WO2010098765A1 - Distributeur et applicateur amenant des substances réactives au contact l'une de l'autre au moment de l'utilisation - Google Patents

Distributeur et applicateur amenant des substances réactives au contact l'une de l'autre au moment de l'utilisation Download PDF

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Publication number
WO2010098765A1
WO2010098765A1 PCT/US2009/035436 US2009035436W WO2010098765A1 WO 2010098765 A1 WO2010098765 A1 WO 2010098765A1 US 2009035436 W US2009035436 W US 2009035436W WO 2010098765 A1 WO2010098765 A1 WO 2010098765A1
Authority
WO
WIPO (PCT)
Prior art keywords
dispenser
contents
applicator tip
recess
vessel
Prior art date
Application number
PCT/US2009/035436
Other languages
English (en)
Inventor
Leslie Cifuentes French
Jonathan B. Levine
Original Assignee
Leslie Cifuentes French
Levine Jonathan B
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leslie Cifuentes French, Levine Jonathan B filed Critical Leslie Cifuentes French
Priority to PCT/US2009/035436 priority Critical patent/WO2010098765A1/fr
Publication of WO2010098765A1 publication Critical patent/WO2010098765A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
    • A61M35/006—Portable hand-held applicators having means for dispensing or spreading integral media using sponges, foams, absorbent pads or swabs as spreading means
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D2200/00—Details not otherwise provided for in A45D
    • A45D2200/05—Details of containers
    • A45D2200/058—Means for mixing different substances prior to application
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D2200/00—Details not otherwise provided for in A45D
    • A45D2200/10—Details of applicators
    • A45D2200/1009—Applicators comprising a pad, tissue, sponge, or the like
    • A45D2200/1018—Applicators comprising a pad, tissue, sponge, or the like comprising a pad, i.e. a cushion-like mass of soft material, with or without gripping means
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
    • A45D34/04—Appliances specially adapted for applying liquid, e.g. using roller or ball
    • A45D34/042—Appliances specially adapted for applying liquid, e.g. using roller or ball using a brush or the like

