WO2010073327A1

WO2010073327A1 - Patch

Info

Publication number: WO2010073327A1
Application number: PCT/JP2008/073488
Authority: WO
Inventors: 誠二郎山; 直樹村井
Original assignee: リードケミカル株式会社
Priority date: 2008-12-24
Filing date: 2008-12-24
Publication date: 2010-07-01

Abstract

[PROBLEMS] The invention aims to provide a patch which is inhibited from the bending of the pharmaceutical preparation and from the adhesion of plaster areas to each other in application and which can be easily and simply applied nearly without failure. [MEANS FOR SOLVING PROBLEMS] A patch comprising a substrate, a plaster layer formed on the substrate, and a release paper lying on the plaster layer in such a way as to cover the nearly whole surface of the plaster layer, characterized in that sections different in bending resistance are formed in one substrate and a section having a bending resistance higher than those of the other sections is localized in an area where the plaster is to be first exposed in application, whereby the adhesion of plaster areas to each other is inhibited in application.

Description

Patch

The present invention is a patch in which a portion having a high bending resistance is provided on a support and a pressure-sensitive adhesive layer is present on the support, and more specifically, bending of a preparation or adhesion between pastes is performed. An object of the present invention is to provide a patch that is easy and easy to control, with little failure in the work of applying to the affected area.

Conventionally, a large number of patches in which a pressure-sensitive adhesive layer containing a drug, an active ingredient or the like is applied to the entire surface of a support have been provided. The patch is applied to the skin and absorbs an active ingredient from the skin into the body to develop a medicinal effect. Therefore, during the pasting (application) time stipulated in the usage, a stretched support or a highly flexible support can be used for the purpose of suppressing the release, detachment or dropout of the preparation, or the preparation itself. A formulation with improved skin followability has been proposed and marketed (patent document 1, patent document 2).

However, since the preparation described above has improved followability, the shape-retaining property of the preparation itself is reduced, and as a result, the portion exposed by the removal of the release sheet is likely to be bent or twisted, and applied to the affected area. There were many failures during the pasting work, such as the pastes exposed during the work sticking to each other (see FIGS. 1 to 4). In this way, when the preparation is used in a state where the preparation is bent or wrinkled in the preparation as it is, the application area is reduced and the medicinal effect as a patch cannot be fully exhibited. Or, the bent part or wrinkled part is the starting point, and during the application period, the exfoliation and removal of the preparation was promoted, and the application time prescribed in the usage could not be completed.

In order to solve this, a preparation using a support with high stiffness is also sold. However, when a patch with high stiffness is applied, (1) it is pulled during application due to a decrease in followability to the skin. There may be a sense of incongruity, such as a feeling of feeling or tension. (2) In addition, there may be a problem that the formulation may be sheared, peeled off or dropped during application. In order to improve this problem, it may be possible to increase the adhesive strength to the skin. In this case, however, (3) after use, when the preparation is peeled off, the skin is damaged by peeling off the stratum corneum and the pain at the peeling is caused. It becomes a problem such as increasing.

On the other hand, for the purpose of improving failures such as bending or wrinkles during the pasting operation, paying attention to the release sheet, and providing a cut line or a broken line part, etc., a method of applying a part of the application surface in advance and sticking it to the affected part Some ideas have been devised (Patent Document 3, Patent Document 4, Patent Document 5 and Patent Document 6).

However, even when a method is used in which the release sheet is cut and a part of the plaster is exposed and pasted, (4) the plaster exposed during the pasting operation may adhere to each other. The exposed plaster part may adhere to the release sheet side of the preparation, and the problem has not been solved.

JP 2000-297032 A specification JP 2001-328935 A International Publication No. 00-69422 Pamphlet Japanese Patent Application Laid-Open No. 2002-306530 Japanese Utility Model Publication No. 3-59327 Japanese Utility Model Publication No. 5-54515

In order to solve the above problems, the present invention provides a highly flexible part on the support of the preparation, prevents bending of the preparation and adhesion of the plaster during the application work, and reduces the failure of the application work. An object of the present invention is to provide a patch capable of simply and easily performing a pasting operation.

The inventors of the present invention have reached the present invention as a result of diligent search to solve the above-mentioned problems. The present invention solves the above-mentioned problems and provides a patch that can reduce the failure of the pasting operation to the affected area without being restricted by the application area or shape of the preparation.

