WO2010091826A1 - Vorrichtung zur extrakorporalen blutbehandlung - Google Patents
Vorrichtung zur extrakorporalen blutbehandlung Download PDFInfo
- Publication number
- WO2010091826A1 WO2010091826A1 PCT/EP2010/000737 EP2010000737W WO2010091826A1 WO 2010091826 A1 WO2010091826 A1 WO 2010091826A1 EP 2010000737 W EP2010000737 W EP 2010000737W WO 2010091826 A1 WO2010091826 A1 WO 2010091826A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- intensity
- radiation source
- electromagnetic radiation
- dialysis fluid
- detector
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 26
- 239000008280 blood Substances 0.000 title claims abstract description 20
- 210000004369 blood Anatomy 0.000 title claims abstract description 20
- 230000005855 radiation Effects 0.000 claims abstract description 65
- 239000000385 dialysis solution Substances 0.000 claims abstract description 41
- 230000005670 electromagnetic radiation Effects 0.000 claims abstract description 33
- 238000010521 absorption reaction Methods 0.000 claims abstract description 28
- 239000012528 membrane Substances 0.000 claims abstract description 7
- 230000035945 sensitivity Effects 0.000 claims abstract description 7
- 238000001816 cooling Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 230000008859 change Effects 0.000 claims description 7
- 230000036770 blood supply Effects 0.000 claims description 4
- 230000003287 optical effect Effects 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 230000017531 blood circulation Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 15
- 230000032683 aging Effects 0.000 description 13
- 210000003734 kidney Anatomy 0.000 description 13
- 230000002485 urinary effect Effects 0.000 description 13
- 239000002699 waste material Substances 0.000 description 12
- 230000009467 reduction Effects 0.000 description 9
- 238000002560 therapeutic procedure Methods 0.000 description 9
- 238000012959 renal replacement therapy Methods 0.000 description 8
- 238000005259 measurement Methods 0.000 description 7
- 231100000614 poison Toxicity 0.000 description 5
- 239000003440 toxic substance Substances 0.000 description 5
- 230000033228 biological regulation Effects 0.000 description 4
- 238000000502 dialysis Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000006641 stabilisation Effects 0.000 description 4
- 238000011105 stabilization Methods 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
- 238000011481 absorbance measurement Methods 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 230000003044 adaptive effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000004611 spectroscopical analysis Methods 0.000 description 2
- 208000000223 Solitary Kidney Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000002431 foraging effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000009256 replacement therapy Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1603—Regulation parameters
- A61M1/1605—Physical characteristics of the dialysate fluid
- A61M1/1609—Physical characteristics of the dialysate fluid after use, i.e. downstream of dialyser
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/027—Control of working procedures of a spectrometer; Failure detection; Bandwidth calculation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0286—Constructional arrangements for compensating for fluctuations caused by temperature, humidity or pressure, or using cooling or temperature stabilization of parts of the device; Controlling the atmosphere inside a spectrometer, e.g. vacuum
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/42—Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
- G01N21/278—Constitution of standards
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
- A61M2205/3313—Optical measuring means used specific wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3324—PH measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3368—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
Definitions
- the invention relates to a device for extracorporeal blood treatment according to the preamble of patent claim 1.
- waste products, including toxic substances are eliminated by renal replacement therapy, the patient's blood being delivered via a blood supply line from the patient to the artificial kidney or dialyzer.
- the patient's blood is brought into contact with dialysis fluid via a semipermeable membrane.
- the dialysis fluid contains different salts in a concentration such that the waste products, including the toxic substances, are conducted by diffusion and convection through the membrane from the patient's blood to the dialysis fluid.
- the blood thus purified from the waste products is returned to the bloodstream of the patient via a blood discharge line connected to the dialyzer.
- Kt / V is a parameter for determining the effectiveness of renal replacement therapy, whereby the clearance K stands for the volume flow of the purified urinary substances, t for the treatment time and V for the distribution volume of the patient. Both K and V are each related to the respective waste product.
- renal replacement therapy efficiency is described as urea waste, such that K describes the urea clearance and V the patient's urea distribution volume, which is essentially the body water of the patient.
