Thoratec Corporation | Systèmes de transfert d'énergie résonnants à accord automatique |
WO2014018974A1 (fr) | 2012-07-27 | 2014-01-30 | Thoratec Corporation | Transmission de puissance magnétique utilisant des réseaux de bobines émettrices et réceptrices à commande de phase |
US10291067B2 (en) | 2012-07-27 | 2019-05-14 | Tc1 Llc | Computer modeling for resonant power transfer systems |
WO2014018973A1 (fr) | 2012-07-27 | 2014-01-30 | Thoratec Corporation | Bobines et systèmes de transmission de puissance résonants |
US10525181B2 (en) | 2012-07-27 | 2020-01-07 | Tc1 Llc | Resonant power transfer system and method of estimating system state |
WO2014018971A1 (fr) | 2012-07-27 | 2014-01-30 | Thoratec Corporation | Systèmes de transfert de puissance résonants avec algorithme de protection |
US20140243970A1 (en) * | 2013-02-25 | 2014-08-28 | Thoratec Corporation | Programming of backup control unit for cardiac assist system |
WO2014145664A1 (fr) | 2013-03-15 | 2014-09-18 | Thoratec Corporation | Boîtier de test implantable intégré comprenant des ailettes et des boucles de bobine |
WO2014145895A1 (fr) | 2013-03-15 | 2014-09-18 | Thoratec Corporation | Bobine de système de transfert d'énergie transcutané (tets) malléable à ajustement anatomique amélioré |
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KR101534914B1 (ko) * | 2013-06-18 | 2015-07-07 | 현대자동차주식회사 | 친환경 차량용 배터리 쿨링 제어 장치 및 방법 |
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US10610692B2 (en) | 2014-03-06 | 2020-04-07 | Tc1 Llc | Electrical connectors for implantable devices |
WO2015160992A1 (fr) * | 2014-04-15 | 2015-10-22 | Thoratec Corporation | Procédés et systèmes de fonctionnement lvad pendant des pertes de communication |
EP3248650B1 (fr) | 2014-04-15 | 2018-12-05 | Heartware, Inc. | Perfectionnements apportés à des systèmes de transfert d'énergie transcutané |
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US10143788B2 (en) | 2014-04-15 | 2018-12-04 | Heartware, Inc. | Transcutaneous energy transfer systems |
WO2015160994A1 (fr) | 2014-04-15 | 2015-10-22 | Thoratec Corporation | Procédés et systèmes de mise à jour de dispositifs d'assistance pour ventricule |
EP3154624A1 (fr) | 2014-06-12 | 2017-04-19 | Heartware, Inc. | Connecteur percutané avec capuchon magnétique et procédés d'utilisation associés |
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CN107567338A (zh) * | 2015-05-06 | 2018-01-09 | 柏林心脏有限公司 | 心脏泵装置和心脏泵装置系统 |
EP3090767A1 (fr) * | 2015-05-06 | 2016-11-09 | Berlin Heart GmbH | Dispositif de pompe cardiaque et système de dispositif de pompe cardiaque |
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- 2010-09-21 CN CN201080041999.4A patent/CN102497910B/zh active Active
- 2010-09-21 KR KR1020127009884A patent/KR101686888B1/ko active IP Right Grant
- 2010-09-21 CA CA2774222A patent/CA2774222A1/fr not_active Abandoned
- 2010-09-21 EP EP10818025.8A patent/EP2480284B1/fr active Active
- 2010-09-21 AU AU2010295272A patent/AU2010295272B2/en not_active Ceased
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2012
- 2012-03-14 IL IL218620A patent/IL218620A/en not_active IP Right Cessation
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2014
- 2014-01-09 US US14/151,720 patent/US9005105B2/en not_active Expired - Fee Related
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2015
- 2015-03-06 US US14/640,718 patent/US10092684B2/en not_active Expired - Fee Related
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2016
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2018
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Cited By (7)
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DE102012020260A1 (de) | 2011-10-14 | 2013-07-18 | Biomet Manufacturing Corp. | Implantierbare subkutane elektrische Steckdose und perkutaner Stecker |
US9153900B2 (en) | 2011-10-14 | 2015-10-06 | Biomet Manufacturing Corp. | Implantable subcutaneous electrical socket and percutaneous plug |
WO2016053688A1 (fr) * | 2014-10-01 | 2016-04-07 | Heartware, Inc. | Système d'organe de commande de secours avec mise à jour |
CN107223062A (zh) * | 2014-10-01 | 2017-09-29 | 心脏器械股份有限公司 | 具有更新的备用控制器系统 |
US10413649B2 (en) | 2014-10-01 | 2019-09-17 | Heartware, Inc. | Back up controller system with updating |
WO2019089367A1 (fr) * | 2017-11-03 | 2019-05-09 | Heartware, Inc. | Mise à jour d'un système de dav sans arrêter la pompe |
US11110265B2 (en) | 2017-11-03 | 2021-09-07 | Heartware, Inc. | Updating a VAD system without stopping the pump |
Also Published As
Publication number | Publication date |
---|---|
US20140128660A1 (en) | 2014-05-08 |
CN102497910A (zh) | 2012-06-13 |
US9005105B2 (en) | 2015-04-14 |
KR20120098630A (ko) | 2012-09-05 |
IL243715A0 (en) | 2016-04-21 |
IL218620A0 (en) | 2012-05-31 |
KR101686888B1 (ko) | 2016-12-15 |
US20190001038A1 (en) | 2019-01-03 |
US10092684B2 (en) | 2018-10-09 |
AU2010295272B2 (en) | 2015-07-09 |
US20150174309A1 (en) | 2015-06-25 |
CA2774222A1 (fr) | 2011-03-24 |
US10695477B2 (en) | 2020-06-30 |
EP2480284A1 (fr) | 2012-08-01 |
EP2480284B1 (fr) | 2016-11-09 |
AU2010295272A1 (en) | 2012-05-10 |
IL218620A (en) | 2016-02-29 |
US20110071336A1 (en) | 2011-03-24 |
CN102497910B (zh) | 2014-12-17 |
US8628460B2 (en) | 2014-01-14 |
EP2480284A4 (fr) | 2014-07-09 |
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