Definitions

  • the present invention relates to a dispenser and an applicator that leaves two reactive substances separate until time of use.
  • uses may include a tooth whitening or polishing system, a treatment for skin and other dermatologic applications, a delivery system for glues or other commercial compounds wherein the substrates are separate until delivery, pharmaceuticals, hemostatic agents, sealants and many other uses.
  • one of the two substances may be hydrogen peroxide and/or carbamide peroxide that is isolated from the other of the two substances, such as sodium bicarbonate.
  • the substances are subsequently mixed together at the time of use, for and during application of the mixture.
  • Peroxide is the active ingredient in many tooth whitening products.
  • a mixture of hydrogen peroxide based whitening compounds with sodium bicarbonate produces notable effervescence in whitening if used immediately after mixing them together.
  • the efficacy of hydrogen peroxide based whitening compounds is enhanced because of the mixing with the sodium bicarbonate.
  • Teeth whitening systems contain different strengths of peroxide.
  • Carbamide peroxide is hydrogen peroxide combined with urea (an aqueous solution). Carbamide peroxide is found in professional tooth whitening formulas, teeth bleaching gels, light-activated tooth whitening gels and whitening toothpastes. Tooth whitening products containing carbamide peroxide typically range from concentrations of less than 10% to about 22%. Professional products may contain as much as 35%.
  • Hydrogen peroxide is found in whitening strips, paint on whiteners and whitening mouth rinses.
  • a solution of about 10% carbamide peroxide is about as effective as a solution of 3% hydrogen peroxide.
  • a solution of about 22% carbamide peroxide is about as effective as a solution of 7.5% hydrogen peroxide.
  • Sodium bicarbonate helps clean teeth, freshen breath and neutralize mouth acids that can destroy tooth enamel. Used for decades for dental care, the FDA recognizes it as safe. It has been mixed conventionally with whitening compounds to whiten teeth.
  • Magnesium peroxide is recognized as an oxidizer that whitens teeth and aluminum oxide is recognized as a tooth surface polisher.
  • US Patent No. 6,929,475 discloses a single use applicator of chemical or medicament material to be applied to a surface to be treated.
  • the material which may be a stable, inactive solid powder, is placed on an absorbent portion of the applicator.
  • a liquid activating agent is released onto the absorbent portion of the applicator to activate the otherwise stable, inactive solid powder.
  • the activated powder is applied to surfaces of the tooth with the applicator to whiten and polish the tooth.
  • the absorbent portion may be a cotton swab.
  • the present invention is directed to a tooth whitening and polishing system that does not require a professional, such as a dentist, to provide assistance or application.
  • the present invention comprises a dispenser that includes a squeezable vessel or fluid container, an applicator tip that defines a fluid passage, a compliant surface at a distal end of the applicator tip, and a cap that closes and seals the applicator tip.
  • a compliant surface is a surface that is yielding or accommodating, as exemplified by foam. The contents of the squeezable vessel or fluid container may be urged out under manual pressure by squeezing together walls of a hollow body of the vessel or fluid container into a flattened condition from a non-flattened condition.
  • the compliant surface may be porous and impregnated with a different material from the contents of the vessel or fluid container, or may cover a chamber that contains such a different material.
  • the applicator tip is elongated to define a length sufficient to reach even deep and hard to reach tooth surfaces to be treated.
  • the contents of the vessel or fluid container may be a whitening compound gel whose active ingredient includes hydrogen peroxide or carbamide peroxide.
  • the different material that impregnates the porous compliant surface may be a solid powder such as sodium bicarbonate or baking soda.
  • the porous, compliant surface may be sponge-like.
  • the sodium bicarbonate or baking soda may be in cake form if the porous compliant surface covers a chamber that contains the different material.
  • a user squeezes the vessel its content (e.g., tooth whitening compound gel) passes through (is urged through) the fluid passage to reach the compliant surface where it mixes or blends with the solid powder to preferably produce foam.
  • the foam is applied to the teeth by pressing the compliant surface against the areas of the teeth to be treated and scrubbing same to whiten the teeth.
  • FIG. 1 shows an isometric view of the dispenser of the present invention with a filled vessel closed by a cap.
  • F!G. 2 shows an isometric view of the dispenser of FIG. 1 , with the filled vessel open due to separation from the cap.
  • FIG. 3 shows a cross-section longitudinally through the filled vessel closed by the cap of FIG. 1.
  • FIG. 4 shows a cross-section longitudinally through the filled vessel of FIG. 2, without showing the cap.