That is, the present invention is to provide the following patches.
(1) In a patch in which a paste layer is provided on the surface of a support, and a release sheet is bonded to the paste layer so as to cover substantially the entire surface;
A patch, wherein two or more parts having different stiffness are formed on one support.
(2) The patch according to item (1), wherein the part having different bending resistance of the support is a part having higher bending resistance than the other part of the support.
(3) The patch according to item (1), wherein the highly flexible portion is localized at a support portion corresponding to a portion where the release sheet is divided and the plaster is exposed.
(4) In a patch in which a paste layer is provided on the surface of a support, and a release sheet is bonded to the paste layer so as to cover substantially the entire surface;
a) A patch for forming two or more parts having different stiffness on a single support,
b) A portion of the support having higher rigidity than other portions is localized at a support portion corresponding to a portion where the release sheet is divided and the plaster is exposed,
c) A patch characterized in that the bending resistance of the low stretchable part is 120% or more higher than the bending resistance of other parts.
(5) A patch having two cuts substantially parallel to the release sheet,
The patch according to any one of items (1) to (4), wherein the highly flexible portion of the support is located in a central portion of the support sandwiched between cuts substantially parallel to the release sheet.
(6) A support made of a knitted fabric having a bending resistance of 5 mm or more according to a 45 ° cantilever method specified in JIS L 1096-1999 is used for the portion having high bending resistance. (1) to (5) The patch according to Item.
(7) The support according to any one of the patches, which has different stiffness and softness, wherein the area of the portion having high stiffness and softness is 5% to 60% of the whole, (1) to (5) Patch.
(8) The patch according to any one of items (1) to (5), wherein the composition of the adhesive layer of the patch comprises an oily base or an aqueous base.
(9) The patch according to (1) to (5), wherein the basis weight of the support is in the range of 60 to 160 g / m ² .
(10) The patch according to any one of (1) to (5), wherein the basis weight of the support is in the range of 80 to 120 g / m ² .
(11) In the items (1) to (5), the patch includes a release sheet adhered to the surface of the pressure-sensitive adhesive layer, and the bending resistance of the release sheet is 60 to 160 mm. The patch according to the description.
(12) The patch according to any one of (1) to (5), wherein the support is made of polyester fiber having a fiber thickness of 30 to 75 denier and having a basis weight of 80 to 120 g / m ² .
(13) In a patch in which a paste layer is provided on the surface of a support, and a release sheet is bonded to the paste layer so as to cover substantially the entire surface;
A patch, characterized in that the support is interspersed with highly rigid portions over the entire surface.
(14) A paste layer is provided on the surface of the support, and a release sheet is laminated on the paste layer so as to cover substantially the entire surface, and there are two cuts substantially parallel to the release sheet. An agent;
a) The patch is a patch in which portions with high flexibility are scattered over the entire surface,
b) having a portion where the release sheet is divided and the plaster is exposed;
c) The support is a support having a bending resistance of 6 mm or more according to a 45 ° cantilever method defined in JIS L 1096-1999.
A patch characterized by that.
(15) The patch according to any one of (13) to (14), wherein the composition of the adhesive layer of the patch comprises an oily base or an aqueous base.
(16) The patch according to (13) to (14), wherein the basis weight of the support is in the range of 60 to 160 g / m ² .
(17) The patch according to (13) to (14), wherein the basis weight of the support is in the range of 80 to 120 g / m ² .
(18) In the items (13) to (14), the patch comprises a release sheet adhered to the surface of the pressure-sensitive adhesive layer, and the bending resistance of the release sheet is 60 to 160 mm. The patch according to the description.
(19) The patch according to (13) to (14), wherein the support is made of polyester fiber having a fiber thickness of 30 to 75 denier and having a basis weight of 80 to 120 g / m ² .

Details of the present invention will be described below.
An embodiment of the present invention is a patch in which a pressure-sensitive adhesive layer is spread on a support having portions having different stiffness and flexibility in one preparation.
In another embodiment of the present invention, a single preparation is a patch in which a pressure-sensitive adhesive layer is spread on a highly rigid support.

The part having high stiffness and softness is preferably a part, that is, a part that is localized in a part where the plaster is first exposed at the time of application near the cut of the release sheet. For example, in the case where a highly rigid portion is localized, it may be provided in accordance with the cut portion of the release sheet, and there may be one or two cuts. In the case of two, what can cover the part pinched by the cut | interruption is good. In addition, it is preferable that the release sheet part to be peeled off first described in the sticking method or the like, that is, the part where the plaster is first exposed at the time of sticking can be covered by a highly rigid part, and the shape of the part is not limited. Although not preferred, preferred examples include the range of the pattern portion shown in FIGS. 5 (a) and 5 (b).

In this way, the support of the part having high rigidity and softness covers the part where the plaster is first exposed at the time of application, so that the rigidity of the support is suppressed. However, there is little elongation at the time of sticking, and wrinkles are harder in the extending direction, so that the pastes do not stick as shown in FIGS.

The shape of the portion having high bending resistance is not particularly limited. The portion having high stiffness and softness may be on one side or both sides of the support (FIG. 6). In the case of localizing partly, it is preferable to make the part to be localized solid, spot or linear.

As another embodiment of the present invention, it is also preferable that one whole preparation has high rigidity and flexibility. For example, a pattern as shown in FIG. 5 for maintaining the height of bending resistance may be applied to the entire support.

There is no particular limitation on the pattern of the part where the stiffness of the support is changed, but considering the stiffness in the biaxial directions (longitudinal and lateral directions), the uniform longitudinal and lateral stiffness is considered. Then, a dot, a lattice pattern, etc. like FIG. 5 etc. are preferable. In addition, it is also preferable to use a stripe pattern or the like in consideration of bending / softening only in the vertical direction or only in the horizontal direction. Furthermore, it is also preferable to use another pattern that utilizes the difference in flexibility, for example, a logo pattern.

