WO2010074450A3 - Ｌｃ-ｍｆｒ-ｍｓ 기반 신약후보물질 스크리닝 방법 및 신약후보물질 스크리닝 장치 - Google Patents

Ｌｃ-ｍｆｒ-ｍｓ 기반 신약후보물질 스크리닝 방법 및 신약후보물질 스크리닝 장치 Download PDF

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WO2010074450A3
WO2010074450A3 PCT/KR2009/007531 KR2009007531W WO2010074450A3 WO 2010074450 A3 WO2010074450 A3 WO 2010074450A3 KR 2009007531 W KR2009007531 W KR 2009007531W WO 2010074450 A3 WO2010074450 A3 WO 2010074450A3
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new drug
present
screening
drug candidate
mass spectrometry
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PCT/KR2009/007531
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English (en)
French (fr)
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WO2010074450A9 (ko
WO2010074450A2 (ko
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김상구
정진우
박찬수
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한국기초과학지원연구원
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Priority to US13/141,727 priority Critical patent/US20110256580A1/en
Publication of WO2010074450A2 publication Critical patent/WO2010074450A2/ko
Publication of WO2010074450A9 publication Critical patent/WO2010074450A9/ko
Publication of WO2010074450A3 publication Critical patent/WO2010074450A3/ko

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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
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  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

본 발명은 액체 크로마토그래피/미세유체소자/질량분석기 시스템을 이용한 신약후보물질 스크리닝 방법 및 액체 크로마토그래피/미세유체소자/질량분석기 시스템 에 관한 것으로, 본 발명에 따르면, 미량의 천연물 혹은 합성 신약후보물질과 타겟물질(단백질 또는 세포 등)과의 미세반응의 조절을 통하여 분자간의 상호작용을 실시간으로 검출할 수 있어, 저비용 및 고효율로 신약후보 물질을 개발할 수 있을 뿐만 아니라, 삶의 질 향상 및 의료비용 절감을 기대할 수 있고, 나노기술, 바이오 기술, 분석화학 기술의 융합을 통한 새로운 과학기술로 영역을 확대하는데 유용하게 사용할 수 있다.
PCT/KR2009/007531 2008-12-26 2009-12-16 Ｌｃ-ｍｆｒ-ｍｓ 기반 신약후보물질 스크리닝 방법 및 신약후보물질 스크리닝 장치 WO2010074450A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/141,727 US20110256580A1 (en) 2008-12-26 2009-12-16 LC-MFR-MS-Based Method and Apparatus for Screening a New Drug Candidate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20080134719 2008-12-26
KR10-2008-0134719 2008-12-26

Publications (3)

Publication Number Publication Date
WO2010074450A2 WO2010074450A2 (ko) 2010-07-01
WO2010074450A9 WO2010074450A9 (ko) 2010-09-10
WO2010074450A3 true WO2010074450A3 (ko) 2010-12-09

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ID=42288254

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PCT/KR2009/007531 WO2010074450A2 (ko) 2008-12-26 2009-12-16 Ｌｃ-ｍｆｒ-ｍｓ 기반 신약후보물질 스크리닝 방법 및 신약후보물질 스크리닝 장치

Country Status (3)

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US (1) US20110256580A1 (ko)
KR (1) KR101060199B1 (ko)
WO (1) WO2010074450A2 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9501822B2 (en) * 2011-01-28 2016-11-22 Cornell University Computer-implemented platform for automated fluorescence imaging and kinetic analysis
WO2015112429A1 (en) 2014-01-23 2015-07-30 Newomics Inc Methods and systems for diagnosing diseases
WO2016183521A1 (en) 2015-05-13 2016-11-17 Newomics Inc. Methods and systems for biomonitoring
WO2022154853A1 (en) * 2021-01-15 2022-07-21 Newomics Inc. Methods and systems for diagnosing diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002023163A1 (en) * 2000-09-15 2002-03-21 California Institute Of Technology Microfabricated crossflow devices and methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6817554B2 (en) * 2001-08-14 2004-11-16 Northeastern University Fluid nanosplitter device
KR100782046B1 (ko) 2004-06-29 2007-12-04 한국과학기술연구원 미세유체제어 형광검출 시스템을 이용한 ｒｎａ 결합 약물검색법

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002023163A1 (en) * 2000-09-15 2002-03-21 California Institute Of Technology Microfabricated crossflow devices and methods

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LUO, C. ET AL.: "PDMS Microfluidic Device for Optical Detection of Protein Immunoassay Using Gold Nanoparticles", LAB CHIP., vol. 5, no. 7, July 2005 (2005-07-01), pages 726 - 729 *
MITSOPOULOS, G. ET AL.: "Tagged Library Approach to Chemical Genomics and Proteomics", CURR. OPIN. CHEM. BIOL., vol. 8, no. 1, February 2004 (2004-02-01), pages 26 - 32 *
NARAYANAN, N. ET AL.: "A Microfabricated Electrical SPLITT System", LAB CHIP., vol. 6, no. 1, January 2006 (2006-01-01), pages 105 - 114 *
TOKUYAMA, T. ET AL.: "Microbioassay System for Antiallergic Drug Screening Using Suspension Cells Retaining in a Poly (dimethylsiloxane) Mcirofluidic Device", ANAL. CHEM., vol. 77, no. 10, May 2005 (2005-05-01), pages 3309 - 3314 *

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WO2010074450A9 (ko) 2010-09-10
US20110256580A1 (en) 2011-10-20
KR20100076879A (ko) 2010-07-06
KR101060199B1 (ko) 2011-08-29
WO2010074450A2 (ko) 2010-07-01

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