WO2010108058A3 - Small molecule inhibitors of dusp6 and uses therefor - Google Patents

Small molecule inhibitors of dusp6 and uses therefor Download PDF

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Publication number
WO2010108058A3
WO2010108058A3 PCT/US2010/027900 US2010027900W WO2010108058A3 WO 2010108058 A3 WO2010108058 A3 WO 2010108058A3 US 2010027900 W US2010027900 W US 2010027900W WO 2010108058 A3 WO2010108058 A3 WO 2010108058A3
Authority
WO
WIPO (PCT)
Prior art keywords
dusp6
compounds
small molecule
molecule inhibitors
uses therefor
Prior art date
Application number
PCT/US2010/027900
Other languages
French (fr)
Other versions
WO2010108058A2 (en
Inventor
Billy W. Day
Waikok Michael Tsang
Vasiliy N. Korotchenko
Original Assignee
University Of Pittsburgh-Of The Commonwealth System Of Higher Education
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Pittsburgh-Of The Commonwealth System Of Higher Education filed Critical University Of Pittsburgh-Of The Commonwealth System Of Higher Education
Priority to US13/256,584 priority Critical patent/US9127016B2/en
Publication of WO2010108058A2 publication Critical patent/WO2010108058A2/en
Publication of WO2010108058A3 publication Critical patent/WO2010108058A3/en
Priority to US14/795,056 priority patent/US9439877B2/en
Priority to US15/243,089 priority patent/US9682919B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compounds can be used to treat wounds, to expand cell populations, such as hematopoietic cells, or to grow tissue in vitro, among other uses.
PCT/US2010/027900 2009-03-20 2010-03-19 Small molecule inhibitors of dusp6 and uses therefor WO2010108058A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/256,584 US9127016B2 (en) 2009-03-20 2010-03-19 Small molecule inhibitors of Dusp6 and uses therefor
US14/795,056 US9439877B2 (en) 2009-03-20 2015-07-09 Small molecule inhibitors of Dusp6 and uses therefor
US15/243,089 US9682919B2 (en) 2009-03-20 2016-08-22 Small molecule inhibitors of Dusp6 and uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21064309P 2009-03-20 2009-03-20
US61/210,643 2009-03-20

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/256,584 A-371-Of-International US9127016B2 (en) 2009-03-20 2010-03-19 Small molecule inhibitors of Dusp6 and uses therefor
US14/795,056 Continuation US9439877B2 (en) 2009-03-20 2015-07-09 Small molecule inhibitors of Dusp6 and uses therefor

Publications (2)

Publication Number Publication Date
WO2010108058A2 WO2010108058A2 (en) 2010-09-23
WO2010108058A3 true WO2010108058A3 (en) 2011-03-17

Family

ID=42740245

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/027900 WO2010108058A2 (en) 2009-03-20 2010-03-19 Small molecule inhibitors of dusp6 and uses therefor

Country Status (2)

Country Link
US (3) US9127016B2 (en)
WO (1) WO2010108058A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10342767B2 (en) 2011-04-21 2019-07-09 Children's Hospital Medical Center Therapy for kinase-dependent malignancies
WO2012145575A2 (en) 2011-04-21 2012-10-26 Children's Hospital Medical Center Therapy for leukemia
ES2612259T3 (en) 2011-12-09 2017-05-16 Chiesi Farmaceutici S.P.A. Kinase inhibitors
WO2013083606A1 (en) 2011-12-09 2013-06-13 Chiesi Farmaceutici S.P.A. Kinase inhibitors
RU2015151886A (en) 2013-06-06 2017-06-08 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. KINAZ INHIBITORS
US10960030B2 (en) * 2016-04-15 2021-03-30 National Health Research Institutes Anti-obesity microbiota compositions and preparation methods and uses thereof
CN113616631B (en) * 2021-08-26 2022-03-08 中国人民解放军陆军军医大学第二附属医院 Application of DUSP6 inhibitor BCI in preparation of osteoporosis drugs
CN116270568B (en) * 2023-02-19 2024-08-16 重庆医科大学 (E) Use of (E) -2-benzylidene-3- (cyclohexylamino) -2, 3-dihydro-1H-inden-1-one for the treatment of mycobacterial infections

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999065495A1 (en) * 1998-06-19 1999-12-23 Smithkline Beecham Corporation INHIBITORS OF TRANSCRIPTION FACTOR NF-λB

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5758663A (en) 1980-09-24 1982-04-08 Otsuka Pharmaceut Co Ltd Alkanoic acid derivative
US6476027B1 (en) 1997-03-04 2002-11-05 Monsanto Company N-hydroxy 4-sulfonyl butanamide compounds
US6541661B1 (en) 1999-11-23 2003-04-01 Methylgene, Inc. Inhibitors of histone deacetylase
EP1976835A2 (en) 2006-01-13 2008-10-08 Takeda San Diego, Inc. Histone deacetylase inhibitors
JP5758663B2 (en) 2011-03-23 2015-08-05 三菱電機株式会社 Air conditioner

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999065495A1 (en) * 1998-06-19 1999-12-23 Smithkline Beecham Corporation INHIBITORS OF TRANSCRIPTION FACTOR NF-λB

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JOHN K. MARK ET AL.: "Over-expression and refolding of MAP kinase phosphatase 4", PROTEIN EXPRESSION AND PURIFICATION, vol. 54, 2007, pages 253 - 260 *
KOROTCHENKO, VASILIY N. ET AL.: "Identification and structure-activity relat ionship of an allosteric inhibitor of the dual specificity phosphatase Dusp6", 237TH ACS NATIONAL MEETING, MEDI-262, 22 March 2009 (2009-03-22) - 26 March 2009 (2009-03-26) *
LISA D. URNESS ET AL.: "Expression of ERK signaling inhibitors DUSP6, DUSP7, and DUSP9 during mouse ear development", DEVELOPMENTAL DYNAMICS, vol. 237, 2008, pages 163 - 169 *

Also Published As

Publication number Publication date
US9127016B2 (en) 2015-09-08
US20160113889A1 (en) 2016-04-28
US9682919B2 (en) 2017-06-20
US20120122992A1 (en) 2012-05-17
US9439877B2 (en) 2016-09-13
US20160355459A1 (en) 2016-12-08
WO2010108058A2 (en) 2010-09-23

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