WO2010117389A1 - Revetements de surface a base de nanocomposites biocompatibles avances pour implants et echafaudages d'ingenierie tissulaire - Google Patents
Revetements de surface a base de nanocomposites biocompatibles avances pour implants et echafaudages d'ingenierie tissulaire Download PDFInfo
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- WO2010117389A1 WO2010117389A1 PCT/US2009/062183 US2009062183W WO2010117389A1 WO 2010117389 A1 WO2010117389 A1 WO 2010117389A1 US 2009062183 W US2009062183 W US 2009062183W WO 2010117389 A1 WO2010117389 A1 WO 2010117389A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/10—Inorganic materials
- A61L29/106—Inorganic materials other than carbon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
- A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D189/00—Coating compositions based on proteins; Coating compositions based on derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D189/00—Coating compositions based on proteins; Coating compositions based on derivatives thereof
- C09D189/04—Products derived from waste materials, e.g. horn, hoof or hair
- C09D189/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
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- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
- C23C14/06—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
- C23C14/08—Oxides
- C23C14/083—Oxides of refractory metals or yttrium
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C26/00—Coating not provided for in groups C23C2/00 - C23C24/00
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- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C30/00—Coating with metallic material characterised only by the composition of the metallic material, i.e. not characterised by the coating process
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/3084—Nanostructures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00598—Coating or prosthesis-covering structure made of compounds based on metal oxides or hydroxides
- A61F2310/00634—Coating made of zirconium oxide or hydroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/10—Mineral substrates
- C12N2533/18—Calcium salts, e.g. apatite, Mineral components from bones, teeth, shells
Definitions
- implants are made of metals, metal oxides, polymeric materials or tissue components obtained from animals or humans
- implant bio-compatibility poses a limitation in many applications as implants need to perform complex functions in the human body and their binding to the host tissue is crucial.
- dental implants need to adhere very strongly to the jaw bone. It is also important for implant surfaces to prevent or reduce biofilm formation, which leads to infection and implant failure.
- implants used for hip or knee replacements must integrate very closely and strongly with the bone structure of the skeleton.
- implants are constructed from biocompatible materials such as titanium, polymeric materials, or ceramic materials.
- Embodiments herein include but are not limited to methods, devices, compositions, kits, materials, tools, instruments, reagents, products, compounds, pharmaceuticals, arrays, computer-implemented algorithms, and computer-implemented methods.
- a coating comprising micro and/or nano materials deposited on a surface.
- the coating is deposited onto a device, such as a medical device.
- a medical device is implantable and can be .delivered into a host organism, such as a human or animal, or used in vitro.
- the medical device may comprise plasmids, genes, nucleic acids, or a DNA or RNA virus.
- the micro and/or nano materials comprise material having a size from about 0.5 nm to about 50 mm.
- the coating covers at least a portion of said device.
- the coating comprises natural or synthetic polymer, metal, metal oxide, oxide, metal nitride, borate, ceramic, zirconia, allograft hard tissue, allograft soft tissue, xenograft hard tissue, xenograft soft tissue, carbon nanostructure, carbon, glasses, natural, or biocompatible material.
- the coating is capable of performing at least one of preventing oxidation; decreasing toxicity; treating infection, preventing infection; promoting cell adhesion; preventing biofilm formation, inhibiting biofilm formation; promoting cell proliferation; promoting binding with a biological or non-biological system, increasing or decreasing a cell function; delivering a drug and/or bioactive agent, or ensuring a better integration of a material into the host tissue.
- the coating is deposited by one or more of ion beam deposition, electron beam deposition, pulsed laser deposition, thermal sputtering and deposition, RF sputtering, laser etching, glancing angle deposition, electrospray, chemical vapor deposition, physical vapor deposition, or molecular epitaxy.
- the coating may be produced by self assembly and self formation during deposition.
- At least one surface of the coating may undergo plasma/ion treatment to induce the formation of surface charges that enhance the binding of bioactive agents, growth factors, and/or drugs, promote cell adhesion and proliferation, and/or increase the hydrophilic nature of the surface.
- the coating comprises nanoparticles and microparticles.
- the coating comprises one or more layers of nanoparticles and/or microparticles.
