WO2011022680A3 - Wound dressings, methods of using the same and methods of forming the same - Google Patents

Wound dressings, methods of using the same and methods of forming the same Download PDF

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Publication number
WO2011022680A3
WO2011022680A3 PCT/US2010/046209 US2010046209W WO2011022680A3 WO 2011022680 A3 WO2011022680 A3 WO 2011022680A3 US 2010046209 W US2010046209 W US 2010046209W WO 2011022680 A3 WO2011022680 A3 WO 2011022680A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
same
wound dressings
forming
polymer matrix
Prior art date
Application number
PCT/US2010/046209
Other languages
French (fr)
Other versions
WO2011022680A2 (en
Inventor
Nathan Stasko
Susanne Bauman
Pranav R. Joshi
Original Assignee
Novan, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novan, Inc. filed Critical Novan, Inc.
Priority to BR112012003804-4A priority Critical patent/BR112012003804B1/en
Priority to DK10747385.2T priority patent/DK2467173T3/en
Priority to US13/256,925 priority patent/US9919072B2/en
Priority to CN201080047383.8A priority patent/CN102695528B/en
Priority to CA2771389A priority patent/CA2771389C/en
Priority to EP10747385.2A priority patent/EP2467173B8/en
Publication of WO2011022680A2 publication Critical patent/WO2011022680A2/en
Publication of WO2011022680A3 publication Critical patent/WO2011022680A3/en
Priority to US15/887,649 priority patent/US11583608B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/225—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/114—Nitric oxide, i.e. NO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)

Abstract

Provided according to some embodiments of the invention are wound dressings that include a polymer matrix and nitric oxide-releasing polysiloxane macromolecules within and/or on the polymer matrix. Also provided are wound dressing kits and methods of using and forming such wound dressings.
PCT/US2010/046209 2009-08-21 2010-08-20 Wound dressings, methods of using the same and methods of forming the same WO2011022680A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
BR112012003804-4A BR112012003804B1 (en) 2009-08-21 2010-08-20 Wound Dressing, Method to Form an Injury Dressing, and Wound Dressing Kit
DK10747385.2T DK2467173T3 (en) 2009-08-21 2010-08-20 WOOLS, PROCEDURES FOR USE THEREOF AND PROCEDURES FOR USING THEREOF
US13/256,925 US9919072B2 (en) 2009-08-21 2010-08-20 Wound dressings, methods of using the same and methods of forming the same
CN201080047383.8A CN102695528B (en) 2009-08-21 2010-08-20 Wound dressing, its using method and forming method thereof
CA2771389A CA2771389C (en) 2009-08-21 2010-08-20 Wound dressings, methods of using the same and methods of forming the same
EP10747385.2A EP2467173B8 (en) 2009-08-21 2010-08-20 Wound dressings, methods of using the same and methods of forming the same
US15/887,649 US11583608B2 (en) 2009-08-21 2018-02-02 Wound dressings, methods of using the same and methods of forming the same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23592709P 2009-08-21 2009-08-21
US23594809P 2009-08-21 2009-08-21
US61/235,927 2009-08-21
US61/235,948 2009-08-21

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/256,925 A-371-Of-International US9919072B2 (en) 2009-08-21 2010-08-20 Wound dressings, methods of using the same and methods of forming the same
US15/887,649 Continuation US11583608B2 (en) 2009-08-21 2018-02-02 Wound dressings, methods of using the same and methods of forming the same

Publications (2)

Publication Number Publication Date
WO2011022680A2 WO2011022680A2 (en) 2011-02-24
WO2011022680A3 true WO2011022680A3 (en) 2011-07-07

Family

ID=43446983

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/046209 WO2011022680A2 (en) 2009-08-21 2010-08-20 Wound dressings, methods of using the same and methods of forming the same

Country Status (7)

Country Link
US (2) US9919072B2 (en)
EP (1) EP2467173B8 (en)
CN (1) CN102695528B (en)
BR (1) BR112012003804B1 (en)
CA (1) CA2771389C (en)
DK (1) DK2467173T3 (en)
WO (1) WO2011022680A2 (en)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5042209B2 (en) 2005-03-24 2012-10-03 ノーラブズ エービー Cosmetic treatment with nitric oxide, apparatus for performing the treatment, and method for manufacturing the same
BRPI0811530B1 (en) 2007-05-14 2019-01-02 Research Foundation Of State Univ Of New York composition comprising inducer (s) of physiological response to decanoic acid dispersion, surface, solution, ex vivo method of treating or inhibiting the formation of a biofilm on a surface
CN102711729B (en) 2009-08-21 2015-04-01 诺万公司 Topical gels
US9610093B2 (en) 2010-08-06 2017-04-04 Kci Licensing, Inc. Microblister skin grafting
US8978234B2 (en) 2011-12-07 2015-03-17 MoMelan Technologies, Inc. Methods of manufacturing devices for generating skin grafts
US9173674B2 (en) 2010-08-06 2015-11-03 MoMelan Technologies, Inc. Devices for harvesting a skin graft
WO2013006608A1 (en) 2011-07-05 2013-01-10 Novan, Inc. Topical compositions
WO2013006613A1 (en) 2011-07-05 2013-01-10 Novan, Inc. Methods of manufacturing topical compositions and apparatus for same
ES2640224T3 (en) * 2011-07-27 2017-11-02 Genewel Co., Ltd Polyurethane foam dressing that has excellent adhesive properties and its manufacturing method
ES2658897T3 (en) 2011-08-24 2018-03-12 Novan, Inc. Adjustable nitric oxide releasing macromolecules that have multiple nitric oxide donor structures
US9669041B2 (en) 2011-10-27 2017-06-06 Novan, Inc. Nitric oxide releasing bath compositions and methods of using the same
CN104168926B (en) * 2012-01-25 2017-08-25 阿克伦大学 Fluorinated polymers hydrogel for wound dressing and preparation method thereof
US11077194B2 (en) 2012-03-14 2021-08-03 Novan, Inc. Nitric oxide releasing pharmaceutical compositions
CN103622917B (en) 2012-08-23 2017-12-29 尼奥克斯(文莱)控股有限公司 Delay based on microencapsulation nitrite and acidifying hydrogel produces nitric oxide production system and method
WO2014124125A2 (en) * 2013-02-07 2014-08-14 The Regents Of The University Of Michigan Thromboresistant/bactericidal s-nitroso-n-acetylpenicillamine (snap)-doped nitric oxide release polymers with enhanced stability
US9855211B2 (en) 2013-02-28 2018-01-02 Novan, Inc. Topical compositions and methods of using the same
AU2014239952B2 (en) * 2013-03-14 2018-09-27 Solventum Intellectual Properties Company Absorbent substrates for harvesting skin grafts
WO2014169281A1 (en) * 2013-04-12 2014-10-16 Colorado State University Research Foundation Surface treatments for vascular stents and methods thereof
DE102013107464A1 (en) * 2013-07-15 2015-01-15 Wilhelm Fleischmann wound dressing
JP6513667B2 (en) 2013-08-08 2019-05-15 ノヴァン，インコーポレイテッド Topical composition and method of using the same
WO2016022170A1 (en) 2014-08-08 2016-02-11 Novan, Inc. Topical emulsions
WO2015057964A2 (en) * 2013-10-16 2015-04-23 The Board Of Regents Of The University Of Texas System Modulation of mrtf-a activity in pathologic fibrosis and wound healing
CA2930189A1 (en) * 2013-10-18 2015-04-23 Bovicor Pharmatech Inc. Preparation and delivery of sustained nitric oxide releasing solutions
US9226890B1 (en) 2013-12-10 2016-01-05 Englewood Lab, Llc Polysilicone base for scar treatment
US10626290B2 (en) * 2013-12-16 2020-04-21 Ppg Industries Ohio, Inc. Method of extending pot life of coating compositions
EP3089681B1 (en) 2013-12-31 2021-09-08 3M Innovative Properties Company Fluid-assisted skin graft harvesting
EP3243453B1 (en) 2013-12-31 2019-10-09 KCI Licensing, Inc. Skin graft harvesting device
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
WO2016007834A1 (en) * 2014-07-11 2016-01-14 Novan, Inc. Topical antiviral compositions and methods of using the same
WO2016010988A1 (en) 2014-07-14 2016-01-21 Novan, Inc. Nitric oxide releasing nail coating compositions, nitric oxide releasing nail coatings, and methods of using the same
FR3025429B1 (en) * 2014-09-08 2018-02-02 Urgo Recherche Innovation Et Developpement ELECTRONEGATIVE FIBER FOR ITS USE IN WOUND HEALING
EP3804774A1 (en) 2015-04-09 2021-04-14 3M Innovative Properties Co. System for harvesting skin grafts
US11439609B2 (en) 2015-06-11 2022-09-13 The Regents Of The University Of Michigan Nitric oxide releasing PLGA microspheres for biomedical applications
US10849864B2 (en) 2015-07-28 2020-12-01 Novan, Inc. Combinations and methods for the treatment and/or prevention of fungal infections
US11006974B2 (en) 2015-11-03 2021-05-18 Kci Licensing, Inc. Devices for creating an epidermal graft sheet
KR102319497B1 (en) 2016-03-02 2021-11-01 노반, 인크. Composition for treating inflammation and method for treating inflammation
KR102426006B1 (en) 2016-04-13 2022-07-29 노반, 인크. Compositions, systems, kits, and methods for treating infections
CN110446521B (en) * 2017-01-21 2022-05-06 生物克瑞德公司 Medical products and methods configured for controlled release of nitric oxide
WO2018236803A1 (en) 2017-06-19 2018-12-27 Novan, Inc. Topical compositions and methods of using the same
GB201713511D0 (en) 2017-08-23 2017-10-04 Scapa Uk Ltd Wound dressing
WO2019114705A1 (en) 2017-12-13 2019-06-20 上海小午医药科技有限公司 Method for preventing or treating disease related to egfr inhibition
JP2021515807A (en) 2018-03-01 2021-06-24 ノーバン，インク． Nitric oxide-releasing suppositories and methods of their use
CN111989095A (en) 2018-04-16 2020-11-24 上海岸阔医药科技有限公司 Method for preventing or treating side effects of tumor therapy
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
CN108755137A (en) * 2018-06-05 2018-11-06 北京服装学院 Anticoagulant weaving base artificial blood vessel material of one kind and preparation method thereof
CN112689518A (en) * 2018-07-16 2021-04-20 乔治亚大学研究基金会 Stable nitric oxide releasing polymers and articles, methods of manufacture and uses thereof
CN109124096B (en) * 2018-08-23 2021-08-06 广州百隆威尔精密五金制品有限公司 Lifting cabinet
US20220143262A1 (en) * 2019-02-26 2022-05-12 University Of Georgia Research Foundation,Inc. Antibacterial wound treatments with clot-promoting properties
CN113825806A (en) * 2019-05-08 2021-12-21 美国圣戈班性能塑料公司 Hydrophilic polymer composition
CN110639052B (en) * 2019-09-30 2021-06-29 新乡医学院 Composite gel system for promoting wound healing and preparation method and application thereof
CN110522766B (en) * 2019-09-30 2021-09-28 新乡医学院 Gel system loaded with tumor exosomes and preparation method and application thereof
CN110563974B (en) * 2019-09-30 2021-09-28 新乡医学院 Active oxygen response self-disintegrating hydrogel and preparation method and application thereof
GB2588748A (en) * 2019-10-07 2021-05-12 Insense Ltd Composition for delivering nitric oxide to skin
WO2021072254A1 (en) * 2019-10-10 2021-04-15 Molecular Express, Inc. Foam patent surfactant
TR201917675A2 (en) * 2019-11-13 2021-05-21 Ulusal Bor Arastirma Enstituesue A WOUND CARE PRODUCT
CN111617304B (en) * 2020-06-15 2022-01-14 江苏阳生生物股份有限公司 High-moisture-absorption wound dressing and preparation method thereof
US20210378870A1 (en) * 2020-08-24 2021-12-09 University Of Utah Research Foundation Multi-functional analgesic-releasing wound dressing
CN112250901B (en) * 2020-11-06 2022-04-01 江苏海洋大学 Application of multifunctional interpenetrating network polymer emulsion in modification of polyurethane soft foam plastic
CN113679874B (en) * 2021-09-03 2022-07-22 明基材料有限公司 Multi-segment release dressing
EP4404944A1 (en) * 2021-09-20 2024-07-31 University of Georgia Research Foundation, Inc. Nitric oxide releasing polysiloxanes and methods for making and using the same
EP4198094A1 (en) * 2021-12-20 2023-06-21 Covestro Deutschland AG Multilayer structure on metal substrates based on polyaspartate coatings
US20240307045A1 (en) * 2023-03-17 2024-09-19 DRS Vascular, Inc. Suture retention device
CN117599260A (en) * 2024-01-23 2024-02-27 四川大学 Medical polyurethane foam with anti-inflammatory function and preparation and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
WO2003026717A1 (en) * 2001-09-26 2003-04-03 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Nitric oxide-releasing coated medical devices and method of preparing same
WO2006128121A2 (en) * 2005-05-27 2006-11-30 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications

