WO2010095912A3 - 난용성 약물 나노복합체의 제조방법 - Google Patents

난용성 약물 나노복합체의 제조방법 Download PDF

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Publication number
WO2010095912A3
WO2010095912A3 PCT/KR2010/001117 KR2010001117W WO2010095912A3 WO 2010095912 A3 WO2010095912 A3 WO 2010095912A3 KR 2010001117 W KR2010001117 W KR 2010001117W WO 2010095912 A3 WO2010095912 A3 WO 2010095912A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanocomplex
soluble drug
manufacturing non
manufacturing
provides
Prior art date
Application number
PCT/KR2010/001117
Other languages
English (en)
French (fr)
Other versions
WO2010095912A2 (ko
Inventor
권대혁
신철수
신재윤
Original Assignee
성균관대학교 산학협력단
주식회사 에이피테크놀로지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 성균관대학교 산학협력단, 주식회사 에이피테크놀로지 filed Critical 성균관대학교 산학협력단
Publication of WO2010095912A2 publication Critical patent/WO2010095912A2/ko
Publication of WO2010095912A3 publication Critical patent/WO2010095912A3/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1275—Lipoproteins; Chylomicrons; Artificial HDL, LDL, VLDL, protein-free species thereof; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)

Abstract

본 발명은 난용성 약물을 가용화할 수 있는 난용성 약물 나노복합체의 제조방법을 제공하는 것이며, 구체적으로 본 발명은 난용성 약물 및 아포리포단백질의 나노복합체를 높은 수율로 제조할 수 있는 제조방법을 제공한다.
PCT/KR2010/001117 2009-02-23 2010-02-23 난용성 약물 나노복합체의 제조방법 WO2010095912A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20090014908 2009-02-23
KR10-2009-0014908 2009-02-23

Publications (2)

Publication Number Publication Date
WO2010095912A2 WO2010095912A2 (ko) 2010-08-26
WO2010095912A3 true WO2010095912A3 (ko) 2010-12-09

Family

ID=42634360

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/001117 WO2010095912A2 (ko) 2009-02-23 2010-02-23 난용성 약물 나노복합체의 제조방법

Country Status (2)

Country Link
KR (1) KR101131202B1 (ko)
WO (1) WO2010095912A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101455909B1 (ko) * 2012-01-20 2014-11-03 성균관대학교산학협력단 ｐＨ-반응 고밀도 리포단백질-유사 입자 결합체
KR101679118B1 (ko) 2014-06-23 2016-11-24 서울대학교산학협력단 폴리감마글루타민산 유도체 및 이를 함유한 제제

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005081743A2 (en) * 2004-01-13 2005-09-09 The Board Of Trustees Of The University Of Illinois Membrane scaffold proteins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287590B1 (en) * 1997-10-02 2001-09-11 Esperion Therapeutics, Inc. Peptide/lipid complex formation by co-lyophilization
KR100817024B1 (ko) 2006-11-09 2008-03-26 재단법인 목암생명공학연구소 핵산 또는 약물을 간에 특이적으로 전달하는 복합체 및이를 포함하는 약학적 조성물

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005081743A2 (en) * 2004-01-13 2005-09-09 The Board Of Trustees Of The University Of Illinois Membrane scaffold proteins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ABHINAV NATH ET AL.: "Applications of Phospholipid Bilayer Nanodiscs in the Study of Membranes and Membrane Proteins", BIOCHEMISTRY, vol. 46, no. 8, 2007, pages 2059 - 2069, XP055218872, DOI: doi:10.1021/bi602371n *
TANAKA M.: "Effects of Membrane Structure on Apolipoprotein A-1 Binding to Lipid", YAKUGAKU ZASSHI, vol. 127, no. 11, 2007, pages 1843 - 1849 *
TIMOTHY H. BAYBURT ET AL.: "Self-Assembly of Discoidal Phospholipid Bilayer Nanoparticles with Membrane Scaffold Proteins", NANO LETTERS, vol. 2, no. 8, 2002, pages 853 - 856, XP002304652, DOI: doi:10.1021/nl025623k *

Also Published As

Publication number Publication date
KR101131202B1 (ko) 2012-04-05
WO2010095912A2 (ko) 2010-08-26
KR20100096038A (ko) 2010-09-01

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