WO2011018593A1

WO2011018593A1 - Packaging

Info

Publication number: WO2011018593A1
Application number: PCT/GB2009/001958
Authority: WO
Inventors: Peter Thomas Bowdler
Original assignee: Convenience Healthcare Limited
Priority date: 2009-08-10
Filing date: 2009-08-10
Publication date: 2011-02-17

Abstract

Medicament packaging arrangement (10) comprising packaging (14) defining a closed cavity, the cavity containing medicament, the packaging arranged to be manually openable to access the medicament, the arrangement further comprising a medicament information carrier (16) attached to the packaging, and the packaging arrangement arranged to be retained with a liquid container.

Description

PACKAGING Technical Field

This invention relates generally to packaging. Background It is known to package medicament (such as for example pain relief, vitamins and supplements) , in tablet, caplet and powder form, in so-called blister packs, and also to package powdered medicament in sachets. Blister packs generally comprise a web (usually of plastics material) formed with cavities. Each cavity holds a dosage unit of medicament and the cavities are closed by way of a lidding/membrane sheet (of foil, paper or plastic) applied to the web. A user can access the medicament by pushing the web towards the lidding sheet thereby pushing the medicament through the sheet.

Conventionally the blister packs are packaged within a box which bears external information relating to the use of the enclosed medicament.

Within the box is a Product Information Leaflet (PIL) , which carries greater informational detail of how to use the medicament and warnings associated with taking the medicament. Such existing blister packs may typically include eight to sixteen dosage units (eg eight to sixteen tablets) .

We have appreciated that it is possible to provide packaged medicament and a PIL in an advantageous arrangement when combined with a container of drinkable liquid for consuming the medicament. Such an arrangement is of particular advantage where fewer dosage units are provided, for example one to four tablets are packaged in a blister pack. Summary

According to one aspect of the invention there is provided medicament packaging arrangement comprising packaging defining a closed cavity, the cavity containing medicament, the packaging arranged to be manually openable to access the medicament, the arrangement further comprising a medicament information carrier attached to the packaging, and the packaging arrangement arranged to be retained with a liquid container.

According to another aspect of the invention there is provided a liquid container arranged for use with the medicament packaging arrangement of the first aspect of the invention.

According to a further aspect of the invention there is provided a closure assembly for a liquid container comprising a closure arranged to be attached to the liquid container, and the assembly further comprising a cover arranged to be removably attached to the closure, and the closure defining a storage recess, and the closure assembly comprises a male-to- female arrangement which is such as to allow the cover to be removed from the closure and when the cover is attached to the closure to prevent relative rotation of the cover and the closure when a torque is applied to the cover. Brief Description of the drawings

Various embodiments of the invention will now be described, by way of example only, with reference to the following drawings in which:

Figure 1 shows a liquid container,

Figures 2 and 3 show a closure assembly of a liquid container, Figures 4a, 4b, 4c and 4d show a medicament packaging arrangement,

Figure 5 shows a medicament packaging arrangement being removed from a closure assembly,

Figures 6 to 9 show a further embodiment,

Figures 10a to 10c show various views of a further embodiment,

Figure 11 shows a further embodiment,

Figures 12a to 12c and Figure 13 shows a further embodiment,

Figures 14, 15 and 16a to 16c show further embodiments of the invention,

Figure 17 shows a further embodiment,

Figure 18 shows a further embodiment,

Figures 19a and 19b, and 20a to 2Od show a further embodiment, Figures 21a and 21b show a further embodiment,

Figures 22 and 23 show further embodiments,

Figures 24a and 24b show a further embodiment,

Figure 25 shows a further embodiment,

Figures 26a and 26b show a further embodiment, Figures 27a and 27b show a further embodiment, Figures 28a and 28b show a further embodiment, Figures 29a and 29b show a further embodiment,

Figures 30 to 33 show exploded views of various medicament packaging arrangements,

Figures 34a, 34b, 34c and 34d show a medicament packaging arrangement for attachment to a liquid container, and

Figures 35a to 35g show a further embodiment of a medicament packaging arrangement. Detailed Description

Reference is made to Figure 1 which shows a liquid container assembly 1. The container 1 comprises a vessel 2 which is provided with a closure assembly 3 which comprises a closure 4 and a removable overcap or protective cover 5. The closure assembly 3 is arranged to house a medicament packaging arrangement 10.

