WO2010122583A3 - Oral pharmaceutical compositions of acid labile substances - Google Patents
Oral pharmaceutical compositions of acid labile substances Download PDFInfo
- Publication number
- WO2010122583A3 WO2010122583A3 PCT/IN2010/000261 IN2010000261W WO2010122583A3 WO 2010122583 A3 WO2010122583 A3 WO 2010122583A3 IN 2010000261 W IN2010000261 W IN 2010000261W WO 2010122583 A3 WO2010122583 A3 WO 2010122583A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pharmaceutical compositions
- acid labile
- oral pharmaceutical
- proton pump
- labile substances
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/288—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Abstract
The present invention relates to oral pharmaceutical compositions of acid labile substances, particularly proton pump inhibitors. These pharmaceutical compositions comprise one or more active units with each active unit comprising a core of a proton pump inhibitor, an intermediate layer of at least one lipophilic substance and an enteric layer. The invention also relates to a method for preparing one or more active units wherein the intermediate layer of lipophilic substances is applied to the core of a proton pump inhibitor in an aqueous emulsified form.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1104/MUM/2009 | 2009-04-24 | ||
IN1104MU2009 | 2009-04-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010122583A2 WO2010122583A2 (en) | 2010-10-28 |
WO2010122583A3 true WO2010122583A3 (en) | 2011-04-28 |
Family
ID=42664650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2010/000261 WO2010122583A2 (en) | 2009-04-24 | 2010-04-26 | Oral pharmaceutical compositions of acid labile substances |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2010122583A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104274423A (en) * | 2013-07-02 | 2015-01-14 | 杭州赛利药物研究所有限公司 | Rabeprazole enteric capsule and preparation method thereof |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102552159B (en) * | 2010-12-22 | 2013-07-17 | 南京长澳医药科技有限公司 | Rabeprazole sodium enteric-coated micro-pellet and preparation method thereof |
KR101739820B1 (en) * | 2012-03-28 | 2017-05-25 | 주식회사유한양행 | Pharmaceutical composition in form of non-aqueous liquid comprising revaprazan or its salt |
CN105377303B (en) * | 2013-07-19 | 2019-04-05 | 株式会社三和化学研究所 | Oral disnitegration tablet |
CA2933202C (en) | 2014-01-21 | 2022-05-31 | Jason Teckoe | Immediate release film coatings containing medium chain glycerides and substrates coated therewith |
CN104352481A (en) * | 2014-11-06 | 2015-02-18 | 成都医路康医学技术服务有限公司 | Preparation method of esomeprazole magnesium slow-release enteric micro capsule |
EP3288556A4 (en) * | 2015-04-29 | 2018-09-19 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
AR105111A1 (en) * | 2015-06-26 | 2017-09-06 | Advanced Bionutrition Corp | COMPOSITION FOR ADMINISTRATION OF ACTIVE AGENTS TO AN ANIMAL |
CN106831709B (en) * | 2015-12-03 | 2019-03-12 | 中国科学院苏州纳米技术与纳米仿生研究所 | Dexlansoprazole-nicotimine eutectic and its application |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
IT201700021879A1 (en) * | 2017-02-27 | 2018-08-27 | Bioscreen Tech S R L | RELEASED COMPOSITION OF PHYSIOLOGICALLY ACTIVE SUBSTANCES AND PROCESS FOR ITS PREPARATION |
IT201700021852A1 (en) * | 2017-02-27 | 2018-08-27 | Bioscreen Tech S R L | RELEASED COMPOSITION OF PHYSIOLOGICALLY ACTIVE SUBSTANCES AND PROCESS FOR ITS PREPARATION |
GB201804621D0 (en) * | 2018-03-22 | 2018-05-09 | Bcm Specials Ltd | Formulation |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5920219A (en) * | 1982-07-26 | 1984-02-01 | Shin Etsu Chem Co Ltd | Preparation of enteric coated pharmaceutical |
US20010053387A1 (en) * | 1997-05-23 | 2001-12-20 | Hamied Yusuf Khwaja | Benzimidazole pharmaceutical composition and process of prepatation |