  • FIG. 5 shows a cross-section longitudinally of the vessel of FIG. 4 in a flattened condition after squeezing out contents.
  • FlG. 6 shows a cross-section longitudinally through the vessel for the filled vessel of FIG. 4, without the contents, to allow view of the interior of the vessel.
  • FIG. 7 shows an end view of the filled vessel of FIG. 4.
  • FIG. 8 shows an opposite end view of the filled vessel of FIG. 7 to show the applicator tip.
  • FIG. 9 shows a side view of the filled vessel and applicator tip of
  • FIG. 4 to illustrate the angle of inclination of the compliant tip.
  • FIG. 10 shows an isometric view of an empty vessel in accordance with a further embodiment of the present invention.
  • FIG. 11 shows an isometric view of the empty vessel of FIG. 10 with a soft, elastomeric application tip.
  • FIG. 12 shows a top plan view of the empty vessel of FIG. 10.
  • FIG. 13 shows a top plan view of the empty vessel with the soft, elastomeric application tip of Fig. 1 1.
  • FIG. 14 shows a top plan view of the empty vessel of Fig. 12, also showing section lines 15-15.
  • FIG. 15 shows a cross section across 15-15 of FIG. 14.
  • FIG. 16 shows a right side view of the vessel of Fig. 14.
  • FIG. 17 shows a rear plan of the vessel of FIG. 14.
  • FIG. 18 shows a front plan view of the vessel of FIG. 14.
  • FIG. 19 shows a detail view of the portion marked B of FIG. 18.
  • FIG. 20 shows an isometric view of the vessel of FIG. 14.
  • FlG. 21 shows an isometric view of the soft, elastomeric application tip of FIGS. 11 and 13.
  • FIG. 22 shows a front view of the soft, elastomeric application tip of the embodiment of FIG. 21.
  • FIG. 23 shows a detailed view of FIG. 22.
  • FIG. 24 shows a top view of the soft, elastomeric application tip of
  • FIG. 21 is a diagrammatic representation of FIG. 21.
  • FIG. 25 shows a bottom view of the soft, elastomeric application tip of FIG. 21.
  • FIG. 26 shows a right side view of the soft, elastomeric application tip of FIG. 21.
  • FIG. 27 shows a left side view of the soft, elastomeric application tip of FIG. 21.
  • FIG. 28 is an isometric view of a dispenser that includes a cap closing the vessel of FIGS. 11 and 13.
  • FIG. 29 is top view of the dispenser of FIG. 28.
  • FIG. 30 is bottom view of the dispenser of FIG. 28.
  • FIG. 31 is a right side view of the dispenser of FIG. 28.
  • FiG. 32 is a front view of the dispenser of FIG. 28.
  • FIG. 33 is a left side view of the dispenser of FIG. 28.
  • FIG. 34 shows an isometric view of a foam sponge application tip in accordance with the invention with a foam sponge tip (shown prior to inserting the foam sponge into a recess).
  • FIG. 35 shows an isometric view of the foam sponge application tip embodiment of FIG. 34 after the foam sponge is inserted into the recess.
  • FIG. 36 shows an isometric view of an application tip in accordance with the invention having tabletized inserts.
  • FIG. 37 shows an isometric view of application tip in accordance with the invention having treated blotter paper.
  • FIGS. 38 - 40 are progressive top views showing a capped dispenser in accordance with the invention assembled ready for fill, heat sealed and trimmed for the finished product, respectively.
  • a cap 10 covers and seals an applicator tip 26 that extends from a vessel or fluid container 20.
  • the cap 10 is molded with a lateral hole 16 that mates with a correspondingly shaped lug 38 when the cap 10 is in the closed position and assists in retaining the cap.
  • the mating structure for the applicator tip 26 and cap 10 includes a stopper 12 and a sealing bead 18 that cooperate with each other in the mated condition to seal the appiicator tip by the cap 10. To effectuate this, the stopper passes through an opening in the compliant surface 40 to reach the mated condition.
  • the cap 10 has the stopper and the applicator tip 26 has the sealing bead.
  • An applicator tip 26 is elongated to terminate at a distal end where there is a porous and compliant surface 40, which may be of a foam or sponge material.
  • the compliant surface 40 is used to evenly apply the whitening compound 44 (FIG. 3) to the tooth surfaces being treated and can additionally be used to gently scrub the tooth surface.
  • a stopper 12 passes through the porous and compliant surface 40 to seal a fluid passage 32 that projects outwardly from a body of the vessel or fluid container 20.
  • a sealing bead 18 provides an annular type seal with the cap 10 to prevent leakage of the contents of the vessel or fluid container 20.
  • the vessel or fluid container 20 may be squeezed in the direction indicated by arrows F, although such squeezing may occur at other areas and does not require pressure from two opposite sides or areas; pressure on one side or area may also be sufficient.
  • a whitening compound 44 (or, for other applications, the corresponding compound) is urged through the fluid passage 32 and through the passage 48 of the applicator tip 26, where the whitening compound 44 mixes with sodium bicarbonate, producing a reactant 46 that becomes accessible on the porous and compliant surface 40.
  • the 20 is able to flatten under manual squeezing pressure, allowing almost all of the contents to be expelled from the interior volume 50.
