WO2010043446A3 - Préparations pour une libération contrôlée de principes actifs - Google Patents

Préparations pour une libération contrôlée de principes actifs Download PDF

Info

Publication number
WO2010043446A3
WO2010043446A3 PCT/EP2009/061379 EP2009061379W WO2010043446A3 WO 2010043446 A3 WO2010043446 A3 WO 2010043446A3 EP 2009061379 W EP2009061379 W EP 2009061379W WO 2010043446 A3 WO2010043446 A3 WO 2010043446A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparations
active agents
controlled release
polymer
preparation
Prior art date
Application number
PCT/EP2009/061379
Other languages
German (de)
English (en)
Other versions
WO2010043446A2 (fr
Inventor
Geoffrey Hills
Saskia KLEE-LAQUAI
Peter Lersch
Mike Farwick
Axel Kobus
Matthias Seiler
Original Assignee
Evonik Goldschmidt Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Goldschmidt Gmbh filed Critical Evonik Goldschmidt Gmbh
Publication of WO2010043446A2 publication Critical patent/WO2010043446A2/fr
Publication of WO2010043446A3 publication Critical patent/WO2010043446A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
    • A23L27/72—Encapsulation
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/85—Polyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une préparation comprenant un matière d'encapsulation et au moins un principe actif qui peut être libéré de la préparation de façon contrôlée. La préparation selon l'invention est caractérisée en ce que la matière d'encapsulation comprend au moins une substance enzymatiquement dégradable, à l'exception de glycérides, présentant un point de fusion d'au moins 35°C et en outre au moins un polymère à unités polyester. Le polymère à unités polyester présente une température de fusion d'au moins 30°C et une viscosité comprise entre 50 mPa*s et 250 Pa*s, mesurée à l'aide d'un viscosimètre rotatif à 110 °C.
PCT/EP2009/061379 2008-10-17 2009-09-03 Préparations pour une libération contrôlée de principes actifs WO2010043446A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008042923.6 2008-10-17
DE102008042923A DE102008042923A1 (de) 2008-10-17 2008-10-17 Präparate zur gesteuerten Freisetzung von Wirkstoffen

Publications (2)

Publication Number Publication Date
WO2010043446A2 WO2010043446A2 (fr) 2010-04-22
WO2010043446A3 true WO2010043446A3 (fr) 2010-06-10

Family

ID=41796510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/061379 WO2010043446A2 (fr) 2008-10-17 2009-09-03 Préparations pour une libération contrôlée de principes actifs

Country Status (2)

Country Link
DE (1) DE102008042923A1 (fr)
WO (1) WO2010043446A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6889726B2 (ja) * 2016-02-29 2021-06-18 シムライズ アーゲー 改善された界面活性剤安定性を有する芳香カプセルを製造するための方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379683B1 (en) * 1999-03-02 2002-04-30 L'oreal Nanocapsules based on dendritic polymers
DE102005051342A1 (de) * 2005-10-25 2007-04-26 Goldschmidt Gmbh Verkapselung und kontrollierte Freisetzung biologisch aktiver Wirkstoffe mit enzymatisch abbaubaren hyperverzweigten Trägerpolymeren
DE102006040123A1 (de) * 2006-08-26 2008-03-20 Evonik Degussa Gmbh Verfahren zur Herstellung von Mikropartikeln
EP1982698A1 (fr) * 2007-04-18 2008-10-22 Evonik Degussa GmbH Préparation destinée à la libération commandée de matériaux naturels bioactifs