- EP 1 083 948 A1 and EP 2 005 982 A1 it is known to spectrophotometrically using a arranged in the flow measuring device using UV radiation and their absorption by urinary substances in the dialysis fluid Kt / V- Value or reduction rate RR for a given waste product during renal replacement therapy.
- the object of the invention is therefore to develop a device according to the preamble of claim 1 such that a reliable and unaltered statement about the Kt / V value or the reduction rate RR of a kidney replacement treatment is obtained by the absorption measurement.
- a further object of the invention is to provide a method whereby a reliable and unadulterated statement about the Kt / V value or the reduction rate RR of a kidney replacement treatment is obtained.
- the device according to the object is achieved by a device having the features of patent claim 1.
- Advantageous embodiments of the invention are the subject matter of subclaims 2 to 14.
- a reliable and unadulterated statement about the Kt / V value or the reduction rate RR of a kidney replacement treatment is obtained by providing means for aging the measuring device during the operating time and occurring changes in the intensity of the electromagnetic radiation of the radiation source and / or compensate for the sensitivity of the detector system during treatment time.
- the decreasing radiation intensity of the radiation source over its operating time is due primarily to an aging process of the radiation source. Since the working intensity I 0 of the radiation source in such devices is generally smaller than the maximum intensity l max of the radiation source, the reduction in radiation intensity attributable to the operating time can be compensated simply by tracking the radiation intensity of the radiation source. By the detector system, the radiation intensity is thus measured after absorption by unused Dia lysier sheer speed at the beginning of each treatment. As soon as deviations of this radiation intensity from the radiation intensity of the predefined setpoint occur, we compensate for this deviation. This measure means that the absorption measurements of the device according to the invention can be normalized over its entire operating time, since the same radiation intensity after absorption by unused dialysis fluid is always used as the basis.
- a temperature control is provided as a means for compensation, by which the temperature of the radiation source to a predefined working temperature range .DELTA.T, and / or the temperature of the detector system to a predefined working temperature range .DELTA.T 2 is adjustable.
- an electronic control with the aid of which the intensity I of the electromagnetic radiation of the radiation source is regulated such that the detector system predefined intensities I 44 , after absorption by unused Dialysis fluid, and / or I 45 , without absorption by unused Dys lysierf 1 üss ⁇ g speed, are detectable.
- the radiation source is designed as a light-emitting diode which emits electromagnetic radiation of substantially 280 nm in its operating temperature range .DELTA.T. It is furthermore advantageous if the detector system consists of at least one photodetector, preferably two photodetectors. When using only one photodetector, however, it must be assumed that the signal intensity of the radiation emitted by the radiation source is not constant over time in order to always determine the absorption of the dialysis fluid on the same basis. It is therefore much better to use two detectors, one of which measures the intensity of the radiation source and one the intensity of the radiation after passing through the used dialysis fluid.
- a particularly effective embodiment of the invention is therefore that a partially transmissive mirror or an optical device for beam splitting or deflection is arranged in the beam path of the electromagnetic radiation between the radiation source and the outflow for spent dialysis fluid, so that a portion of the electromagnetic radiation through the consumed Dialysis fluid on the first photodetector and the remaining part is passed directly to the second detector.
- control variable of the control loop is the intensity of the electromagnetic radiation at the first detector and the manipulated variable the electric current of the radiation source, wherein the then determined intensity at the second detector can be stored as a reference value for the respective renal replacement treatment.
- the reference intensity determined at the second detector during the respective kidney replacement treatment is the control variable of a second control loop and that the electric current of the radiation source is the manipulated variable of this second control loop.
- the temperature control has a heat sink for the light emitting diode and / or the detector system or the detectors.
- the temperature control it is of course also possible for the temperature control to have water cooling for the light-emitting diode and / or the detectors.
- the temperature control can have one or more fans for the light-emitting diode and / or the detectors.
- the temperature control alternatively or additionally has one or more electrothermal transducers, for example Peltier elements for controlling the temperature of the light-emitting diode and / or the detectors.
- one or more electrothermal transducers for example Peltier elements for controlling the temperature of the light-emitting diode and / or the detectors.
