WO2010057934A1 - Flexible catheter - Google Patents

Flexible catheter Download PDF

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Publication number
WO2010057934A1
WO2010057934A1 PCT/EP2009/065419 EP2009065419W WO2010057934A1 WO 2010057934 A1 WO2010057934 A1 WO 2010057934A1 EP 2009065419 W EP2009065419 W EP 2009065419W WO 2010057934 A1 WO2010057934 A1 WO 2010057934A1
Authority
WO
WIPO (PCT)
Prior art keywords
tip
elongated body
catheter
flexible catheter
veins
Prior art date
Application number
PCT/EP2009/065419
Other languages
French (fr)
Inventor
Rudi Devers
Original Assignee
F Care Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Care Systems filed Critical F Care Systems
Priority to EP09759714A priority Critical patent/EP2367494A1/en
Publication of WO2010057934A1 publication Critical patent/WO2010057934A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1477—Needle-like probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00071—Electrical conductivity
    • A61B2018/00083—Electrical conductivity low, i.e. electrically insulating

Definitions

  • the present invention relates to a flexible catheter for thermal coagulation of veins according to the preamble of the first claim.
  • Thermal coagulation is a technology for treating varicose veins based on thermal-based destruction of the veins.
  • catheters or needles are used to penetrate the veins and these catheters or needles are consequently heated by means of radiofrequency waves. The increase in temperature will make the vein coagulate after which the bleeding stops and the vein will finally disappear.
  • a very high radiofrequency energy pulse is delivered into the varicose vein via an ultra-fine needle with a diameter of 0.075 which is protected by a specific isolating layer. These needles are made of nickel. This set-up allows that an amount of energy is delivered where needed.
  • the elongated body is provided to be inserted in and coagulate veins having a diameter of between 1 - 4 mm.
  • the varicose vein is thermally coagulated surprisingly without damaging effects on the epidermis and surrounding tissue.
  • the inventor moreover found that the thermal coagulation-based therapy with the catheter according to the current invention can be performed all year round because the treated areas may, surprisingly, be exposed to the sun.
  • the comfort of the patient is much higher as it has been found that there is no need to ware supporting stockings after the treatment.
  • the success rate using the catheter of the current invention is higher than existing treatments for varicose veins between 1 - 4 mm.
  • a preferred embodiment is characterized in that the layer of insulating material, the insulating layer, along at least part of its length mainly consists of a single layer of insulating material.
  • the single insulating layer can be sufficient to shield the radiofrequency waves from the surrounding tissue during transport to the tip along the conductor and that the radiofrequency waves do not need to be shielded from the surrounding tissue or be transported back from the tip to the radiofrequency source by additional conductive layers surrounding the conductor.
  • the current invention also relates to a method for coagulating a vein having a diameter of between 1 - 4mm, preferably 1 - 3mm, using the flexible catheter according to the current invention by inserting the conductive tip of the flexible catheter according to present invention into the vein until the tip reaches the vein location which needs to be coagulated after which the vein is coagulated at the vein location at the tip by sending a radiofrequency signal along the conductor to the tip.
  • Figure 1 shows a first embodiment of the catheter according to the invention.
  • Figure 2 shows a different embodiment of the catheter according to the invention.
  • Figure 1 shows a flexible catheter for thermal coagulation of veins comprising an elongated body with a proximal end 1 and a distal end 2.
  • the distal end 2 of the elongated body comprises a tip 3 in a conductive material.
  • the elongated body further comprises a conductor 4 which makes contact with the tip and extends between the distal end 2 and the proximal
  • the outside of the elongated body is provided over at least part of its length, but not at the tip with a layer of insulating material 5.
  • the elongated body is provided to be inserted in and coagulate veins having a diameter of between 1 - 4 mm.
  • the tip 3 preferably is rounded, as for example shown in figure 2. This improves the gliding in the vein and avoids perforation of the vein wall by the catheter. However, the tip 3 can also be sharp, as for example shown in figure 1.
  • the tip 3 preferably is made from a conductive material which conducts radiofrequency waves and which heats up under influence of appropriate radiofrequency waves.
  • the conductive material is chosen from the group comprising nickel and gold.
  • the tip 3 is made from nickel.
  • the diameter of the tip 3 preferably ranges from 0,3 -
  • the diameter from the tip 3 ranges from 0,3 - 1 ,4 mm.
  • the length of the tip 3 ranges from 1 ,5 - 5 mm. Most preferably, the length of the tip 3 ranges from 2 - 4 mm.
  • the conductor 4 preferably comprises several twisted wires of a conductive material, as for example shown in figure 2.
