WO2010052342A3 - Capteur de messager chimique - Google Patents

Capteur de messager chimique Download PDF

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Publication number
WO2010052342A3
WO2010052342A3 PCT/EP2009/064942 EP2009064942W WO2010052342A3 WO 2010052342 A3 WO2010052342 A3 WO 2010052342A3 EP 2009064942 W EP2009064942 W EP 2009064942W WO 2010052342 A3 WO2010052342 A3 WO 2010052342A3
Authority
WO
WIPO (PCT)
Prior art keywords
serotonin
sensor
conducting
cyclodextrin
polymer
Prior art date
Application number
PCT/EP2009/064942
Other languages
English (en)
Other versions
WO2010052342A2 (fr
Inventor
John Colleran
Claire Harley
Bernadette Alcock
Carmel Breslin
Niall Finnerty
Original Assignee
National University Of Ireland, Maynooth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Of Ireland, Maynooth filed Critical National University Of Ireland, Maynooth
Publication of WO2010052342A2 publication Critical patent/WO2010052342A2/fr
Publication of WO2010052342A3 publication Critical patent/WO2010052342A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/942—Serotonin, i.e. 5-hydroxy-tryptamine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention porte sur un capteur pour la détection de messagers chimiques, plus particulièrement sur un capteur pour la détection de la sérotonine. La sérotonine joue un rôle central en tant que neurotransmetteur dans la modulation d'une myriade de réponses physiologiques dont la peur, l'agression, l'humeur, le sommeil, la sexualité et l'appétit. Une électrode pour détecter la sérotonine comprend un substrat conducteur ou semi-conducteur, et un matériau polymère sur ledit substrat. Ledit polymère comprend un polymère conducteur dopé par un macrocycle de cyclodextrine. Des matériaux polymères appropriés comprennent des polypyrroles et des polythiophènes, par exemple, PEDOT. Des macrocycles de cyclodextrine appropriés comprennent des macrocycles de cyclodextrine anioniques, par exemple des β-cyclodextrines sulfonées (CD). L'invention porte également sur un capteur capable de détecter sélectivement la sérotonine en présence d'acide ascorbique, d'épinéphrine, de norépinéphrine et de dopamine.
PCT/EP2009/064942 2008-11-10 2009-11-10 Capteur de messager chimique WO2010052342A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IES20080900 IES20080900A2 (en) 2008-11-10 2008-11-10 Chemical messenger sensor
IES2008/0900 2008-11-10

Publications (2)

Publication Number Publication Date
WO2010052342A2 WO2010052342A2 (fr) 2010-05-14
WO2010052342A3 true WO2010052342A3 (fr) 2010-07-15

Family

ID=42107372

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/064942 WO2010052342A2 (fr) 2008-11-10 2009-11-10 Capteur de messager chimique

Country Status (2)

Country Link
IE (1) IES20080900A2 (fr)
WO (1) WO2010052342A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170027184A (ko) * 2015-09-01 2017-03-09 (주) 원메디칼 전기화학적 검출방법에 의한 알레르겐 검출 장치
CN106353376A (zh) * 2016-08-30 2017-01-25 南京师范大学 一种β‑肾上腺受体激动剂多残留检测电化学传感器及其检测方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587466A (en) * 1993-06-03 1996-12-24 Commissariat A L'energie Atomique Conductive polymer doped by a sulphonated cyclodextrin salt and device for obtaining and/or supplying an active substance incorporating said polymer
US20030027239A1 (en) * 2000-05-16 2003-02-06 Schaffar Berhard Peter Harald Creatinine biosensor
US6582583B1 (en) * 1998-11-30 2003-06-24 The United States Of America As Represented By The Department Of Health And Human Services Amperometric biomimetic enzyme sensors based on modified cyclodextrin as electrocatalysts
WO2006127023A2 (fr) * 2004-08-24 2006-11-30 University Of South Florida Membrane polymere amelioree par resine epoxyde, pour augmenter la longevite de capteurs biologiques

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587466A (en) * 1993-06-03 1996-12-24 Commissariat A L'energie Atomique Conductive polymer doped by a sulphonated cyclodextrin salt and device for obtaining and/or supplying an active substance incorporating said polymer
US6582583B1 (en) * 1998-11-30 2003-06-24 The United States Of America As Represented By The Department Of Health And Human Services Amperometric biomimetic enzyme sensors based on modified cyclodextrin as electrocatalysts
US20030027239A1 (en) * 2000-05-16 2003-02-06 Schaffar Berhard Peter Harald Creatinine biosensor
WO2006127023A2 (fr) * 2004-08-24 2006-11-30 University Of South Florida Membrane polymere amelioree par resine epoxyde, pour augmenter la longevite de capteurs biologiques

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIDAN G ET AL: "Incorporation of sulphonated cyclodextrins into polypyrrole: An approach for the electro-controlled delivering of neutral drugs", BIOSENSORS AND BIOELECTRONICS, vol. 10, no. 1-2, 1995, pages 219 - 229, XP002579616, ISSN: 0956-5663 *
LAGROST ET AL: "Host-guest complexation: a new strategy for electrodeposition of processable polythiophene composites from aqueous medium", CHEMICAL COMMUNICATIONS - CHEMCOM, ROYAL SOCIETY OF CHEMISTRY, GB LNKD- DOI:10.1039/A707862E, no. 4, 1 January 1998 (1998-01-01), pages 489 - 490, XP002144876, ISSN: 1359-7345 *
VASANTHA V S ET AL: "Effect of hydroxypropyl-[beta]-cyclodextrin on the electrochemical oxidation and polymerization of 3,4-ethylenedioxythiophene", JOURNAL OF ELECTROANALYTICAL CHEMISTRY 20020222 ELSEVIER NL LNKD- DOI:10.1016/S0022-0728(01)00748-3, vol. 520, no. 1-2, 22 February 2002 (2002-02-22), pages 79 - 88, XP002579617 *

Also Published As

Publication number Publication date
WO2010052342A2 (fr) 2010-05-14
IES20080900A2 (en) 2010-05-12

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