WO2010061402A3 - An improved process for the preparation of capecitabine - Google Patents

An improved process for the preparation of capecitabine Download PDF

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Publication number
WO2010061402A3
WO2010061402A3 PCT/IN2009/000676 IN2009000676W WO2010061402A3 WO 2010061402 A3 WO2010061402 A3 WO 2010061402A3 IN 2009000676 W IN2009000676 W IN 2009000676W WO 2010061402 A3 WO2010061402 A3 WO 2010061402A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
improved process
capecitabine
fluorocystidine
isopyridene
Prior art date
Application number
PCT/IN2009/000676
Other languages
French (fr)
Other versions
WO2010061402A2 (en
Inventor
Vishwanath Kannan
Original Assignee
Vishwanath Kannan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vishwanath Kannan filed Critical Vishwanath Kannan
Publication of WO2010061402A2 publication Critical patent/WO2010061402A2/en
Publication of WO2010061402A3 publication Critical patent/WO2010061402A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical

Abstract

The present invention direct to an improved process for the preparation of the compound 5-deoxy-2, 3-O-isopyridene-N-[(pentyloxy) carbonyl]-5-fluorocystidine of the formula (I).
PCT/IN2009/000676 2008-11-25 2009-11-23 An improved process for the preparation of capecitabine WO2010061402A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2483/MUM/2008 2008-11-25
IN2483MU2008 2008-11-25

Publications (2)

Publication Number Publication Date
WO2010061402A2 WO2010061402A2 (en) 2010-06-03
WO2010061402A3 true WO2010061402A3 (en) 2012-05-10

Family

ID=42226186

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000676 WO2010061402A2 (en) 2008-11-25 2009-11-23 An improved process for the preparation of capecitabine

Country Status (1)

Country Link
WO (1) WO2010061402A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2883959A1 (en) 2013-12-13 2015-06-17 Plasmia Biotech, S.L. Enzymatic production of cytosinic nucleoside analogues

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0602478A1 (en) * 1992-12-18 1994-06-22 F. Hoffmann-La Roche Ag Novel process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
GB2403950A (en) * 2003-07-18 2005-01-19 Mitsui Chemicals Inc Pyrimidine nucleosides from reaction of sugar phosphate with pyrimidine base derivative & enzyme having cytosine nucleoside phosphorylase activity
WO2005063786A2 (en) * 2003-12-22 2005-07-14 F.Hoffman-La Roche Ag Process for fluorocytidine derivatives
WO2005080351A1 (en) * 2004-02-23 2005-09-01 Shanghai Desano Pharmaceutical Holding Co., Ltd. The preparation and application of a n4-oxycarbonylcytosine derivatives
CN1935828A (en) * 2006-10-31 2007-03-28 浙江海正药业股份有限公司 Fluoropyrimidine compound carbalkoxylation method
WO2008131062A2 (en) * 2007-04-20 2008-10-30 Dr. Reddy's Laboratories Ltd. Process for preparing capecitabine

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0602478A1 (en) * 1992-12-18 1994-06-22 F. Hoffmann-La Roche Ag Novel process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
GB2403950A (en) * 2003-07-18 2005-01-19 Mitsui Chemicals Inc Pyrimidine nucleosides from reaction of sugar phosphate with pyrimidine base derivative & enzyme having cytosine nucleoside phosphorylase activity
WO2005063786A2 (en) * 2003-12-22 2005-07-14 F.Hoffman-La Roche Ag Process for fluorocytidine derivatives
WO2005080351A1 (en) * 2004-02-23 2005-09-01 Shanghai Desano Pharmaceutical Holding Co., Ltd. The preparation and application of a n4-oxycarbonylcytosine derivatives
CN1935828A (en) * 2006-10-31 2007-03-28 浙江海正药业股份有限公司 Fluoropyrimidine compound carbalkoxylation method
WO2008131062A2 (en) * 2007-04-20 2008-10-30 Dr. Reddy's Laboratories Ltd. Process for preparing capecitabine

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS 2012, accession no. STN Database accession no. 2005:962225 *
DATABASE CAPLUS 2012, accession no. STN Database accession no. 2007:363083 *
DATABASE CASREACT 2012, SHIMMA, N. ET AL.: "The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine", accession no. STN Database accession no. 133:252646 *
SHIMMA, N. ET AL.: "The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 8, no. 7, 2000, pages 1697 - 1706 *

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Publication number Publication date
WO2010061402A2 (en) 2010-06-03

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