As best seen in Figures 4a, 4b, 4c and 4d, the arrangement 10 comprises a finger grippable tab 12, a blister packaging 14 and a medicament information leaflet 16. The medicament packaging arrangement 10 is essentially of concertina form by virtue of folds 19 and 20 which hingeably connect the tab 12, the packaging 14 and the leaflet 16.

The blister packaging 14 comprises two closed cavities 15 which house respective tablets (not illustrated) . The medicament information leaflet 16 comprises a backing card 16a and a folded multi-page leaflet 16b (which carries printed information) , which is attached to the backing card.

As can be seen from Figures 4a to 4d, the arrangement 10 can be arranged to adopt a (compact) folded condition and an (expanded) unfolded condition.

With reference now to Figure 2, the arrangement 10, in the folded condition is contained within a space 30 defined by the closure assembly 3, and specifically by inner surfaces of the overcap 5 and the closure 4. The closure 4 defines an upper recess 30a bounded by a surrounding wall 6. The recess 30a defines in part the space 30.

As can be seen from Figure 2, the closure assembly 3 attaches to the vessel 2 by way of a threaded connection 9 which engages with a threaded neck 20 of the vessel 2. Thus, the closure is replaceably removable from the vessel 2 to allow a user to drink the liquid in the vessel 2, and then replace the closure onto the vessel. It will be appreciated that the threaded arrangement allows the closure assembly in its entirety (ie with the overcap 5 attached to the closure 4) to be removed and replaced from the vessel 2. This allows the user to remove and replace the combined overcap and closure without removing the blister and so even when removed from the bottle, the arrangement 10 is kept safe and protected (within the closure assembly) . As best seen in Figure 3, the closure 4 is provided with a plurality of longitudinal ribs or splines 13a which are circumferentially spaced and arranged to receive ribs or splines 13b provided on an inner surface of the overcap 5. Accordingly the ribs/splines 13a and 13b engage and cooperate by way of a male-to-female arrangement which allows the overcap 5 to be removed and replaced from the closure 4. However, the arrangement provides that, when the overcap is attached to the closure 4, an attempt to rotate the overcap 5 relative to the closure 4 is prevented by way of balking engagement between the ribs/ splines. Thus, when a user wishes to remove the entire closure assembly from the vessel 2, he can do so by applying a couple to the overcap 5, and this will transmit torque to the closure so as to disengage the threaded engagement between the closure and the vessel at 9 and 20. The male-to-female engagement prevents the overcap from rotating around the closure 4 .and so hindering removal of the closure assembly by the user. The overcap 5 is releasably attachable to the closure 4 by way of snap-fit arrangement comprising an inwardly protruding circumferential ridge 7 of the overcap 5 and an outwardly protruding circumferential ridge 17 of the closure 4. The ridge 7 is provided on a lowermost resilient flexible skirt portion 11 of the overcap, and is arranged to deflect outwardly to allow the ridge 7 to pass over the ridge 17, thereby allowing the overcap to either be removed from the closure or to be attached to the closure by way of a force applied by the user to the overcap. It will be appreciated that either the ridge 7 or the ridge 17 need not necessarily extend around the entire circumference and so may be continuous or may comprise one or more breaks/gaps (and so be discontinuous) .

As can be seen from Figure 5, in order to remove the medicament packaging arrangement 10 from the closure 4 after the over the overcap has been removed, a user grips the tab 12 and lifts the arrangement out. The user can then unfold the arrangement 10 (in the manner shown in Figures 4a, 4b, 4c and 4d) . The user is then able to read the printed text provided on the leaflet 16 to understand the instructions for use of the medicament. If the user requires to take only one of the tablets he can return the arrangement 10 to its folded condition (with one of the tablets still remaining in its respective closed cavity of the blister pack) , and replace the arrangement into the recess 30a for later use. The overcap 5 can then be urged onto the closure 4 and so retain the arrangement 10. The overcap 5 allows the tablets to be secured within the cap protecting the arrangement 10 and preventing tearing and damaging the tablet(s) if the arrangement 10 is placed within the users pocket or bag for example.