  • the inventor has found that by increasing the number of twisted wires, while maintaining the diameter of the conductor 4 substantially the same, flexibility increases. Thus, in other words, the number of wires used, determines the flexibility of the catheter. Depending on the diameter of the catheter, between 4 and 10 wires are used.
  • the diameter of the tip 3 is larger than or, more preferably, substantially equal to the outer diameter of the part of the elongated boy comprising the conductor, more preferably, the outer diameter of the insulating layer 5, more preferably the single insulating layer, surrounding the conductor 4 so that the tip 3 and the insulating layer 5 can be substantially seamlessly inserted in the catheter.
  • This is for example illustrated in figures 1 and 2.
  • the conductor 4 preferably is made of a conductive material able to conduct radiofrequency waves.
  • the conductive material is chosen from the group comprising nickel, silver and gold. Most preferably, nickel is used. Nickel has the advantage being a good conductor for radiofrequency waves and having a good flexibility to generate the twisted wires used to make the conductor.
  • the layer of insulating material 5 next to substantially electrically isolating the conductor from the surrounding tissue preferably is also able to isolate against radiofrequency waves to prevent heating of tissue surrounding the conductor.
  • the layer of insulating material 5 preferably is made of polytetrafluoroethylene (PTFE), medical PTFE or another insulating material.
  • the layer of insulating material 5 preferably consists of a single layer of insulating material.
  • this single layer of insulating material comprises one or more layers of the same insulating material.
  • This single layer of insulating material may also be composed of different types of insulating material possible, but not necessarily superimposed in different layers.
  • the layer of insulating material 5 coaxially covers the outside of the conductor 4 of the elongated body of the flexible catheter extending between the distal 2 and the proximal 1 end of the elongated body.
  • the layer of insulating material 5 is provided over at least part of the length of the elongated body, but not at the tip 3. This results in a thermal coating of the elongated part of the catheter, but not of the tip 3.
  • the radiofrequency waves are transported from the conductive material of the conductor 4, which is insulated by the insulating material 5, to conductive tip 3. There the radiofrequency waves are able to heat the tip and to thermally coagulate the vein.
  • the conductive tip 3 of the flexible catheter according to present invention is inserted into the vein that needs to be coagulated.
  • This catheter is connected to a thermal coagulation device, capable of sending a radiofrequency signal into the cable connected to the catheter according to present invention.
  • a radiofrequency signal is sent into this flexible catheter.
  • a radiofrequency signal having a wavelength between 2 MHz and 12 MHz is used.
  • the catheter transports the temperature to the exact place in the vein where coagulation is desired.
  • only the tip 3 of the catheter is not insulated, only tissues making contact with the tip 3 are heated. Tissues making contact with the conductor 4 coated with insulating material 5 of the catheter are not heated and radiofrequency waves are not transported through these tissues.
  • the insulated catheter with a non-insulated tip 3 makes sure that when a radiofrequency signal is sent into the catheter, the temperature along the catheter remains the same, so that the vein does not heat up alongside the catheter.
  • the vein Due to the local increase in temperature, the vein will be locally coagulated and will therefore be sealed. This will lead to rejection of the vein by the patient's body and eventually the vein will disappear.
  • the temperature at the non-insulated tip 3 of the insulated catheter, generated by the radiofrequency signal is preferably at least 50 C°, more preferably at least 60 C° and most preferably at least 70 C°.
  • the flexibility of the catheter according to present invention is preferred so that the catheter can follow the vein even when the vein is not straight, but for example curved.
  • the insulated catheter with a non-insulated tip 3 according to present invention is preferably used for thermal coagulation of veins of 1 - 4 mm in size, in particular for treatment by means of thermal coagulation of varicose veins of 1 - 4 mm in size.
  • the insulated catheter with a non-insulated tip 3 according to present invention is more preferably used for thermal coagulation of veins of 1 - 3 mm in size, in particular for treatment by means of thermal coagulation of varicose veins of 1 - 3 mm in size.
  • Thermal coagulation using the catheter of present invention may replace the currently used sclerotherapy for small varicose veins between 1 - 4 mm. Indeed, thermal coagulation has not been performed yet for small varicose veins between 1 - 4 mm but exhibits multiple advantages related to the comfort of the patients when compared to sclerotherapy.
  • Effectiveness of this treatment by means of thermal coagulation using catheter of present invention is expected to be between 55 and 100 %.
  • Substantially improved disappearance of the coagulated varicose veins by use of the insulated catheter with a non-insulated tip according to present invention is expected around 60 days after treatment.