Family Cites Families (464)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173691A (en) 1978-02-21 1979-11-06 M&T Chemicals Inc. Catalyst composition for flexible polyurethane foams
US4182827A (en) * 1978-08-31 1980-01-08 Union Carbide Corporation Polyurethane hydrogels having enhanced wetting rates
US4507466A (en) 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
US4631337A (en) 1983-01-07 1986-12-23 The Dow Chemical Company Hydrolytically-stable dense star polyamine
US4568737A (en) 1983-01-07 1986-02-04 The Dow Chemical Company Dense star polymers and dendrimers
US4558120A (en) 1983-01-07 1985-12-10 The Dow Chemical Company Dense star polymer
US4737550A (en) 1983-01-07 1988-04-12 The Dow Chemical Company Bridged dense star polymers
US4600001A (en) * 1984-08-15 1986-07-15 The Kendall Company Combined wound dressing and delivery means composite
US4587329A (en) 1984-08-17 1986-05-06 The Dow Chemical Company Dense star polymers having two dimensional molecular diameter
US4550126A (en) * 1985-01-25 1985-10-29 Hydromer, Inc. Hydrophilic, flexible, open cell polyurethane-poly(N-vinyl lactam) interpolymer foam and dental and biomedical products fabricated therefrom
US4871779A (en) 1985-12-23 1989-10-03 The Dow Chemical Company Ion exchange/chelation resins containing dense star polymers having ion exchange or chelate capabilities
US4694064A (en) 1986-02-28 1987-09-15 The Dow Chemical Company Rod-shaped dendrimer
US4713975A (en) 1986-05-30 1987-12-22 The Dow Chemical Company Dense star polymers for calibrating/characterizing sub-micron apertures
US4857599A (en) 1988-02-08 1989-08-15 The Dow Chemical Company Modified dense star polymers
US5061487A (en) 1988-05-09 1991-10-29 Dow Corning Corporation Antimicrobial superabsorbent compositions and methods
US5035892A (en) 1988-05-09 1991-07-30 Dow Corning Corporation Antimicrobial superabsorbent compositions and methods
US4985023A (en) 1988-05-09 1991-01-15 Dow Corning Corporation Antimicrobial superabsorbent articles
US4990338A (en) 1988-05-09 1991-02-05 Dow Corning Corporation Antimicrobial superabsorbent compositions and methods
US5045322A (en) 1988-05-09 1991-09-03 Dow Corning Corporation Antimicrobial superabsorbent sanitary napkin
US5079004A (en) 1990-08-06 1992-01-07 Dow Corning Corporation Antimicrobial superabsorbent compositions and method
GB9102660D0 (en) * 1991-02-07 1991-03-27 Ultra Lab Ltd Wound dressing materials
US5380758A (en) 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US6291424B1 (en) 1991-11-14 2001-09-18 Brigham And Women's Hospital Nitrosated and nitrosylated heme proteins
DK1023905T3 (en) 1991-11-14 2005-05-30 Brigham & Womens Hospital Pharmaceutical preparation containing S-nitroso immunoglobulins and use thereof
US5194325A (en) 1992-02-25 1993-03-16 Renosol Corporation Molded polyurethane foam system utilizing HFC blowing agents
SE9200564L (en) 1992-02-26 1993-03-15 Perstorp Ab DENDRITIC MACROMOLECYLE OF POLYESTER TYPE, PROCEDURES FOR PRODUCING THEREOF AND USING THEREOF
US5814666A (en) 1992-04-13 1998-09-29 The United States As Represented By The Department Of Health And Human Services Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
US5691423A (en) 1992-08-24 1997-11-25 The United States Of America As Represented By The Department Of Health And Human Services Polysaccharide-bound nitric oxide-nucleophile adducts
US5632981A (en) 1992-08-24 1997-05-27 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5525357A (en) 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US6200558B1 (en) 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5650447A (en) 1992-08-24 1997-07-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitric oxide-releasing polymers to treat restenosis and related disorders
US5910316A (en) 1992-08-24 1999-06-08 The United States Of America, As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents to treat impotency
US5891459A (en) 1993-06-11 1999-04-06 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of vascular function by modulation of endogenous nitric oxide production or activity
US5428070A (en) 1993-06-11 1995-06-27 The Board Of Trustees Of The Leland Stanford Junior University Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity
US5861168A (en) 1993-06-11 1999-01-19 The Board Of Trustees Of The Leland Stanford Junior University Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury
US5852058A (en) 1993-06-11 1998-12-22 The Board Of Trustees Of The Leland Stanford Junior University Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury
US6087479A (en) 1993-09-17 2000-07-11 Nitromed, Inc. Localized use of nitric oxide-adducts to prevent internal tissue damage
US6255277B1 (en) 1993-09-17 2001-07-03 Brigham And Women's Hospital Localized use of nitric oxide-adducts to prevent internal tissue damage
WO1995007691A1 (en) 1993-09-17 1995-03-23 Brigham And Women's Hospital Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces
US5840759A (en) 1993-10-08 1998-11-24 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents
EP0722320B1 (en) 1993-10-08 2000-07-19 THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services Use of nitric oxide-releasing compounds as medicaments for hypoxic cell radiation sensitization
EP0726768B1 (en) 1993-11-02 2000-05-17 THE UNITED STATES OF AMERICA, represented by THE SECRETARY, Department of Health and Human Services Use of nitric oxide releasing compounds for the manufacture of a medicament for protection in ischemia reperfusion injury
US5786332A (en) 1995-03-06 1998-07-28 Trega Biosciences, Inc. Cytokine restraining agents and methods of use in pathologies and conditions associated with altered cytokine levels
US5726156A (en) 1995-03-06 1998-03-10 Trega Biosciences, Inc. Cytokine regulatory agents and methods of use in pathologies and conditions associated with altered cytokine levels
US6008255A (en) 1994-01-21 1999-12-28 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
US5599984A (en) 1994-01-21 1997-02-04 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
DK0746327T3 (en) 1994-02-21 2004-05-10 Univ Aberdeen Acidified nitrite as an antimicrobial agent
US6709681B2 (en) 1995-02-17 2004-03-23 Aberdeen University Acidified nitrite as an antimicrobial agent
US5504117A (en) 1994-05-27 1996-04-02 Neptune Pharmaceutical Corporation Pharmacologic preparation for the treatment of anal disorders
PT1051972E (en) 1994-05-27 2007-12-07 Strakan Internat Ltd Uma Socie Nitric oxide donor composition and method for treatment of anal disorders
US6190704B1 (en) 1994-09-23 2001-02-20 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Regulation of wound healing by nitric oxide
US6747062B2 (en) 1994-09-26 2004-06-08 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Regulation of wound healing by nitric oxide
US5519020A (en) 1994-10-28 1996-05-21 The University Of Akron Polymeric wound healing accelerators
US5629322A (en) 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
US5700830A (en) 1994-11-22 1997-12-23 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents for reducing metastasis risk
US5810010A (en) 1995-01-03 1998-09-22 Anbar; Michael Detection of cancerous lesions by their effect on the periodic modulation of perfusion in the surrounding tissues
US6035225A (en) 1995-01-03 2000-03-07 Omnicorder Technologies Detection of cancerous lesions by measuring nitric oxide concentrations in tissue
US5999843A (en) 1995-01-03 1999-12-07 Omnicorder Technologies, Inc. Detection of cancerous lesions by their effect on the spatial homogeneity of skin temperature
US5961466A (en) 1995-01-03 1999-10-05 Omnicorder Technologies, Inc. Method of detection of cancerous lesions by their effect on the spatial distribution of modulation of temperature and homogeneity of tissue
ATE252894T1 (en) 1995-01-05 2003-11-15 Univ Michigan SURFACE-MODIFIED NANOPARTICLES AND METHODS FOR THEIR PRODUCTION AND USE
US5665077A (en) 1995-04-24 1997-09-09 Nitrosci Pharmaceuticals Llc Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis
US5623981A (en) 1995-08-17 1997-04-29 Service Station Products Company Safety barrier for rim holding tire changers
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
DE69637676D1 (en) 1995-11-09 2008-10-23 Univ R Use of locally administered lysines to IMPROVE VASCULAR FUNCTION
US5821261A (en) 1995-12-08 1998-10-13 Merck & Co., Inc. Substituted saturated aza heterocycles as inhibitors of nitric oxide synthase