It will be appreciated that the tab 12 has the advantage of significantly reducing the risk that a user could damage the integrity of the blister pack when removing the arrangement 10 from the closure assembly. Because of the inherently limited space for storage of the arrangement 10, problems may occur when a user tries to remove the arrangement. The user may damage the (lidding) foil on the blister by bending the blister with his fingertips whilst trying to remove it. Alternatively, the user may inadvertently scratch the foil. The consequence of this action may break the sealed cavity and expose the tablet (s) /medicament held by the blister pack to the environment external of the closed storage cavity of the blister pack, potentially allowing various foreign bodies such as dirt or air-born bacteria to enter the blister and react with the tablet/s. Some tablets or medication react to moisture causing them to react in a manner that makes them unsuitable for human consumption. For example, effervescent tablets react to moisture and as a consequence of the blister being damaged air born moisture can enter the blister causing the tablet to start to dissolve.

Furthermore, if the user takes one tablet with the fluid provided but fails to replace the closure 4 onto the vessel 2 correctly, the tab 12 ensures that the user does not need to invert the vessel and closure and tap vessel to remove the arrangement 10. Valuable information regarding manufacturing references known as the 'manufacturing lot number/s' are required by organisations that govern the packaging and licensing of medication, as is the 'sell-by-date' or 'best before date' information. This information is usually stamped or printed into or onto boxes that house the blister and/or at the end of the blister pack and away from the tablet/s. Since the arrangement 10 is of limited dimensions, provision of this information is likely to be problematic. Advantageously, and as can be seen from Figure 3, a region 40 is provided on the tab 12 where the stamped or printed information to be is to be provided. By providing the information at region 40, and so away from the closed cavities of blister pack damage to the (sealed) integrity of the blister pack during application of the information is significantly reduced. The region 40 is advantageously dimensioned so that the information can be printed a certain size to ensure that it is legible.

It will be appreciated that advantage lies in providing the various information attached to the blister pack 14 since a user can check the sell by date or other information stamped or printed on the tab 12 and read the leaflet 16 at the time of use of the medicament. The likelihood of the information becoming separated from the blister pack at a later date after taking an initial dose is reduced since the information is attached to the blister pack.

It will also be appreciated that in the event of the packaging arrangement 10 not being replaced within the combined closure/over-cap, - if for example the consumer uses all of the fluid in the vessel 2 and then disposes of the vessel - the blister still carries enough information relating to the remaining medicament included within the blister pack. Without this information, the user could potentially take a medicament that could cause harm. The closure 4 provides the advantage of improved manufacturing/packaging in relation to placing the arrangement 10 onto the closure 4. As the combined vessels 2 and closures 4 move along an automated production line, the arrangement 10 has to be put into place and then the overcap 5 placed onto the closure. The recess 30a and the sidewalls 6 are advantageously arranged so that once the arrangement 10 is positioned into the recess 30a, the arrangement will remain in the correct position despite the inherent vibrations during the production process which would otherwise act to displacement the arrangement. In particular, the sidewalls 6 are sloped from the bottom of the receptacle to the top which guides the arrangement into the correct position, making the placing/replacing of the blister easier, both in manufacture and for the user. This is especially helpful for users who are infirm or shortsighted. As can be seen from Figure 1 , the overcap 5 is transparent and so allows a user to view the arrangement 10, and in particular the blister pack 14.