The highly flexible part of the present invention is such that the pastes adhere to each other at the time of applying the patch, and the exposed part of the paste does not adhere to the release sheet side on the preparation. It means having the bending and softness. In addition, if the bending resistance is too high, it is not preferable because it causes wrinkles due to application of the patch, uncomfortable feeling during application, and a decrease in motility.
The bending resistance in the highly flexible portion of the present invention refers to a property having moderate stretchability. The bending resistance can be measured by a 45 ° cantilever method defined in JIS L 1096-1999.
The preferred bending resistance of the support of the present invention is 5 mm or more. The bending resistance of the portion having high bending resistance is 6 mm or more. It is preferable that the bending resistance of the portion having high bending resistance is 120% or more higher than that of the untreated portion.

The means for changing the stiffness of the support is not particularly limited. However, the method of changing the structure of the support (fibers, materials, etc.), the method of pressing, the method of applying resin, ink, etc., than the support The method etc. which stick a tape etc. with high bending resistance are mentioned. In consideration of the production process and economy of the support, a method by pressing, a method of applying a resin or ink, or a method of changing the structure of the support is preferable.

For means for pressing the support in order to change the stiffness of the support,
For example, processing with a pressing roll, compression of fibers, and embossing may be mentioned, but the invention is not limited thereto.

Examples of means for applying a resin or ink in order to change the bending resistance of the support include, but are not limited to, the following methods.
Although it does not specifically limit as resin applied in order to change the bending resistance of the support body which can be used in this invention, A natural resin or a synthetic resin is mentioned. These resins can be used alone or in combination of two or more.

Examples of the ink applied to change the stiffness of the support that can be used in the present invention include pigments (organic pigments, inorganic pigments), dyes (dispersion dyes, acid dyes, reactive dyes, etc.), pearls (mica), Although foil (aluminum etc.) is mentioned, it is not limited to these.
In particular, organic pigments and inorganic pigments that do not require a washing step are preferably used. It is not particularly limited as long as it is a known ink resin used for printing, and examples thereof include a urethane resin, an acrylic resin, a silicon resin, a polyamide resin, a polyester resin, and an epoxy resin, and a urethane resin and an acrylic resin are particularly preferably used. However, it is not limited to these.
The resin treatment method may be any of textile printing, gravure, thermal transfer, ink jet, spraying, and the like, and textile printing is particularly preferred, but is not limited thereto.

Examples of the tape or the like when a tape is applied to change the bending resistance of the support include, but are not limited to, polyolefin film, polyester film, polyurethane film, and the like.
Moreover, the method of sticking a film can consider the method of using an adhesive, the method of heat processing, etc.

When changing the structure of the support in order to change the stiffness of the support, for example, changing the thickness of the yarn only in a portion having high stiffness or changing the density by changing the density. However, it is not limited to these.

The pressure-sensitive adhesive component that can be used in the present invention is not particularly limited, and both a non-hydrated base and a hydrous base can be used.

Examples of the non-water-containing base include, but are not limited to, rubber adhesives, acrylic adhesives, silicone adhesives, and the like.

The rubber component of the rubber-based adhesive was selected from, for example, natural rubber, polyisoprene, styrene-isoprene-styrene block copolymer, styrene-butanediene-styrene block copolymer, styrene-butadiene rubber, and polyisobutylene. Although it is preferable to use one kind alone or two or more kinds in combination, it is not limited to these.

Specific examples of the acrylic adhesive include (acrylic acid-2-ethylhexyl acrylate) copolymer, (acrylic acid-butyl acrylate) copolymer, (acrylic acid-octyl acrylate) copolymer, (acrylic) Acid-acrylic acid 2-ethylhexyl-vinyl acetate) copolymer, (acrylic acid-2-ethylhexyl acrylate-hydroxyethyl acrylate) copolymer, (acrylic acid-hydroxyethyl acrylate-vinyl pyrrolidone) copolymer, (Acrylic acid-2-ethylhexyl acrylate-hydroxyethyl acrylate-vinyl pyrrolidone) copolymer and the like. Commercial products such as DURO-TAK 87-2194, 87-2510, 87-2516 (manufactured by National Starch and Chemical Co., Ltd.) can also be used. In particular, a copolymer containing an acrylate ester having a hydroxy group in the side chain in the monomer structural unit is preferred. Moreover, you may add a crosslinking agent as needed. Examples of the crosslinking agent include amino compounds, phenol compounds, epoxy compounds, isocyanate compounds, organic peroxides, metal alcoholates, and metal chelates.

In addition, specific examples of the silicone pressure-sensitive adhesive include silicone rubber such as polyorganosiloxane.

