WO2012122462A3 - Use of magnetic resonance techniques for molecular detection - Google Patents
Use of magnetic resonance techniques for molecular detection Download PDFInfo
- Publication number
- WO2012122462A3 WO2012122462A3 PCT/US2012/028455 US2012028455W WO2012122462A3 WO 2012122462 A3 WO2012122462 A3 WO 2012122462A3 US 2012028455 W US2012028455 W US 2012028455W WO 2012122462 A3 WO2012122462 A3 WO 2012122462A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- molecular species
- magnetic resonance
- quantification
- invasive
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/4828—Resolving the MR signals of different chemical species, e.g. water-fat imaging
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5607—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by reducing the NMR signal of a particular spin species, e.g. of a chemical species for fat suppression, or of a moving spin species for black-blood imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
- G01R33/383—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field using permanent magnets
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/4625—Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
- G01R33/485—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy based on chemical shift information [CSI] or spectroscopic imaging, e.g. to acquire the spatial distributions of metabolites
Abstract
System and methods are provided to perform non-invasive, real-time, continuous or episodic molecular detection and quantification of molecular species in a sample or animal or human subject using magnetic resonance. Such systems and methods may be applied to identify and quantify molecular species found in the body, which may be useful for many aspects of medical care including without limitation prenatal diagnosis, detecting deep skin infections, performing cerebral spinal fluid assessment, measuring arterial blood gases, blood glucose, cardiac biomarkers, and creatinine flow rates. The non-invasive, quantification of such molecular species continuously in real time enables significantly more attractive methods of diagnosis, monitoring and therapy than existing methods and protocols.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161450809P | 2011-03-09 | 2011-03-09 | |
US61/450,809 | 2011-03-09 |
Publications (2)
Publication Number | Publication Date |
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WO2012122462A2 WO2012122462A2 (en) | 2012-09-13 |
WO2012122462A3 true WO2012122462A3 (en) | 2012-12-06 |
Family
ID=46798830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/028455 WO2012122462A2 (en) | 2011-03-09 | 2012-03-09 | Use of magnetic resonance techniques for molecular detection |
Country Status (1)
Country | Link |
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WO (1) | WO2012122462A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106383364A (en) * | 2016-06-16 | 2017-02-08 | 山东大学 | Pseudo-random frequency-sweeping nuclear magnetic resonance detection instrument |
CN106850172A (en) * | 2017-01-18 | 2017-06-13 | 南京理工大学 | Millimeter wave mobile subscriber's localization method based on channel condition information |
CN107122534B (en) * | 2017-04-18 | 2020-09-18 | 中广核研究院有限公司 | Method and device for calculating power multiplication period of nuclear reactor |
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TWI481385B (en) * | 2012-10-02 | 2015-04-21 | Univ Lunghwa Sci & Technology | Non - invasive blood glucose measurement circuit module |
US10335075B2 (en) | 2013-03-14 | 2019-07-02 | Dexcom, Inc. | Advanced calibration for analyte sensors |
EP3021874B1 (en) * | 2013-07-18 | 2022-04-27 | The University of Hong Kong | Methods for classifying pleural fluid |
KR102509504B1 (en) | 2015-08-24 | 2023-03-13 | 인터디지털 매디슨 페턴트 홀딩스 에스에이에스 | Coding and decoding methods and corresponding devices |
CN107024919B (en) * | 2017-03-07 | 2019-05-17 | 福建福清核电有限公司 | A method of realizing nuclear leve digitlization I&C system in-service monitoring diagnosis |
EP3460500A1 (en) * | 2017-09-26 | 2019-03-27 | Siemens Healthcare GmbH | Medical imaging apparatus for combined magnetic resonance imaging and irradiation and method for determining the equipment of shim units |