- FIG. 1 shows a schematic representation of an exemplary embodiment of a device according to the invention
- FIG. 2 shows a schematic representation of an embodiment of a device
- FIG. 1 shows an exemplary embodiment of a device according to the invention in a state connected to a patient 1.
- the patient 1 is connected by means of a blood supply line 14 with a dialyzer 10.
- a blood discharge line 15 returns the purified blood to the patient's bloodstream.
- the dialyzer 10 is divided by means of a semi-permeable membrane 11 into two chambers 12, 13, wherein the blood to be purified by the first chamber 13 of the patient 1 and through the second chamber 12 dialysis fluid, which is capable of contained in the blood of the patient 1 Waste products and toxic substances.
- the transport of waste products and toxic substances from the blood of the patient 1 into the dialysis fluid takes place by means of diffusion and convection via the semipermeable membrane 1 1.
- the dialysis fluid is supplied by means of an inlet 20 of the second chamber 12 of the dialyzer 10.
- a pump for delivering the dialysis fluid is provided in the inlet 20 as well as a valve 60, through which the dialysis fluid instead of the dialyzer 10 via a bypass past this can be passed into a drain 30 for the dialysis fluid.
- a valve 61 is also arranged, which is connected by means of the bypass 62 with the valve 60 in the inlet 20.
- a measuring device 40 is arranged, with which by means of a radiation source 41 for electromagnetic radiation, in particular with a working in the UV light emitting diode 43, and a detector system 42, which in the present embodiment according to Figure 2 from a half mirror 46 and two photodetectors 44, 45, the absorption of the used dialysis fluid can be determined.
- the mode of operation of the measuring device 40 and of the detector system 42 is as follows: According to the principle of two-beam spectroscopy as shown in FIG.
- the light-emitting diode 43 emits as radiation 53 UV light of a wavelength of approximately 280 nm, which is divided by the semitransparent mirror 46.
- a portion 54 of the radiation 53 passes through the semitransparent mirror 46 and the remaining portion 56 of the radiation 53 is reflected by the semitransparent mirror 46 onto the detector 45.
- the urinary substances contained in the used dialyzing fluid 55 a certain proportion of the electromagnetic radiation of the part 54 is absorbed.
- the non-urinary substance absorbed portion of the portion 54 is recorded by the detector 44.
- the portion 56 of the electromagnetic radiation recorded on the detector 45 is thus directly independent of urinary substances in the dialysis fluid 55 and, via the semitransparent mirror, directly proportional to the intensity I of the radiation source.
- urinary substances contained in the dialyser are contained and these urinary substances absorb electromagnetic radiation of wavelength 280 nm, the absorption of urinary substances in the outflow 30 can be determined with the aid of the intensity determined at the detector 44 , Thus, the course of absorption by urinary substances during the treatment is measurable, which serves as a basis for the calculation of Kt / V.
- the signal at the detector 44 is reduced as absorption increases. From the course of the absorption, an e-function is then determined, from which the Kt / V value is calculated.
- U 44 1 signal at the detector 44 at time t during therapy
- U 45 1 signal at the detector 45 at time t during therapy
- the problem of aging can occur in particular in the case of the radiation source 41 or the light-emitting diode 43, the outlet 30 and the detector system 42 or the two detectors 44 and 45 and bring about a change in the properties.
- electronic control it is possible to compensate for changes due to aging and temperature fluctuations very precisely.
- the electromagnetic radiation of the light-emitting diode 43 loses its intensity due to aging at a constant current during the operating time and also reacts with increasing electromagnetic radiation as the temperature increases.
- the semipermeable mirror affects by aging in addition to the permeability and the ratio of the beam path between and I 0 and I 44 and I 46 .
- a constant turbidity may occur.
- the measuring range or the resolution of the detector system 42 and the detector 44 is optimally used.
- changes in the system are detected and compensated for by aging, whereby a review of the performance of the Messsvstems done. This ensures that the signal quality, the measuring range, the measurement resolution and the reproducibility are constant throughout the lifetime.
- the electrical regulation takes place in two steps:
- the control can also be done with any other type of control, but this would result in a slower transient.