The plasticizer that can be used in the present invention is not particularly limited, and examples thereof include petroleum oil (paraffinic process oil, naphthenic process oil, aromatic process oil, etc.), squalane, squalene, vegetable oil (olive oil). , Camellia oil, castor oil, tall oil, peanut oil), silicon oil, dibasic esters (dibutyl phthalate, dioctyl phthalate, etc.), liquid rubber (polybutene, liquid isoprene rubber), liquid fatty acid esters (isopropyl myristate, lauric acid) Hexyl, diethyl sebacate, diisopropyl sebacate, etc.), diethylene glycol, polyethylene glycol, polyethylene glycol, glycol salicylate, propylene glycol, dipropylene glycol, triacetylene, quee Triethyl citrate, crotamiton and the like. Among these plasticizers, liquid paraffin, isopropyl myristate, diethyl sebacate and hexyl laurate are preferable, and liquid paraffin is particularly preferable.

These plasticizers may be used alone or in combination of two or more. The blending amount of these plasticizers is not particularly limited, but is preferably 5 to 70% by weight, more preferably 10 to 60% by weight based on the total amount of compounds contained in the pressure-sensitive adhesive layer, and 10 to 50%. It is particularly preferred that it is wt%. If the blending amount of the plasticizer is less than 5% by weight, the effect of improving the cohesive force of the patch by blending the plasticizer tends to be insufficient. On the other hand, if it exceeds 70% by weight, the skin permeability of the drug is poor. It tends to be sufficient.

The adhesive layer in the transdermal absorption preparation of the present invention can further contain a tackifier.
The tackifier that can be used in the present invention is not limited, and examples thereof include rosin derivatives (such as rosin, rosin glycerin ester, hydrogenated rosin, hydrogenated rosin glycerin ester, rosin pentaerythrester). Aromatic saturated hydrocarbon resin (Alcon P100 (Arakawa Chemical Industries, Ltd.)), aliphatic hydrocarbon resin (Quinton B-170 (Nippon Zeon Corporation, etc.)), terpene resin (Clearon P-125 (Yasuhara Chemical Co., Ltd.)) Etc.), maleic acid resin, etc., among which glycerin ester of hydrogenated rosin, aliphatic hydrocarbon resin, and terpene resin are preferable.

These tackifiers may be used alone or in combination of two or more, and the blending amount is not particularly limited, but is 5 to 5 on the basis of the total amount of compounds contained in the pressure-sensitive adhesive layer. It is preferably 70% by weight, more preferably 5 to 60% by weight, and particularly preferably 10 to 50% by weight. If the amount of the tackifier is less than 5% by weight, the effect of improving the adhesive strength of the patch due to the addition of the tackifier tends to be insufficient. On the other hand, if the amount exceeds 70% by weight, the patch is peeled off. The skin irritation tends to increase.

The pressure-sensitive adhesive layer of the percutaneous absorption preparation of the present invention can also contain an absorption enhancer for the purpose of improving the skin permeability of the drug.
The absorption promoter is not particularly limited as long as it is a compound that has been conventionally recognized as having an absorption promoting action on the skin, and specifically, a fatty acid, aliphatic alcohol, fatty acid ester, amide or ether having 6 to 20 carbon atoms. , Aromatic organic acids, aromatic alcohols, aromatic organic acid esters or ethers. These compounds may be saturated or unsaturated, and may be linear, branched, or cyclic.

Furthermore, in the present invention, lactic acid esters, acetic acid esters, monoterpene compounds, sesquiterpene compounds, azone, azone derivatives, glycerin fatty acid esters, propylene glycol fatty acid esters, sorbitan fatty acid esters (Span), polysorbate compounds (Tween), polyethylene glycol fatty acid esters, polyoxyethylene hydrogenated castor oil compounds (HCO), polyoxyethylene alkyl ethers, sucrose fatty acid esters, vegetable oil, etc. It can be used as an agent.

Among these absorption enhancers, caprylic acid, capric acid, caproic acid, lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, lauryl alcohol, myristyl alcohol, oleyl alcohol, Isostearyl alcohol, cetyl alcohol, methyl laurate, hexyl laurate, diethanolamide laurate, isopropyl myristate, myristyl myristate, octyldodecyl myristate, cetyl palmitate, salicylic acid, methyl salicylate, ethylene glycol salicylate, cinnamic acid, Methyl cinnamate, cresol, cetyl lactate, lauryl lactate, ethyl acetate, propyl acetate, geraniol, thymol, eugenol, terpineol, 1-menthol Borneolol, d-limonene, isoeugenol, isoborneol, nerol, dl-camphor, glycerin molcaprylate, glycerin monocaprate, glycerin monolaurate, glycerin monooleate, sorbitan monolaurate, sucrose monolaurate, polysorbate 20, Propylene glycol, propylene glycol monolaurate, polyethylene glycol monolaurate, polyethylene glycol monostearate, polyoxyethylene lauryl ether, HCO-60, pyrothiodecane, olive oil are preferred, lauryl alcohol, myristyl alcohol, isostearyl alcohol, laurin Acid diethanolamide, glycerol monocaprylate, glycerol monocaprate, glycerol monoolea , Sorbitan monolaurate, propylene glycol monolaurate, polyoxyethylene lauryl er Ether, pirotiodecane are more preferable.