Medicaments are available in many different shapes and sizes and users generally have a preferred shape that they usually purchase. The transparent overcap 5 accordingly allows consumers considering purchasing the product to ascertain whether the blister pack houses their preferred choice. The part of the blister pack may be transparent, which, together with the transparent characteristic of the overcap allow serve to allow users to view the colour of the medicament which may be indicative of the flavour /type of medicament. For example, Orange flavoured tablets are coloured orange, blackcurrant is coloured deep purple. In alternative embodiments, it may be preferred that the overcap is substantially opaque and so prevents a user from viewing the stored medicament packaging arrangement. Reference is now made to Figures 6, 7, 8 and 9, which show a variant embodiment to that described above. Like features are shown by like reference numerals. As can be seen from the figures, the closure 4 is provided with a headed upstand 48 which extends upwardly from an upper surface 41 of the closure 4. The headed upstand 48 serves to locate and releasably retain a medicament packaging arrangement 50, which is essentially of identical form to the arrangement 10, save that a stamped cross-shaped aperture 51 is provided through the arrangement. The aperture 51 is dimensioned to be capable of resiliently passing over the head of the upstand 48, either to remove the arrangement 50 from the storage position shown in Figure 6, using the tab 12, to the removed position shown in Figure 9, or to replace the arrangement 50 to the storage position. When in the storage position, the headed upstand retains the arrangement 50 in that position. Reference is now made to Figures 10a, 10b and 10c, which show a variant embodiment 60 of a medicament packaging arrangement to that shown in Figures 7 to 9. The arrangement 60 comprises a tab 12, a blister packaging 62, a medicament leaflet 61 and an end portion 63. The medicament packaging arrangement 60 is essentially of concertina form by virtue of hinges 66 and 67 which hingeably connect the tab 12, the packaging 62 and the leaflet 61. The medicament information leaflet 62 comprises a backing card 61a and a folded multi-page leaflet 61b, which is attached to the backing card. The end portion 63 is provided with the cross-shaped aperture 51 and is arranged to cooperate with the headed upstand 48 (in the manner described above) . In the folded position (as shown in Figure 10a) , by virtue of the blister packaging 62 being interposed between the leaflet 61 and the end portion 63, the components 63 and (in particular) component 61 serve to protect the blister packaging. Reference is now made to Figure 11 which shows a further variant embodiment, similar to that shown in Figures 7 to 9, comprising a closure 70 and a medicament packaging arrangement 80. Like reference numerals are used for like or similar features. The closure 70 comprises a (non-headed) upstand or pin 71 which is arranged to provide a friction or interference fit with a through-hole 81.

Figures 12a, 12b, 12c and 13 show an alternative medicament packaging arrangement 90 arranged for storage in a space of a closure assembly of a liquid container. The arrangement 90 comprises a two-part blister packaging comprising a first part 91 which is connected to a second part 92 by way of a hinge 95. The first part comprises a single blister recess 91a and the second part comprises a single blister recess 92a. A tab 94 is hingeably connected by way of a fold 96 to the first part 91. Advantageously, the blister recesses are positioned at different distances from the hinge 95, and so allow the arrangement to adopt the folded position shown in Figure 13. It will be appreciated that a product information leaflet could be attached to the arrangement 90, but has been omitted for the sake of ease of representation.

There will now be described various embodiments in which a medicament packaging arrangement is arranged to be provided in a sidewall of a liquid container. Reference is first made to Figures 14 and 15, which show a liquid container 100 comprising a liquid storage vessel 102 and a closure assembly 103. The vessel 102 is provided with a recess 130 in a sidewall of the vessel. The recess 130 is arranged to accommodate a medicament packaging arrangement 110, which will be described in detail below. Attached to a sidewall of the vessel 102 there is attached medicament information leaflet 116 and an outer label 117. The information leaflet and the label are arranged to fit around at least part of the perimeter of the vessel, and in particular a recessed region bounded by two shoulders 118 and 119. The outer cover/label is of greater length as compared to the length of the leaflet 116, and a distal end comprises a tab portion 115. The tab portion 115 is arranged to be attached, but manually detachable, to the vessel 102. It will be appreciated that Figures 14 and 15 show the leaflet and label in which the tab portion is in a detached condition.

