WO2012122462A3 - Use of magnetic resonance techniques for molecular detection - Google Patents

Use of magnetic resonance techniques for molecular detection Download PDF

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Publication number
WO2012122462A3
WO2012122462A3 PCT/US2012/028455 US2012028455W WO2012122462A3 WO 2012122462 A3 WO2012122462 A3 WO 2012122462A3 US 2012028455 W US2012028455 W US 2012028455W WO 2012122462 A3 WO2012122462 A3 WO 2012122462A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
molecular species
magnetic resonance
quantification
invasive
Prior art date
Application number
PCT/US2012/028455
Other languages
French (fr)
Other versions
WO2012122462A2 (en
Inventor
Ching-Hua Tseng
Shyamal Somaroo
Grum Teklemariam
Original Assignee
Thimbletech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thimbletech, Inc. filed Critical Thimbletech, Inc.
Publication of WO2012122462A2 publication Critical patent/WO2012122462A2/en
Publication of WO2012122462A3 publication Critical patent/WO2012122462A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4828—Resolving the MR signals of different chemical species, e.g. water-fat imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5607—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by reducing the NMR signal of a particular spin species, e.g. of a chemical species for fat suppression, or of a moving spin species for black-blood imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
    • G01R33/383—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field using permanent magnets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4625—Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
    • G01R33/485—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy based on chemical shift information [CSI] or spectroscopic imaging, e.g. to acquire the spatial distributions of metabolites

Abstract

System and methods are provided to perform non-invasive, real-time, continuous or episodic molecular detection and quantification of molecular species in a sample or animal or human subject using magnetic resonance. Such systems and methods may be applied to identify and quantify molecular species found in the body, which may be useful for many aspects of medical care including without limitation prenatal diagnosis, detecting deep skin infections, performing cerebral spinal fluid assessment, measuring arterial blood gases, blood glucose, cardiac biomarkers, and creatinine flow rates. The non-invasive, quantification of such molecular species continuously in real time enables significantly more attractive methods of diagnosis, monitoring and therapy than existing methods and protocols.
PCT/US2012/028455 2011-03-09 2012-03-09 Use of magnetic resonance techniques for molecular detection WO2012122462A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161450809P 2011-03-09 2011-03-09
US61/450,809 2011-03-09

Publications (2)

Publication Number Publication Date
WO2012122462A2 WO2012122462A2 (en) 2012-09-13
WO2012122462A3 true WO2012122462A3 (en) 2012-12-06

Family

ID=46798830

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/028455 WO2012122462A2 (en) 2011-03-09 2012-03-09 Use of magnetic resonance techniques for molecular detection

Country Status (1)

Country Link
WO (1) WO2012122462A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106383364A (en) * 2016-06-16 2017-02-08 山东大学 Pseudo-random frequency-sweeping nuclear magnetic resonance detection instrument
CN106850172A (en) * 2017-01-18 2017-06-13 南京理工大学 Millimeter wave mobile subscriber's localization method based on channel condition information
CN107122534B (en) * 2017-04-18 2020-09-18 中广核研究院有限公司 Method and device for calculating power multiplication period of nuclear reactor

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TWI481385B (en) * 2012-10-02 2015-04-21 Univ Lunghwa Sci & Technology Non - invasive blood glucose measurement circuit module
US10335075B2 (en) 2013-03-14 2019-07-02 Dexcom, Inc. Advanced calibration for analyte sensors
EP3021874B1 (en) * 2013-07-18 2022-04-27 The University of Hong Kong Methods for classifying pleural fluid
KR102509504B1 (en) 2015-08-24 2023-03-13 인터디지털 매디슨 페턴트 홀딩스 에스에이에스 Coding and decoding methods and corresponding devices
CN107024919B (en) * 2017-03-07 2019-05-17 福建福清核电有限公司 A method of realizing nuclear leve digitlization I&C system in-service monitoring diagnosis
EP3460500A1 (en) * 2017-09-26 2019-03-27 Siemens Healthcare GmbH Medical imaging apparatus for combined magnetic resonance imaging and irradiation and method for determining the equipment of shim units
US11793429B2 (en) * 2017-11-12 2023-10-24 Synex Medical Inc. Wearable blood analyte measurement device and method for measuring blood analyte concentration
US10524762B2 (en) 2017-11-16 2020-01-07 United States Of America As Represented By The Secretary Of The Air Force Fetal heartbeat phantom
US10985629B2 (en) * 2018-09-07 2021-04-20 GM Global Technology Operations LLC Integrated power electronics component for mitigating noise, vibration, and harshness
WO2020205788A1 (en) * 2019-03-29 2020-10-08 The Regents Of The University Of California Systems, devices and methods for imaging cortical and trabecular bone
CN113552025A (en) * 2021-06-23 2021-10-26 安图实验仪器(郑州)有限公司 Method for detecting blood sample resonance frequency and blood sample resonance detector