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)

Abstract

Flexible catheter for thermal coagulation of veins comprising an elongated body with a proximal end (1) and a distal end (2), whereby the distal end (2) of the elongated body comprises a tip (3) in a conductive material, whereby the elongated body comprises a conductor (4) which makes contact with the tip (3) and extends between the distal end and the proximal end, and whereby the outside of the elongated body is provided over at least part of its length, but not at the tip (3) with a layer of insulating material (5), characterized in that the elongated body is provided to be inserted in veins having a diameter of between 1 - 4 mm.

Description

Flexible catheter
The present invention relates to a flexible catheter for thermal coagulation of veins according to the preamble of the first claim.
Thermal coagulation is a technology for treating varicose veins based on thermal-based destruction of the veins. Thereby, catheters or needles are used to penetrate the veins and these catheters or needles are consequently heated by means of radiofrequency waves. The increase in temperature will make the vein coagulate after which the bleeding stops and the vein will finally disappear.
It is known from the prior art to treat very small (up to
1 mm in size) varicose veins by thermal coagulation. A very high radiofrequency energy pulse is delivered into the varicose vein via an ultra-fine needle with a diameter of 0.075 which is protected by a specific isolating layer. These needles are made of nickel. This set-up allows that an amount of energy is delivered where needed.
It is also known from the prior art to treat larger varicose veins, having a diameter of more than 4 mm, such as for example the vena Saphena, by means of thermal coagulation with a flexible single-insulated catheter. As such a catheter has a large diameter adapted to the diameter of the larger varicose veins such as the vena Saphena, a relative large opening is required in the human body to insert it in the vein and such a procedure must be performed in an operating room.
It is also known from the prior art to treat smaller varicose veins between 1 - 4 mm by means of sclerotherapy. This is a treatment whereby varicose veins are injected with a sclerosing solution in order to press the top and bottom of the vein together. The blood flow in this vein is thereby inhibited and this leads to dissolving and disappearance of the unwanted vein. This treatment is only effective on these parts of the vein that are pressed together adequately. The average effectiveness of the treatment is therefore only 55%. Furthermore, another disadvantage of sclerotherapy is that patients need to ware supporting stocking for approximately 2 weeks. Moreover, after this treatment, patients cannot expose the treated body parts to the sun for a certain time. It is an aim of the present invention to provide a device with an improved treating of varicose veins of diameter 1 - 4 mm which for example has a higher success rate or increases comfort of the patients by exhibiting less disadvantages such as wearing of supporting stockings and prohibition of exposure of treated body parts to the sun.
This is achieved according to the present invention with a flexible catheter for thermal coagulation of veins showing the technical features of the characterizing part of the first claim.
Thereto, the elongated body is provided to be inserted in and coagulate veins having a diameter of between 1 - 4 mm.
The inventor surprisingly found that such catheters can be used to coagulate veins having a diameter of between 1 - 4 mm and therefore use of a catheter of the present invention may replace existing sclerotherapy. By using the flexible catheter for thermal coagulation of present invention, the varicose vein is thermally coagulated surprisingly without damaging effects on the epidermis and surrounding tissue. The inventor moreover found that the thermal coagulation-based therapy with the catheter according to the current invention can be performed all year round because the treated areas may, surprisingly, be exposed to the sun. Furthermore, the comfort of the patient is much higher as it has been found that there is no need to ware supporting stockings after the treatment. Moreover, the success rate using the catheter of the current invention is higher than existing treatments for varicose veins between 1 - 4 mm.
A preferred embodiment is characterized in that the layer of insulating material, the insulating layer, along at least part of its length mainly consists of a single layer of insulating material.