- the first control process at the beginning of the therapy takes place before the connection of the patient 1 or in the bypass 62, in which by appropriate adjustment of the valves 60 and 61, the pure dialysis fluid is passed to the dialyzer 10, with pure dialysis without ham stricte substances.
- the control process is carried out on the predefined setpoint of the radiation intensity I 44 S0U ⁇ U 44 50 ,, the detector 44.
- the compensation of aging by changing the electrical current of the light emitting diode 43.
- the amplification factors of the electronic detector circuits at the detectors 44 and 45 are adjusted, if the signal quality allows this.
- the measured value then applied to the detector 45 is stored as the desired value U 45 for the second control process and serves as a setpoint during the therapy in order to compensate for temperature fluctuations.
- the measured value recording of U 4 takes place at the detector 44.
- the measured value changes at the detector 44 and the absorption results from:
- this procedure also allows a constant measuring range and also a constant signal quality.
- therapy ie during a single renal replacement therapy
- aging of the detectors 44 and 45 is negligible.
- the system is then controlled during the kidney replacement treatment to the setpoint U 45 at the detector 45, which allows a stable and constant emitted electromagnetic radiation, regardless of the dialysis fluid flow.
- the control value of the control is the electric current of the light emitting diode 43, which is proportional to the intensity I 0 of the radiation emitted by the light emitting diode 43.
- a pure control of the detector 44 by a default value at the beginning, however, does not make sense, since influences during therapy can not be compensated.
- the specification of the predefined setpoint value in the first control process serves to define the measuring range of the electronics and at the same time defines the measuring resolution of the absorption of the measuring signal.
- Amplifier circuits within the electronic controller 52 convert the signal from the detectors 44 and 45 into a measurement voltage for which analog-to-digital converters with a microprocessor measurement pickup are available.
- This adaptation of the amplifier circuits which can be done only before each kidney replacement treatment, could be done automatically before the kidney replacement treatment in parallel with regulation of the current of the light emitting diode 43. During the treatment, however, only a regulation of the current is possible.
- an optimum operating temperature is achieved for the light-emitting diode 43 and the detectors 44 and 45.
- the current must be increased as a control variable of the light emitting diode 43 in order to keep the emitted electromagnetic radiation at constant temperatures at increasing temperatures.
- the current must be reduced as the manipulated variable of the light-emitting diode 43.
- An increase of the current is possible only in the operating range of the light emitting diode 43 and accelerates the aging process. In a dialysis machine Experience shows that enormous temperature fluctuations occur. Therefore, it makes sense to compensate for temperature fluctuations by a temperature control 51, so that the device can be operated in the optimum temperature range. Such measures also slow down the aging process.
- the aim of the temperature control is to operate the light-emitting diode 43 and the detectors 45 in the optimum temperature range or to quickly reach the optimum temperature range for these components, so that a temperature change can be reduced to a minimum during the therapy.
- heating of the system can lead to elevated temperatures at the measuring device 40 or the light-emitting diode 43 and / or the detector array 42 or the detectors 44 and 45.
- the self-heating of the system results in cooling, whereby a very low temperature is initially present.
- the temperature stabilization is carried out with a cooling body with water cooling, which couples the flow temperature of the dialysis fluid directly to the heat sink 43 of the LED and / or the detectors 44 & 45
- the heat capacity of the dialysis fluid is significantly higher than that of the heat sink of the light emitting diode 43 and therefore defines the temperature, which without additional technical effort is possible. This makes it possible to keep the temperature approximately constant in the operating range of the components and to bring the system quickly in the optimum temperature range.
- Cooling can also be done with other active and passive cooling methods.
- passive cooling the light-emitting diode 43 or detectors 44 and 45 can be temperature-stabilized via the housing or water cooling.
- active cooling the use of a fan is possible, which can regulate the temperature depending on the ambient temperature.
- a direct control with a Peltier element or similar electrothermal transducers for temperature stabilization is possible.