These absorption promoters may be used alone or in combination of two or more. The amount of these absorption accelerators is not particularly limited, but is preferably 0.01 to 20% by weight, particularly 0.05 to 10% by weight, based on the total amount of compounds contained in the pressure-sensitive adhesive layer. preferable. If the blending amount of the absorption accelerator is less than 0.01% by weight, the effect of improving the skin permeability of the drug due to the blending of the absorption promoter tends to be insufficient. The skin irritation tends to increase, and the adhesion to the skin tends to decrease.

Furthermore, in the present invention, an antioxidant, a filler, a crosslinking agent, an antiseptic, an ultraviolet absorber and the like can be blended in the pressure-sensitive adhesive layer as necessary.

As the antioxidant, for example, tocopherol and their ester derivatives, ascorbic acid, ascorbic acid stearic acid ester, nordihuman rogayaretic acid, dibutylhydroxytoluene (BHT), and butylhydroxyanisole are preferable; Calcium, magnesium carbonate, silicate (for example, aluminum silicate, magnesium silicate, etc.), silicic acid, barium sulfate, calcium sulfate, calcium zincate, zinc oxide, titanium oxide are preferable; Thermosetting resins such as phenol resins, epoxy resins, alkyd resins, unsaturated polyesters, isocyanate compounds, block isocyanate compounds, organic crosslinking agents, inorganic crosslinking agents such as metals or metal compounds are preferably used. Not intended to be constant.

Further, as the preservative, ethyl paraoxybenzoate, propyl paraoxybenzoate and butyl paraoxybenzoate are preferable; as the ultraviolet absorber, p-aminobenzoic acid derivatives, anthranilic acid derivatives, salicylic acid derivatives, coumarin derivatives, amino acid compounds , An imidazoline derivative, a pyrimidine derivative, and a dioxane derivative are preferable.

Although the formulation of each of the above antioxidant, filler, crosslinking agent, preservative, and ultraviolet absorber is not particularly limited, the total amount of the antioxidant, filler, crosslinking agent, preservative, and ultraviolet absorber is It is preferably 0 to 10% by weight, more preferably 0 to 5% by weight, and particularly preferably 0 to 2% by weight, based on the total amount of compounds contained in the pressure-sensitive adhesive layer.

The water-containing base contains water so that the medicinal effect on the skin can be sufficiently obtained, has adhesiveness, and softens even at room temperature or higher so that the plaster does not remain on the skin. Formed to have.

As a thickener, it is desirable that moisture can be stably maintained at 30% to 80% and that it has water retention. Specific examples include guar gum, locust bean gum, carrageenan, alginic acid, sodium alginate, agar, gum arabic, tragacanth gum, karaya gum, pectin, starch and other microbial systems, sansan gum, acacia gum and other microbial systems, gelatin, collagen and the like. Natural polymers such as animal systems, cellulose systems such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose sodium, semi-synthetic polymers such as starch systems such as soluble starch, carboxymethyl starch, and dialdehyde starch, polyvinyl alcohol, polyvinyl pyrrolidone, Vinyl-based materials such as polyvinyl methacrylate, acrylic-based materials such as polyacrylic acid and sodium polyacrylate, other polyethylene oxide, methyl vinyl ether / Water-soluble polymer of water-soluble polymers such as synthetic polymers such as water-maleic acid copolymers are suitably used. In particular, sodium polyacrylate is preferable. This is because the gel strength is strong and the water retention is excellent. Furthermore, sodium polyacrylate having an average degree of polymerization of 20000 to 70000 is preferred. As the average degree of polymerization becomes smaller than 20000, the thickening effect becomes poor and sufficient gel strength tends to be obtained. As the average degree of polymerization becomes larger than 70000, the thickening effect becomes too strong and workability tends to decrease. It appears and neither is desirable. Further, by using three or more kinds of the water-soluble polymers in combination, for example, a polymer complex with a strong ionic polymer of sodium polyacrylate can be formed, and an elastic gel with higher gel strength can be obtained.

Polyhydric alcohols such as glycerin, propylene glycol and sorbitol as wetting agents, and kaolin, zinc oxide, talc, titanium, bentonite, aluminum silicate, titanium oxide, zinc oxide, aluminum metasilicate, calcium sulfate, calcium phosphate as fillers Etc. may be added. Further, as a solubilizer or absorption promoter, propylene carbonate, crotamiton, 1-menthol, mint oil, limonene, diisopropyl adipate and the like, and as a medicinal aid, methyl salicylate, glycol salicylate, 1-menthol, thymol, mint oil, Nonyl acid vanillylamide, pepper extract, etc. may be added. Furthermore, you may add a stabilizer, an antioxidant, an emulsifier, etc. as needed.