The inventor surprisingly found that the single insulating layer can be sufficient to shield the radiofrequency waves from the surrounding tissue during transport to the tip along the conductor and that the radiofrequency waves do not need to be shielded from the surrounding tissue or be transported back from the tip to the radiofrequency source by additional conductive layers surrounding the conductor.
The current invention also relates to a method for coagulating a vein having a diameter of between 1 - 4mm, preferably 1 - 3mm, using the flexible catheter according to the current invention by inserting the conductive tip of the flexible catheter according to present invention into the vein until the tip reaches the vein location which needs to be coagulated after which the vein is coagulated at the vein location at the tip by sending a radiofrequency signal along the conductor to the tip.
The catheter according to the invention and the method for coagulation will be further elucidated by means of the following description of preferred embodiments and drawings, without limiting the invention. The reference numerals relate to the appended drawings.
Figure 1 shows a first embodiment of the catheter according to the invention.
Figure 2 shows a different embodiment of the catheter according to the invention.
Figure 1 shows a flexible catheter for thermal coagulation of veins comprising an elongated body with a proximal end 1 and a distal end 2. The distal end 2 of the elongated body comprises a tip 3 in a conductive material. The elongated body further comprises a conductor 4 which makes contact with the tip and extends between the distal end 2 and the proximal
1 end. The outside of the elongated body is provided over at least part of its length, but not at the tip with a layer of insulating material 5. The elongated body is provided to be inserted in and coagulate veins having a diameter of between 1 - 4 mm.
The tip 3 preferably is rounded, as for example shown in figure 2. This improves the gliding in the vein and avoids perforation of the vein wall by the catheter. However, the tip 3 can also be sharp, as for example shown in figure 1.
The tip 3 preferably is made from a conductive material which conducts radiofrequency waves and which heats up under influence of appropriate radiofrequency waves. Preferably, the conductive material is chosen from the group comprising nickel and gold. Most preferably, the tip 3 is made from nickel.
The diameter of the tip 3 preferably ranges from 0,3 -
2 mm. Most preferably, the diameter from the tip 3 ranges from 0,3 - 1 ,4 mm. The length of the tip 3 ranges from 1 ,5 - 5 mm. Most preferably, the length of the tip 3 ranges from 2 - 4 mm.
Such diameters have been found to allow a surprisingly good penetration of a vein and allow a surprisingly good delivery of the radiofrequency waves to the tissue which needs to be coagulated.
The conductor 4 preferably comprises several twisted wires of a conductive material, as for example shown in figure 2. The inventor has found that by increasing the number of twisted wires, while maintaining the diameter of the conductor 4 substantially the same, flexibility increases. Thus, in other words, the number of wires used, determines the flexibility of the catheter. Depending on the diameter of the catheter, between 4 and 10 wires are used.
Preferably, the diameter of the tip 3 is larger than or, more preferably, substantially equal to the outer diameter of the part of the elongated boy comprising the conductor, more preferably, the outer diameter of the insulating layer 5, more preferably the single insulating layer, surrounding the conductor 4 so that the tip 3 and the insulating layer 5 can be substantially seamlessly inserted in the catheter. This is for example illustrated in figures 1 and 2.
The conductor 4 preferably is made of a conductive material able to conduct radiofrequency waves. Preferably, the conductive material is chosen from the group comprising nickel, silver and gold. Most preferably, nickel is used. Nickel has the advantage being a good conductor for radiofrequency waves and having a good flexibility to generate the twisted wires used to make the conductor.
The layer of insulating material 5 next to substantially electrically isolating the conductor from the surrounding tissue preferably is also able to isolate against radiofrequency waves to prevent heating of tissue surrounding the conductor. The layer of insulating material 5 preferably is made of polytetrafluoroethylene (PTFE), medical PTFE or another insulating material.
