WO2010111166A3 - Compact dual pass monochromator - Google Patents

Compact dual pass monochromator Download PDF

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Publication number
WO2010111166A3
WO2010111166A3 PCT/US2010/028104 US2010028104W WO2010111166A3 WO 2010111166 A3 WO2010111166 A3 WO 2010111166A3 US 2010028104 W US2010028104 W US 2010028104W WO 2010111166 A3 WO2010111166 A3 WO 2010111166A3
Authority
WO
WIPO (PCT)
Prior art keywords
optically
exit aperture
wavelength band
radiation
dispersive
Prior art date
Application number
PCT/US2010/028104
Other languages
French (fr)
Other versions
WO2010111166A2 (en
Inventor
Josef Atzler
Andreas Kenda
Original Assignee
Beckman Coulter, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter, Inc. filed Critical Beckman Coulter, Inc.
Publication of WO2010111166A2 publication Critical patent/WO2010111166A2/en
Publication of WO2010111166A3 publication Critical patent/WO2010111166A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/30—Measuring the intensity of spectral lines directly on the spectrum itself
    • G01J3/32—Investigating bands of a spectrum in sequence by a single detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0208—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using focussing or collimating elements, e.g. lenses or mirrors; performing aberration correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/024—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using means for illuminating a slit efficiently (e.g. entrance slit of a spectrometer or entrance face of fiber)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0291—Housings; Spectrometer accessories; Spatial arrangement of elements, e.g. folded path arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/06—Scanning arrangements arrangements for order-selection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G01J2003/1204—Grating and filter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G01J2003/1208—Prism and grating
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices

Abstract

A dual pass monochromator for generating excitation radiation and isolating emission radiation at prescribed wavelengths, useful for analyzing florescence in multi-assay micro-titer plate readers is disclosed. The optically dispersive element can be used to receive radiation through an entrance aperture; isolate a prescribed wavelength band; and then direct the prescribed wavelength band through a first exit aperture onto a sample. The excited emissions from the sample can then be received back through the first exit aperture and be directed to the optically dispersive element to isolate the emission wavelength band and direct it onto a detector through a second exit aperture. Band pass elements can be optically coupled to the optically dispersive element to tune the excitation and emission wavelength bands. Band pass optical elements can be dispersive diffraction gratings, or non-dispersive optical filters. The dual pass monochromator can be modular and include a number of optically isolated compartments.
PCT/US2010/028104 2009-03-23 2010-03-22 Compact dual pass monochromator WO2010111166A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21086509P 2009-03-23 2009-03-23
US61/210,865 2009-03-23

Publications (2)

Publication Number Publication Date
WO2010111166A2 WO2010111166A2 (en) 2010-09-30
WO2010111166A3 true WO2010111166A3 (en) 2011-01-13

Family

ID=42781798

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/028104 WO2010111166A2 (en) 2009-03-23 2010-03-22 Compact dual pass monochromator

Country Status (1)

Country Link
WO (1) WO2010111166A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE202013002752U1 (en) 2013-03-14 2013-04-10 Berthold Technologies Gmbh & Co. Kg Device for detecting fluorescence properties of samples
CN107063456B (en) * 2017-04-24 2018-07-13 中国科学院上海光学精密机械研究所 Time resolution diffraction efficiency of grating spectral measurement device in situ and method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268170A (en) * 1979-09-18 1981-05-19 Acton Research Corporation Multi-path monochromator
JPH05256701A (en) * 1992-03-16 1993-10-05 Hitachi Ltd Diffraction grating monochromator
JP2002048644A (en) * 2000-08-01 2002-02-15 Asahi Spectra Co Ltd Compact-shape double monochromator
US20040046956A1 (en) * 1999-04-21 2004-03-11 Chromagen, Inc. Novel scanning spectrophotometer for high throughput fluorescence detection

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268170A (en) * 1979-09-18 1981-05-19 Acton Research Corporation Multi-path monochromator
JPH05256701A (en) * 1992-03-16 1993-10-05 Hitachi Ltd Diffraction grating monochromator
US20040046956A1 (en) * 1999-04-21 2004-03-11 Chromagen, Inc. Novel scanning spectrophotometer for high throughput fluorescence detection
JP2002048644A (en) * 2000-08-01 2002-02-15 Asahi Spectra Co Ltd Compact-shape double monochromator

Also Published As

Publication number Publication date
WO2010111166A2 (en) 2010-09-30

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