US5994294A (en) 1996-02-02 1999-11-30 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
US20020061879A1 (en) 1996-02-02 2002-05-23 Garvey David S. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US20020143007A1 (en) 1996-02-02 2002-10-03 Garvey David S. Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
US20050065161A1 (en) 1996-02-02 2005-03-24 Nitromed, Inc. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US6294517B1 (en) 1996-02-02 2001-09-25 Nitromed, Inc. Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use
US6323211B1 (en) 1996-02-02 2001-11-27 Nitromed, Inc. Compositions and methods for treating sexual dysfunctions
US6469065B1 (en) 1996-02-02 2002-10-22 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
US5932538A (en) 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
IT1282686B1 (en) 1996-02-26 1998-03-31 Nicox Sa COMPOUNDS ABLE TO REDUCE DRUG TOXICITY
US6605447B2 (en) 1996-03-15 2003-08-12 Yale University Methods and means of detecting nitric oxide synthase
US5968001A (en) 1996-05-14 1999-10-19 Bristol-Myers Squibb Company Wound dressings with leak prevention seal
US6143037A (en) 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US5789451A (en) 1996-07-29 1998-08-04 The Dow Chemcial Company Alkanolamine/carbon dioxide adduct and polyurethane foam therewith
US6232434B1 (en) 1996-08-02 2001-05-15 Duke University Medical Center Polymers for delivering nitric oxide in vivo
US5770645A (en) 1996-08-02 1998-06-23 Duke University Medical Center Polymers for delivering nitric oxide in vivo
EP0946160A4 (en) 1996-08-27 2007-05-09 Univ Akron Lipophilic polyamine esters for the site specific delivery of nitric oxide in pharmaceutical use
US20030093143A1 (en) 1999-03-01 2003-05-15 Yiju Zhao Medical device having surface depressions containing nitric oxide releasing compound
US5797887A (en) 1996-08-27 1998-08-25 Novovasc Llc Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation
EP0929538B1 (en) 1996-09-27 2004-11-24 THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES O?2 -arylated or o?2 -glycosylated 1-substituted diazen-1-ium-1,2-diolates and o?2 -substituted 1- (2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates
GB9622997D0 (en) 1996-11-05 1997-01-08 Univ St Andrews Nitric oxide donor drugs
US5958427A (en) 1996-11-08 1999-09-28 Salzman; Andrew L. Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications
US6372796B1 (en) 1996-11-13 2002-04-16 Cold Spring Harbor Laboratory Therapeutic uses for nitric oxide inhibitors
US5891472A (en) 1996-11-19 1999-04-06 Meri Charmyne Russell Treatment of equine laminitis
EP0957901B1 (en) 1996-12-31 2009-11-18 Antioxidant Pharmaceuticals Corporation Pharmaceutical preparations of glutathione and methods of administration thereof
US6896899B2 (en) 1996-12-31 2005-05-24 Antioxidant Pharmaceuticals Corp. Pharmaceutical preparations of glutathione and methods of administration thereof
ES2210716T3 (en) 1997-01-17 2004-07-01 Cascade Engineering, Inc. PANEL WITH INTEGRALLY MOLDED DOOR.
EP1001677A4 (en) 1997-02-04 2003-01-08 Gen Hospital Corp A novel method for treating epidermal or dermal conditions
US6034752A (en) 1997-03-22 2000-03-07 Kent Displays Incorporated Display device reflecting visible and infrared radiation
IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
US5968528A (en) 1997-05-23 1999-10-19 The Procter & Gamble Company Skin care compositions
US6171232B1 (en) 1997-06-26 2001-01-09 Cordis Corporation Method for targeting in vivo nitric oxide release
DE69842142D1 (en) 1997-07-03 2011-04-07 Us Gov Health & Human Serv NITROGEN OXIDE COMPOSITE AMIDINE- AND ENAMINE-RELATED DIZENIUM DIOLATE, PREPARATIONS AND USES AND METHOD OF PREPARING THEREOF
US6796966B2 (en) 1997-10-15 2004-09-28 Jeffrey E. Thomas Apparatus, and kits for preventing of alleviating vasoconstriction or vasospasm in a mammal
AU9596698A (en) 1997-10-15 1999-05-03 Thomas Jefferson University Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal
US5994444A (en) 1997-10-16 1999-11-30 Medtronic, Inc. Polymeric material that releases nitric oxide
US20020013304A1 (en) 1997-10-28 2002-01-31 Wilson Leland F. As-needed administration of an androgenic agent to enhance female sexual desire and responsiveness
CA2219867A1 (en) 1997-10-31 1999-04-30 Jiangping Wu The use of proteasome inhibitors for treating cancer, inflammation, autoimmune disease, graft rejection and septic shock
US6180082B1 (en) 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
DE69826528T2 (en) 1997-12-23 2006-02-23 Amersham Health As NITROGEN OXIDE RELEASING CHELATE FIGURES AND THEIR USE THERAPEUTIC
GB9801398D0 (en) 1998-01-22 1998-03-18 Anggard Erik E Chemical compounds
IT1298338B1 (en) 1998-03-05 1999-12-20 Nicox Sa PHARMACEUTICAL COMPOSITIONS FOR THE ULCER
US6151522A (en) 1998-03-16 2000-11-21 The Research Foundation Of Cuny Method and system for examining biological materials using low power CW excitation raman spectroscopy
US6560478B1 (en) 1998-03-16 2003-05-06 The Research Foundation Of City University Of New York Method and system for examining biological materials using low power CW excitation Raman spectroscopy
US5962520A (en) 1998-04-02 1999-10-05 The University Of Akron Hydrolytically unstable, biocompatible polymer
US6103266A (en) 1998-04-22 2000-08-15 Tapolsky; Gilles H. Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues
US6103275A (en) 1998-06-10 2000-08-15 Nitric Oxide Solutions Systems and methods for topical treatment with nitric oxide
US6207855B1 (en) 1998-06-23 2001-03-27 Duke University Medical Center Stable no-delivering compounds
US20020068365A1 (en) 1998-07-28 2002-06-06 Eric H. Kuhrts Controlled release nitric oxide producing agents
US20060240070A1 (en) * 1998-09-24 2006-10-26 Cromack Keith R Delivery of highly lipophilic agents via medical devices
US6379691B1 (en) 1998-09-29 2002-04-30 Medtronic/Ave, Inc. Uses for medical devices having a lubricious, nitric oxide-releasing coating
US6299980B1 (en) 1998-09-29 2001-10-09 Medtronic Ave, Inc. One step lubricious coating
US20040043068A1 (en) 1998-09-29 2004-03-04 Eugene Tedeschi Uses for medical devices having a lubricious, nitric oxide-releasing coating
DE19852681A1 (en) * 1998-11-16 2000-05-18 Basf Ag Carbamate solutions
CA2254645A1 (en) 1998-11-23 2000-05-23 Pulmonox Medical Corporation Method and apparatus for treatment of respiratory infections by nitric oxide inhalation
US20070275100A1 (en) 1998-11-23 2007-11-29 Miller Christopher C Use of gaseous nitric oxide as an anti-cancer agent
US20070086954A1 (en) 1998-11-23 2007-04-19 Miller Christopher C Method and apparatus for treatment of respiratory infections by nitric oxide inhalation
US6261594B1 (en) 1998-11-25 2001-07-17 The University Of Akron Chitosan-based nitric oxide donor compositions
US7179475B1 (en) 1998-12-04 2007-02-20 Johnson & Johnson Consumer Companies, Inc. Anhydrous topical skin preparations
US6238683B1 (en) 1998-12-04 2001-05-29 Johnson & Johnson Consumer Companies, Inc. Anhydrous topical skin preparations
GB9905425D0 (en) 1999-03-09 1999-05-05 Queen Mary & Westfield College Pharmaceutical composition
US20050142218A1 (en) 2000-03-09 2005-06-30 Queen Mary & Westfield College Pharmaceutical composition containing nitrate source and an acidifying agent for treating skin ischaemia
US6312663B1 (en) 1999-03-19 2001-11-06 Joseph V. Boykin, Jr. Prediction of diabetes impaired wound healing by urinary nitrate assay
US6562785B1 (en) 1999-03-23 2003-05-13 Howard M. Shapiro Method for overcoming bacterial antibiotic resistance
EP1176995A1 (en) * 1999-05-07 2002-02-06 Salviac Limited A tissue engineering scaffold
CN101310772B (en) 1999-06-14 2012-02-08 亨利福特保健系统公司 Nitric oxide donors for inducing neurogenesis
US7655423B2 (en) 1999-06-14 2010-02-02 Henry Ford Health System Nitric oxide donors for inducing neurogenesis
US7135498B1 (en) 1999-06-14 2006-11-14 Henry Ford Health System Nitric oxide donors for inducing neurogenesis
US20010012851A1 (en) 1999-07-29 2001-08-09 Kristin M. Lundy Nitric oxide releasing oxindole prodrugs for anagesic, anti-inflammatory and disease-modifying use
US20020049157A1 (en) 1999-08-25 2002-04-25 Jiangping Wu Use of proteasome inhibitors for treating cancer, inflammation, autoimmune disease, graft rejection and septic shock
MXPA01005338A (en) 1999-09-02 2003-07-14 Rice University Nitric oxide-producing hydrogel materials.
US7052711B2 (en) 1999-09-02 2006-05-30 Rice University Nitric oxide-producing hydrogel materials