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317265A (en) * 1992-09-16 1994-05-31 Weinstock Ronald J Computerized magnetic resonance analyzer
US20070194788A1 (en) * 2004-07-22 2007-08-23 Alexander Pines Nuclear magnetic resonance detection in inhomogeneous magnetic fields
US20070196280A1 (en) * 2006-02-21 2007-08-23 The Government Of The U.S.A. As Represented By The Sec. Of The Dept. Of Health And Human Services In vivo magnetic resonance spectroscopy of aspartate transaminase activity
US20080129298A1 (en) * 2006-02-17 2008-06-05 Vaughan J T High field magnetic resonance
WO2010110881A1 (en) * 2009-03-27 2010-09-30 Hetherington Hoby P Improved transceiver apparatus, system, and methodology for superior in-vivo imaging of human anatomy
US20100271020A1 (en) * 2009-04-22 2010-10-28 Allegheny-Singer Research Institute Steady-state-free-precession (SSFP) magnetic resonance imaging (MRI) and method
US20100286502A1 (en) * 2007-09-26 2010-11-11 The Johns Hopkins University Frequency referencing for chemical exchange saturation transfer (cest) mri
US20110279117A1 (en) * 2008-10-27 2011-11-17 Jamu Alford System and method for magnetic resonance imaging

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317265A (en) * 1992-09-16 1994-05-31 Weinstock Ronald J Computerized magnetic resonance analyzer
US20070194788A1 (en) * 2004-07-22 2007-08-23 Alexander Pines Nuclear magnetic resonance detection in inhomogeneous magnetic fields
US20080129298A1 (en) * 2006-02-17 2008-06-05 Vaughan J T High field magnetic resonance
US20070196280A1 (en) * 2006-02-21 2007-08-23 The Government Of The U.S.A. As Represented By The Sec. Of The Dept. Of Health And Human Services In vivo magnetic resonance spectroscopy of aspartate transaminase activity
US20100286502A1 (en) * 2007-09-26 2010-11-11 The Johns Hopkins University Frequency referencing for chemical exchange saturation transfer (cest) mri
US20110279117A1 (en) * 2008-10-27 2011-11-17 Jamu Alford System and method for magnetic resonance imaging
WO2010110881A1 (en) * 2009-03-27 2010-09-30 Hetherington Hoby P Improved transceiver apparatus, system, and methodology for superior in-vivo imaging of human anatomy
US20120112748A1 (en) * 2009-03-27 2012-05-10 Hetherington Hoby P Transceiver apparatus, system and methodology for superior In-Vivo imaging of human anatomy
US20100271020A1 (en) * 2009-04-22 2010-10-28 Allegheny-Singer Research Institute Steady-state-free-precession (SSFP) magnetic resonance imaging (MRI) and method

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106383364A (en) * 2016-06-16 2017-02-08 山东大学 Pseudo-random frequency-sweeping nuclear magnetic resonance detection instrument
CN106850172A (en) * 2017-01-18 2017-06-13 南京理工大学 Millimeter wave mobile subscriber's localization method based on channel condition information
CN107122534B (en) * 2017-04-18 2020-09-18 中广核研究院有限公司 Method and device for calculating power multiplication period of nuclear reactor

Also Published As

Publication number Publication date
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