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- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Mathematical Physics (AREA)
- Analytical Chemistry (AREA)
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- Anesthesiology (AREA)
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- Animal Behavior & Ethology (AREA)
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- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/148,371 US8834720B2 (en) | 2009-02-11 | 2010-02-05 | Apparatus for the extracorporeal treatment of blood |
BRPI1008085A BRPI1008085B8 (pt) | 2009-02-11 | 2010-02-05 | aparelho para tratamento extracorpóreo de sangue |
RU2011137416/14A RU2529692C2 (ru) | 2009-02-11 | 2010-02-05 | Устройство для экстракорпоральной очистки крови |
CN201080007333.7A CN102325555B (zh) | 2009-02-11 | 2010-02-05 | 体外血液处理的设备 |
EP10704748A EP2396051A1 (de) | 2009-02-11 | 2010-02-05 | Vorrichtung zur extrakorporalen blutbehandlung |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09001890.4A EP2218472B2 (de) | 2009-02-11 | 2009-02-11 | Vorrichtung zur extrakorporalen Blutbehandlung |
EP09001890.4 | 2009-02-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2010091826A1 true WO2010091826A1 (de) | 2010-08-19 |
Family
ID=40885966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2010/000737 WO2010091826A1 (de) | 2009-02-11 | 2010-02-05 | Vorrichtung zur extrakorporalen blutbehandlung |
Country Status (10)
Country | Link |
---|---|
US (1) | US8834720B2 (de) |
EP (2) | EP2218472B2 (de) |
CN (1) | CN102325555B (de) |
AT (1) | ATE524205T1 (de) |
BR (1) | BRPI1008085B8 (de) |
DE (1) | DE202009017986U1 (de) |
ES (1) | ES2372563T5 (de) |
PL (1) | PL2218472T5 (de) |
RU (2) | RU2529692C2 (de) |
WO (1) | WO2010091826A1 (de) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012051638A1 (de) | 2010-10-20 | 2012-04-26 | Scan Messtechnik Gesellschaft M.B.H. | Spektrometer |
EP2510958A1 (de) | 2011-04-11 | 2012-10-17 | Fresenius Medical Care Deutschland GmbH | Verfahren und Vorrichtung zur Überwachung einer Behandlung eines Patienten, vorzugsweise zur Überwachung einer Hämodialyse, Hämodiafiltration und/oder Peritonealdialyse |
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Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8105487B2 (en) | 2007-09-25 | 2012-01-31 | Fresenius Medical Care Holdings, Inc. | Manifolds for use in conducting dialysis |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999023479A1 (en) * | 1997-10-31 | 1999-05-14 | Technical Chemicals & Products, Inc. | Reflectometer |
WO1999062574A1 (en) * | 1998-06-04 | 1999-12-09 | Althin Medical Ab | Method for determining waste products in the dialysis liquid in dialysis treatment |
US20030048432A1 (en) * | 1998-08-27 | 2003-03-13 | Tzyy-Wen Jeng | Reagentless analysis of biological samples |
DE102005063263A1 (de) * | 2005-12-30 | 2007-07-05 | Opsolution Mobile Gmbh | Verfahren und System zur Generierung eines hinsichtlich der Präsenz eines Stoffes innerhalb einer Probe indikativen Messergebnisses auf Grundlage einer spektrometrischen Messung |
EP2005982A1 (de) | 2007-06-20 | 2008-12-24 | B. Braun Avitum AG | Verfahren zur Bestimmung des Reduktionsverhältnisses oder des Kt/V-Verhältnisses einer Nierenersatzbehandlung und Vorrichtung zur Durchführung dieses Verfahrens |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE415397B (sv) | 1978-06-02 | 1980-09-29 | Asea Ab | Fiberoptiskt metdon |
SE424022B (sv) | 1980-10-21 | 1982-06-21 | Asea Ab | Fiberoptiskt metdon for spektralanalys |