  • the sides 56 conform closely to the contours of bulkhead 52.
  • FIG. 6 shows a bulkhead 52 attaching applicator tip 26 to fluid container sides 56, having a wedge shape, allowing said sides 56 to drape.
  • FIGS. 7 and 8 opposite end views of the vessel or fluid container 20 with applicator tip 26 are depicted. Sides 56 (FIG. 6) come to a sharp seam without sidewalls, allowing them to collapse flat. [0066] Turning to FIG. 9, an angle of inclination B of the compliant surface
  • the reactants become active by squeezing on the surface, thereby causing the whitening compound contents (e.g., hydrogen peroxide or other contents for other applications) to move within the vessel or fluid container 20 through the applicator tip 26 and to deposit onto the impregnated absorbent, compliant surface 40 (impregnated with sodium bicarbonate, baking soda or other substrates for other applications).
  • the whitening compound contents e.g., hydrogen peroxide or other contents for other applications
  • ingredients may be added, such as ingredients suited to polish teeth, for added benefit.
  • FIGS. 10 and 12 a further embodiment of a dispenser is depicted that includes a vessel 60 that has an integrally formed rigid substructure 62.
  • a dispenser 70 is shown that includes the vessel 60 of FIGS. 10 and 12 and includes a contoured, soft, elastomeric application tip 72 that is fitted over or with the rigid substructure 62.
  • the contoured, soft, elastomeric application tip 72 allows for squeegee like, even spreading of the gel over the tooth surfaces and its softness helps prevent injury to the gums or teeth (or skin, etc. for other applications) that is more apt to occur with harder material.
  • the rigid substructure 62 may be elongated with a central tube 64 that extends in a direction of elongation of the rigid substructure 62. On both sides may be formed a series of spaced apart channels 66 that likewise extend in a direction of elongation of the rigid substructure 62 substantially parallel to each other.
  • FIGS. 13-20 the structure of the vessel 60 can be seen in greater detail.
  • the rigid structure 62 preferably widens toward the central tube 64 from the opposite ends to define an elliptical outline broken by the spaced apart channels 66 (see FlG. 19).
  • FIGS. 21-27 the structure of the contoured, soft, elastomeric application tip 72 can be seen in greater detail.
  • the contoured, soft, elastomeric application tip 72 includes a recess 74 at one end and a slot 76 that spaces two symmetric legs 78 apart from each other.
  • the shape of the contoured, soft, elastomeric application tip 72 may be such that it diverges outwardly from the recess 74 to a location near the recess and then converges or tapers along the symmetric legs 78 until termination.
  • the symmetric legs may each have grooves 79 spaced apart from each other.
  • FIGS. 28-33 show the dispenser 70 in greater detail when closed by a cap 80.
  • the cap 80 may be formed with structures that complement the symmetric legs 78 and slot 76 so as to engage and seal off the dispenser 70.
  • FIGS. 34-35 a preferred embodiment is depicted for attaching a bicarbonate of soda treated sponge foam pad 90 to the tip 100.
  • the sponge foam pad 90 is formed of a die cut open cell foam rubber that has been dipped in a solution of bicarbonate of soda and allowed to dry. This treated sponge foam pad 90 is then attached to a recess 112 at an end of the tip 100 with adhesive or heat sealing.
  • the sponge foam pad 90 holds a quantity of treated gel at the tip 100 during application without having the gel drain or slide off. This allows for thicker, more even coating.
  • the tip 100 can have additional ribbing in the form of tabletized inserts 120, which captures powdered or tabularized bicarbonate of soda.
  • the tabletized inserts 120 are fitted into complementary-shaped channels 122 in the end of the tip 100.
  • treated blotter paper material 130 can replace the sponge material of the sponge foam pad 90 of FIGS. 34-35 at the tip 100. This provides a means of capturing larger amounts of powder in the grooves of the tip by sealing to the perimeter, thereby forming a cover.
  • FIGS. 38-40 show a progression of views for filling the dispenser 70 with contents to be dispensed.
  • the dispenser 70 and cap 80 are formed separately, with the dispenser 70 being open at opposite ends. One of the open ends is closed and sealed by cap 80.
  • the assembly is ready to be filled as in FIG. 38.
  • the opening is closed by heat sealing inwardly from the periphery (within heat seal area 130) in the manner of FIG. 39.
  • the portion of the dispenser between the heat seal and the periphery may be trimmed off (trim area 132) to yield the finished product of FIG. 40.
  • the applicator of the present invention may be used other than for teeth whitening or polishing.
  • the following applications are contemplated: dermatological applications by delivering skin treatment applications; adhesives, such as epoxies, sealants, pharmaceutical treatments, remedies and drugs; naturopathic applications; and many others.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Coating Apparatus (AREA)