Other cross-linking agents and polymerizing agents may be added as necessary. The plaster can be strengthened and water retention can be provided. This crosslinking agent and polymerization agent are appropriately selected according to the type of thickener and the like. For example, when polyacrylic acid or polyacrylate is applied to the thickener, compounds having at least two epoxy groups in the molecule, hydrochlorides such as Ca, Mg, Al, sulfates, phosphates, Inorganic acid salts such as carbonate, organic acid salts such as citrate, tartrate, gluconate and stearate, oxides such as zinc oxide and anhydrous silicic acid, hydroxides such as aluminum hydroxide and magnesium hydroxide A polyvalent metal compound such as is preferably used. When polyvinyl alcohol is applied as a thickener, adipic acid, thioglycolic acid, epoxy compound (epichlorohydrin), aldehydes, N-methylol compound, Al, Ti, Zr, Sn, V, Cu, B, Cr Complexes such as compounds such as are preferably used. When polyvinylpyrrolidone is applied as the thickener, methyl vinyl ether / maleic anhydride copolymer, polyacid compound or alkali metal salt thereof (polyacrylic acid, tannic acid and derivatives thereof), etc. are preferably used. In addition, when polyethylene oxide is applied to the thickener, peroxide, polysulfone azide, and the like are preferably used. In addition, when a methyl vinyl ether / maleic anhydride copolymer is applied to the thickener, polyfunctional hydroxy compounds, polyamines, iodine, gelatin, polyvinyl pyrrolidone, iron, mercury, lead salts and the like are preferably used. When gelatin is used as the thickener, aldehydes such as formaldehyde, glutaraldehyde, and dialdehyde starch, diepoxides such as glyoxal and butadiene oxide, diketones such as divinyl ketone, and diisocyanates are preferably used. When sodium polyacrylate is applied as the thickener, a polyvalent metal salt such as lithium hydroxide, zinc hydroxide, aluminum hydroxide or sodium borate is preferably added as a crosslinking agent. Particularly preferred are zinc salts and aluminum salts. Cross-linking reaction is promoted. The concentration of the polyvalent metal salt added as a crosslinking agent is preferably 0.5 to 1.5 equivalents relative to 1 equivalent of the thickener (or water-soluble polymer). As the concentration of the polyvalent metal salt becomes smaller than 0.5 equivalent, the reaction tends to be too slow and the gel strength tends to decrease, and as the concentration of the polyvalent metal salt becomes larger than 1.5 equivalent, the reaction becomes too fast. There is a tendency for gelation to become non-uniform and workability to deteriorate, both of which are not preferred.

As a water-containing base, it has good skin adhesion, enhances skin absorption of active ingredients, contains as much water as possible, and removes heat from the skin when moisture in the plaster evaporates. This calorific value gives a refreshing sensation, and the stratum corneum is hydrated by water molecules evaporating from the inside, promoting the absorption of the drug, not being at room temperature or in the vicinity, and hurting when peeling off For example, no dirt remains and it is not sticky. For this reason, the plaster comprises 5 to 20% by weight of a thickener, preferably 10 to 15% by weight, 5 to 40% by weight of a wetting agent, 20% by weight or less of a filler, 10 to 10% by weight of water. 80% by weight, solubilizing agent 0 to 8% by weight, drug 5% by weight or less, preferably 0.5% to 5% by weight.

The rigid / soft support used in the patch of the present invention can be used without any limitation as long as it can support the pressure-sensitive adhesive layer. Specific examples of such a support include cloth, nonwoven fabric, polyurethane, polyethylene, polyvinyl acetate, polyvinylidene chloride, polyethylene, polyethylene terephthalate, aluminum sheet, or a laminate or composite material thereof. Can be mentioned. The fiber material of the cloth or nonwoven fabric is not particularly limited, but may be a thermoplastic fiber alone or a blend of thermoplastic fiber and non-thermoplastic fiber.

Examples of the thermoplastic fiber include materials made of a thermoplastic resin such as polyurethane, polyester, polypropylene, acrylic, and nylon, for example, polyester fiber, polyamide fiber, and polyvinyl chloride fiber. These may be used alone or in combination of two or more. It can be used by mixing. Examples of non-thermoplastic fibers include rayon, cupola, hemp and silk.
The thickness of the support is not particularly limited, but the thickness is preferably in the range of 5 to 1000 μm. If the thickness of the support is less than 5 μm, the workability at the time of peeling tends to be reduced. On the other hand, if the thickness exceeds 1000 μm, it becomes difficult to cut the support or the pressure-sensitive adhesive layer in the preparation production process. The manufacturing ease tends to decrease.

The thermoplastic fibers of the support used in the patch of the present invention, it is preferable that the basis weight of the support is in the range of from 50 200g / m ^2. The range is preferably 60 to 160 g / m ² , more preferably 80 to 120 g / m ² .
The thermoplastic fiber of the support used in the patch of the present invention preferably has a basis weight of 80 to 120 g / m ² made of polyester fiber having a fiber thickness of 30 to 75 denier.
Preferably, the basis weight is 90 to 110 g / m ² made of 50 denier polyester fibers, and more preferably the basis weight is about 100 g / m ² made of 50 denier polyester fibers.

The bending resistance of the support used in the patch of the present invention is preferably 5 mm or more according to the 45 ° cantilever method specified in JIS L 1096-1999.

The release sheet in which the patch is attached to the surface of the pressure-sensitive adhesive layer preferably has, for example, a bending softness of 60 to 160 mm.

The thickness of the adhesive layer in the patch of the present invention is not particularly limited, but is preferably 20 to 3000 μm.

In the production of the patch of the present invention, the method for arranging the pressure-sensitive adhesive layer on the support is not particularly limited.