US7279176B1 (en) 1999-09-02 2007-10-09 Rice University Nitric oxide-producing hydrogel materials
EP1218425A1 (en) 1999-09-09 2002-07-03 Creavis Gesellschaft für Technologie und Innovation mbH Microbicidal additives
US6737447B1 (en) 1999-10-08 2004-05-18 The University Of Akron Nitric oxide-modified linear poly(ethylenimine) fibers and uses thereof
WO2001045732A2 (en) 1999-12-20 2001-06-28 Sa Majesté La Reine Du Chef Du Canada Agriculture Et Agroalimentaire Canada Method and composition for treatment and/or prevention of antibiotic-resistant microorganism infections
US6492405B2 (en) 1999-12-30 2002-12-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nitric oxide donors and pharmaceutical compositions containing them
US20020132234A1 (en) 2000-01-24 2002-09-19 Moskowitz David W. Nitric oxide synthase gene diagnostic polymorphisms
US6758214B2 (en) 2000-01-28 2004-07-06 Cyterra Corporation Simple nitric oxide generator for ambulatory and/or bedside inhaled no treatment
US6699846B2 (en) 2000-03-17 2004-03-02 Corixa Corporation Mono- and disaccharides for the treatment of nitric oxide related disorders
EP1267837A4 (en) 2000-03-20 2006-05-03 Novovascular Inc Matrices containing nitric oxide donors and reducing agents and their use
US20010038832A1 (en) 2000-04-11 2001-11-08 Benjamin Bonavida Nitric oxide and analogues thereof effectuate sensitization of neoplasm and immunologically undesired tissues to cytotoxicity
US20050142217A1 (en) 2000-04-26 2005-06-30 Adams Michael A. Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
US7678391B2 (en) 2000-04-26 2010-03-16 Queen's University At Kingston Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
WO2001080890A2 (en) 2000-04-26 2001-11-01 Queen's University At Kingston Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
US20010053772A1 (en) 2000-04-28 2001-12-20 Benjamin Bonavida Aza analogues of alkyl lysophospholipids exert immunomodulatory effects
US6270779B1 (en) 2000-05-10 2001-08-07 United States Of America Nitric oxide-releasing metallic medical devices
WO2001089519A1 (en) 2000-05-22 2001-11-29 Nitromed, Inc. Thromboxane inhibitors, compositions and methods of use related applications
US6623728B2 (en) 2000-06-30 2003-09-23 Unilever Home & Personal Care Usa Division Of Conopco, Inc. Cosmetic skin care compositions and containing gum mastic
US6475500B2 (en) 2000-07-10 2002-11-05 The Procter & Gamble Company Anhydrous cosmetic compositions
US6538033B2 (en) 2000-08-29 2003-03-25 Huntington Medical Research Institutes Nitric oxide donor compounds
GB0021317D0 (en) 2000-08-30 2000-10-18 Queen Mary & Westfield College Transdermal pharmaceutical delivery composition
JP4841066B2 (en) 2000-09-01 2011-12-21 ライスユニバーシティ Nitric oxide-forming hydrogel materials
GB0022084D0 (en) 2000-09-08 2000-10-25 Univ Aberdeen Treatment of multiply antibiotic-resistant organisms
US6410622B1 (en) 2000-09-11 2002-06-25 Gregory W. Endres Method of preventing fouling organisms in marine environments and polymer-bound nitric oxide/nitric oxide-releasing compositions usable therefor
EP1333823B1 (en) 2000-10-16 2010-03-31 Duke University Therapeutic use of aerosolized s-nitrosoglutathione in cystic fibrosis
WO2002032413A2 (en) 2000-10-17 2002-04-25 Board Of Regents, The University Of Texas System A method to incorporate n-(4-hydroxyphenyl) retinamide in liposomes
US6359182B1 (en) 2000-10-26 2002-03-19 Duke University C-nitroso compounds and use thereof
US7049308B2 (en) 2000-10-26 2006-05-23 Duke University C-nitroso compounds and use thereof
KR100383149B1 (en) 2000-12-12 2003-05-12 한국생명공학연구원 A novel use of diterpene compounds as therapeutic agents of inflammation, immune disease and cancer
DE10063937A1 (en) 2000-12-20 2002-07-18 Bayer Ag Process for the preparation of trimethylol compounds and formic acid
US6780849B2 (en) 2000-12-21 2004-08-24 Scimed Life Systems, Inc. Lipid-based nitric oxide donors
US7329412B2 (en) 2000-12-22 2008-02-12 The Trustees Of Columbia University In The City Of New York Antimicrobial medical devices containing chlorhexidine free base and salt
US20040009238A1 (en) 2002-07-09 2004-01-15 Chris Miller Exogenenous nitric oxide gas (gNO) therapy in wound healing
US7122018B2 (en) 2000-12-26 2006-10-17 Sensormedics Corporation Device and method for treatment of wounds with nitric oxide
US6432077B1 (en) 2000-12-26 2002-08-13 Sensormedics Corporation Device and method for treatment of surface infections with nitric oxide
EP1358240A1 (en) * 2000-12-27 2003-11-05 World Properties, Inc. Polyurethane foams and method of manafacture thereof
ES2312547T3 (en) 2001-01-16 2009-03-01 The Regents Of The University Of Michigan IN SITU BIOCATALITICS AND BIOMIMETIC GENERATION OF NITRIC OXIDE IN SUBSTRATE / BLOOD INTERFASES.
US7335383B2 (en) 2001-01-16 2008-02-26 The Regents Of The University Of Michigan Generation of nitric oxide in vivo from nitrite, nitrate or nitrosothiols endogenous in blood
US7128904B2 (en) 2001-01-16 2006-10-31 The Regents Of The University Of Michigan Material containing metal ion ligand complex producing nitric oxide in contact with blood
US6706274B2 (en) * 2001-01-18 2004-03-16 Scimed Life Systems, Inc. Differential delivery of nitric oxide
ITMI20010426A1 (en) 2001-03-01 2002-09-01 Consiglio Nazionale Ricerche NITROGEN OXIDE DONORS BASED ON METAL CENTERS
US7012098B2 (en) 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
US20020138051A1 (en) 2001-03-26 2002-09-26 Hole Douglas R. System and method for the prevention and treatment of animal wound infections using nitric oxide
US7122027B2 (en) 2001-05-25 2006-10-17 Medtronic, Inc. Implantable medical device with controllable gaseous agent release system
ES2180446B1 (en) 2001-07-02 2004-01-16 Esteve Labor Dr EMPLOYMENT OF 2,5-DIHYDROXIBENCENOSULPHONIC ACID DERIVATIVES IN THE PREPARATION OF A MEDICINAL PRODUCT TO POWER THE EFFECT OF OTHER PHARMACOS IN THE TREATMENT OF ERECTILE DYSFUNCTION.
WO2003006427A1 (en) 2001-07-12 2003-01-23 Johns Hopkins University Compounds that release nitric oxide at controlled rates upon photolysis
GB0119011D0 (en) 2001-08-03 2001-09-26 Univ Aberdeen Treatment of nail infections
EP1427323A4 (en) 2001-08-20 2004-09-15 Univ Virginia Use of s-nitrosothiol signaling to treat disordered control of breathing
US6841166B1 (en) 2001-08-21 2005-01-11 The Regents Of The University Of Michigan Nitric oxide-releasing polymers incorporating diazeniumdiolated silane derivatives
US7135189B2 (en) 2001-08-23 2006-11-14 Boston Scientific Scimed, Inc. Compositions and techniques for localized therapy
EP2565157B1 (en) 2001-09-05 2017-10-04 Geno LLC Nitric oxide generation
US6673338B1 (en) 2001-09-10 2004-01-06 The United States Of America As Represented By The Department Of Health And Human Services Nitric oxide-releasing imidate and thioimidate diazeniumdiolates, compositions, uses thereof and method of making same
US6703046B2 (en) 2001-10-04 2004-03-09 Medtronic Ave Inc. Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use
EP1300083A1 (en) 2001-10-04 2003-04-09 Societe Des Produits Nestle S.A. Milk-based snack
GB0125222D0 (en) 2001-10-19 2001-12-12 Barts & London Nhs Trust Composition for the treatment of microbial infections
US6472390B1 (en) 2001-11-13 2002-10-29 Duke University Use of therapeutic dosages for nitric oxide donors which do not significantly lower blood pressure or pulmonary artery pressure
US20040110691A1 (en) 2001-11-13 2004-06-10 Stamler Jonathan S. Thiol reactive agents as a therapeutic modality
US6627602B2 (en) 2001-11-13 2003-09-30 Duke University Preventing desensitization of receptors
MXPA04005332A (en) * 2001-12-03 2005-05-16 Bard Inc C R Microbe-resistant medical device, microbe-resistant polymeric coating and methods for producing same.
CA2472581C (en) 2002-01-15 2012-06-26 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US6474508B1 (en) 2002-01-24 2002-11-05 Saint-Gobain Calmar Inc. Unit dose tube and cap assembly
CA2480033C (en) 2002-03-21 2011-05-10 The University Of Utah Research Foundation In vivo use of glutathionone s-transferase activated nitric oxide donors
US20030219854A1 (en) 2002-03-21 2003-11-27 Micrologix Biotech Inc. Methods for producing modified anti-infective peptides
KR101130879B1 (en) * 2002-04-04 2012-03-28 더 유니버시티 오브 아크론 Non-woven fiber assemblies
AU2003223491A1 (en) 2002-04-05 2003-10-27 Nitromed, Inc. Nitric oxide donors, compositions and methods of use
