WO2010148288A3 - Pharmaceutical formulations with low aqueous levels of free unbound drug - Google Patents

Pharmaceutical formulations with low aqueous levels of free unbound drug Download PDF

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Publication number
WO2010148288A3
WO2010148288A3 PCT/US2010/039139 US2010039139W WO2010148288A3 WO 2010148288 A3 WO2010148288 A3 WO 2010148288A3 US 2010039139 W US2010039139 W US 2010039139W WO 2010148288 A3 WO2010148288 A3 WO 2010148288A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical formulations
free unbound
low aqueous
unbound drug
propofol
Prior art date
Application number
PCT/US2010/039139
Other languages
French (fr)
Other versions
WO2010148288A2 (en
Inventor
David M. Anderson
Original Assignee
Lyotropic Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lyotropic Therapeutics, Inc. filed Critical Lyotropic Therapeutics, Inc.
Publication of WO2010148288A2 publication Critical patent/WO2010148288A2/en
Publication of WO2010148288A3 publication Critical patent/WO2010148288A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals

Abstract

The complexation properties of cyclodextrins are combined with the partitioning properties of reversed lyotropic liquid crystalline phase microparticles to prepare pharmaceutical formulation dispersions with reduced levels of free unbound aqueous drug. Safe to inject formulations including, for example, propofol, include dispersions of reversed lyotropic liquid crystalline phase microparticles with propofol in an aqueous carrier together with cyclodextrins.
PCT/US2010/039139 2009-06-19 2010-06-18 Pharmaceutical formulations with low aqueous levels of free unbound drug WO2010148288A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21873809P 2009-06-19 2009-06-19
US61/218,738 2009-06-19
US29450910P 2010-01-13 2010-01-13
US61/294,509 2010-01-13

Publications (2)

Publication Number Publication Date
WO2010148288A2 WO2010148288A2 (en) 2010-12-23
WO2010148288A3 true WO2010148288A3 (en) 2011-05-19

Family

ID=43357065

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/039139 WO2010148288A2 (en) 2009-06-19 2010-06-18 Pharmaceutical formulations with low aqueous levels of free unbound drug

Country Status (1)

Country Link
WO (1) WO2010148288A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2528602B2 (en) 2010-01-28 2020-02-12 Eagle Pharmaceuticals, Inc. Formulations of bendamustine
WO2013142359A1 (en) 2012-03-20 2013-09-26 Eagle Pharmaceuticals, Inc. Method of treating bendamustine-responsive conditions in patients requiring reduced volumes for administration
CN104302291A (en) 2012-03-20 2015-01-21 鹰制药股份有限公司 Formulations of bendamustine
IT201700060645A1 (en) * 2017-06-01 2018-12-01 Abiogen Pharma Spa USE OF XIBORNOL AS AN ACTIVE AGENT IN ACNE VOLGARE TREATMENT

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001058994A (en) * 1999-08-19 2001-03-06 Eisai Co Ltd Stabilized amoxicillin inclusion complex
US20020012680A1 (en) * 1999-02-26 2002-01-31 Patel Mahesh V. Compositions and methods for improved delivery of lipid regulating agents
US20040014718A1 (en) * 2000-06-21 2004-01-22 Pai Srikanth Annappa Clear aqueous anaesthetic composition
US20060140895A1 (en) * 2004-12-23 2006-06-29 Avon Products, Inc. Two-part cosmetic product
KR20060130646A (en) * 2004-01-14 2006-12-19 가부시키가이샤 오츠까 세이야꾸 고죠 Propofol-containing fat emulsion preparation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020012680A1 (en) * 1999-02-26 2002-01-31 Patel Mahesh V. Compositions and methods for improved delivery of lipid regulating agents
JP2001058994A (en) * 1999-08-19 2001-03-06 Eisai Co Ltd Stabilized amoxicillin inclusion complex
US20040014718A1 (en) * 2000-06-21 2004-01-22 Pai Srikanth Annappa Clear aqueous anaesthetic composition
KR20060130646A (en) * 2004-01-14 2006-12-19 가부시키가이샤 오츠까 세이야꾸 고죠 Propofol-containing fat emulsion preparation
US20060140895A1 (en) * 2004-12-23 2006-06-29 Avon Products, Inc. Two-part cosmetic product

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DAVID C. WARLTIER, PROPOFOL. ANESTHESIOLOGY., vol. 103, no. 4, October 2005 (2005-10-01), pages 860 - 87 6 *

Also Published As

Publication number Publication date
WO2010148288A2 (en) 2010-12-23

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