WO2010132447A2 - Methods for detecting pre-diabetes and diabetes using differential protein glycosylation - Google Patents

Methods for detecting pre-diabetes and diabetes using differential protein glycosylation Download PDF

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Publication number
WO2010132447A2
WO2010132447A2 PCT/US2010/034385 US2010034385W WO2010132447A2 WO 2010132447 A2 WO2010132447 A2 WO 2010132447A2 US 2010034385 W US2010034385 W US 2010034385W WO 2010132447 A2 WO2010132447 A2 WO 2010132447A2
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WIPO (PCT)
Prior art keywords
sample
lectin
subject
diabetes
protein
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PCT/US2010/034385
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English (en)
French (fr)
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WO2010132447A3 (en
Inventor
Srinivasa R. Nagalla
Charles T. Roberts
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Diabetomics, Llc
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Application filed by Diabetomics, Llc filed Critical Diabetomics, Llc
Publication of WO2010132447A2 publication Critical patent/WO2010132447A2/en
Publication of WO2010132447A3 publication Critical patent/WO2010132447A3/en
Priority to US13/457,243 priority Critical patent/US8497077B2/en
Priority to US13/457,225 priority patent/US8530175B2/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/415—Assays involving biological materials from specific organisms or of a specific nature from plants
    • G01N2333/42—Lectins, e.g. concanavalin, phytohaemagglutinin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/38—Post-translational modifications [PTMs] in chemical analysis of biological material addition of carbohydrates, e.g. glycosylation, glycation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
PCT/US2010/034385 2009-05-11 2010-05-11 Methods for detecting pre-diabetes and diabetes using differential protein glycosylation WO2010132447A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/457,243 US8497077B2 (en) 2009-05-11 2012-04-26 Methods for detecting pre-diabetes and diabetes using differential protein glycosylation
US13/457,225 US8530175B2 (en) 2009-05-11 2012-04-26 Methods for detecting pre-diabetes and diabetes using differential protein glycosylation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17713009P 2009-05-11 2009-05-11
US61/177,130 2009-05-11

Publications (2)

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WO2010132447A2 true WO2010132447A2 (en) 2010-11-18
WO2010132447A3 WO2010132447A3 (en) 2011-03-03

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Family Applications (1)

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PCT/US2010/034385 WO2010132447A2 (en) 2009-05-11 2010-05-11 Methods for detecting pre-diabetes and diabetes using differential protein glycosylation

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US (4) US8168396B2 (US08168396-20120501-C00001.png)
WO (1) WO2010132447A2 (US08168396-20120501-C00001.png)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2924436A1 (en) * 2014-03-26 2015-09-30 DiabetOmics, Inc. Salivary protein glycosylation test for diagnosis and monitoring of diabetes
JP2018515762A (ja) * 2015-04-30 2018-06-14 アイデックス ラボラトリーズ インコーポレイテッドＩＤＥＸＸ Ｌａｂｏｒａｔｏｒｉｅｓ， Ｉｎｃ． クラステリンアイソフォームの特異的検出

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US8748352B2 (en) * 2011-08-16 2014-06-10 Battelle Memorial Institute Peptide and protein biomarkers for type 1 diabetes mellitus
CN102426231B (zh) * 2011-09-15 2014-09-03 长沙三诺生物传感技术股份有限公司 一种免疫层析试条用封闭剂组合物以及一种免疫层析试条
WO2013159025A1 (en) * 2012-04-20 2013-10-24 Ezose Sciences, Inc Biomarkers for diagnosis of diabetes and monitoring of anti-diabetic therapy
US20150083906A1 (en) * 2012-04-20 2015-03-26 Merck Sharp & Dohme Corp. Biomarkers for monitoring intervention therapies for diabetes
TWI667034B (zh) * 2016-09-21 2019-08-01 惠眾生技股份有限公司 關刀豆用於製備保護膀胱避免損傷藥劑之用途
CN106771120B (zh) * 2016-11-29 2018-10-30 陕西中药研究所 快速检测禽流感和人流感易感人群的方法以及试纸条
TWI688770B (zh) * 2018-10-11 2020-03-21 臺北醫學大學 一種檢測糖尿病腎病變的方法
CN110045127A (zh) * 2019-04-03 2019-07-23 中国医学科学院北京协和医院 一种IgG4相关性疾病多器官受累的生物标志物及其用途
CN110763849B (zh) * 2019-11-28 2023-03-31 陕西医药控股医药研究院有限公司 ELISA检测唾液样品中SAα2-3Gal糖链含量的方法
US20210311043A1 (en) * 2020-04-06 2021-10-07 Medicortex Finland Oy Method for determining a lectin-binding glycan indicative to traumatic brain injury
CN111735963A (zh) * 2020-06-15 2020-10-02 中国人民解放军总医院 特定凝集素在基于唾液糖蛋白糖链鉴别糖尿病/非糖尿病肾病方面的应用

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2924436A1 (en) * 2014-03-26 2015-09-30 DiabetOmics, Inc. Salivary protein glycosylation test for diagnosis and monitoring of diabetes
CN104965085A (zh) * 2014-03-26 2015-10-07 迪亚贝托米克斯有限公司 用于诊断和监测糖尿病的唾液蛋白糖基化测试
US9383352B2 (en) 2014-03-26 2016-07-05 Diabetomics, Inc. Salivary protein glycosylation test for diagnosis and monitoring of diabetes
JP2018515762A (ja) * 2015-04-30 2018-06-14 アイデックス ラボラトリーズ インコーポレイテッドＩＤＥＸＸ Ｌａｂｏｒａｔｏｒｉｅｓ， Ｉｎｃ． クラステリンアイソフォームの特異的検出
JP2021099342A (ja) * 2015-04-30 2021-07-01 アイデックス ラボラトリーズ インコーポレイテッドＩＤＥＸＸ Ｌａｂｏｒａｔｏｒｉｅｓ， Ｉｎｃ． クラステリンアイソフォームの特異的検出

Also Published As

Publication number Publication date
US8530175B2 (en) 2013-09-10
US20120208218A1 (en) 2012-08-16
US8497076B2 (en) 2013-07-30
US8168396B2 (en) 2012-05-01
US20100285498A1 (en) 2010-11-11
US20120208217A1 (en) 2012-08-16
US8497077B2 (en) 2013-07-30
WO2010132447A3 (en) 2011-03-03
US20120214179A1 (en) 2012-08-23

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