EP1501563A1 (en) 2002-05-03 2005-02-02 Duke University Medical Center Carbon nanotubules for storage of nitric oxide
WO2003095398A2 (en) 2002-05-07 2003-11-20 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same
US6974801B2 (en) 2002-05-13 2005-12-13 The Trustees Of Dartmounth College Inhibitors and methods of use thereof
US7070798B1 (en) 2002-06-21 2006-07-04 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine
MXPA04012863A (en) 2002-06-21 2005-03-31 Univ Pittsburgh Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation.
US6949530B2 (en) 2002-07-18 2005-09-27 The United States Of America As Represented By The Department Of Health And Human Services Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same
WO2004009253A1 (en) 2002-07-19 2004-01-29 University Of North Carolina At Chapel Hill Surface-localized release of an anti-biofouling agent via micropatterning
US20050245492A1 (en) 2004-04-28 2005-11-03 Lephart Edwin D Use of equol for treating skin diseases
AU2003252515A1 (en) 2002-07-26 2004-02-16 Merck Frosst Canada And Co. Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
US7303575B2 (en) * 2002-08-01 2007-12-04 Lumen Biomedical, Inc. Embolism protection devices
AU2003281815A1 (en) 2002-08-02 2004-02-23 The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Hu Cross-linked nitric oxide-releasing polyamine coated substrates, compositions comprising same and method of making same
US20040076582A1 (en) 2002-08-30 2004-04-22 Dimatteo Kristian Agent delivery particle
US20050080024A1 (en) 2002-08-15 2005-04-14 Joseph Tucker Nitric oxide donating derivatives for the treatment of cardiovascular disorders
US20040033480A1 (en) 2002-08-15 2004-02-19 Wong Norman C.W. Use of resveratrol to regulate expression of apolipoprotein A1
US20050080021A1 (en) 2002-08-15 2005-04-14 Joseph Tucker Nitric oxide donating derivatives of stilbenes, polyphenols and flavonoids for the treatment of cardiovascular disorders
US6951902B2 (en) 2002-08-16 2005-10-04 Michigan Biotechnology Institute Two dimensional polymer that generates nitric oxide
US7674482B2 (en) 2002-08-27 2010-03-09 Targeted Medical Pharma Inc. Method and compositions for potentiating pharmaceuticals with amino acid based medical foods
US20100210745A1 (en) * 2002-09-09 2010-08-19 Reactive Surfaces, Ltd. Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes
US20030039697A1 (en) 2002-09-12 2003-02-27 Yi-Ju Zhao Matrices containing nitric oxide donors and reducing agents and their use
CA2503063A1 (en) 2002-10-22 2004-05-06 Merck Frosst Canada & Co./Merck Frosst Canada & Cie Nitric oxide releasing selective cyclooxygenase-2 inhibitors
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US20070292359A1 (en) 2002-10-25 2007-12-20 Foamix Ltd. Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof
US20050271596A1 (en) 2002-10-25 2005-12-08 Foamix Ltd. Vasoactive kit and composition and uses thereof
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US20080031907A1 (en) 2002-10-25 2008-02-07 Foamix Ltd. Cosmetic and pharmaceutical foam
US20080206161A1 (en) 2002-10-25 2008-08-28 Dov Tamarkin Quiescent foamable compositions, steroids, kits and uses thereof
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US20080317679A1 (en) 2002-10-25 2008-12-25 Foamix Ltd. Foamable compositions and kits comprising one or more of a channel agent, a cholinergic agent, a nitric oxide donor, and related agents and their uses
US20070292461A1 (en) 2003-08-04 2007-12-20 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
GB0224986D0 (en) * 2002-10-28 2002-12-04 Smith & Nephew Apparatus
ES2477118T3 (en) 2002-11-18 2014-07-15 Polaris Group Method to inhibit viral replication in vivo
WO2004060283A2 (en) 2002-12-16 2004-07-22 Nitromed, Inc. Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
WO2004064767A2 (en) 2003-01-23 2004-08-05 Kahn Nighat N Nitric oxide inducing agents
FR2850578B1 (en) 2003-02-03 2006-07-28 Oreal USE OF N-ARYLMETHYLENE ETHYLENEDIAMINETRIACETATES, N-ARYLMETHYLENEIMINODIACETATES OR N, N'-DIARYLMETHYLENE ETHYLENEDIAMINEACETATES AS DONORS OF NO
DE602004021238D1 (en) 2003-03-05 2009-07-09 Merck Frosst Company NITROGEN MONOXIDE RELEASING PRODRUGS OF DIARYL-2- (5H) FURANOES AS INHIBITORS OF CYCLOOXYGENASE-2
CA2518506A1 (en) 2003-03-13 2004-11-18 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods of use
SE0300971D0 (en) 2003-04-03 2003-04-03 Aga Ab Nitric oxide in the treatment of inflammation
US20050079132A1 (en) 2003-04-08 2005-04-14 Xingwu Wang Medical device with low magnetic susceptibility
US20040254419A1 (en) 2003-04-08 2004-12-16 Xingwu Wang Therapeutic assembly
US7972137B2 (en) 2003-06-30 2011-07-05 Rosen Gerald M Anti-microbial dental formulations for the prevention and treatment of oral mucosal disease
US7256921B2 (en) 2003-07-01 2007-08-14 Transitions Optical, Inc. Polarizing, photochromic devices and methods of making the same
PL1648826T3 (en) 2003-07-03 2018-02-28 The University Court Of The University Of St. Andrews Zeolites for delivery of nitric oxide
DE10330960B4 (en) 2003-07-08 2005-09-08 Stockhausen Gmbh Active substance-doped absorbent polymer particles, composition comprising polycondensate matrix and absorbent polymer for release of a wound healing substance
US7234079B2 (en) 2003-07-11 2007-06-19 Agency For Science, Technology & Research Method and system for enabling recovery of data stored in a computer network; a method and a system for recovering data stored in a computer network
WO2005004984A1 (en) 2003-07-14 2005-01-20 Power Paper Ltd. Device and method for the treatment of pilosebaceous disorders
US20050054714A1 (en) 2003-07-17 2005-03-10 Benito Munoz Nitric oxide releasing drugs for Alzheimer's disease
US20090136410A1 (en) 2003-07-25 2009-05-28 Smith Daniel J Stabilization and ionic triggering of nitric oxide release
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US20080069779A1 (en) 2003-08-04 2008-03-20 Foamix Ltd. Foamable vehicle and vitamin and flavonoid pharmaceutical compositions thereof
US7314857B2 (en) 2003-08-25 2008-01-01 Kane Biotech Inc. Synergistic antimicrobial compositions and methods of inhibiting biofilm formation
AU2004270162B2 (en) 2003-08-28 2010-05-13 Nicox S.A. Nitrosated ad nitrosylated diuretic compouds, compositions and methods of use
BRPI0414813A (en) 2003-09-26 2006-11-14 David R Whitlock method for the use of ammonia-oxidizing bacteria
US20070037821A1 (en) 2003-09-26 2007-02-15 Nitromed, Inc. Nitrosated glutamic acid compounds, compositions and methods of use
US7485324B2 (en) 2003-09-29 2009-02-03 Pulmonox Technologies Corporation Use of exogenous gaseous nitric oxide in the treatment and disinfection of biofilms
US20050074506A1 (en) 2003-10-02 2005-04-07 Brainsgate Ltd. Targeted release of nitric oxide in the CNS circulation for modulating the BBB and treating disorders
WO2005037339A1 (en) 2003-10-14 2005-04-28 Cube Medical A/S A balloon for use in angioplasty
US20050171199A1 (en) 2003-10-17 2005-08-04 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Treatment of overuse tendinopathy using transdermal nitric oxide-generating agents
US20070053966A1 (en) 2003-10-17 2007-03-08 Robert Ang Medicated orthopedic support structures for treatment of damaged musculoskeletal tissue
US20070059351A1 (en) 2003-10-17 2007-03-15 Murrell George A C Transdermal patches containing a nitric oxide-donor and a second active agent and associated methods
US20060286158A1 (en) 2003-10-17 2006-12-21 Calvert Murrell George A Treatment of overuse tendinopathy using transdermal nitric oxide-generating agents
US20060286159A1 (en) 2003-10-17 2006-12-21 Calvert Murrell George A Treatment of persistent active tendinopathy using transdermal glyceryl trinitrate providing durability of effect
AU2004296174A1 (en) 2003-12-15 2005-06-23 Nitricare Hb Device and method for administering therapeutic agents
US8703066B2 (en) 2004-01-07 2014-04-22 Noxilizer, Inc. Sterilization system and method
US8017074B2 (en) 2004-01-07 2011-09-13 Noxilizer, Inc. Sterilization system and device
US20090131342A1 (en) 2004-01-22 2009-05-21 Nitromed, Inc. Nitrosated and/or nitrosylated compounds, compositions and methods of use
US8298563B2 (en) 2004-01-22 2012-10-30 The University Of Akron Polymer no donor predrug nanofiber coating for medical devices and therapy
JP2007520484A (en) 2004-01-27 2007-07-26 メルク フロスト カンパニー Diaryl-2- (5H) -furanone nitric oxide releasing prodrug as cyclooxygenase-2 inhibitor