Reference is now made to Figures 16a, 16b, 16c and 16d to describe the medicament packaging arrangement 110, which progressively show the arrangement being unfolded. The arrangement 110 comprises a grippable tab 122, a blister packaging 123, and a medicament information leaflet 124. The tab 122 may advantageously be provided with printed or stamped information, of the kind referred to above. The leaflet 124 comprises a portion 124a which is provided with information in Braille and a portion 124b provided with printed text. The portion 124a is provided with information 126 in Braille, and a raised rib 125 is provided on each side of the Braille information. Advantageously, when in the folded condition, the ribs maintain a spatial relationship between the Braille 126 and an opposing surface of the leaflet portion 124b. This ensures that the integrity of the Braille information is not compromised by pressure exerted by the portion 124b.

The tab 122 is connected to the blister pack 123 by way of a limb portion 122a, which is of smaller width than that of the blister pack, and the limb 122a extends away from the blister pack. The limb portion 122a is connected to the tab 122 by way of a hinge 122b

Returning to Figure 15, which shows the arrangement 110 having been removed from the recess 130, a glue spot 135 is provided in order to releasably attach the arrangement 110 in position in the recess. When a user needs to access the medicament stored in the blister packaging, having released the end of the label 117 from the vessel, and holding the label and the leaflet clear of the recess 130, the user grips the tab 122 and detaches the bond between the glue spot 135 and the arrangement 110. Advantageously, the glue spot attaches to the limb portion 122a and not to the foil/membrane of the blister pack 123 , and so avoiding the risk of the foil being damaged by removable of the arrangement from the glue spot.

It will be appreciated that the leaflet 116, in the form of a multi-page booklet, may comprise the same or additional information as compared to the information included in the leaflet 124.

Should the user require only some of the medicament provided in the blister packaging 128, he can return the arrangement 110 to its folded condition and replace the arrangement into the recess 130. He can then re-secure the tab 115 of the label 117 to the vessel 102.

In the instance that information in Braille is provided on an external surface of the label 117, the shoulders 118 and 119 ensure that when like liquid containers are placed side-by-side, either in transportation, or during display of the containers in an outlet, that the integrity of the Braille is not damaged. This protection afforded to the external Braille information is advantageously achieved whilst maintaining a minimal overall spatial envelope.

Turning to Figure 17, there is shown an alternative arrangement in which two arrangements 110 are provided within respective recesses 130. Each arrangement 110 is held in its recess by way of a (preferably transparent) retaining portion 140, in sheet form, which is releasably secured to that part of the sidewall which defines the margin of the recess (the portion 140 being of a larger dimensional footprint than the recess) . A user is able to remove the portion 140 and then grip the tab 122 in order to remove the arrangement 110.

Figure 18 shows a variant embodiment of that shown in Figure 17, in which a recess 150, arranged to receive the arrangement 110, comprises an upper recessed region 150a which is of extended length as compared to that required to accommodate the limb portion 122a. A retaining portion 140, is secured to the margin of the recess at 140b. A user wishing to the remove the arrangement 110, can insert a finger into the extended recess 150 to grip the central sheet portion 140a and remove the sheet by tearing the frangible connection shown by the broken line. The user can then grip the tab 122 so as to remove the arrangement 110.

Reference is now made to Figures 19a, 19b, 20a, 20b, 20c and 2Od which show a further embodiment in which a medicament packaging arrangement 180 is provided in a container 170, and the container is arranged to fit into a recess 160 provided in a sidewall of a liquid vessel by way of an interference or friction fit. As best seen in Figures 20a to 2Od, the container 170 comprises a finger tab 171 which allows a user to remove the arrangement 180 from the recess 160. Once so removed, a lid 172 of the container can be opened and the arrangement 180 can be removed from the container 170 by way of the user gripping a finger tab 181 of the arrangement 180. As can be seen from Figure 2Od, the arrangement 180 comprises a blister packaging and an information leaflet, which are provided with folds so that the arrangement can conveniently adopt a folded condition or an unfolded condition. The container 170 conveniently allows a user to safely carry the arrangement 180, say in a pocket, once removed from the recess, and the container 170 serves to protect the arrangement 180. Figures 21a and 21b show a further embodiment in which a blister packaging 210 is attached to the vessel 102 by way of an attachment portion 212, which is itself secured to the vessel and at least in part, is arranged to wrap-around the periphery of the vessel. In the condition shown in Figure 21a, the blister packaging is retained in a recess 230 of the sidewall of the vessel. By manually releasing the tab 115 from being attached to the vessel, the blister packaging 210 can be moved out of the recess 230 so that medicament can be accessed. It will be appreciated that the label 117, the leaflet 116, the attachment portion 212 and the blister packaging 210 may be provided as single connected entity and so facilitate attaching the entity to the vessel during manufacture. The entity connects the various components at what may be termed a spine, and the spine being attached to the vessel such that it is not intended to be removed from the bottle by way of a bonding. Figures 22 and 23 show very similar arrangements to that shown in Figures 21a and 21b. In Figure 22, a single dose unit of medicament is packaged in a tear-open packaging in which a notch 219 is provided. In Figure 23, two unit doses of medicament (for example in caplet form) are provided in respective tear-open packaging, each provided with a respective notch 223.