DE4128458C2 (de) * | 1991-08-28 | 1994-02-10 | Siemens Ag | Verfahren und Vorrichtung zur Bestimmung der Konzentration einer Komponente, insbesondere von Glucose, einer flüssigen optisch aktiven Substanz, insbesondere der Körperflüssigkeit eines Patienten, durch Polarimetrie |
DE4235768A1 (de) * | 1992-10-24 | 1994-05-19 | Cho Ok Kyung | Modifizierte Halbleiterlaserdiode mit integriertem Temperaturregelungsteil |
US5591344A (en) * | 1995-02-13 | 1997-01-07 | Aksys, Ltd. | Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof |
US5825399A (en) | 1996-02-28 | 1998-10-20 | Eastman Kodak Company | Data-dependent thermal compensation for an LED printhead |
US6027256A (en) * | 1997-02-07 | 2000-02-22 | Coherent, Inc. | Composite laser diode enclosure and method for making the same |
DE10051943B4 (de) * | 2000-10-19 | 2015-01-15 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Vorrichtung zur Pulswellenlaufzeitbestimmung und extrakorporale Blutbehandlungseinrichtung mit einer solchen Vorrichtung |
US7002670B2 (en) * | 2002-06-12 | 2006-02-21 | Baxter International Inc. | Optical sensor and method for measuring concentration of a chemical constituent using its intrinsic optical absorbance |
US20040000012A1 (en) | 2002-06-26 | 2004-01-01 | Borregaard Chemcell | Treatment of a mixture containing cellulose |
US7326576B2 (en) * | 2003-04-09 | 2008-02-05 | Prescient Medical, Inc. | Raman spectroscopic monitoring of hemodialysis |
WO2005028001A1 (en) * | 2003-09-23 | 2005-03-31 | Gambro Lundia Ab | An apparatus, a system and a method relating to hemodialysis, hemodiafiltration, hemofiltration or peritoneal dialysis |
JP2006178349A (ja) | 2004-12-24 | 2006-07-06 | Sanyo Electric Co Ltd | 背面投写型映像表示装置 |
RU2306955C2 (ru) * | 2005-05-26 | 2007-09-27 | Государственное учреждение Российский научный центр хирургии РАМН (РНЦХ РАМН) | Способ биогемофильтрации организма и устройство для его осуществления |
US9717834B2 (en) * | 2011-05-24 | 2017-08-01 | Deka Products Limited Partnership | Blood treatment systems and methods |
DE102006029899B4 (de) * | 2006-06-29 | 2009-06-04 | Fresenius Medical Care Deutschland Gmbh | Spektroskopischer Detektor und Verfahren zur Bestimmung von Blut und biologischen Markersubstanzen in Flüssigkeiten |
WO2008144577A1 (en) | 2007-05-18 | 2008-11-27 | Optiscan Biomedical Corporation | Fluid mixing systems and methods |
-
2009
- 2009-02-11 ES ES09001890T patent/ES2372563T5/es active Active
- 2009-02-11 AT AT09001890T patent/ATE524205T1/de active
- 2009-02-11 EP EP09001890.4A patent/EP2218472B2/de active Active
- 2009-02-11 PL PL09001890.4T patent/PL2218472T5/pl unknown
- 2009-02-11 DE DE202009017986U patent/DE202009017986U1/de not_active Expired - Lifetime
-
2010
- 2010-02-05 BR BRPI1008085A patent/BRPI1008085B8/pt active IP Right Grant
- 2010-02-05 CN CN201080007333.7A patent/CN102325555B/zh active Active
- 2010-02-05 EP EP10704748A patent/EP2396051A1/de not_active Withdrawn
- 2010-02-05 US US13/148,371 patent/US8834720B2/en active Active
- 2010-02-05 RU RU2011137416/14A patent/RU2529692C2/ru active
- 2010-02-05 RU RU2014133177/14A patent/RU2594440C2/ru active
- 2010-02-05 WO PCT/EP2010/000737 patent/WO2010091826A1/de active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999023479A1 (en) * | 1997-10-31 | 1999-05-14 | Technical Chemicals & Products, Inc. | Reflectometer |
WO1999062574A1 (en) * | 1998-06-04 | 1999-12-09 | Althin Medical Ab | Method for determining waste products in the dialysis liquid in dialysis treatment |
