WO2011008117A3 - The use of a sirna oligonucleotide - Google Patents

The use of a sirna oligonucleotide Download PDF

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Publication number
WO2011008117A3
WO2011008117A3 PCT/PL2010/000059 PL2010000059W WO2011008117A3 WO 2011008117 A3 WO2011008117 A3 WO 2011008117A3 PL 2010000059 W PL2010000059 W PL 2010000059W WO 2011008117 A3 WO2011008117 A3 WO 2011008117A3
Authority
WO
WIPO (PCT)
Prior art keywords
sirna oligonucleotide
wnt
nucleotides
beta
disclose
Prior art date
Application number
PCT/PL2010/000059
Other languages
French (fr)
Other versions
WO2011008117A2 (en
Inventor
Monika Lamparska-Przybysz
Piotr Guzenda
Joanna Hucz
Maria Majorek
Aleksandra STAŃCZAK
Maciej Wieczorek
Original Assignee
Celon Pharma Sp. Z.O.O.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celon Pharma Sp. Z.O.O. filed Critical Celon Pharma Sp. Z.O.O.
Publication of WO2011008117A2 publication Critical patent/WO2011008117A2/en
Publication of WO2011008117A3 publication Critical patent/WO2011008117A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

We disclose the use of a siRNA oligonucleotide comprising at least 19 nucleotides, complementary to the target mRNA encoding proteins of the WNT/beta-catenin pathway, in the production of a drug for systemic administration in the treatment of cancer.
PCT/PL2010/000059 2009-07-12 2010-07-12 The use of a sirna oligonucleotide WO2011008117A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL388513A PL388513A1 (en) 2009-07-12 2009-07-12 Application of siRNA oligonucleotide
PLPL388513 2009-07-12

Publications (2)

Publication Number Publication Date
WO2011008117A2 WO2011008117A2 (en) 2011-01-20
WO2011008117A3 true WO2011008117A3 (en) 2011-11-17

Family

ID=43450014

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PL2010/000059 WO2011008117A2 (en) 2009-07-12 2010-07-12 The use of a sirna oligonucleotide

Country Status (2)

Country Link
PL (1) PL388513A1 (en)
WO (1) WO2011008117A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008109518A1 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting wnt gene expression and uses thereof
US20090081282A1 (en) * 2007-09-21 2009-03-26 Korea University Industrial & Academic Collaboration Foundation Pharmaceutical composition for treating cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL378857A1 (en) 2006-01-31 2007-08-06 Celon Pharma Spółka Z Ograniczoną Odpowiedzialnością Double twisted oligonucleotides interfering with mRNA of gene WNT1 (siRNA) used in order to inhibit polypheration of tumour cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008109518A1 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting wnt gene expression and uses thereof
US20090081282A1 (en) * 2007-09-21 2009-03-26 Korea University Industrial & Academic Collaboration Foundation Pharmaceutical composition for treating cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
P PU ET AL: "Downregulation of Wnt2 and [beta]-catenin by siRNA suppresses malignant glioma cell growth", CANCER GENE THERAPY, vol. 16, no. 4, 1 April 2009 (2009-04-01), pages 351 - 361, XP055001526, ISSN: 0929-1903, DOI: 10.1038/cgt.2008.78 *

Also Published As

Publication number Publication date
WO2011008117A2 (en) 2011-01-20
PL388513A1 (en) 2011-01-17

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