US20050042277A1 (en) * | 2003-07-17 | 2005-02-24 | Irukulla Srinivas | Pharmaceutical compositions having a swellable coating |
US20060018964A1 (en) * | 2004-07-26 | 2006-01-26 | Astrazeneca Ab | Pharmaceutical formulation and process for its preparation |
WO2006111853A2 (en) * | 2005-04-18 | 2006-10-26 | Aurobindo Pharma Limited | Stable solid dosage forms of acid labile drug |
US20070122470A1 (en) * | 2005-11-30 | 2007-05-31 | Dick Johansson | New Combination Dosage Form |
US20080096979A1 (en) * | 2004-11-08 | 2008-04-24 | Rubicon Research Pvt. Ltd. | Aqueous Pharmaceutical Coating |
WO2008065107A1 (en) * | 2006-11-28 | 2008-06-05 | Monteresearch S.R.L. | Storage stable tablets based on benzimidazole derivatives coated with a gastro-resistant film |
US20080317841A1 (en) * | 2004-12-15 | 2008-12-25 | Pascal Grenier | Pharmaceutical Composition Containing Coated, Floating Particles |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8301182D0 (en) | 1983-03-04 | 1983-03-04 | Haessle Ab | NOVEL COMPOUNDS |
IL75400A (en) | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
JPS6150978A (en) | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | Pyridine derivative and preparation thereof |
GB2189698A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
FR2692146B1 (en) | 1992-06-16 | 1995-06-02 | Ethypharm Sa | Stable compositions of gastro-protected omeprazole microgranules and process for obtaining them. |
SE9302396D0 (en) | 1993-07-09 | 1993-07-09 | Ab Astra | A NOVEL COMPOUND FORM |
SE9500478D0 (en) | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
SE510650C2 (en) | 1997-05-30 | 1999-06-14 | Astra Ab | New association |
DK173431B1 (en) | 1998-03-20 | 2000-10-23 | Gea Farmaceutisk Fabrik As | Pharmaceutical formulation comprising a 2 - [[(2-pyridinyl) methyl] sulfinyl] benzimidazole with anti-ulcer activity and progress |
SE9900274D0 (en) | 1999-01-28 | 1999-01-28 | Astra Ab | New compound |
CN100335040C (en) | 2000-12-07 | 2007-09-05 | 奥坦纳医药公司 | Rapidly disintegrating tablet comprising acid-sensitive active ingredient |
WO2003075825A2 (en) | 2002-03-08 | 2003-09-18 | Modi, Rajiv, Indravadan | The method of treating tuberculosis |
WO2006085335A2 (en) | 2005-01-03 | 2006-08-17 | Lupin Limited | Pharmaceutical composition of acid labile substances |
US9198862B2 (en) | 2005-07-22 | 2015-12-01 | Rubicon Research Private Limited | Dispersible tablet composition |
-
2010
- 2010-04-26 WO PCT/IN2010/000261 patent/WO2010122583A2/en active Application Filing
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5920219A (en) * | 1982-07-26 | 1984-02-01 | Shin Etsu Chem Co Ltd | Preparation of enteric coated pharmaceutical |
US20010053387A1 (en) * | 1997-05-23 | 2001-12-20 | Hamied Yusuf Khwaja | Benzimidazole pharmaceutical composition and process of prepatation |
US20050042277A1 (en) * | 2003-07-17 | 2005-02-24 | Irukulla Srinivas | Pharmaceutical compositions having a swellable coating |
US20060018964A1 (en) * | 2004-07-26 | 2006-01-26 | Astrazeneca Ab | Pharmaceutical formulation and process for its preparation |
US20080096979A1 (en) * | 2004-11-08 | 2008-04-24 | Rubicon Research Pvt. Ltd. | Aqueous Pharmaceutical Coating |
US20080317841A1 (en) * | 2004-12-15 | 2008-12-25 | Pascal Grenier | Pharmaceutical Composition Containing Coated, Floating Particles |
WO2006111853A2 (en) * | 2005-04-18 | 2006-10-26 | Aurobindo Pharma Limited | Stable solid dosage forms of acid labile drug |
US20070122470A1 (en) * | 2005-11-30 | 2007-05-31 | Dick Johansson | New Combination Dosage Form |
WO2008065107A1 (en) * | 2006-11-28 | 2008-06-05 | Monteresearch S.R.L. | Storage stable tablets based on benzimidazole derivatives coated with a gastro-resistant film |
Non-Patent Citations (1)
Title |
---|
DATABASE WPI Week 198411, Derwent World Patents Index; AN 1984-065033, XP002623013 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104274423A (en) * | 2013-07-02 | 2015-01-14 | 杭州赛利药物研究所有限公司 | Rabeprazole enteric capsule and preparation method thereof |