- the one or more layers comprises a single type of nanoparticle and/or microparticle, or a combination of more than one type of nanoparticle and/or microparticle.
- one or more layers comprises silver nanoparticles.
- one or more layers comprises a combination of metal, nanoparticles, metal oxides, carbon nanotubes, polymeric nanoparticles, ceramics, calcium phosphate, collagen, and/or hydroxyapatite nanoparticles.
- the coating is biodegradable and/or biocompatible, and nanoparticles can be released from said nanoparticle composition as each layer degrades.
- a drug, growth factor, and/or bioactive agent is deposited within at least one layer and/or on the surface layer of said coating.
- the nanoparticles comprise gold, silver, metals, oxides, carbon nanostructures (single, double, multi walled nanotubes, graphenes, fullerenes, nanofibers), hydroxyapatite, zirconia, natural or synthetic polymers, ceramics, or metal oxide.
- the medical device is an orthopedic implant, dental implant, veterinary prosthetic device, graft, needle, bone material, contact lens, catheter, ear tube, endotracheal tube, stent, shunt, scaffold, or tissue engineering matrix, breast implant, allograft hard tissue, allograft soft tissue, xenograft hard tissue, xenograft soft tissue, polymeric mesh, or ceramic mesh.
- the orthopedic implant is a hip implant, knee implant, shoulder implant, plate, pin, screw, wire, or rod.
- the dental implant is an abutment, healing screw, or cover screw.
- the veterinary prosthetic device is an implant, pin, screw, plate, or rod.
- the coating comprises one or more layers comprise at least one of a protein, amino acid, enzyme, nucleic acid, bioactive agent, growth factor, drug, antibiotic, nucleic acid, hormone, antibody, or agent that inhibits biofilm formation and may be released as layer(s) degrade.
- the growth factor is a bone morphogenic protein capable of promoting bone formation adjacent to or on the surface of a device.
- the bioactive agent is in or on the surface coating of a medical device and affects adjacent tissue or cells in at least one or more of bone formation, protein synthesis, gene expression, cell proliferation, mitosis, DNA transcription, hormone production, enzyme production, cell death, gene delivery, or drug delivery.
- the bioactive agent may be linked to said nanoparticles and the linkage may be a covalent, ionic, hydrogen bond, sulfide bond, or polar covalent bond.
- a structured surface can be prepared by at least one of flame spraying, acid etching, grit blasting, casting-in, forging-in, laser texturing, micromachining, plasma treatment, ion bombardment, physical vapor deposition, or chemical vapor deposition [0012]
- a method for inhibiting biofilm formation on a medical implant comprising coating said implant with an agent(s) that prevents biofilm formation and/or growth of bacteria.
- a biofilm is a bacterial, fungal, or protozoan biofilm.
- a medical implant is an orthopedic or dental implant, graft, needle, bone material, contact lens, catheter, ear tube, endotracheal tube, stent, shunt, breast implant, scaffold, allograft hard tissue, allograft soft tissue, xenograft hard tissue, xenograft soft tissue ,or tissue engineering matrix.
- the agent is triclosan, iodine, silver, phenol, chloride compounds, fluoride compounds, iodine, quaternary ammonium compounds, chlorhexidine, antibiotic, antifungal agent, or any other agent that inhibits biofilm formation and/or growth.
- a method for inhibiting microbial colonization on a medical device or implant comprising coating said device or implant with an agent or surface treatment that prevents microbial colonization.
- the device or implant is a dental implant, healing screw or cover screw for a dental implant, orthopedic implant, veterinary implant, cardiovascular device, stent, defibrillator, graft, needle, catheter, scaffold, breast implant, or tissue engineering matrix.
- the surface treatment is plasma treatment, ion or electron treatment, to induce electrostatic charges that inhibit biofilm formation and bacterial growth.
- a device comprising nanoparticles, wherein said nanoparticles are positioned in one or more layers.
- one or more layers are biodegradable and release nanoparticles upon degradation.
- said layers comprise hydroxyapatite, wherein said layers degrade over time and release nanoparticles and/or microparticles of hydroxyapatite for stimulating bone formation adjacent to a surface of said device.