Figures 24a and 24b show yet a further embodiment in which the blister packaging 210 is connected to an attachment portion 240, and a medicament information leaflet 245 is attached to the blister packaging 210. The leaflet 245 is folded in such a way that it can unfolded generally perpendicular to the extent of the blister packaging and the attachment portion (as best seen in Figure 24b) . It will be appreciated that with this, any of the other embodiments disclosed herein, the leaflet may be provided with any suitable arrangement of folds such that it can be unfolded (and folded) in any suitable way or ways.

Figure 25 shows a variant embodiment to that shown in Figures 24a and 24b in which the attachment portion or spine 240 is connected to the blister packaging 210 by way of a frangible connection (shown by broken lines) which allows the user to detach the blister packaging and the leaflet from the vessel if so desired. The blister packaging comprises a grip portion or spine 210a. Conveniently the attachment portion 240 (which in use serves as a grip portion/ spine) and the grip portion 210a are of sufficient dimensions to allow a user to grip the attachment portion with one hand the grip portion with the other to enable the blister packaging to be removed. The inclusion of the grip portion 210a is of particular advantage since it avoids the user needing to directly grip either the cavities of the blister pack or the foil membrane and so avoids the risk that the medicament in the blister packaging could be inadvertently removed whilst removing said blister packaging. The attachment portion 240 ensures that a user a force applied to remove the blister packaging 210 from the attachment portion does not result in detachment of the attachment portion from the vessel. Figures 26a and 26b show an embodiment in which the leaflet 116 is connected to an attachment portion 260 by way of a frangible connection to allow the leaflet to be removed from being attached to the vessel. It will be appreciated that in this embodiment, in contract, the blister packaging is not arranged to be readily removable from the attachment portion 240. The leaflet 116 conveniently comprises a grip portion or spine 116a which allows the user to remove the leaflet with reduced risk of damaging the leaflet in doing so (since he can avoid needing to directly hold the pages of the leaflet) . Figures 27a and 27b show a further embodiment in which a medicament information leaflet 266 is provided intermediate of the attachment portion 240 and the blister packaging 210. The blister packaging is connected to the leaflet 266 by way a frangible connection to allow a user to remove the blister package from being attached to the leaflet 266, and so from the vessel.

Figures 28a and 28b show a variant embodiment to that shown in Figures 27a and 27b, in which a frangible connection is provided between the attachment portion 240 and the (combined) leaflet 266 and the blister packaging 210. It is intended that the leaflet 266 and the blister packaging 210 are not readily separable. The leaflet 266 comprises a grip portion or spine 266a which is similar in function and construction as the grip portions 210a and 116a described above.

Figures 29a and 29b show a variant embodiment to that shown in Figures 28a and 28b and 27a and 27b in which the leaflet 266 and the blister packaging 210 are arranged to separable both individually and in combination from the being attached to the vessel.

Reference will now be made to Figures 30, 31 , 32 and 33, which show exploded views of various components of packaging arrangements, similar to those described above, are constructed. As can be seen from Figures 30 and 31 , which shows an arrangement essentially like that shown in Figures 28a and 28b, respective end portions 280, 281, 282 and 283 are provided with an region of adhesive which attach to an opposing surface of an adjacent component. It is to be noted that the adhesive region of attachment component 240, attaches to an inner sheet component 119. As can be seen in Figure 31 , a jointing component 290 connects the packaging 210 to the leaflet 116. Figure 32 shows an arrangement essentially corresponding to that in Figures 29 and 29b. Figure 33 shows a further embodiment which is not provided without frangible connects between the blister packaging and the leaflet.