Further, when the patch of the present invention is provided with a release paper, it is not particularly limited. Specifically, a film such as polyester such as polyethylene terephthalate, polyvinyl chloride, polyvinylidene chloride, a laminate film of fine paper and polyolefin, etc. Can be used. In these release sheets, a silicone treatment may be applied to the surface on the side in contact with the pressure-sensitive adhesive layer.

Drugs include methyl salicylate, glycol salicylate, 1-menthol, red pepper extract, nonylic acid vanillylamide, mint oil, diclofenac, ibupufen, indomethacin, ketoprofen, loxoprofen, sulindac, tolmetine, lobenzalite, penicillamine, fempfen, flurbiprofen, prolbiprofen , Pranoprofen, thiaprofen, suprofen, felbinac, ketorolac, oxaprozin, etodolac, zaltoprofine, piroxicam, pentazocine, buprenorphine hydrochloride, butorphanol tartrate, etc. and at least one non-steroidal anti-inflammatory Drugs, prednisolone, dexamethasone, hydrocortisone, betamethasone, fluocinide, Luocinolone acetonide, prednisolone acetate valerate, dexamethasone dipropionate, diflucortron valerate, difluprednate, betamethasone valerate, hydrocortisone acetate, clobetasone butyrate, betamethasone butyrate, clobetasone propionate, dexamethasone succinate, prednisolone 21- (2E, 6E) steroidal anti-inflammatory drugs such as falsinate, hydrocortisone valerate, diflorazone acetate, dexamethasone propionate, betamethasone dipropionate, amsinonide, dexamethasone valerate, harsinonide, butesonide, alcrometasone propionate, etc. It is not limited to these. Two or more kinds of drugs can be used in combination as necessary. In addition, these drugs can be applied in the form of an ester-derived compound, an amide-derived compound, an acetal-derived compound, or a medically acceptable inorganic salt or organic salt as necessary. It may be contained or attached to the body. The amount of the drug is appropriately selected according to the type and use of the patch so that an effective amount preset when applied to the patient can be applied to the affected area.

Hereinafter, although an example is given and explained, the present invention is not limited to these examples.

(Production Example 1: Production of support)
A crimped 50 denier polyester multifilament processed yarn is knitted into a circular knitted fabric with a basis weight of about 100 g / m ² , and a knitted fabric with a thickness of 500 μm is filled with 10% hydroxymethylcellulose aqueous solution of about 4 cm as shown in FIG. After applying in width, it was dried.

(Production Example 2: Production of support)
As shown in FIG. 8, a polyester resin was applied to a knitted fabric having a thickness of 500 μm in which a crimped 50 denier polyester multifilament processed yarn was knitted into a circular knitting having a basis weight of about 100 g / m ² .

(Production Example 3: Production of support)
A polyester resin was applied to a knitted fabric having a thickness of 500 μm, in which a crimped 50 denier polyester multifilament processed yarn was knitted into a circular knitting having a basis weight of about 100 g / m ² , as shown in FIG.

(Production Example 4: Production of support)
A polyester-based pressure-sensitive adhesive tape was applied to a knitted fabric having a thickness of 500 μm, in which a crimped 50 denier polyester multifilament processed yarn was knitted into a circular knitting having a basis weight of about 100 g / m ² as shown in FIG.

Example 1
Styrene-isoprene-styrene block copolymer 25 parts by weight Liquid paraffin 39 parts by weight Polyisobutylene 10 parts by weight Rosin ester resin 25 parts by weight Anti-aging agent 1 part by weight Menthol 4 parts by weight Salicylic acid glycol 4 parts by weight The above ingredients are mixed and mixed Then, it was coated on a release sheet, coated with the support mentioned in the above Production 1 to 4 and pressure-bonded. Furthermore, it cut | judged to the desired magnitude | size.

Comparative Example 1
Manufactured in the same manner as in Example 1 except that unprocessed circular knitted woven fabric was used.

Test Example 1: Method for measuring bending resistance The bending resistance of each support was measured by the 45 ° cantilever method defined in JIS L 1096-1999.
In addition, for Example 1, Example 2, and Example 3, the bending resistance of the processed part was measured.

Test Example 2: Sticking test A sticking test was performed using the preparations produced in the above Examples and Comparative Examples. In the sticking test, each Example and Comparative Example 1 were cut into a size of 10 cm × 14 cm and used. The pasting work was carried out on the lumbar region of 10 healthy people aged 30 to 60 years old. Evaluation was performed according to the evaluation criteria shown in Table 2. Table 3 shows the evaluation results for the ease of sticking work and the uncomfortable feeling when sticking.

Table 2. Evaluation items and evaluation

Table 3. Evaluation results for ease of application and discomfort during application.

As shown in Table 3, in the preparation using the support subjected to processing with high rigidity and softness, the ease of application during the pasting operation was higher than that in Comparative Example 1. Moreover, about the uncomfortable feeling during formulation sticking, although Example 1 and Example 4 felt a little uncomfortable, Example 2 and Example 3 were almost the same evaluation as Comparative Example 1.