The layer of insulating material 5 preferably consists of a single layer of insulating material. Preferably, this single layer of insulating material comprises one or more layers of the same insulating material. This single layer of insulating material may also be composed of different types of insulating material possible, but not necessarily superimposed in different layers. Preferably, the layer of insulating material 5 coaxially covers the outside of the conductor 4 of the elongated body of the flexible catheter extending between the distal 2 and the proximal 1 end of the elongated body. The layer of insulating material 5 is provided over at least part of the length of the elongated body, but not at the tip 3. This results in a thermal coating of the elongated part of the catheter, but not of the tip 3. The radiofrequency waves are transported from the conductive material of the conductor 4, which is insulated by the insulating material 5, to conductive tip 3. There the radiofrequency waves are able to heat the tip and to thermally coagulate the vein.
The conductive tip 3 of the flexible catheter according to present invention is inserted into the vein that needs to be coagulated. This catheter is connected to a thermal coagulation device, capable of sending a radiofrequency signal into the cable connected to the catheter according to present invention. Then, a radiofrequency signal is sent into this flexible catheter. Preferably, a radiofrequency signal having a wavelength between 2 MHz and 12 MHz is used. Thereby, an increase in temperature in the non-insulated, conductive metal tip of the catheter is generated. As the conductive tip 3 of the catheter is not isolated with insulation, the catheter transports the temperature to the exact place in the vein where coagulation is desired. As only the tip 3 of the catheter is not insulated, only tissues making contact with the tip 3 are heated. Tissues making contact with the conductor 4 coated with insulating material 5 of the catheter are not heated and radiofrequency waves are not transported through these tissues.
The insulated catheter with a non-insulated tip 3 makes sure that when a radiofrequency signal is sent into the catheter, the temperature along the catheter remains the same, so that the vein does not heat up alongside the catheter.
Due to the local increase in temperature, the vein will be locally coagulated and will therefore be sealed. This will lead to rejection of the vein by the patient's body and eventually the vein will disappear.
The temperature at the non-insulated tip 3 of the insulated catheter, generated by the radiofrequency signal, is preferably at least 50 C°, more preferably at least 60 C° and most preferably at least 70 C°. The flexibility of the catheter according to present invention is preferred so that the catheter can follow the vein even when the vein is not straight, but for example curved.
The insulated catheter with a non-insulated tip 3 according to present invention is preferably used for thermal coagulation of veins of 1 - 4 mm in size, in particular for treatment by means of thermal coagulation of varicose veins of 1 - 4 mm in size.
The insulated catheter with a non-insulated tip 3 according to present invention is more preferably used for thermal coagulation of veins of 1 - 3 mm in size, in particular for treatment by means of thermal coagulation of varicose veins of 1 - 3 mm in size.
Thermal coagulation using the catheter of present invention may replace the currently used sclerotherapy for small varicose veins between 1 - 4 mm. Indeed, thermal coagulation has not been performed yet for small varicose veins between 1 - 4 mm but exhibits multiple advantages related to the comfort of the patients when compared to sclerotherapy.
Moreover, treatment of small varicose veins between
1 - 4 mm by means of thermal coagulation using catheter of present invention can be performed in doctor's practice and is no longer necessary to be conducted in an operating room. As a result, patients are able to leave doctor's practice immediately after this treatment. This is in contrast to use of thermal coagulation for treatment of the vena Saphena, whereby the patient has to be partially sedated and the treatment is performed in the operating room.
Effectiveness of this treatment by means of thermal coagulation using catheter of present invention is expected to be between 55 and 100 %.
Substantially improved disappearance of the coagulated varicose veins by use of the insulated catheter with a non-insulated tip according to present invention is expected around 60 days after treatment.