Abstract

L'invention concerne un récipient compressible contenant un composé de blanchissement et un embout applicateur allongé s'étendant vers l'extérieur à partir du récipient. Un bouchon ferme et isole l'embout applicateur, mais peut être retiré par un effort manuel. Une fois le bouchon retiré, les parois du récipient peuvent être pressées l'une contre l'autre afin de pousser le contenu du récipient à s'écouler à travers un passage de fluide traversant l'embout applicateur allongé pour atteindre une surface réceptrice. Ladite surface réceptrice peut soit être imprégnée d'un matériau différent qui réagit par contact avec le contenu du récipient, soit recouvrir une chambre qui contient elle-même un tel matériau différent.
PCT/US2009/035436 2009-02-27 2009-02-27 Distributeur et applicateur amenant des substances réactives au contact l'une de l'autre au moment de l'utilisation WO2010098765A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2009/035436 WO2010098765A1 (fr) 2009-02-27 2009-02-27 Distributeur et applicateur amenant des substances réactives au contact l'une de l'autre au moment de l'utilisation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2009/035436 WO2010098765A1 (fr) 2009-02-27 2009-02-27 Distributeur et applicateur amenant des substances réactives au contact l'une de l'autre au moment de l'utilisation

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WO2010098765A1 true WO2010098765A1 (fr) 2010-09-02

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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102764478A (zh) * 2011-05-04 2012-11-07 抛罗根有限公司 使用泡腾片剂用于美容护理的装置和方法
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US8615367B2 (en) 2003-09-18 2013-12-24 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
US8691594B2 (en) 1996-04-25 2014-04-08 Bioarray Solutions, Ltd. Method of making a microbead array with attached biomolecules
US8691754B2 (en) 2003-09-22 2014-04-08 Bioarray Solutions, Ltd. Microparticles with enhanced covalent binding capacity and their uses
US8712123B2 (en) 2002-11-15 2014-04-29 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US8795960B2 (en) 2003-10-28 2014-08-05 Bioarray Solutions, Ltd. Optimization of gene expression analysis using immobilized capture probes
US9147037B2 (en) 2004-08-02 2015-09-29 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US9436088B2 (en) 2001-06-21 2016-09-06 Bioarray Solutions, Ltd. Un-supported polymeric film with embedded microbeads
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
CN109106041A (zh) * 2017-06-23 2019-01-01 M&L实验室 一对装配在一起并且分别包含两个待混合的不同相的胶囊
US10415081B2 (en) 2001-10-15 2019-09-17 Bioarray Solutions Ltd. Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
USD988141S1 (en) * 2016-10-17 2023-06-06 Bulgari S.P.A. Bottle

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Publication number Priority date Publication date Assignee Title
US3985146A (en) * 1975-05-29 1976-10-12 Lawrence Peska Associates, Inc. Disposable shaving kit
KR200341782Y1 (ko) * 2003-10-10 2004-02-14 전득양 화장품 도포용 팁
KR100725583B1 (ko) * 2004-12-27 2007-06-08 변영광 액상 화장품용기
KR200436891Y1 (ko) * 2006-12-20 2007-10-17 (주)아모레퍼시픽 파우치 립글로스 용기

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985146A (en) * 1975-05-29 1976-10-12 Lawrence Peska Associates, Inc. Disposable shaving kit
KR200341782Y1 (ko) * 2003-10-10 2004-02-14 전득양 화장품 도포용 팁
KR100725583B1 (ko) * 2004-12-27 2007-06-08 변영광 액상 화장품용기
KR200436891Y1 (ko) * 2006-12-20 2007-10-17 (주)아모레퍼시픽 파우치 립글로스 용기

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691594B2 (en) 1996-04-25 2014-04-08 Bioarray Solutions, Ltd. Method of making a microbead array with attached biomolecules
US9400259B2 (en) 1996-04-25 2016-07-26 Bioarray Solutions, Ltd. Method of making a microbead array with attached biomolecules
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US9436088B2 (en) 2001-06-21 2016-09-06 Bioarray Solutions, Ltd. Un-supported polymeric film with embedded microbeads
US10415081B2 (en) 2001-10-15 2019-09-17 Bioarray Solutions Ltd. Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
US9251583B2 (en) 2002-11-15 2016-02-02 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US8712123B2 (en) 2002-11-15 2014-04-29 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US8615367B2 (en) 2003-09-18 2013-12-24 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
US8691754B2 (en) 2003-09-22 2014-04-08 Bioarray Solutions, Ltd. Microparticles with enhanced covalent binding capacity and their uses
US9637777B2 (en) 2003-10-28 2017-05-02 Bioarray Solutions, Ltd. Optimization of gene expression analysis using immobilized capture probes
US8795960B2 (en) 2003-10-28 2014-08-05 Bioarray Solutions, Ltd. Optimization of gene expression analysis using immobilized capture probes
US9147037B2 (en) 2004-08-02 2015-09-29 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
CN102764478A (zh) * 2011-05-04 2012-11-07 抛罗根有限公司 使用泡腾片剂用于美容护理的装置和方法
EP2609830A1 (fr) * 2011-05-04 2013-07-03 Pollogen Ltd Appareil et procédé permettant d'utiliser des comprimés effervescents de soin cosmétique
USD988141S1 (en) * 2016-10-17 2023-06-06 Bulgari S.P.A. Bottle
CN109106041A (zh) * 2017-06-23 2019-01-01 M&L实验室 一对装配在一起并且分别包含两个待混合的不同相的胶囊
CN109106041B (zh) * 2017-06-23 2023-06-06 M&L实验室 一对装配在一起并且分别包含两个待混合的不同相的胶囊

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