WO2010045478A3 - System and method for differential perfusion analysis of tissues with multiple vascular supplies - Google Patents

System and method for differential perfusion analysis of tissues with multiple vascular supplies Download PDF

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Publication number
WO2010045478A3
WO2010045478A3 PCT/US2009/060875 US2009060875W WO2010045478A3 WO 2010045478 A3 WO2010045478 A3 WO 2010045478A3 US 2009060875 W US2009060875 W US 2009060875W WO 2010045478 A3 WO2010045478 A3 WO 2010045478A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissues
enhancement
time
perfusion analysis
multiple vascular
Prior art date
Application number
PCT/US2009/060875
Other languages
French (fr)
Other versions
WO2010045478A2 (en
Inventor
Michael H. Rosenthal
Francine L. Jacobson
Hiroto Hatabu
Original Assignee
Brigham And Women's Hospital, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham And Women's Hospital, Inc. filed Critical Brigham And Women's Hospital, Inc.
Publication of WO2010045478A2 publication Critical patent/WO2010045478A2/en
Publication of WO2010045478A3 publication Critical patent/WO2010045478A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0263—Measuring blood flow using NMR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/481—Diagnostic techniques involving the use of contrast agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/50—Clinical applications
    • A61B6/504—Clinical applications involving diagnosis of blood vessels, e.g. by angiography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
    • G01R33/56366—Perfusion imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/50—Clinical applications
    • A61B6/507—Clinical applications involving determination of haemodynamic parameters, e.g. perfusion CT
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Abstract

A method for calculating the contribution of multiple vascular blood flow sources to tissues in a region of interest undergoing perfusion analysis establishes a model time-enhancement reference curve comprised of the weighted combination of reference time-enhancement curves calculated for each blood flow source. The weighting coefficients are calculated for each region of interest being analyzed using the model time-enhancement curve and a time-enhancement curve of the tissue at that location.
PCT/US2009/060875 2008-10-15 2009-10-15 System and method for differential perfusion analysis of tissues with multiple vascular supplies WO2010045478A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10574508P 2008-10-15 2008-10-15
US61/105,745 2008-10-15

Publications (2)

Publication Number Publication Date
WO2010045478A2 WO2010045478A2 (en) 2010-04-22
WO2010045478A3 true WO2010045478A3 (en) 2010-07-22

Family

ID=42107246

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/060875 WO2010045478A2 (en) 2008-10-15 2009-10-15 System and method for differential perfusion analysis of tissues with multiple vascular supplies

Country Status (1)

Country Link
WO (1) WO2010045478A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102014201499A1 (en) * 2014-01-28 2015-07-30 Siemens Aktiengesellschaft Method and medical imaging device for determining perfusion
CN111528885B (en) * 2020-04-15 2023-09-05 脑玺(上海)智能科技有限公司 Image processing method based on energy spectrum enhanced CT

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004057812A (en) * 2002-06-03 2004-02-26 Ge Medical Systems Global Technology Co Llc Method for quantitative analysis of cerebral blood flow and device therefor
EP1886254A2 (en) * 2005-05-20 2008-02-13 Advanced MRI Technologies LLC Efficient visualization of cortical vascular territories and functional mri by cycled arterial spin labeling mri
KR20080032916A (en) * 2006-10-11 2008-04-16 한국과학기술원 Machine to analyze tissue perfusion using concentration of indocyanine green in blood

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004057812A (en) * 2002-06-03 2004-02-26 Ge Medical Systems Global Technology Co Llc Method for quantitative analysis of cerebral blood flow and device therefor
EP1886254A2 (en) * 2005-05-20 2008-02-13 Advanced MRI Technologies LLC Efficient visualization of cortical vascular territories and functional mri by cycled arterial spin labeling mri
KR20080032916A (en) * 2006-10-11 2008-04-16 한국과학기술원 Machine to analyze tissue perfusion using concentration of indocyanine green in blood

Also Published As

Publication number Publication date
WO2010045478A2 (en) 2010-04-22

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