WO2010059537A1 - Optique polarisée pour dispositif de diagnostic optique - Google Patents

Optique polarisée pour dispositif de diagnostic optique Download PDF

Info

Publication number
WO2010059537A1
WO2010059537A1 PCT/US2009/064502 US2009064502W WO2010059537A1 WO 2010059537 A1 WO2010059537 A1 WO 2010059537A1 US 2009064502 W US2009064502 W US 2009064502W WO 2010059537 A1 WO2010059537 A1 WO 2010059537A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
readhead
test areas
detectors
sample
Prior art date
Application number
PCT/US2009/064502
Other languages
English (en)
Inventor
James A. Profitt
Original Assignee
Siemens Healthcare Diagnostics Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Inc. filed Critical Siemens Healthcare Diagnostics Inc.
Priority to CN2009801458391A priority Critical patent/CN102216745A/zh
Priority to EP09828064A priority patent/EP2370797A4/fr
Priority to CA2744028A priority patent/CA2744028A1/fr
Priority to US13/129,937 priority patent/US20110223673A1/en
Publication of WO2010059537A1 publication Critical patent/WO2010059537A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21—Polarisation-affecting properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/8483—Investigating reagent band
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/8483—Investigating reagent band
    • G01N2021/8488—Investigating reagent band the band presenting reference patches
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

Definitions

  • Calibration 202 includes actuating or otherwise exposing the calibration material to light source (s) 20 for a pre-determined time and pre-determined current (e.g., when using an electrically actuated source 20) at 203, and capturing and storing reflectances of the calibration material (e.g., per Table I above) at 205. These calibration reflectances are used to effect sample measurement 210 as discussed in detail below with respect to Fig. 6.
  • the instrument may prompt the user to insert sample media 40, 40', 40'' at step 204.
  • the system checks for an appropriate signal, e.g., from one or more of detectors 70, (or alternatively from nominally any other electromechanical switch, actuator, etc.) indicating that sample 40 has been fully inserted/positioned between filters 72, 74. If this signal has not been received, then the system loops back to step 204 to re-prompt the user to fully insert/position the sample. If the signal was received, then reflectance is captured 208 and measured 210 (described in greater detail below with respect to Fig. 6), and compared to calibration values generated during calibration 202.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Selon l'invention, une tête de lecture pour un instrument de diagnostic photométrique comprend un support conçu pour y recevoir un milieu d'échantillon réactif. Le milieu d'échantillon possède une pluralité de zones de test configurées pour réagir et changer de couleur en fonction d'une quantité d'un analyte dans un échantillon. Le support est dimensionné et conformé pour s'ajuster de façon indexée avec le milieu d'échantillon. Une ou plusieurs sources de lumière sont configurées pour émettre de la lumière sur les zones de test. Des premier et second filtres de lumière polarisés sont disposés respectivement entre les sources de lumière et les zones de test, et entre les zones de test et un ou plusieurs détecteurs de lumière, de telle sorte que les détecteurs de lumière reçoivent les réflexions non spéculaires diffuses de la lumière provenant des zones de test, tout en empêchant sensiblement les détecteurs de lumière de recevoir des réflexions spéculaires de la lumière.
PCT/US2009/064502 2008-11-19 2009-11-16 Optique polarisée pour dispositif de diagnostic optique WO2010059537A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN2009801458391A CN102216745A (zh) 2008-11-19 2009-11-16 用于光学诊断设备的偏振光学元件
EP09828064A EP2370797A4 (fr) 2008-11-19 2009-11-16 Optique polarisée pour dispositif de diagnostic optique
CA2744028A CA2744028A1 (fr) 2008-11-19 2009-11-16 Optique polarisee pour dispositif de diagnostic optique
US13/129,937 US20110223673A1 (en) 2008-11-19 2009-11-16 Polarized Optics for Optical Diagnostic Device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11595708P 2008-11-19 2008-11-19
US61/115,957 2008-11-19

Publications (1)

Publication Number Publication Date
WO2010059537A1 true WO2010059537A1 (fr) 2010-05-27

Family

ID=42198458

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/064502 WO2010059537A1 (fr) 2008-11-19 2009-11-16 Optique polarisée pour dispositif de diagnostic optique

Country Status (5)