- the layers comprise either externally or internally at least one antibiotic, growth factor, drug, or biofilm inhibitory agent, wherein said layers degrade and release said antibiotic, growth factor, drug, and/or biofilm inhibitory agent.
- an implant comprising titanium, wherein zirconia coats at least one surface of said implant.
- the implant is a dental implant or an abutment for a dental implant.
- a method for coating a portion or surface with zirconia comprising: depositing zirconia on said surface by one or more of ion beam deposition, electron beam deposition, pulsed laser deposition, thermal sputtering and deposition, RF sputtering, laser etching, glancing angle deposition, physical vapor deposition, molecular epitaxy and chemical vapor deposition, wherein said deposition produces a crystalline film.
- the coating may be produced by self assembly and self formation during deposition.
- the surface is a dental implant or an abutment for a dental implant.
- the method further comprises depositing zirconia and at least one other coating agent and/or nanoparticle on at least one portion of said implant or abutment.
- the surface is heated during said depositing or after said depositing in order to alter the crystallinity of said film.
- a method of sterilizing a nanocomposite- coated device comprising exposing said device to either ethylene oxide or gamma radiation.
- a package comprising a nanocomposite- coated medical device, wherein said device is sealed in an airtight or vacuum packed container.
- the medical device is a dental implant, an abutment for a dental implant, or any medical device.
- a nanoparticle composition comprising: (a) a core made of one nanoparticle material; and (b) at least one layer surrounding said core, wherein said layer comprises a nanoparticle material that is not the same as said core.
- the nanoparticle composition is deposited to form one or more layers on a medical device or implantable medical device for use in humans and/or animals and/or in vitro.
- each layer may be comprised of different or similar heterogeneous nanoparticles.
- each layer may be formed from any combination of natural or synthetic polymer, metal, metal oxide, oxide, metal nitride, borate, ceramic, zirconia, allograft hard tissue, allograft soft tissue, xenograft hard tissue, xenograft soft tissue, carbon nano structure, carbon, glasses, or natural or biocompatible material.
- the composition further comprising at least one bioactive agent.
- the nanoparticle material and bioactive agent can be positioned in any orientation and place within said composition or on a surface layer of said composition.
- a method for enhancing bone cell growth comprising (a) depositing hydroxyapatite nanoparticles on a surface to create a surface coating; (b) exposing said surface coating to plasma treatment; and (c) culturing osteoblasts on said surface.
- a method for producing an orthodontic wire comprising depositing zirconia on said wire by one or more of ion beam deposition, electron beam deposition, pulsed laser deposition, thermal sputtering and deposition, RF sputtering, laser etching, glancing angle deposition, physical vapor deposition, molecular epitaxy and chemical vapor deposition, wherein said deposition produces a crystalline film.
- here is a method for producing an orthodontic wire, comprising depositing zirconia on said wire by pulsed laser deposition.
- FIGURE 1 illustrates polyurethane-hydroxyapatite nanocomposites created by in-situ polymerization. Observe polymeric pores and nanostructural hydroxyapatite at the surface.
- FIGURE 2 illustrates the number of osteoblast cells counted on the polymeric surfaces as a function of the titanium (Ti) control.
- the number of osteoblast cells on the polymeric films that were doped with hydroxyapatite (HA) nanoparticles and/or exposed to plasma treatment increased significantly as compared to the regular polymeric films.
- HA hydroxyapatite
- FIGURE 3 illustrates the enhanced growth of osteoblast cells on the polymeric surfaces exposed to plasma treatment and doped with HA nanoparticles (b) as compared to the regular Ti surfaces (a).
- FIGURE 4 displays an application of a surface coating during manufacturing.
- FIGURE 5 displays an application of a surface coating during manufacturing.
- FIGURE 6 displays an Atomic Force Microscopy (AFM) image of a polyurethane-hydroxyapatite nanocomposite film made by pulsed laser deposition.
- AFM Atomic Force Microscopy
- a coating that can be applied to the surface of an implant. More specifically, and as described below, a surface coating can be applied to any implant, such as a medical or dental implant, wherein the coating is bio-compatible, optionally bio-degradable, and facilitates surface adherence and proliferation of cells adjacent to and/or on an implant surface.