Claims

1. A flexible catheter for thermal coagulation of veins comprising an elongated body with a proximal end (1 ) and a distal end (2), whereby the distal end (2) of the elongated body comprises a tip (3) in a conductive material, whereby the elongated body comprises a conductor (4) which makes contact with the tip (3) and extends between the distal end and the proximal end, and whereby the outside of the elongated body is provided over at least part of its length, but not at the tip (3) with a layer of insulating material (5), characterized in that the elongated body is provided to be inserted in and coagulate veins having a diameter of between 1 - 4 mm.
2. A flexible catheter according to claim 1 , wherein the layer of insulating material (5) along at least part of its length mainly consists of a single layer of insulating material.
3. The flexible catheter according to claim 1 or 2 wherein the conductive material for the tip (3) is chosen from the group of conductive metals, in particular nickel, or gold.
4. The flexible catheter according to any one of the preceding claims wherein the conductor (4) comprises conductive metals, in particular nickel, silver or gold.
5. The flexible catheter according to any one of the preceding claims wherein the conductive tip (3) has a rounded tip.
6. The flexible catheter according to any one of the preceding claims wherein the insulating material (5) is chosen from the group of insulators, in particular PTFE more particularly medical PTFE.
7. The flexible catheter according to any one of the preceding claims characterized in that the elongated body is provided to be inserted in and coagulate veins having a diameter of between 1 - 3 mm.
PCT/EP2009/065419 2008-11-18 2009-11-18 Flexible catheter WO2010057934A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09759714A EP2367494A1 (en) 2008-11-18 2009-11-18 Flexible catheter

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08169373 2008-11-18
EP08169373.1 2008-11-18

Publications (1)

Publication Number Publication Date
WO2010057934A1 true WO2010057934A1 (en) 2010-05-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/065419 WO2010057934A1 (en) 2008-11-18 2009-11-18 Flexible catheter

Country Status (2)

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EP (1) EP2367494A1 (en)
WO (1) WO2010057934A1 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2501034A1 (en) * 1981-03-06 1982-09-10 Francis Brunelle Combined anticoagulation electrode and catheter - has bipolar operation and operates on HF AC
DE19734506A1 (en) * 1997-08-08 1999-02-25 Stockert Gmbh Device for the high-frequency treatment of body tissues
WO1999011185A1 (en) * 1997-08-30 1999-03-11 Steffen Hoffmann Device for treating vascular defects, especially varicose veins
GB2333964A (en) * 1999-03-04 1999-08-11 Falah Hasan Ali Intravenous coagulation catheter for treatment of varicose veins
DE102006047366A1 (en) * 2006-10-04 2008-04-10 Celon Ag Medical Instruments Flexible soft catheter for radiofrequency therapy of biological tissue
EP1967154A1 (en) * 2007-03-02 2008-09-10 F-CARE SYSTEMS, naamloze vennootschap Needle or catheter for the termal coagulation of blood vessels

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2501034A1 (en) * 1981-03-06 1982-09-10 Francis Brunelle Combined anticoagulation electrode and catheter - has bipolar operation and operates on HF AC
DE19734506A1 (en) * 1997-08-08 1999-02-25 Stockert Gmbh Device for the high-frequency treatment of body tissues
WO1999011185A1 (en) * 1997-08-30 1999-03-11 Steffen Hoffmann Device for treating vascular defects, especially varicose veins
GB2333964A (en) * 1999-03-04 1999-08-11 Falah Hasan Ali Intravenous coagulation catheter for treatment of varicose veins
DE102006047366A1 (en) * 2006-10-04 2008-04-10 Celon Ag Medical Instruments Flexible soft catheter for radiofrequency therapy of biological tissue
EP1967154A1 (en) * 2007-03-02 2008-09-10 F-CARE SYSTEMS, naamloze vennootschap Needle or catheter for the termal coagulation of blood vessels

Also Published As

Publication number Publication date
EP2367494A1 (en) 2011-09-28

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