WO2010101750A3 - Salmonella enterica serovar paratyphi a atténuée et ses utilisations - Google Patents
Salmonella enterica serovar paratyphi a atténuée et ses utilisations Download PDFInfo
- Publication number
- WO2010101750A3 WO2010101750A3 PCT/US2010/025221 US2010025221W WO2010101750A3 WO 2010101750 A3 WO2010101750 A3 WO 2010101750A3 US 2010025221 W US2010025221 W US 2010025221W WO 2010101750 A3 WO2010101750 A3 WO 2010101750A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- salmonella enterica
- enterica serovar
- paratyphi
- attenuated salmonella
- serovar paratyphi
- Prior art date
Links
- 230000002238 attenuated effect Effects 0.000 title abstract 3
- 241001138501 Salmonella enterica Species 0.000 title 1
- 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 abstract 3
- 108010060123 Conjugate Vaccines Proteins 0.000 abstract 2
- 229940031670 conjugate vaccine Drugs 0.000 abstract 2
- 239000013612 plasmid Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La présente invention concerne une souche de S. paratyphi A vivante atténuée, une souche de S. paratyphi A vivante atténuée comprenant un système d'expression plasmidique stabilisé, et un vaccin conjugué contre S. paratyphi, ainsi que des procédés d'utilisation de ces souches et de ce vaccin conjugué.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES10749113.6T ES2644766T3 (es) | 2009-03-06 | 2010-02-24 | Salmonella entérica atenuada serovariedad Parathypy y usos de la misma |
EP10749113.6A EP2403525B1 (fr) | 2009-03-06 | 2010-02-24 | Salmonella enterica serovar paratyphi a atténuée et ses utilisations |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/399,091 US8137930B2 (en) | 2005-10-28 | 2009-03-06 | Attenuated Salmonella enterica serovar paratyphi A and uses thereof |
US12/399,091 | 2009-03-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010101750A2 WO2010101750A2 (fr) | 2010-09-10 |
WO2010101750A3 true WO2010101750A3 (fr) | 2011-01-06 |
Family
ID=42710167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/025221 WO2010101750A2 (fr) | 2009-03-06 | 2010-02-24 | Salmonella enterica serovar paratyphi a atténuée et ses utilisations |
Country Status (4)
Country | Link |
---|---|
US (1) | US8137930B2 (fr) |
EP (1) | EP2403525B1 (fr) |
ES (1) | ES2644766T3 (fr) |
WO (1) | WO2010101750A2 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2148698A4 (fr) * | 2007-04-20 | 2010-12-08 | Nucleonics Inc | Systeme de complementation hote-vecteur microbien |
WO2010083477A2 (fr) * | 2009-01-16 | 2010-07-22 | University Of Maryland, Baltimore | Vaccin à large spectre contre les salmonelles non typhoïdiques |
WO2011060431A2 (fr) | 2009-11-16 | 2011-05-19 | University Of Maryland Baltimore | Vaccin à vecteur vivant polyvalent dirigé contre une malade associée à clostridium difficile |
US9011871B2 (en) | 2011-11-07 | 2015-04-21 | University Of Maryland, Baltimore | Broad spectrum vaccine against typhoidal and non-typhoidal Salmonella disease |
EP3156487A4 (fr) * | 2014-06-13 | 2018-01-10 | Ouro Fino Saúde Animal Ltda. | Vecteur d'expression t7 d'escherichia coli, vecteurs pour la co-expression et la co-purification de polypeptides recombinants dans/avec des protéines porteuses, utilisation de vecteurs d'expression pour l'obtention de complexes avec de multiples antigènes et immunomodulateurs |
EP3193918A4 (fr) | 2014-09-18 | 2018-06-20 | University of Maryland, Baltimore | Vaccin conjugué à large spectre permettant de prévenir des infections par klebsiella pneumoniae et pseudomonas aeruginosa |