Reference is now made to Figures 34a, to 34d, which show how the outer sheet/label component 317 may be secured around the vessel/bottle 102. An end portion 318 of the component 318 is provided with adhesive which is secured to a distal end portion 319. A frangible tab 325 is provided which can be removed by the user (as shown in Figure 34d) and so allow the user to unwrap the component 317 and so access a medicament packaging an information leaflet. It will be appreciated that this embodiment is of particular use in relation to single-use medicaments which are intended to be disposed once opened. However, some of the embodiments above allow the outer component to be re-secured to the bottle for later use.

Reference is now made to Figures 35a, 35b, 35c, 35d, 58e, 35f and 35g which show a medicament packaging arrangement 400 in various folded/unfolded conditions. The arrangement 400 comprises a blister packaging 402, a leaflet 404 and a cover portion 406. As can seen, the arrangement 400 can be folded to adopt a compact, self-sealed condition, as shown in Figure 35g. The leaflet 404 is attached to the blister packaging 402, and as shown can be folded up into and within the footprint area of the blister packaging 402 (as best seen in Figure 35c) . The cover portion 406 is hinged towards the blister pack 402 and a portion of adhesive 406a provided on tab 406b, is then secured to the outer surface of the blister pack 402. It is to be noted that the spatial extent of the foil/lidding 402a of the blister pack is limited so that the tab is not attached to the foil/lidding. A finger grippable tab 410, attached to the blister pack is then folded down over the cover portion 406. The tab 410 allows a user to remove the arrangement from a vessel and by removing detaching the tab 406a, the user can access the leaflet and blister pack.

The arrangement 400 is particularly advantageous during production when the arrangement attached to a liquid vessel since the arrangement 400 is a self-contained unit, protecting the medicament and the leaflet within.

It will be appreciated that further embodiments comprise combinations of the features of the embodiments described above. For example, the packaging arrangements which are arranged to be held in a side wall of a liquid vessel, may be adapted (as required) to be held in the storage space of a closure assembly, and vice versa.

Claims

1. Medicament packaging arrangement comprising packaging defining a closed cavity, the cavity containing medicament, the packaging arranged to be manually openable to access the medicament, the arrangement further comprising a medicament information carrier attached to the packaging, and the packaging arrangement arranged to be retained with a liquid container.

2. Medicament packaging arrangement as claimed in claim 1 in which at least one of the packaging and the carrier arranged to be moveable relative to the liquid container.

3. Medicament packaging arrangement as claimed in claim 2 in which the packaging comprises a finger grippable tab arranged to allow the packaging to be moved relative to the liquid container.

4. Medicament packaging arrangement as claimed in claim 1, claim 2 or claim 3, the packaging and the carrier arranged to be substantially non-detachable from each other.

5. Medicament packaging arrangement as claimed in any of claims 1 to 4, the packaging and the carrier arranged to be manually detachable from each other.

6. Medicament packaging as claimed in claim 5, the packaging and the carrier connected by a weakened region arranged to be manually frangible.

7. Medicament packaging arrangement as claimed in any preceding claim which is of concertina form, wherein at least one fold allows the packaging and the carrier to adopt a folded condition and an unfolded condition.

8. Medicament packaging arrangement as claimed in claim 7, wherein the fold is positioned between the packaging and the carrier.

9. Medicament packaging arrangement as claimed in any of claims 7 or 8 wherein the carrier comprises a fold.

10. Medicament packaging arrangement as claimed in claim 9 wherein at least two portions of the carrier interposed between folds comprise medicament information in different respective formats.

11. Medicament packaging arrangement as claimed in which a respective format comprises Braille.

12. Medicament packaging arrangement as claimed in any of claims 7 to 11 in which the carrier comprises medicament information in Braille, and the arrangement comprises a topographic arrangement such that, when in the folded condition, the Braille is maintained a spaced relationship from an opposing surface of the arrangement.