- the surface coating can also deliver drugs and/or bioactive agents that can lead to increased cell proliferation and bone mineralization at the implant surface.
- An illustrative surface coating can be applied to any tissue matrix or implant used for any internal/medical purpose. Surface coatings can also reduce and prevent growth of biofilm.
- Tissue culture supplies and reagents are available from commercial vendors such as Gibco/BRL, Nalgene-Nunc International, Sigma Chemical Co., and ICN Biomedicals.
- a surface coating can be deposited on a material by any method known in the art.
- Non-limiting deposition methods include any one or more of ion beam deposition, electron beam deposition, pulsed laser deposition, thermal sputtering and deposition, RF sputtering, laser etching, glancing angle deposition, electrospray, chemical vapor deposition, physical vapor deposition, and molecular epitaxy.
- any technique by which molecules are delivered to a substrate of interest may be used.
- Coating can be done at the micro level or nano scale, depending on the intended use. Such methodologies are known in the art and may be found in, for example, Marc J.
- a surface-coated implant can be delivered to a host organism by any suitable method known in the art.
- a surface-coated implant can be delivered by epidermal translation, direct surgical placement, topical application, or oral administration. Delivery can be directed to any cell type or tissue in any organism.
- a surface-coated implant may be delivered to any eukaryotic cell or tissue of interest.
- a cell is a mammalian cell.
- Cells may be of human or non-human origin. For example, they may be of mouse, rat, or non-human primate origin.
- Exemplary cell types include but are not limited to endothelial cells, epithelial cells, neurons, hepatocytes, myocytes, chondrocytes, osteoblasts, osteoclasts, lymphocytes, macrophages, neutrophils, fibroblasts, keratinocytes, etc.
- Cells can be primary cells, immortalized cells, transformed cells, terminally differentiated cells, stem cells (e.g.
- Cells can be wild type or mutant cells, e.g., they may have a mutation in one or more genes. Cells may be quiescent or actively proliferating. Cells may be in any stage of the cell cycle. In some embodiments, cells may be in the context of a tissue. In some embodiments, cells may be in the context of an organism.
- Cells can be normal cells or diseased cells.
- cells are cancer cells, e.g. they originate from a tumor or have been transformed in cell culture (e.g. by transfection with an oncogene).
- cells are infected with a virus or other infectious agent(s).
- a virus may be, e.g. a DNA virus, RNA virus, retrovirus, etc.
- cells can be infected with a human pathogen such as a hepatitis virus, a respiratory virus, human immunodeficiency virus, etc.
- Cells can be cells of a cell line.
- Exemplary cell lines include HeLa, CHO, COS, BHK, NIH-3T3, HUVEC, etc.
- ATCC® American Type Culture Collection catalog
- Manassas, Va. Manassas, Va.
- speed or delivery rate of nanoparticles, drugs, and/or bioactive agents to a cell type and/or tissue may be increased by exposing said cell and/or tissue comprising a surface-coated implant to radiation, which permits faster penetration of the host cell and/or tissue.
- Any suitable radiation technique may be used, including laser radiation and electromagnetic radiation.
- nanoparticle and/or microparticle compositions provided herein may be used in a variety of products, including but not limited to implants, devices, compositions, nutraceuticals, topicals, gels, creams, kits, reagents, implants, scaffolds, cell culture dishes, and related tools.
- nanoparticle and/or microparticle compositions may be used to coat a variety of implants, including but not limited to an orthopedic implant, dental implant, veterinary prosthetic device, graft, needle, bone material, contact lens, catheter, ear tube, endotracheal tube, stent, shunt, scaffold, tissue engineering matrix, breast implant, allograft hard tissue, allograft soft tissue, xenograft hard tissue, xenograft soft tissue, polymeric mesh, hip implant, knee implant, shoulder implant, plate, pin, screw, wire, rod, or ceramic mesh.
- implants including but not limited to an orthopedic implant, dental implant, veterinary prosthetic device, graft, needle, bone material, contact lens, catheter, ear tube, endotracheal tube, stent, shunt, scaffold, tissue engineering matrix, breast implant, allograft hard tissue, allograft soft tissue, xenograft hard tissue, xenograft soft tissue, polymeric mesh, hip implant, knee implant, shoulder implant, plate, pin, screw
- any component of a dental implant may be coated or otherwise comprise nanoparticle and/or microparticle compositions.
