WO2010117285A3 - Process for the preparation of grignard compounds - Google Patents
Process for the preparation of grignard compounds Download PDFInfo
- Publication number
- WO2010117285A3 WO2010117285A3 PCT/PL2010/000024 PL2010000024W WO2010117285A3 WO 2010117285 A3 WO2010117285 A3 WO 2010117285A3 PL 2010000024 W PL2010000024 W PL 2010000024W WO 2010117285 A3 WO2010117285 A3 WO 2010117285A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- organic solvent
- preparation
- grignard compounds
- metallic magnesium
- organic
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000004820 halides Chemical class 0.000 abstract 2
- 229910052749 magnesium Inorganic materials 0.000 abstract 2
- 239000011777 magnesium Substances 0.000 abstract 2
- 239000012190 activator Substances 0.000 abstract 1
- 238000011437 continuous method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to a process for the preparation of Grignard compounds using a continuous method which involves the reaction of an organic halide dissolved in an organic solvent with metallic magnesium which, together with the activator solution in an organic solvent, fills the flow reactor or optionally a system of flow reactors, and subsequently, the resulting reaction mixture is fed into the terminal flow reactor containing metallic magnesium in order to achieve complete conversion of the organic halide, whereby preferably the organic solvent is re-circulated to flow reactors in a form of vapour.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL387728A PL387728A1 (en) | 2009-04-07 | 2009-04-07 | Method of obtaining Grignard compounds |
PLP.387728 | 2009-04-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010117285A2 WO2010117285A2 (en) | 2010-10-14 |
WO2010117285A3 true WO2010117285A3 (en) | 2010-12-02 |
Family
ID=42735268
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/PL2010/000024 WO2010117285A2 (en) | 2009-04-07 | 2010-03-29 | Process for the preparation of grignard compounds |
Country Status (2)
Country | Link |
---|---|
PL (1) | PL387728A1 (en) |
WO (1) | WO2010117285A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102649796A (en) * | 2011-02-24 | 2012-08-29 | 四川滇虹医药开发有限公司 | Preparation method for important intermediates of butoconazole nitrate |
CN103880596B (en) * | 2012-12-21 | 2015-12-23 | 凌沛学 | A kind of preparation method of Nitric acid butoconazole intermediate of applicable suitability for industrialized production |
FR3012145B1 (en) * | 2013-10-18 | 2015-12-18 | Yriel | CONTINUOUS PROCESS FOR THE PREPARATION OF BORONIC ACIDS AND THEIR DERIVATIVES |
CN106588958B (en) * | 2015-10-14 | 2018-09-28 | 上虞新和成生物化工有限公司 | A kind of continuous production system and method for preparing alkynol di Grignard reagent |
DE102016206211B4 (en) * | 2016-04-13 | 2018-12-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Continuous process for the preparation of Grignard adducts and apparatus for carrying it out |
CN111138461B (en) * | 2019-12-05 | 2023-01-20 | 海利尔药业集团股份有限公司 | Continuous preparation method of o-chlorobenzyl chloride Grignard reagent |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2464685A (en) * | 1946-12-02 | 1949-03-15 | Diamond Alkali Co | Continuous grignard method |
US3911037A (en) * | 1973-11-21 | 1975-10-07 | Nalco Chemical Co | Continuous Grignard reactors |
-
2009
- 2009-04-07 PL PL387728A patent/PL387728A1/en not_active Application Discontinuation
-
2010
- 2010-03-29 WO PCT/PL2010/000024 patent/WO2010117285A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2464685A (en) * | 1946-12-02 | 1949-03-15 | Diamond Alkali Co | Continuous grignard method |
US3911037A (en) * | 1973-11-21 | 1975-10-07 | Nalco Chemical Co | Continuous Grignard reactors |
Non-Patent Citations (1)
Title |
---|
JENNINGS ET AL: "A novel, continuous high-yield synthesis of Grignard reagents", JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER-SEQUOIA S.A. LAUSANNE, CH LNKD- DOI:10.1016/0022-328X(87)80384-4, vol. 325, no. 1-2, 12 May 1987 (1987-05-12), pages 25 - 29, XP026611033, ISSN: 0022-328X, [retrieved on 19870512] * |
Also Published As
Publication number | Publication date |
---|---|
PL387728A1 (en) | 2010-10-11 |
WO2010117285A2 (en) | 2010-10-14 |
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