Country Link
US (1) US20110223673A1 (fr)
EP (1) EP2370797A4 (fr)
CN (1) CN102216745A (fr)
CA (1) CA2744028A1 (fr)
WO (1) WO2010059537A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012149243A1 (fr) 2011-04-29 2012-11-01 Siemens Healthcare Diagnostics Inc. Dispositif d'éclairage à haut degré de collimation du flux et procédé d'éclairage uniforme du champ
WO2020049066A1 (fr) * 2018-09-04 2020-03-12 Ams Ag Lecteur de biomarqueurs
WO2023287281A1 (fr) * 2021-07-14 2023-01-19 Micronit Holding B.V. Appareil d'analyse d'échantillon biologique à des fins de diagnostic
EP2615453B1 (fr) * 2010-09-10 2023-03-22 Ceragem Medisys Inc. Appareil de mesure

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2450351B (en) 2007-06-20 2012-01-18 Cozart Bioscience Ltd Monitoring an Immunoassay
WO2013090655A1 (fr) * 2011-12-16 2013-06-20 Siemens Healthcare Diagnostics Inc. Système et procédé d'alignement de cartes de réactifs
WO2013134491A1 (fr) * 2012-03-09 2013-09-12 Siemens Healthcare Diagnostics Inc. Procédé d'étalonnage pour analyseur de carte de réactif
US10101342B2 (en) 2014-02-12 2018-10-16 Church & Dwight Co., Inc. Devices and methods for electronic analyte assaying
US9651532B2 (en) * 2014-02-27 2017-05-16 Honeywell International, Inc. Multi-point gas detector
US9986165B2 (en) * 2014-12-31 2018-05-29 Invent.ly LLC Remote analyte testing system
CA3053301A1 (fr) * 2017-02-16 2018-08-23 Essenlix Corporation Dosage a surface texturee
US11039765B2 (en) * 2017-09-26 2021-06-22 International Business Machines Corporation Smart pellet for sample testing
US11287404B2 (en) 2017-12-21 2022-03-29 International Business Machines Corporation Analysis apparatus with spectrometer
US10393667B2 (en) 2017-12-21 2019-08-27 International Business Machines Corporation Analysis using optical sensors and signal enhancing agents
US11585804B2 (en) 2018-10-19 2023-02-21 Youcount Inc. Urinalysis device and test strip for home and point of care use
US11199735B2 (en) * 2019-03-28 2021-12-14 Lumcolor Smart optical filter for pixel-selectively adjusting light intensity
JP2023539444A (ja) * 2020-08-12 2023-09-14 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド 内蔵光源を有する回路板

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877863A (en) * 1997-03-20 1999-03-02 Bayer Corporation Readhead for a photometric diagnostic instrument
US6122042A (en) * 1997-02-07 2000-09-19 Wunderman; Irwin Devices and methods for optically identifying characteristics of material objects
US7339673B2 (en) * 2004-03-05 2008-03-04 Siemens Healthcare Diagnostics Inc. Miniature optical readhead for optical diagnostic device