- Dental implant components include but are not limited to an abutment, healing screw, and cover screw.
- Other dental applications include archwires used in orthodontics and removable partial denture clasps and connectors used in dentistry which may be coated with a nanoparticle or microparticle composition.
- Polyurethane - hydroxyapatite (HA) composite materials are prepared by in- situ polymerization.
- the nanomaterials are mixed in the solvent of the polymeric scaffold and deposited by air spraying.
- the composite films can be deposited by e-beam deposition, ion beam deposition, pulsed laser deposition, electrospray, or any other method known in the art, on the implant surfaces.
- the coating can be exposed to any type of plasma discharge and covered with growth factors, proteins, amino acids, drugs, hydroxyapatite, or any other bioactive agent.
- Figure 1 presents a surface created by the deposition of the polymeric/nano- hydroxyapatite nanocomposites.
- Osteoblast cells were incubated in tissue culture on top of the coatings and controls for 7 days at 37 deg. C. At day 0, at the start of the experiment, the number of cells was 10 5 .
- the control surfaces were a roughened titanium surface and an untreated polymer surface. After 7 days in tissue culture, osteoblasts were counted using standardized cell counting methods. The number of cells on the untreated polymer surface was 10 s . The number of cells on the second control (titanium surface) was 10 6 .
- the results for the polyurethane coatings and HA are shown in Figure 2. [0048] As show in Figure 2, there is a significant increase in the number of cells on the plasma treated polymer coatings, as well as the polymer treated and HA coatings.
- the polymer surfaces which were plasma treated between 10 and 15 minutes demonstrated approximately 20 times more cells per unit area versus the controls.
- the plasma treated polymer surface with hydroxyapatite nano-particles exhibited 20 times the number of cells per unit area versus the controls.
- FIG. 3 shows enhanced growth of bone cells on the polymeric surfaces exposed to plasma and doped with HA nanoparticles (b) as compared to the regular Ti surfaces (a).
- the visualization was done with optical microscopy and cellular staining.
- Zirconia deposition can be achieved by pulsed laser deposition, e-beam deposition, or any of the processes involving atomic or molecular deposition.
- Many surfaces can be used for zirconia deposition, including but not limited to an orthopedic implant, dental implant, abutement for a dental implant, orthodontic archwires, removable partial denture clasps, and connectors used in dentistry.
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Abstract
L'invention concerne des méthodologies et des compositions pour matériaux de revêtement pouvant servir dans diverses applications biologiques.
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PCT/US2010/050666 WO2011049719A2 (fr) | 2009-10-23 | 2010-09-29 | Revêtements de surface céramiques pour applications dentaires |
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US21211009P | 2009-04-07 | 2009-04-07 | |
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US12/604,964 US20100255447A1 (en) | 2009-04-07 | 2009-10-23 | Advanced bio-compatible polymer surface coatings for implants and tissue engineering scaffolds |
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ITRM20110687A1 (it) * | 2011-12-27 | 2013-06-28 | Vincenzo Quaranta | Dispositivo per rilascio controllato di farmaco. |
WO2013142308A1 (fr) * | 2012-03-22 | 2013-09-26 | The Curators Of The University Of Missouri | Nanocomposites pour la réparation et le remplacement d'un tissu mou |
US8613943B2 (en) | 2009-01-23 | 2013-12-24 | Royal College Of Surgeons In Ireland | Process for producing a multi-layered scaffold suitable for osteochondral repair |
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US10052407B2 (en) | 2009-01-23 | 2018-08-21 | Royal College Of Surgeons In Ireland | Layered collagen and ha scaffold suitable for osteochondral repair |
US9072815B2 (en) | 2009-01-23 | 2015-07-07 | Royal College Of Surgeons In Ireland | Layered collagen and HA scaffold suitable for osteochondral repair |
US9615910B2 (en) | 2009-01-23 | 2017-04-11 | Royal College Of Surgeons In Ireland | Layered collagen and HA scaffold suitable for osteochondral repair |
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