EP1083948A1 (de) | 1998-06-04 | 2001-03-21 | Althin Medical Ab | Verfahren und bestimmung von abfallprodukten in dialyseflüssigkeiten während dialysebehandlungen |
US20030048432A1 (en) * | 1998-08-27 | 2003-03-13 | Tzyy-Wen Jeng | Reagentless analysis of biological samples |
DE102005063263A1 (de) * | 2005-12-30 | 2007-07-05 | Opsolution Mobile Gmbh | Verfahren und System zur Generierung eines hinsichtlich der Präsenz eines Stoffes innerhalb einer Probe indikativen Messergebnisses auf Grundlage einer spektrometrischen Messung |
EP2005982A1 (de) | 2007-06-20 | 2008-12-24 | B. Braun Avitum AG | Verfahren zur Bestimmung des Reduktionsverhältnisses oder des Kt/V-Verhältnisses einer Nierenersatzbehandlung und Vorrichtung zur Durchführung dieses Verfahrens |
Non-Patent Citations (1)
Title |
---|
FRIDOLIN I ET AL: "ON-LINE MONITORING OF SOLUTES IN DIALYSATE USING ABSORPTION OF ULTRAVIOLET RADIATION: TECHNIQUE DESCRIPTION", INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, MILAN, IT, vol. 25, no. 8, 1 August 2002 (2002-08-01), pages 748 - 761, XP008101248, ISSN: 0391-3988 * |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012051638A1 (de) | 2010-10-20 | 2012-04-26 | Scan Messtechnik Gesellschaft M.B.H. | Spektrometer |
AT510631A1 (de) * | 2010-10-20 | 2012-05-15 | Scan Messtechnik Ges M B H | Spektrometer |
AT510631B1 (de) * | 2010-10-20 | 2013-01-15 | Scan Messtechnik Ges M B H | Spektrometer |
EP2510958A1 (de) | 2011-04-11 | 2012-10-17 | Fresenius Medical Care Deutschland GmbH | Verfahren und Vorrichtung zur Überwachung einer Behandlung eines Patienten, vorzugsweise zur Überwachung einer Hämodialyse, Hämodiafiltration und/oder Peritonealdialyse |
WO2012140022A1 (en) | 2011-04-11 | 2012-10-18 | Fresenius Medical Care Deutschland Gmbh | Method and apparatus for monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration, and/or peritoneal dialysis |
EP2510958B1 (de) | 2011-04-11 | 2015-07-22 | Fresenius Medical Care Deutschland GmbH | Verfahren und Vorrichtung zur Überwachung einer Behandlung eines Patienten, vorzugsweise zur Überwachung einer Hämodialyse, Hämodiafiltration und/oder Peritonealdialyse |
US9215985B2 (en) | 2011-04-11 | 2015-12-22 | Fresenius Medical Care Deutschland Gmbh | Method and apparatus for monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration, and/or peritoneal dialysis |
EA027703B1 (ru) * | 2011-04-11 | 2017-08-31 | Фрезениус Медикл Кэа Дойчланд Гмбх | Способ и установка для контроля лечения пациента, предпочтительно для контроля гемодиализа, гемодиафильтрации и/или перитонеального диализа |
US10010289B2 (en) | 2012-06-15 | 2018-07-03 | Fresenius Medical Care Deutschland Gmbh | Method and device for monitoring an extracorporeal blood treatment of a patient |
Also Published As
Publication number | Publication date |
---|---|
DE202009017986U1 (de) | 2010-10-07 |
PL2218472T3 (pl) | 2012-04-30 |
US8834720B2 (en) | 2014-09-16 |
RU2014133177A (ru) | 2016-02-27 |
RU2594440C2 (ru) | 2016-08-20 |
EP2218472B1 (de) | 2011-09-14 |
ES2372563T3 (es) | 2012-01-23 |
EP2396051A1 (de) | 2011-12-21 |
BRPI1008085B8 (pt) | 2021-06-22 |
EP2218472A1 (de) | 2010-08-18 |
EP2218472B2 (de) | 2022-03-16 |
PL2218472T5 (pl) | 2023-03-13 |
BRPI1008085A2 (pt) | 2016-03-15 |
US20110309019A1 (en) | 2011-12-22 |
CN102325555B (zh) | 2015-10-21 |
BRPI1008085B1 (pt) | 2020-09-15 |
RU2529692C2 (ru) | 2014-09-27 |
ATE524205T1 (de) | 2011-09-15 |
ES2372563T5 (es) | 2022-06-14 |
CN102325555A (zh) | 2012-01-18 |
RU2011137416A (ru) | 2013-03-20 |
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