CN105734001B (zh) * | 2014-12-08 | 2020-04-07 | 中国人民解放军军事医学科学院生物工程研究所 | 一种o抗原糖链延长的甲型副伤寒沙门氏菌及其应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998026799A1 (fr) * | 1996-12-18 | 1998-06-25 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Vaccin conjugue contre la salmonella paratyphi a |
US6130082A (en) * | 1988-05-05 | 2000-10-10 | American Cyanamid Company | Recombinant flagellin vaccines |
WO2007053489A2 (fr) * | 2005-10-28 | 2007-05-10 | University Of Maryland, Baltimore | Salmonella enterica serotype paratyphi a attenue et procedes de son utilisation |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6190669B1 (en) | 1998-05-13 | 2001-02-20 | University Of Maryland, Baltimore | Attenuated mutants of salmonella which constitutively express the Vi antigen |
US6703233B1 (en) | 1998-12-02 | 2004-03-09 | University Of Maryland, Baltimore | Plasmid maintenance system for antigen delivery |
US8076130B2 (en) | 1998-12-02 | 2011-12-13 | University Of Maryland, Baltimore | Plasmid maintenance system for antigen delivery |
ATE463505T1 (de) * | 2001-04-20 | 2010-04-15 | Inst Systems Biology | Toll-ähnlichen-rezeptor-5-liganden und verwendungsverfahren |
US20050180985A9 (en) | 2001-10-04 | 2005-08-18 | Vladoianu Ion R. | Live attenuated salmonella strains for producing monovalent or multivalent vaccines |
WO2005042564A1 (fr) | 2003-10-20 | 2005-05-12 | Sidney Kimmel Cancer Center | Proteines de fusion flagelline, comme adjuvants ou vaccins, et procedes d'utilisation |
EP1853289A4 (fr) | 2005-01-31 | 2008-04-09 | Vaxinnate Corp | Nouveaux ligands de polypeptides destines a un recepteur de type toll 2 (tlr2) |
WO2007125535A1 (fr) * | 2006-05-01 | 2007-11-08 | Biondvax Pharmaceuticals Ltd. | Gène de flagelline recombinant et utilisations de celui-ci |
-
2009
- 2009-03-06 US US12/399,091 patent/US8137930B2/en active Active
-
2010
- 2010-02-24 EP EP10749113.6A patent/EP2403525B1/fr active Active
- 2010-02-24 WO PCT/US2010/025221 patent/WO2010101750A2/fr active Application Filing
- 2010-02-24 ES ES10749113.6T patent/ES2644766T3/es active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6130082A (en) * | 1988-05-05 | 2000-10-10 | American Cyanamid Company | Recombinant flagellin vaccines |
WO1998026799A1 (fr) * | 1996-12-18 | 1998-06-25 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Vaccin conjugue contre la salmonella paratyphi a |
WO2007053489A2 (fr) * | 2005-10-28 | 2007-05-10 | University Of Maryland, Baltimore | Salmonella enterica serotype paratyphi a attenue et procedes de son utilisation |
Non-Patent Citations (2)
Title |
---|
BRETT, P.J. ET AL.: "Structural and Immunological Characterization of Burkholderia pseudomallei 0-Polysaccharide–Flagellin Protein Conjugates.", INFECTION AND IMMUNITY, vol. 64, no. 7, 1996, pages 2824 - 2828, XP002421921 * |
KOMORIYA, K. ET AL.: "Flagellar proteins and type III-exported virulence factors are the predominant proteins secreted into the culture media of Salmonella typhimurium.", MOLECULAR MICROBIOLOGY, vol. 34, no. 4, 1999, pages 767 - 779, XP055097424 * |
Also Published As
Publication number | Publication date |
---|---|
EP2403525B1 (fr) | 2017-09-27 |
EP2403525A2 (fr) | 2012-01-11 |
WO2010101750A2 (fr) | 2010-09-10 |
ES2644766T3 (es) | 2017-11-30 |
US20120029173A1 (en) | 2012-02-02 |
US8137930B2 (en) | 2012-03-20 |
EP2403525A4 (fr) | 2013-04-03 |
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