WO2010145793A1 - Bispecific, tetravalent antigen binding proteins - Google Patents
Bispecific, tetravalent antigen binding proteins Download PDFInfo
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- WO2010145793A1 WO2010145793A1 PCT/EP2010/003560 EP2010003560W WO2010145793A1 WO 2010145793 A1 WO2010145793 A1 WO 2010145793A1 EP 2010003560 W EP2010003560 W EP 2010003560W WO 2010145793 A1 WO2010145793 A1 WO 2010145793A1
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- Prior art keywords
- antibody
- domain
- antigen binding
- bispecific
- binding protein
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Classifications
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- C07K16/46—Hybrid immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Description
Claims
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
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MX2011013616A MX2011013616A (en) | 2009-06-18 | 2010-06-14 | Bispecific, tetravalent antigen binding proteins. |
CN201080036158.4A CN102803295B (en) | 2009-06-18 | 2010-06-14 | Bispecific, tetravalent antigen binding proteins |
KR1020127001020A KR101431344B1 (en) | 2009-06-18 | 2010-06-14 | Bispecific, tetravalent antigen binding proteins |
RU2012101485/10A RU2604189C2 (en) | 2009-06-18 | 2010-06-14 | Bispecific, tetravalent antigen binding proteins |
CA2764393A CA2764393C (en) | 2009-06-18 | 2010-06-14 | Bispecific, tetravalent antigen binding proteins |
EP10724717.3A EP2443153B1 (en) | 2009-06-18 | 2010-06-14 | Bispecific, tetravalent antigen binding proteins |
JP2012515382A JP5689118B2 (en) | 2009-06-18 | 2010-06-14 | Bispecific tetravalent antigen binding protein |
BRPI1010109A BRPI1010109A2 (en) | 2009-06-18 | 2010-06-14 | tetravalent and bispecific antigen binding protein, method for the preparation of a tetravalent and bispecific antigen binding protein, host cell, pharmaceutical composition, use of the bispecific tetravalent antigen binding protein and method for treating a patient in need of therapy |
ES10724717.3T ES2442917T3 (en) | 2009-06-18 | 2010-06-14 | Antigen, tetravalent and bispecific binding proteins |
SG2011093655A SG177272A1 (en) | 2009-06-18 | 2010-06-14 | Bispecific, tetravalent antigen binding proteins |
AU2010262130A AU2010262130A1 (en) | 2009-06-18 | 2010-06-14 | Bispecific, tetravalent antigen binding proteins |
IL216620A IL216620A0 (en) | 2009-06-18 | 2011-11-27 | Bispecific, tetravalent antigen binding proteins |
ZA2011/08922A ZA201108922B (en) | 2009-06-18 | 2011-12-05 | Bispecific,tetravalent antigen binding proteins |
HK13101811.0A HK1174645A1 (en) | 2009-06-18 | 2013-02-08 | Bispecific, tetravalent antigen binding proteins |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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EP09007966 | 2009-06-18 | ||
EP09007966.6 | 2009-06-18 |
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WO2010145793A1 true WO2010145793A1 (en) | 2010-12-23 |
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PCT/EP2010/003560 WO2010145793A1 (en) | 2009-06-18 | 2010-06-14 | Bispecific, tetravalent antigen binding proteins |
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Country | Link |
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US (2) | US8703132B2 (en) |
EP (1) | EP2443153B1 (en) |
JP (1) | JP5689118B2 (en) |
KR (1) | KR101431344B1 (en) |
CN (1) | CN102803295B (en) |
AR (1) | AR077111A1 (en) |
AU (1) | AU2010262130A1 (en) |
BR (1) | BRPI1010109A2 (en) |
CA (1) | CA2764393C (en) |
CL (1) | CL2011003149A1 (en) |
ES (1) | ES2442917T3 (en) |
HK (1) | HK1174645A1 (en) |
IL (1) | IL216620A0 (en) |
MX (1) | MX2011013616A (en) |
PE (1) | PE20120414A1 (en) |
RU (1) | RU2604189C2 (en) |
SG (1) | SG177272A1 (en) |
TW (1) | TW201111394A (en) |
WO (1) | WO2010145793A1 (en) |
ZA (1) | ZA201108922B (en) |
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