WO2010111595A3 - Markers related to age-related macular degeneration and uses therefor - Google Patents

Markers related to age-related macular degeneration and uses therefor Download PDF

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Publication number
WO2010111595A3
WO2010111595A3 PCT/US2010/028834 US2010028834W WO2010111595A3 WO 2010111595 A3 WO2010111595 A3 WO 2010111595A3 US 2010028834 W US2010028834 W US 2010028834W WO 2010111595 A3 WO2010111595 A3 WO 2010111595A3
Authority
WO
WIPO (PCT)
Prior art keywords
age
macular degeneration
uses therefor
markers
related macular
Prior art date
Application number
PCT/US2010/028834
Other languages
French (fr)
Other versions
WO2010111595A2 (en
Inventor
Johanna M. Seddon
Mark Daly
Original Assignee
Tufts - New England Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts - New England Medical Center filed Critical Tufts - New England Medical Center
Priority to CA2756569A priority Critical patent/CA2756569A1/en
Priority to AU2010229767A priority patent/AU2010229767C1/en
Priority to EP10756913.9A priority patent/EP2411541B1/en
Priority to US13/260,457 priority patent/US20120046189A1/en
Publication of WO2010111595A2 publication Critical patent/WO2010111595A2/en
Publication of WO2010111595A3 publication Critical patent/WO2010111595A3/en
Priority to US14/101,915 priority patent/US20140309125A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/918—Carboxylic ester hydrolases (3.1.1)
    • G01N2333/92—Triglyceride splitting, e.g. by means of lipase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/16—Ophthalmology
    • G01N2800/164—Retinal disorders, e.g. retinopathy

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Described herein are compositions, kits and methods for diagnosing and tracking the progression of AMD in a subject by detecting the presence or absence of particular lipid metabolism markers associated with AMD. Predictive computer models of disease risk are also disclosed.
PCT/US2010/028834 2009-03-27 2010-03-26 Markers related to age-related macular degeneration and uses therefor WO2010111595A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA2756569A CA2756569A1 (en) 2009-03-27 2010-03-26 Markers related to age-related macular degeneration and uses therefor
AU2010229767A AU2010229767C1 (en) 2009-03-27 2010-03-26 Markers related to age-related macular degeneration and uses therefor
EP10756913.9A EP2411541B1 (en) 2009-03-27 2010-03-26 Markers related to age-related macular degeneration and uses therefor
US13/260,457 US20120046189A1 (en) 2009-03-27 2010-03-26 Markers related to age-related macular degeneration and uses therefor
US14/101,915 US20140309125A1 (en) 2009-03-27 2013-12-10 Markers related to age-related macular degeneration and uses therefor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16424509P 2009-03-27 2009-03-27
US61/164,245 2009-03-27
US31749810P 2010-03-25 2010-03-25
US61/317,498 2010-03-25

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/260,457 A-371-Of-International US20120046189A1 (en) 2009-03-27 2010-03-26 Markers related to age-related macular degeneration and uses therefor
US14/101,915 Continuation US20140309125A1 (en) 2009-03-27 2013-12-10 Markers related to age-related macular degeneration and uses therefor

Publications (2)

Publication Number Publication Date
WO2010111595A2 WO2010111595A2 (en) 2010-09-30
WO2010111595A3 true WO2010111595A3 (en) 2011-04-21

Family

ID=42781909

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/028834 WO2010111595A2 (en) 2009-03-27 2010-03-26 Markers related to age-related macular degeneration and uses therefor

Country Status (5)

Country Link
US (2) US20120046189A1 (en)
EP (2) EP2894229A1 (en)
AU (1) AU2010229767C1 (en)
CA (1) CA2756569A1 (en)
WO (1) WO2010111595A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2825561A1 (en) * 2011-01-25 2012-08-02 The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services Methods of diagnosing and treating age-related macular degeneration
CN111690728A (en) * 2019-03-12 2020-09-22 上海市第一人民医院 Method for diagnosing age-related macular degeneration by measuring peripheral blood EFEMP1 protein

Family Cites Families (20)

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US5449754A (en) 1991-08-07 1995-09-12 H & N Instruments, Inc. Generation of combinatorial libraries
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US6974666B1 (en) 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
JP2002515738A (en) 1996-01-23 2002-05-28 アフィメトリックス，インコーポレイティド Nucleic acid analysis
JP2000504575A (en) 1996-02-08 2000-04-18 アフィメトリックス，インコーポレイテッド Chip-based speciation and phenotypic characterization of microorganisms
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
AU751956B2 (en) 1997-03-20 2002-09-05 University Of Washington Solvent for biopolymer synthesis, solvent microdroplets and methods of use
US6242266B1 (en) 1999-04-30 2001-06-05 Agilent Technologies Inc. Preparation of biopolymer arrays
US6180351B1 (en) 1999-07-22 2001-01-30 Agilent Technologies Inc. Chemical array fabrication with identifier
US6232072B1 (en) 1999-10-15 2001-05-15 Agilent Technologies, Inc. Biopolymer array inspection
US6171797B1 (en) 1999-10-20 2001-01-09 Agilent Technologies Inc. Methods of making polymeric arrays
US7206438B2 (en) 2003-04-30 2007-04-17 Agilent Technologies, Inc. Feature locations in array reading
CA2705500A1 (en) * 2007-05-11 2008-11-20 Tufts Medical Center Polynucleotides associated with age-related macular degeneration and methods for evaluating patient risk
EP2963128A1 (en) * 2009-07-10 2016-01-06 The Regents of the University of Michigan Compositions and methods for diagnosing and treating macular degeneration

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEN ET AL.: "Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration", VISION RES, vol. 48, no. 5, February 2008 (2008-02-01), pages 690 - 694, XP022475586 *
FRANCIS ET AL.: "Haplotypes in the complement factor H (CFH) gene: associations with drusen and advanced age-related macular degeneration", PLOS ONE, vol. 2, no. 11, 28 November 2007 (2007-11-28), pages E1197, XP008102569 *
MORI ET AL.: "Coding and noncoding variants in the CFH gene and cigarette smoking influence the risk of age-related macular degeneration in a Japanese population", INVEST OPHTHALMOL VIS SCI, vol. 48, no. 11, November 2007 (2007-11-01), pages 5315 - 5319, XP008162666 *
NG ET AL.: "Multiple gene polymorphisms in the complement factor h gene are associated with exudative age-related macular degeneration in chinese", INVEST OPHTHALMOL VIS SCI, vol. 49, no. 8, 17 April 2008 (2008-04-17), pages 3312 - 3317, XP002580199 *
SPENCER ET AL.: "Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration", HUM MOL GENET, vol. 17, no. 7, 15 December 2007 (2007-12-15), pages 971 - 977, XP008151867 *
TSAI ET AL.: "Interleukin gene polymorphisms in age-related macular degeneration", INVEST OPHTHALMOL VIS SCI., vol. 49, no. 2, February 2008 (2008-02-01), pages 693 - 698, XP008160279 *

Also Published As

Publication number Publication date
AU2010229767C1 (en) 2015-02-19
EP2894229A1 (en) 2015-07-15
US20140309125A1 (en) 2014-10-16
AU2010229767B2 (en) 2014-09-11
EP2411541A2 (en) 2012-02-01
US20120046189A1 (en) 2012-02-23
WO2010111595A2 (en) 2010-09-30
CA2756569A1 (en) 2010-09-30
AU2010229767A1 (en) 2011-10-27
EP2411541B1 (en) 2015-02-11
EP2411541A4 (en) 2012-08-29

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