WO2005070883A1 (en) 2004-01-27 2005-08-04 Merck Frosst Company Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
US20050165452A1 (en) 2004-01-28 2005-07-28 Medtronic, Inc. Antithrombogenic medical device
US7569559B2 (en) 2004-02-09 2009-08-04 Noxilizer, Inc. Nitric oxide-releasing molecules
WO2005081753A2 (en) 2004-02-09 2005-09-09 Noxilizer, Inc. Nitric oxide-releasing molecules
US20070166227A1 (en) 2004-02-10 2007-07-19 Shuang Liu Crowned dithiocarbamate metal complexes and methods for their use
EP1732577B1 (en) 2004-02-23 2013-04-10 Strategic Science & Technologies, LLC Topical delivery of l-arginine to improve body and skin appearance
AU2005239995A1 (en) 2004-03-31 2005-11-17 Nitromed, Inc. Methods for treating blood disorders with nitric oxide donor compounds
ES2429443T3 (en) 2004-04-19 2013-11-14 Strategic Science & Technologies, Llc Transdermal supply of beneficial substances by means of an environment of high ionic strength
US8529548B2 (en) * 2004-04-27 2013-09-10 Smith & Nephew Plc Wound treatment apparatus and method
WO2005115440A2 (en) 2004-04-29 2005-12-08 Kahn Nighat N Compositions and method for modulating insulin-activated nitric oxide synthase
US20060240065A1 (en) * 2005-04-26 2006-10-26 Yung-Ming Chen Compositions for medical devices containing agent combinations in controlled volumes
KR20070040332A (en) 2004-05-03 2007-04-16 네오실 인코퍼레이티드 Polycationic antimicrobial therapeutic
US8791073B2 (en) 2004-05-14 2014-07-29 William Marsh Rice University Peptide-modified polyurethane compositions and associated methods
WO2005112954A1 (en) 2004-05-14 2005-12-01 William Marsh Rice University Nitric oxide releasing compositions and associated methods
US7582623B2 (en) 2004-05-20 2009-09-01 The Regents Of The University Of California Photoactive metal nitrosyls for blood pressure regulation and cancer therapy
WO2005120493A1 (en) 2004-06-10 2005-12-22 Tohoku University Anticancer effect enhancer
US20060008529A1 (en) 2004-07-12 2006-01-12 Meyerhoff Mark E Use of additive sites to control nitric oxide release from nitric oxide donors contained within polymers
US20060039950A1 (en) 2004-08-23 2006-02-23 Zhengrong Zhou Multi-functional biocompatible coatings for intravascular devices
WO2006037105A2 (en) 2004-09-27 2006-04-06 Government Of The United States Of America, Represented By The Secretary Department Of Health And Human Services Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof
US20070154570A1 (en) 2004-09-29 2007-07-05 Miller Christopher C Use of nitric oxide in the treatment and disinfection of biofilms
WO2006041855A2 (en) 2004-10-04 2006-04-20 Nitromed, Inc. Compositions and methods using apocynin compounds and nitric oxide donors
FR2877004B1 (en) 2004-10-21 2007-03-09 Oreal ESTERS AND SILANIC AMIDES OF 2-OXOTHIAZOLIDINE-4-CARBOXYLIC ACID AND THEIR COSMETIC USES.
US8388677B2 (en) 2004-10-29 2013-03-05 Boston Scientific Scimed, Inc. Anti-thrombogenic and anti-restenotic vascular medical devices
JP2008520578A (en) 2004-11-15 2008-06-19 ニトロメッド インコーポレーティッド Diuretic compounds containing heterocyclic nitric oxide donor groups, compositions and methods of use
US20070166255A1 (en) 2004-11-22 2007-07-19 Gupta Shyam K Treatment of Topical Discomforts Including Acne, Sunburn, Diaper Rash, Wound, Wrinkles and Dandruff/Hair Loss by Natural Lignans via Fatty Acid Desaturase Inhibition
EP1827332A4 (en) 2004-11-29 2010-03-17 Univ Akron Topical nitric oxide donor devices and methods for their therapeutic use
WO2006064056A2 (en) 2004-12-16 2006-06-22 Nolabs Ab Anti-pathogen and anti-cancer filtering device and method comprising nitric oxide
EP1681068A1 (en) 2004-12-16 2006-07-19 NOLabs AB Anti-pathogen and anti-cancer filtering device and method comprising nitric oxide
WO2006066362A1 (en) 2004-12-24 2006-06-29 The University Of Queensland Methods of treating pain
JP2008528626A (en) 2005-01-31 2008-07-31 マイラン ラボラトリーズ インク． Pharmaceutical composition comprising hydroxylated nebivolol
BRPI0606829A2 (en) 2005-02-11 2009-07-21 Nolabs Ab configured device, configured device manufacturing process, uses of nitric oxide eluting polymer (no), method of treatment and use of nitric oxide (no)
EP1700611A1 (en) 2005-02-11 2006-09-13 NOLabs AB Device for treatment of disorders in the oral cavity, and manufacturing process for the same
CA2594407C (en) 2005-02-11 2014-06-10 Nolabs Ab Device method, and use for treatment of neuropathy involving nitric oxide
EP1690557A1 (en) 2005-02-11 2006-08-16 NOLabs AB Device for treatment of rectal disorders, and manufacturing process for the same
EP1690558A1 (en) 2005-02-11 2006-08-16 NOLabs AB Device for treatment of diabetic disorders
WO2006084914A2 (en) 2005-02-11 2006-08-17 Nolabs Ab Device for gastric treatment and manufacturing process for the same
EP1846009A2 (en) 2005-02-11 2007-10-24 NOLabs AB Improved device for application of medicaments, manufacturing method therefor, and method of treatment
EP1690532A1 (en) 2005-02-11 2006-08-16 NOLabs AB Device for gastric treatment and manufacturing process for the same
EP1757278A1 (en) 2005-08-23 2007-02-28 NOLabs AB Device, system, and method comprising microencapsulated liquid for release of nitric oxide from a polymer
WO2006084913A2 (en) 2005-02-11 2006-08-17 Nolabs Ab Device for treatment of rectal disorders, and manufacturing process for the same, involving nitric oxide
EP1690554A1 (en) 2005-02-11 2006-08-16 NOLabs AB Device for treatment of infections, including dermatophytosis and onychomycosis
WO2007086884A2 (en) 2005-02-16 2007-08-02 Nitromed, Inc. Organic nitric oxide donor salts of antimicrobial compounds, compositions and methods of use
CA2597460A1 (en) 2005-02-24 2006-08-31 Nitromed, Inc. Nitric oxide enhancing diuretic compounds, compositions and methods of use
US8119840B2 (en) 2005-03-04 2012-02-21 The University Of Akron Ethambutol based nitric oxide donors
WO2006099058A2 (en) 2005-03-09 2006-09-21 Nitromed, Inc. Organic nitric oxide enhancing salts of angiotensin ii antagonists, compositions and methods of use
GB0505035D0 (en) 2005-03-11 2005-04-20 Insense Ltd Improvements relating to skin dressings
WO2006097348A1 (en) 2005-03-15 2006-09-21 L'oreal Use of agents such as nonpolymeric nitric oxide donors for making the lips full again and/or colouring the lips
EP1704879A1 (en) 2005-03-24 2006-09-27 NOLabs AB Intravascular, interstitial or intraorgan medical device comprising a nitric oxide eluting polymer
WO2006100155A1 (en) 2005-03-24 2006-09-28 Nolabs Ab Device for wound care, and manufacturing method thereof, involving the use of nitric oxide
EP1704877A1 (en) 2005-03-24 2006-09-27 NOLabs AB A wound care device comprising a nitric oxide eluting polymer
WO2006100156A2 (en) 2005-03-24 2006-09-28 Nolabs Ab Intravascular, interstitial or intraorgan medical access device, and manufacturing method thereof, involving nitric oxide
JP5042209B2 (en) 2005-03-24 2012-10-03 ノーラブズ エービー Cosmetic treatment with nitric oxide, apparatus for performing the treatment, and method for manufacturing the same
EP1704876A1 (en) 2005-03-24 2006-09-27 NOLabs AB Cosmetic treatment, device for performing said treatment and manufacturing method thereof
JP2008540508A (en) 2005-05-09 2008-11-20 フォーミックス エルティーディー． Foaming vehicle and pharmaceutical composition thereof
CA2608627A1 (en) 2005-05-16 2006-11-23 The Governors Of The University Of Alberta Novel nsaids possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety
EP2151216B1 (en) 2005-05-17 2013-03-13 Syntach AG A device for treatment of disorders in the heart rhythm regulation system
US20090048219A1 (en) 2005-05-23 2009-02-19 Nitromed Inc. Organic nitric oxide donor salts of nonsteroidal antiinflammatory compounds, compositions and methods of use
WO2006125262A1 (en) 2005-05-24 2006-11-30 Environmental Biotechnology Crc Pty Limited Methods and compositions for regulating biofilm development
JP2008542327A (en) 2005-06-01 2008-11-27 ノーラブズ エービー Treatment and pretreatment device involving nitric oxide and method for producing the same
WO2006128743A1 (en) 2005-06-01 2006-12-07 Nolabs Ab Feedstuff
EP1728438A1 (en) 2005-06-01 2006-12-06 NOLabs AB Feedstuff
EP1731176A1 (en) 2005-06-01 2006-12-13 NOLabs AB Pre-treatment device comprising nitric oxide
WO2006130982A1 (en) 2005-06-09 2006-12-14 University Of Manitoba Compositions and methods for enhancing nitric oxide delivery