US11793429B2 (en) * | 2017-11-12 | 2023-10-24 | Synex Medical Inc. | Wearable blood analyte measurement device and method for measuring blood analyte concentration |
US10524762B2 (en) | 2017-11-16 | 2020-01-07 | United States Of America As Represented By The Secretary Of The Air Force | Fetal heartbeat phantom |
US10985629B2 (en) * | 2018-09-07 | 2021-04-20 | GM Global Technology Operations LLC | Integrated power electronics component for mitigating noise, vibration, and harshness |
WO2020205788A1 (en) * | 2019-03-29 | 2020-10-08 | The Regents Of The University Of California | Systems, devices and methods for imaging cortical and trabecular bone |
CN113552025A (en) * | 2021-06-23 | 2021-10-26 | 安图实验仪器(郑州)有限公司 | Method for detecting blood sample resonance frequency and blood sample resonance detector |
Citations (8)
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US5317265A (en) * | 1992-09-16 | 1994-05-31 | Weinstock Ronald J | Computerized magnetic resonance analyzer |
US20070194788A1 (en) * | 2004-07-22 | 2007-08-23 | Alexander Pines | Nuclear magnetic resonance detection in inhomogeneous magnetic fields |
US20070196280A1 (en) * | 2006-02-21 | 2007-08-23 | The Government Of The U.S.A. As Represented By The Sec. Of The Dept. Of Health And Human Services | In vivo magnetic resonance spectroscopy of aspartate transaminase activity |
US20080129298A1 (en) * | 2006-02-17 | 2008-06-05 | Vaughan J T | High field magnetic resonance |
WO2010110881A1 (en) * | 2009-03-27 | 2010-09-30 | Hetherington Hoby P | Improved transceiver apparatus, system, and methodology for superior in-vivo imaging of human anatomy |
US20100271020A1 (en) * | 2009-04-22 | 2010-10-28 | Allegheny-Singer Research Institute | Steady-state-free-precession (SSFP) magnetic resonance imaging (MRI) and method |
US20100286502A1 (en) * | 2007-09-26 | 2010-11-11 | The Johns Hopkins University | Frequency referencing for chemical exchange saturation transfer (cest) mri |
US20110279117A1 (en) * | 2008-10-27 | 2011-11-17 | Jamu Alford | System and method for magnetic resonance imaging |
-
2012
- 2012-03-09 WO PCT/US2012/028455 patent/WO2012122462A2/en active Application Filing
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5317265A (en) * | 1992-09-16 | 1994-05-31 | Weinstock Ronald J | Computerized magnetic resonance analyzer |
US20070194788A1 (en) * | 2004-07-22 | 2007-08-23 | Alexander Pines | Nuclear magnetic resonance detection in inhomogeneous magnetic fields |
US20080129298A1 (en) * | 2006-02-17 | 2008-06-05 | Vaughan J T | High field magnetic resonance |
US20070196280A1 (en) * | 2006-02-21 | 2007-08-23 | The Government Of The U.S.A. As Represented By The Sec. Of The Dept. Of Health And Human Services | In vivo magnetic resonance spectroscopy of aspartate transaminase activity |
US20100286502A1 (en) * | 2007-09-26 | 2010-11-11 | The Johns Hopkins University | Frequency referencing for chemical exchange saturation transfer (cest) mri |
US20110279117A1 (en) * | 2008-10-27 | 2011-11-17 | Jamu Alford | System and method for magnetic resonance imaging |
WO2010110881A1 (en) * | 2009-03-27 | 2010-09-30 | Hetherington Hoby P | Improved transceiver apparatus, system, and methodology for superior in-vivo imaging of human anatomy |
US20120112748A1 (en) * | 2009-03-27 | 2012-05-10 | Hetherington Hoby P | Transceiver apparatus, system and methodology for superior In-Vivo imaging of human anatomy |
US20100271020A1 (en) * | 2009-04-22 | 2010-10-28 | Allegheny-Singer Research Institute | Steady-state-free-precession (SSFP) magnetic resonance imaging (MRI) and method |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106383364A (en) * | 2016-06-16 | 2017-02-08 | 山东大学 | Pseudo-random frequency-sweeping nuclear magnetic resonance detection instrument |
CN106850172A (en) * | 2017-01-18 | 2017-06-13 | 南京理工大学 | Millimeter wave mobile subscriber's localization method based on channel condition information |
CN107122534B (en) * | 2017-04-18 | 2020-09-18 | 中广核研究院有限公司 | Method and device for calculating power multiplication period of nuclear reactor |
Also Published As
Publication number | Publication date |
---|---|
WO2012122462A2 (en) | 2012-09-13 |
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