13. Medicament packaging arrangement as claimed in any of claims 7 to 12 wherein the packaging comprises a fold.

14. Medicament packaging arrangement as claimed in claim 13 which comprises a medicament holding cavity at each side of the fold.

15. Medicament packaging arrangement as claimed in any preceding claim, wherein at least the packaging arranged to be held in a recess of a sidewall of the liquid container.

16. Medicament packaging arrangement as claimed in claim 15 the packaging and the carrier arranged to be held in the recess.

17. Medicament packaging arrangement as claimed in any preceding claim, the packaging and the carrier arranged to be held in a volume defined by a closure assembly of the liquid container.

18. Medicament packaging arrangement as claimed in any preceding claim comprising a spine arranged to enable the packaging and the carrier to be attached to the liquid container.

19. Medicament packaging arrangement as claimed in claim 18 in which the carrier is connected to the spine and the packaging is connected to the carrier.

20. Medicament packaging as claimed in claim 18 or claim 19, the leaflet arranged to wrap or extend around at least part of a perimeter of the container.

21. Medicament packaging arrangement as claimed in any of claims 18 to 20 in which the carrier and the packaging are substantially in the form of a multi-page booklet.

22. Medicament packaging arrangement as claimed in any preceding claim comprising a removable container in which the leaflet and the packaging are stored, the removable container arranged to be secured to the liquid container.

23. Medicament packaging arrangement as claimed in any preceding claim in which the packaging is of multi-part form wherein each part comprises one closed cavity and the parts hingeably connected by way of a hinge, and the cavities located at different distances from the hinge.

24. A medicament packaging arrangement as claimed in any preceding claim which comprises a container to house the packaging and the carrier, and the container arranged to be received in a recess of a liquid container.

25. A medicament packaging arrangement as claimed in claim 24 in which the container is arranged to form and be held in the recess by way of frictional engagement.

26. A medicament packaging arrangement as claimed in any preceding claim which is arranged to be attached to the liquid container by way of an adhesive.

27. A medicament packaging arrangement as claimed in any preceding claim which comprises a retainer portion arranged to retain at least the packaging within a recess of the liquid container, and arranged to be removable so as to be able to remove the packaging.

28. A liquid container arranged for use with the medicament packaging arrangement of any of claims 1 to 27.

29. A liquid container as claimed in claim 28 comprising a recess in a sidewall thereof arranged to hold at least the packaging of the medicament packaging arrangement, the packaging defining a closed cavity, the cavity containing medicament, the packaging arranged to be manually openable to access the medicament.

30. A liquid container as claimed in claim 29, the recess arranged to hold the packaging and the leaflet.

31. A liquid container as claimed in any of claims 28 or 30, comprising a closure assembly which defines a volume arranged to accommodate the packaging and the leaflet.

32. A liquid container as claimed in claim 31 , the closure assembly comprises an openable cover, an inner surface of which at least in part defines the volume.

33. A liquid container as claimed in claim 32 in which the cover is transparent.

34. A liquid container as claimed in any of claims 31 to 33 in which the closure assembly comprises a headed upstand arranged to engage with the medicament packaging arrangement so as to releasably locate the medicament packaging arrangement in position in the volume.

35. A liquid container as claimed in any of claims 28 to 34 in which a sidewall of the container comprises outer shoulders and the recess positioned between and inwardly of the shoulders.

36. A closure assembly for a liquid container comprising a closure arranged to be attached to the liquid container, and the assembly further comprising cover arranged to be removably attached to the closure, and the closure defining a storage recess, and the closure assembly comprises a male-to-female arrangement which is such as to allow the cover to be removed from the closure and when the cover is attached to the closure to prevent relative rotation of the cover and the closure when a torque is applied to the cover.

37. A closure assembly as claimed in claim 36 in which the cover comprises a downwardly depending skirt in which the male-to-female arrangement comprises a plurality of co-operable spaced apart formations provided on an inner surface of the skirt and on an outward surface of the closure.