EP1896091B1 (en) 2005-06-30 2011-06-22 Accord Biomaterials, Inc. Nitric oxide coatings for medical devices
US20080241208A1 (en) 2005-06-30 2008-10-02 Charles Shanley Methods, Compositions and Devices For Promoting Anglogenesis
WO2007003028A1 (en) 2005-07-01 2007-01-11 Kane Biotech Inc. Antimicrobial compositions for inhibiting growth and proliferation of a microbial biofilm on medical devices
US20080139450A1 (en) 2005-07-01 2008-06-12 Srinivasa Madhyastha Antimicrobial Compositions and Uses Thereof
US20080152596A1 (en) 2005-07-19 2008-06-26 Foamix Ltd. Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof
BRPI0503201B8 (en) 2005-07-28 2021-05-25 Sci Tech Produtos Medicos Ltda stents coated with hydrophilic polymer blends, eluting nitric oxide and s-nitrosothiols
US20090018091A1 (en) 2005-08-02 2009-01-15 Nitromed, Inc. Nitric Oxide Enhancing Antimicrobial Compounds, Compositions and Methods of Use
JP2009505727A (en) 2005-08-25 2009-02-12 メドトロニック ヴァスキュラー インコーポレイテッド Nitric oxide releasing biodegradable polymers useful as medical devices and their coatings
JP5371429B2 (en) 2005-08-26 2013-12-18 ネステク ソシエテ アノニム Compositions and methods for improving functional vascular integrity and cell survival and reducing apoptosis in or after cerebral ischemia
US20070048344A1 (en) 2005-08-31 2007-03-01 Ali Yahiaoui Antimicrobial composition
US20070053952A1 (en) 2005-09-07 2007-03-08 Medtronic Vascular, Inc. Nitric oxide-releasing polymers derived from modified polymers
EP1764119A1 (en) 2005-09-09 2007-03-21 NOLabs AB Implants with improved osteointegration
US20090010989A1 (en) 2005-09-12 2009-01-08 N0Labs Ab Coating For Implants and Implants With Improved Osteointegration, and Manufacturing Method
EP1937287B1 (en) 2005-10-11 2012-02-29 Bayer Consumer Care AG Mixture of iron and copper salts masking metallic taste
US20070088345A1 (en) 2005-10-13 2007-04-19 Ust Inc. Applications of HIFU and chemotherapy
US7531164B2 (en) 2005-10-21 2009-05-12 Duke University Preventing bacterial or viral infectivity and composition containing infection preventing additive
WO2007053292A2 (en) 2005-10-31 2007-05-10 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates
WO2007053578A2 (en) 2005-10-31 2007-05-10 Amulet Pharmaceuticals, Inc. Multi-phasic nitric oxide and drug co-eluting stent coatings
EP1790335A1 (en) 2005-11-14 2007-05-30 NOLabs AB Composition and its use for the manufacture of a medicament for treating, prophylactically treating, preventing cancer and/or infections in the urinary tract
EP1954685A4 (en) 2005-11-16 2009-11-11 Nitromed Inc Furoxan compounds, compositions and methods of use
US20070116785A1 (en) 2005-11-18 2007-05-24 Miller Christopher C Nitric oxide as an anti-viral agent, vaccine and vaccine adjuvant
US20070129690A1 (en) 2005-12-02 2007-06-07 Joel Rosenblatt Catheter with polymeric coating
WO2007064895A2 (en) 2005-12-02 2007-06-07 The Regents Of The University Of Michigan Polymer compositions, coatings and devices, and methods of making and using the same
WO2007067477A1 (en) 2005-12-06 2007-06-14 Amulet Pharmaceuticals, Inc. Nitric oxide-releasing polymers
US20070243262A1 (en) 2005-12-21 2007-10-18 Hurley Kevin P Stable S-nitrosothiol formulations
US9801902B2 (en) 2006-01-17 2017-10-31 The University Of Akron Debridement method using topical nitric oxide donor devices and compositions
US20070225250A1 (en) 2006-01-26 2007-09-27 Bebaas, Inc. Cobalamin compositions for the treatment of cancer
CA2641815C (en) 2006-02-03 2015-06-09 Giulio Cossu Method of treatment for muscular dystrophy
KR20080097989A (en) 2006-02-03 2008-11-06 니콕스 에스. 에이. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US20070202155A1 (en) 2006-02-03 2007-08-30 Cure Therapeutics, Inc. Low dose no donor-containing transdermal patch
US20070203242A1 (en) 2006-02-27 2007-08-30 Calwood Nutritionals, Inc. Method for treating gastric reflux
US20070219208A1 (en) 2006-02-27 2007-09-20 Balaraman Kalyanaraman Methods for Treating Cancer
US7645748B2 (en) 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol phosphorylnitroderivatives and use thereof
US7645749B2 (en) 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol nitroderivatives and use thereof
WO2007127725A2 (en) 2006-04-24 2007-11-08 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Diazeniumdiolated non-steroidal anti-inflammatory drugs, compositions thereof, and related methods
US8241619B2 (en) 2006-05-15 2012-08-14 Medtronic Vascular, Inc. Hindered amine nitric oxide donating polymers for coating medical devices
US20080171351A1 (en) 2006-05-22 2008-07-17 University Of Notre Dame Du Lac Probes for anionic cell surface detection
EP2029106A2 (en) 2006-06-07 2009-03-04 Foamix Ltd. Foamable vehicle comprising polypropylene glycol alkyl ether and pharmaceutical compositions thereof
US20090263416A1 (en) 2006-06-16 2009-10-22 Dawson Karl A Reduction of antibiotic resistance in bacteria
WO2007149520A2 (en) 2006-06-21 2007-12-27 Albert Einstein College Of Medicine Of Yeshiva University Compositions for sustained release of nitric oxide, methods of preparing same and uses thereof
WO2008110872A2 (en) 2006-06-23 2008-09-18 Foamix Ltd. Foamable compositions and kits comprising one or more of a channel agent, a cholinergic agent, a nitric oxide donor, and related agents and their uses
PT2494959E (en) 2006-07-05 2015-02-20 Foamix Pharmaceuticals Ltd Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
WO2008012845A1 (en) 2006-07-26 2008-01-31 Stmicroelectronics S.R.L. Use of nitroaniline derivatives for the production of nitric oxide
US20080025972A1 (en) 2006-07-26 2008-01-31 Duke University Treating sex steriod responsive disorders
WO2008019051A2 (en) * 2006-08-03 2008-02-14 The Board Of Trustees Of The Leland Stanford Junior University Devices and bandages for the treatment or prevention of scars and/or keloids and methods and kits therefor
GB0616350D0 (en) 2006-08-17 2006-09-27 Univ St Andrews Adsorption and release of nitric oxide in metal organic frameworks
EP2068798A4 (en) * 2006-08-30 2009-12-16 Southeastern Medical Technolog Methods, compositions and apparatuses to treat wounds with pressures altered from atmospheric
EP1895012A1 (en) 2006-08-30 2008-03-05 Universitätsklinikum Freiburg Method for inducing tumor apoptosis by increasing nitric oxide levels
JP2010502690A (en) 2006-09-08 2010-01-28 フォーミックス エルティーディー． Colored or colorable foamable composition
GB0618711D0 (en) 2006-09-22 2006-11-01 Univ Exeter Agricultural treatment
US20080206155A1 (en) 2006-11-14 2008-08-28 Foamix Ltd. Stable non-alcoholic foamable pharmaceutical emulsion compositions with an unctuous emollient and their uses
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
MY151457A (en) 2006-11-15 2014-05-30 Arthritis Relief Plus Ltd Topical formulation and uses thereof
GB0623531D0 (en) 2006-11-25 2007-01-03 Univ St Andrews Nitric oxide storage and production
EP2097065A2 (en) 2006-11-29 2009-09-09 Foamix Ltd. Foamable waterless compositions with modulating agents
US8221690B2 (en) 2007-10-30 2012-07-17 The Invention Science Fund I, Llc Systems and devices that utilize photolyzable nitric oxide donors
US20090110933A1 (en) 2007-10-30 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems and devices related to nitric oxide releasing materials
US7862598B2 (en) 2007-10-30 2011-01-04 The Invention Science Fund I, Llc Devices and systems that deliver nitric oxide
US8642093B2 (en) 2007-10-30 2014-02-04 The Invention Science Fund I, Llc Methods and systems for use of photolyzable nitric oxide donors
US20090112197A1 (en) 2007-10-30 2009-04-30 Searete Llc Devices configured to facilitate release of nitric oxide
US20080292560A1 (en) 2007-01-12 2008-11-27 Dov Tamarkin Silicone in glycol pharmaceutical and cosmetic compositions with accommodating agent
US20080175881A1 (en) 2007-01-18 2008-07-24 Boston Scientific Scimed, Inc. Blood-contacting medical devices for the release of nitric oxide and anti-restenotic agents
WO2008094275A1 (en) 2007-01-30 2008-08-07 New York University Peptides for treatment of conditions associated with nitric oxide
ES2604562T3 (en) 2007-02-05 2017-03-07 Nicox Science Ireland Nitric Oxide Donor Compounds
US20080193385A1 (en) 2007-02-08 2008-08-14 Todd Maibach Compositions and methods for treating neuropathy
US20080193566A1 (en) 2007-02-09 2008-08-14 Miller Christopher C Use of high dose concentrations of gaseous nitric oxide
WO2008100591A2 (en) 2007-02-14 2008-08-21 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