CN104274423B (en) * | 2013-07-02 | 2018-08-17 | 杭州赛利药物研究所有限公司 | Rabeprazole capsulae enterosolubilis and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2010122583A2 (en) | 2010-10-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2010122583A3 (en) | Oral pharmaceutical compositions of acid labile substances | |
WO2011099832A3 (en) | Novel benzimidazole compound, preparation method thereof and pharmaceutical composition comprising the same | |
GB2477257B (en) | Peracetic acid oil-field biocide and method | |
WO2010037066A3 (en) | Dosage units of 3-(6-(1-(2,2-difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid | |
EP2311498A4 (en) | External preparation comprising fatty acid salt or benzoic acid salt of basic pharmacologically active component, and method for production thereof | |
BR112013014242A2 (en) | compound of the formula, pharmaceutical composition, method of treating gaucher disease and method of increasing the amount of beta glucocerebrosidase in white blood cells. | |
BRPI0807718A2 (en) | STABLE DIGESTIVE ENZYME COMPOSITIONS, METHOD OF DOSAGE, PACKAGING, USE AND PREPARATION PROCESS OF SUCH COMPOSITIONS | |
WO2009089494A3 (en) | Pharmaceutical compositions | |
SMP201000003B (en) | Composition, method and preparation of synthetic bile acids. | |
WO2013177594A3 (en) | Xylitol-based anti-mucosal compositions and related methods and compositions | |
MA31149B1 (en) | A new method for the preparation of functional benzocyclopeptin, applied in the synthesis of ivabradine and additional salts to an acceptable pharmacist acid. | |
WO2008093303A3 (en) | Method for decreasing inflammation and stress in a mammal using glucose antimetaboltes, avocado or avocado extracts | |
PT2482648T (en) | Oil borne wood preserving composition for treatment of poles, posts, piling, cross-ties and other wooded structures comprising fatty acid and bivalent copper | |
WO2010072958A3 (en) | Topical pharmaceutical composition containing a water-sensitive active principle | |
CL2013001833A1 (en) | Immunomodulatory composition comprising a vehicle for administration of cationic liposome and a nucleic acid molecule; and its use to treat a bovine respiratory disease in cattle. | |
WO2010021607A3 (en) | Pharmaceutical formulation | |
BRPI1015441A2 (en) | "composition comprising caffeoyloxycemic acids, protocatechuic acid hydroxytyrosol, hydroxybenzoic acid and derivatives thereof, and method of preparation" | |
CL2014000267A1 (en) | Liquid pharmaceutical formulation comprising ketoprofen, amitriptyline and oxymetazoline; pharmaceutical kit; method to prevent or treat inflammation. | |
DK2350026T3 (en) | SULFOXIMIN-SUBSTITUTED ANILINOPYRIMIDE INGREDIENTS AS CDK INHIBITORS, PREPARATION AND USE THEREOF AS A MEDICINE | |
EP2407472A4 (en) | Polyfluoroalkylphosphonic acid, method for producing same and mold-releasing agent comprising same as active ingredient | |
CL2015000375A1 (en) | Pharmaceutical composition in the form of microparticles comprising an inert core and at least a first layer of active ingredient; microparticle formation process; pharmaceutical combination; pharmaceutical kit; use to treat and / or prevent edema, cardiovascular diseases, diabetes, hypertension, among others. | |
WO2012162439A3 (en) | Compositions comprising fusidic acid and packages therefor | |
WO2010090494A3 (en) | Medical use of 5-benzylaminosalicylic acid derivatives or salts thereof | |
AR090874A1 (en) | FORMULATION | |
ZA201203028B (en) | Compositions, use and method for the use of surface active proteins in topical drug delivery across keratin |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 10740760 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 10740760 Country of ref document: EP Kind code of ref document: A2 |