FIG. 1 shows an example of failure in a state in which pastes are stuck to each other after removal of a release sheet during a pasting operation of a patch (state in which pastes exposed when there is one liner break are stuck together) ). Fig. 2 shows an example of failure in a state where the pastes are stuck to each other after the release sheet is removed during the pasting operation of the patch (the plaster exposed when the liner has one cut sticks to the release paper) FIG. FIG. 3 shows an example of failure in a state in which the pastes are stuck to each other after the release sheet is removed during the pasting operation of the patch (a state in which the exposed pastes are stuck to each other when there are two liner breaks) ). FIG. 4 shows an example of failure in a state in which the pastes are stuck to each other after removing the release sheet during the pasting operation of the patch (exposed paste is stuck to the release paper when there are two liner breaks. FIG. FIG. 5 is a front view ((a), (b)) of the patch in the embodiment of the present invention. FIG. 6 is a perspective view and a diagram schematically showing a cross section of the patch in the embodiment of the present invention. In the schematic view of the cross section, 1 is a patch such as an ointment or a poultice in the embodiment of the present invention, 2 is a plaster layer of the patch, 3 is a support having rigidity and flexibility made of a woven fabric, etc. A low stretchable part 5 in the support is a release paper. FIG. 7 is a diagram showing the pattern of the support used in Production Example 1. FIG. 8 is a diagram showing the pattern of the support used in Production Example 2. FIG. 9 is a diagram showing the pattern of the support used in Production Example 3. FIG. 10 is a diagram showing the pattern of the support used in Production Example 4.

Claims

In a patch in which a paste layer is provided on the surface of a support, and a release sheet is bonded to the paste layer so as to cover substantially the entire surface thereof;
A patch, wherein two or more parts having different stiffness are formed on one support.
The patch according to claim 1, wherein the part having different bending resistance of the support is a part having higher bending resistance than the other part of the support.
The patch according to claim 1, wherein the highly flexible portion is localized at a support portion corresponding to a portion where the peel sheet is divided and the plaster is exposed.
In a patch in which a paste layer is provided on the surface of a support, and a release sheet is bonded to the paste layer so as to cover substantially the entire surface thereof;
a) A patch for forming two or more parts having different stiffness on a single support,
b) A portion of the support having higher rigidity than other portions is localized at a support portion corresponding to a portion where the release sheet is divided and the plaster is exposed,
c) A patch characterized in that the bending resistance of the low stretchable part is 120% or more higher than the bending resistance of other parts.
A patch having two cuts substantially parallel to the release sheet,
The patch according to any one of claims 1 to 4, wherein the highly rigid portion of the support is located in a central portion of the support sandwiched between cuts substantially parallel to the release sheet.
6. The patch according to any one of claims 1 to 5, wherein a support comprising a knitted fabric having a bending resistance of 5 mm or more according to a 45 ° cantilever method specified in JIS L 1096-1999 is used for the portion having a high bending resistance.
6. The patch according to any one of claims 1 to 5, which is a support having different stiffness and flexibility in one patch, and the area of the portion having high stiffness is 5% to 60% of the whole.
6. The patch according to claim 1, wherein the composition of the adhesive layer of the patch comprises an oily base or an aqueous base.
Patch according to 5 to basis weight of said support claims 1 ranges to the 160 g / m 2 no 60.
It patches according to 5 to the basis weight of the support claims 1 ranges to the 120 g / m 2 80 no.
The patch according to any one of claims 1 to 5, wherein the patch comprises a release sheet adhered to the surface of the pressure-sensitive adhesive layer, and the bending resistance of the release sheet is 60 to 160 mm.
The patch according to any one of claims 1 to 5, wherein the support has a basis weight of 80 to 120 g / m 2 made of polyester fiber having a fiber thickness of 30 to 75 denier.
In a patch in which a paste layer is provided on the surface of a support, and a release sheet is bonded to the paste layer so as to cover substantially the entire surface thereof;
A patch, characterized in that the support is interspersed with highly rigid portions over the entire surface.
This is a patch in which a paste layer is provided on the surface of a support, and a release sheet is laminated on the paste layer so as to cover substantially the entire surface, and the release sheet has two cuts that are substantially parallel to each other. And
a) The patch is a patch in which portions with high flexibility are scattered over the entire surface,
b) having a part where the release sheet is divided and the plaster is exposed;
c) The support is a support having a bending resistance of 6 mm or more according to a 45 ° cantilever method defined in JIS L 1096-1999.
A patch characterized by that.
The patch according to any one of claims 13 to 14, wherein the composition of the adhesive layer of the patch comprises an oily base or an aqueous base.
Patch according to claims 13 to 14 to the 60 basis weight of the support is in the range of 160 g / m 2.
Patch according to claims 13 to 14 to the 80 basis weight of the support is in the range of 120 g / m 2.
The patch according to any one of claims 13 to 14, wherein the patch comprises a release sheet adhered to the surface of the pressure-sensitive adhesive layer, and the bending resistance of the release sheet is 60 to 160 mm.
The patch according to any one of claims 13 to 14, wherein the support has a basis weight of 80 to 120 g / m 2 made of polyester fiber having a fiber thickness of 30 to 75 denier.