WO2010046808A3 - A process for the preparation of venlafaxine hydrochloride - Google Patents

A process for the preparation of venlafaxine hydrochloride Download PDF

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Publication number
WO2010046808A3
WO2010046808A3 PCT/IB2009/054496 IB2009054496W WO2010046808A3 WO 2010046808 A3 WO2010046808 A3 WO 2010046808A3 IB 2009054496 W IB2009054496 W IB 2009054496W WO 2010046808 A3 WO2010046808 A3 WO 2010046808A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
methoxyphenyl
venlafaxine hydrochloride
cyclohexanol
cyano
Prior art date
Application number
PCT/IB2009/054496
Other languages
French (fr)
Other versions
WO2010046808A2 (en
Inventor
Ravi Ponnaiah
Sunil Arora
Sanjay Desai
Dhiraj Rathod
Original Assignee
Alembic Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alembic Limited filed Critical Alembic Limited
Publication of WO2010046808A2 publication Critical patent/WO2010046808A2/en
Publication of WO2010046808A3 publication Critical patent/WO2010046808A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to a process for the preparation of Venlafaxine Hydrochloride comprising steps of i) treating 4-methoxyphenyl acetonitrile with cyclohexanone in presence of alkali hydroxide and super base to get 1-[cyano (4-methoxyphenyl) methyl] cyclohexanol and ii) reducing 1-[cyano (4-methoxyphenyl) methyl] cyclohexanol in presence of catalyst, activator and alcoholic ammonia under hydrogen pressure.
PCT/IB2009/054496 2008-10-21 2009-10-13 A process for the preparation of venlafaxine hydrochloride WO2010046808A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2266MU2008 2008-10-21
IN2266/MUM/2008 2008-10-21

Publications (2)

Publication Number Publication Date
WO2010046808A2 WO2010046808A2 (en) 2010-04-29
WO2010046808A3 true WO2010046808A3 (en) 2011-04-07

Family

ID=42119765

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/054496 WO2010046808A2 (en) 2008-10-21 2009-10-13 A process for the preparation of venlafaxine hydrochloride

Country Status (1)

Country Link
WO (1) WO2010046808A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9527800B2 (en) 2013-10-29 2016-12-27 Council Of Scientific And Industrial Research Process for total synthesis of venlafaxine
CN104177268B (en) * 2014-09-22 2015-10-28 山东华生化学股份有限公司 A kind of preparation method of 1-[2-amino-1-(4-p-methoxy-phenyl) ethyl] hexalin
CN112094230A (en) * 2020-08-21 2020-12-18 合肥华方医药科技有限公司 Synthesis method of venlafaxine hydrochloride related substances

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
WO2002050017A1 (en) * 2000-12-20 2002-06-27 Ciba Specialty Chemicals Holding Inc. Process for the preparation of phenethylamine derivatives
WO2006067808A1 (en) * 2004-12-22 2006-06-29 Calyx Chemicals & Pharmaceuticals Private Limited An improved process for production of intermediate of antidepressant agent

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
WO2002050017A1 (en) * 2000-12-20 2002-06-27 Ciba Specialty Chemicals Holding Inc. Process for the preparation of phenethylamine derivatives
WO2006067808A1 (en) * 2004-12-22 2006-06-29 Calyx Chemicals & Pharmaceuticals Private Limited An improved process for production of intermediate of antidepressant agent

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE CASREACT accession no. STN Database accession no. 145:271483 *
DATABASE CASREACT accession no. STN Database accession no. 150:237143 *
GOWDA, NARENDRA B. ET AL: "Synthesis and antidepressant activity of venlafaxine and its derivatives", JOURNAL OF PHARMACY AND CHEMISTRY, vol. 1, no. 1, 2007, pages 31 - 34 *

Also Published As

Publication number Publication date
WO2010046808A2 (en) 2010-04-29

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