US7811600B2 (en) 2007-03-08 2010-10-12 Medtronic Vascular, Inc. Nitric oxide donating medical devices and methods of making same
JP5172940B2 (en) 2007-03-27 2013-03-27 ノーラブズ エービー Topical skin delivery device for nitric oxide delivery
WO2008130567A1 (en) 2007-04-20 2008-10-30 Duke University Stable neutral nitric oxide source
US20100255062A1 (en) 2007-06-01 2010-10-07 Amulet Pharmaceuticals, Inc. Compounds, polymers and methods for treating gastrointestinal dysfunction
EP2155213A1 (en) 2007-06-15 2010-02-24 Ikaria, Inc. Compositions comprising sulfide alone or in combination with nitric oxide and their use to
US8273828B2 (en) 2007-07-24 2012-09-25 Medtronic Vascular, Inc. Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation
EP2170157B1 (en) 2007-07-26 2016-09-07 Duke University Measuring amount of bound and combined nitric oxide in blood
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
GB0715556D0 (en) 2007-08-09 2007-09-19 Insense Ltd Improvements relating to skin dressings
GB0715554D0 (en) 2007-08-09 2007-09-19 Insense Ltd Improvements relating to skin dressings
CA2599082A1 (en) 2007-08-27 2009-02-27 Ping I. Lee Supramacromolecular polymer complexes providing controlled nitric oxide release for healing wounds
WO2009071990A2 (en) 2007-08-31 2009-06-11 Topigen Pharmaceuticals Inc. No-donating cordicosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
US8617100B2 (en) 2007-09-04 2013-12-31 Foamix Ltd. Device for delivery of a foamable composition
CA2700172A1 (en) 2007-09-21 2009-03-26 Enox Biopharma, Inc. Antimicrobial gas-releasing ear drainage tubes
US9453115B2 (en) 2007-10-12 2016-09-27 Honeywell International Inc. Stabilization of polyurethane foam polyol premixes containing halogenated olefin blowing agents
WO2009049208A1 (en) * 2007-10-12 2009-04-16 The University Of North Carolina At Chapel Hill Use of nitric oxide to enhance the efficacy of silver and other topical wound care agents
US20090112055A1 (en) 2007-10-30 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Sleeves configured to facilitate release of nitric oxide
US20090112193A1 (en) 2007-10-30 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems and devices that utilize photolyzable nitric oxide donors
US7897399B2 (en) 2007-10-30 2011-03-01 The Invention Science Fund I, Llc Nitric oxide sensors and systems
US8877508B2 (en) 2007-10-30 2014-11-04 The Invention Science Fund I, Llc Devices and systems that deliver nitric oxide
US8349262B2 (en) 2007-10-30 2013-01-08 The Invention Science Fund I, Llc Nitric oxide permeable housings
WO2009064861A2 (en) 2007-11-13 2009-05-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nitric oxide-releasing diazeniumdiolated polymers, compositions, medical devices, and uses thereof
US20090130029A1 (en) 2007-11-21 2009-05-21 Foamix Ltd. Glycerol ethers vehicle and pharmaceutical compositions thereof
WO2009069006A2 (en) 2007-11-30 2009-06-04 Foamix Ltd. Foam containing benzoyl peroxide
WO2009073643A2 (en) 2007-12-03 2009-06-11 Cleveland State University Nitric oxide release coatings incorporating nitric oxide synthase enzyme
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
BRPI0705396B1 (en) 2007-12-12 2021-10-05 Universidade Estadual De Campinas - Unicamp PHTHLIMID DERIVED COMPOUNDS
IE20070934A1 (en) 2007-12-21 2009-06-24 Trinity College Dublin Efficient aspirin prodrugs
WO2009086470A2 (en) 2007-12-27 2009-07-09 Aires Pharmaceuticals, Inc. Aerosolized nitrite and nitric oxide - donating compounds and uses thereof
US20090177133A1 (en) * 2008-01-04 2009-07-09 Kristine Kieswetter Reduced pressure dressing coated with biomolecules
CA2994586C (en) 2008-01-04 2020-07-21 Nestec S.A. Compositions comprising unsaturated fatty acids and nitric oxide releasing compounds and use thereof for enhancing cognitive and related functions
WO2009087578A2 (en) 2008-01-08 2009-07-16 Foamix Ltd. Sensation modifying topical composition foam
JP5623916B2 (en) 2008-01-31 2014-11-12 バンダービルト・ユニバーシティＶａｎｄｅｒｂｉｌｔ Ｕｎｉｖｅｒｓｉｔｙ Pharmaceutical composition for aneurysmal subarachnoid hemorrhage and vasospasm
US8720436B2 (en) 2008-01-31 2014-05-13 Genosys, Inc. Nitric oxide gel apparatus and method
CA2706082C (en) 2008-02-07 2017-10-03 Nicox S.A. Nitric oxide donor compounds
US20090222088A1 (en) 2008-02-29 2009-09-03 Medtronic Vascular, Inc. Secondary Amine Containing Nitric Oxide Releasing Polymer Composition
US20090232868A1 (en) 2008-03-17 2009-09-17 Medtronic Vascular, Inc. Nitric Oxide Releasing Polymer Composition
US20090232863A1 (en) 2008-03-17 2009-09-17 Medtronic Vascular, Inc. Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers
WO2009124379A1 (en) 2008-04-09 2009-10-15 Enox Biopharma, Inc. Biofilm-inhibiting catheters and tubings
JP2011518222A (en) 2008-04-21 2011-06-23 スリーエム イノベイティブ プロパティズ カンパニー Nitric oxide releasing composition, device and method
US20120141384A1 (en) 2008-05-06 2012-06-07 Dov Tamarkin Antibacterial conjugated boronic acids and pharmaceutical compositions thereof
WO2009155690A1 (en) 2008-06-24 2009-12-30 Micropharma Limited Nitric oxide compositions and devices and methods for cosmesis
US8852640B2 (en) 2008-07-03 2014-10-07 Ecole Polytechnique Federale De Lausanne (Epfl) Micelles for delivery of nitric oxide
US20100040703A1 (en) 2008-08-13 2010-02-18 Chris Miller Use of nitric oxide
EP2331606B1 (en) 2008-09-19 2016-11-02 Northwestern University Biodegradable nitric oxide generating polymers and related biomedical devices
US7807716B2 (en) 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
US20100086530A1 (en) 2008-10-06 2010-04-08 Martinov Norman P Cancer-tumor necrosis by artery nutrient-oxygen blocking
US9700246B2 (en) 2008-10-15 2017-07-11 The University Of Tennessee Research Foundation Method and device for detection of bioavailable drug concentration in a fluid sample
US20100099766A1 (en) 2008-10-16 2010-04-22 Novartis Ag Topical NSAID compositions having sensate component
EP2334279A4 (en) * 2008-10-16 2013-03-20 Novan Inc Nitric oxide releasing particles for oral care applications
CA2740135A1 (en) 2008-10-30 2010-05-06 Chris Miller Wound dressings comprising a nitric oxide gas producing component and an oxygen releasing component
US20100166603A1 (en) 2008-10-31 2010-07-01 Noxilizer, Inc. Powder Sterilization
US8158187B2 (en) 2008-12-19 2012-04-17 Medtronic Vascular, Inc. Dry diazeniumdiolation methods for producing nitric oxide releasing medical devices
US20100197702A1 (en) 2009-02-04 2010-08-05 Hellberg Mark R Ophthalmic composition with nitric oxide donor compound and method of forming and using same
EP2398761A4 (en) 2009-02-18 2015-11-04 Bezwada Biomedical Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
US8062653B2 (en) 2009-02-18 2011-11-22 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
US9216198B2 (en) 2009-03-30 2015-12-22 The Board Of Regents, The University Of Texas System Compositions and medical devices for controlled release of nitric oxide and methods of production thereof
US8236341B2 (en) 2009-04-02 2012-08-07 Medtronic Vascular, Inc. Poly(tetrafluoroethylene) polymer with nitric oxide donating surface
WO2010114633A1 (en) * 2009-04-03 2010-10-07 Biomerix Corporation At least partially resorbable reticulated elastomeric matrix elements and methods of making same
US8709465B2 (en) 2009-04-13 2014-04-29 Medtronic Vascular, Inc. Diazeniumdiolated phosphorylcholine polymers for nitric oxide release
CA2763804C (en) 2009-06-22 2018-02-06 Geno Llc Nitric oxide therapies
US20110059189A1 (en) 2009-09-08 2011-03-10 Cisne Enterprises Inc. Method and composition for treating cancer, effecting apoptosis and treating retroviral infections
US20110086234A1 (en) 2009-10-13 2011-04-14 Nathan Stasko Nitric oxide-releasing coatings

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
WO2003026717A1 (en) * 2001-09-26 2003-04-03 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Nitric oxide-releasing coated medical devices and method of preparing same
WO2006128121A2 (en) * 2005-05-27 2006-11-30 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NORIO IWAKIRI ET AL: "Synthesis of amphiphilic polysiloxanes and their properties for formation of nano-aggregates", COLLOID AND POLYMER SCIENCE ; KOLLOID-ZEITSCHRIFT UND ZEITSCHRIFT FÜR POLYMERE, SPRINGER, BERLIN, DE, vol. 287, no. 5, 13 February 2009 (2009-02-13), pages 577 - 582, XP019712758, ISSN: 1435-1536 *

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