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1152407A (en) * 1968-02-02 1969-05-21 Sphere Invest Ltd Photometric Sorting Apparatus
US4755058A (en) * 1984-06-19 1988-07-05 Miles Laboratories, Inc. Device and method for measuring light diffusely reflected from a nonuniform specimen
US5055261A (en) * 1984-09-11 1991-10-08 Miles Inc. Reagent test strip reading instrument
DK163837C (da) * 1987-11-10 1994-09-05 Neltec As Apparat til farvekontrol af genstande
US4890926A (en) * 1987-12-21 1990-01-02 Miles Inc. Reflectance photometer
DE4300723C2 (de) * 1993-01-14 1995-10-05 Boehringer Mannheim Gmbh Gerät zur Messung der Fluoreszenz einer Probe, inbesondere zur medizinisch-analytischen Bestimmung der Konzentration eines Bestandteils einer Körperflüssigkeit
US5408535A (en) * 1993-09-07 1995-04-18 Miles Inc. Video test strip reader and method for evaluating test strips
US5661563A (en) * 1996-05-09 1997-08-26 Bayer Corporation Reflectance spectroscope with read head for minimizing singly-reflected light rays
US5724148A (en) * 1996-05-09 1998-03-03 Bayer Corporation Apparatus and method for determination of urine color
IL121279A (en) * 1996-07-16 2001-05-20 Roche Diagnostics Gmbh An analytical system with means for testing samples with too small volumes
US6180409B1 (en) * 1998-10-13 2001-01-30 Bayer Corporation Spectrophotometric apparatus with multiple readheads
US7459127B2 (en) * 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
CN100483106C (zh) * 2002-09-29 2009-04-29 天津市先石光学技术有限公司 可分离介质表层与深层信息的光学检测方法
US7400754B2 (en) * 2003-04-08 2008-07-15 The Regents Of The University Of California Method and apparatus for characterization of chromophore content and distribution in skin using cross-polarized diffuse reflectance imaging
JP2007528491A (ja) * 2004-03-05 2007-10-11 バイエル・ヘルスケア・エルエルシー 画像システムアレイを有するハンディ型光学診断装置
US8128871B2 (en) * 2005-04-22 2012-03-06 Alverix, Inc. Lateral flow assay systems and methods
US7264971B2 (en) * 2004-07-20 2007-09-04 Siemens Medical Solutions Diagnostics Read-head for optical diagnostic device
JP2008530536A (ja) * 2005-02-09 2008-08-07 インライト ソリューションズ，インク． 検体の非侵襲性を測定する方法および装置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6122042A (en) * 1997-02-07 2000-09-19 Wunderman; Irwin Devices and methods for optically identifying characteristics of material objects
US5877863A (en) * 1997-03-20 1999-03-02 Bayer Corporation Readhead for a photometric diagnostic instrument
US7339673B2 (en) * 2004-03-05 2008-03-04 Siemens Healthcare Diagnostics Inc. Miniature optical readhead for optical diagnostic device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2370797A4 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2615453B1 (fr) * 2010-09-10 2023-03-22 Ceragem Medisys Inc. Appareil de mesure
WO2012149243A1 (fr) 2011-04-29 2012-11-01 Siemens Healthcare Diagnostics Inc. Dispositif d'éclairage à haut degré de collimation du flux et procédé d'éclairage uniforme du champ
EP2691759A4 (fr) * 2011-04-29 2015-07-29 Siemens Healthcare Diagnostics Dispositif d'éclairage à haut degré de collimation du flux et procédé d'éclairage uniforme du champ
WO2020049066A1 (fr) * 2018-09-04 2020-03-12 Ams Ag Lecteur de biomarqueurs
CN112654858A (zh) * 2018-09-04 2021-04-13 ams有限公司 生物标志物读取器
WO2023287281A1 (fr) * 2021-07-14 2023-01-19 Micronit Holding B.V. Appareil d'analyse d'échantillon biologique à des fins de diagnostic
NL2028727B1 (en) * 2021-07-14 2023-01-20 Micronit Holding B V Apparatus for analysing a biological sample for diagnostics purposes

Also Published As

Publication number Publication date
CA2744028A1 (fr) 2010-05-27
US20110223673A1 (en) 2011-09-15
CN102216745A (zh) 2011-10-12
EP2370797A1 (fr) 2011-10-05
EP2370797A4 (fr) 2013-03-06

Similar Documents

Publication Publication Date Title
US20110223673A1 (en) Polarized Optics for Optical Diagnostic Device
US7339673B2 (en) Miniature optical readhead for optical diagnostic device
US5986754A (en) Medical diagnostic apparatus using a Fresnel reflector
US7499154B2 (en) Readhead for optical inspection apparatus
EP1582598B1 (fr) Système optoélectronique rapid pour tests de diagnostic rapide
KR100251999B1 (ko) 시험 스트립용 판독 장치
JP3559975B2 (ja) 試験片を用いる分析方法
US7768645B2 (en) Miniature optical readhead and colorimeter for analysis media
WO2005088519A1 (fr) Dispositif de diagnostic portatif comprenant un ensemble de systemes d'imagerie
US7847946B2 (en) Verification apparatus and methods for optical inspection machine
WO2006019543A2 (fr) Tete de lecture pour dispositif de diagnostic optique
US20230324307A1 (en) Circuit board with onboard light sources
JP2002228658A (ja) 分析装置
US20060128034A1 (en) Diagnostic test using gated measurement of fluorescence from quantum dots
US11287404B2 (en) Analysis apparatus with spectrometer

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200980145839.1

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09828064

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2744028

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 13129937

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2009828064

Country of ref document: EP