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725658A (en) 1985-09-12 1988-02-16 General Electric Company Novel silicone-ester waxes
SE468771B (sv) 1992-02-26 1993-03-15 Perstorp Ab Dendritisk makromolekyl av polyestertyp, foerfarande foer framstaellning daerav samt anvaendning daerav
FR2772771B1 (fr) 1997-12-19 2000-01-28 Oreal Utilisation de polymeres hyperbranches et de dendrimeres comportant un groupement particulier, en tant qu'agent filmogene, les compositions filmogenes les comprenant et leur utilisation notamment en cosmetique ou en pharmacie
FR2772770B1 (fr) 1997-12-19 2000-01-28 Oreal Nouveaux composes choisis parmi les polymeres hyperbranches et les dendrimeres ayant un groupement particulier, procede de preparation, utilisation et compositions les comprenant
US6758749B2 (en) 1998-07-31 2004-07-06 Radical Gaming Concepts Ltd. Enhanced payout feature for gaming machines
US6328988B1 (en) 1999-04-23 2001-12-11 Rutgers, The State University Of New Jersey Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules
GB0125216D0 (en) 2001-10-19 2001-12-12 Univ Strathclyde Dendrimers for use in targeted delivery
WO2003037383A1 (fr) 2001-10-29 2003-05-08 The Dow Chemical Company Systeme d'administration d'un medicament contenant un dendrimere antineoplasique
US7150789B2 (en) 2002-07-29 2006-12-19 Micron Technology, Inc. Atomic layer deposition methods
MXPA05002959A (es) 2002-09-24 2005-06-03 Gumlink As Polimero degradable para goma de mascar.
CA2516548A1 (fr) 2003-02-13 2004-08-26 National Center For Scientific Research "Demokritos" Dendrimeres multifonctionnels et polymeres hyperramifies pour des systemes d'administration de medicaments et des systemes de distribution de genes
EP1525890A1 (fr) 2003-10-02 2005-04-27 Complex Biosystems GmbH Complexes protéine-protéophore
FR2873702B1 (fr) 2004-07-29 2006-12-22 Oreal Copolymere hyperbranche comprenant des monomeres selectionnes, composition le comprenant, et procede cosmetique
US20060088489A1 (en) 2004-10-27 2006-04-27 Paolo Giacomoni Sustained release of active molecules from polymers topically applied to skin or hair
DE502005000752D1 (de) 2005-06-11 2007-07-05 Tutech Innovation Gmbh Verfahren zur Mikroverkapselung von organischen Stoffen in Partikelform mittels Einsprühen eines inerten überkritischen Trägergases zusammen mit Beschichtungsmaterial für die organischen Stoffe in eine Hochdruckwirbelschicht in einem Autoklaven
DE102005037210A1 (de) 2005-08-06 2007-02-08 Degussa Ag Verfahren zur Extraktion von Fruchtwachsen
DE102005037209A1 (de) 2005-08-06 2007-02-08 Degussa Ag Verfahren zur Gewinnung von natürlichen Ölen aus pflanzlichen Bestandteilen

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379683B1 (en) * 1999-03-02 2002-04-30 L'oreal Nanocapsules based on dendritic polymers
DE102005051342A1 (de) * 2005-10-25 2007-04-26 Goldschmidt Gmbh Verkapselung und kontrollierte Freisetzung biologisch aktiver Wirkstoffe mit enzymatisch abbaubaren hyperverzweigten Trägerpolymeren
DE102006040123A1 (de) * 2006-08-26 2008-03-20 Evonik Degussa Gmbh Verfahren zur Herstellung von Mikropartikeln
EP1982698A1 (fr) * 2007-04-18 2008-10-22 Evonik Degussa GmbH Préparation destinée à la libération commandée de matériaux naturels bioactifs

Also Published As

Publication number Publication date
WO2010043446A2 (fr) 2010-04-22
DE102008042923A1 (de) 2010-04-22

Similar Documents

Publication Publication Date Title
WO2006127559A3 (fr) Conditionnement portant un marquage pour des systemes de distribution destines a gerer la liberation d'ingredients fonctionnels dans une composition comestible
GB2488075B (en) Polymer composition, swellable composition comprising the polymer composition, and articles including the swellable composition
IL208937A0 (en) Cell binding agent cytotoxic drug conjugates, compositions comprising the same and uses thereof
RU2018129725A (ru) Изделия, высвобождающие активный ингредиент
WO2008104960A8 (fr) Compositions et/ou articles comprenant un matériau complexe à cyclodextrine
WO2008104954A3 (fr) Compositions et/ou articles comprenant une matière complexant la cyclodextrine
IL208936A0 (en) Cell binding agent drug conjugates, compositions comprising the same and uses thereof
WO2011000686A3 (fr) Composition de mousse
MX2010004884A (es) Composicion cosmetica en polvo.
WO2009097508A3 (fr) Procédés et compositions pour la cicatrisation
WO2010095151A3 (fr) Composition granulaire hydro-dispersible
MX2010004366A (es) Materiales inmiscibles en agua como vehiculos para suministro de farmacos.
WO2011084620A3 (fr) Particules pour administration de plusieurs agents
WO2008039901A3 (fr) Composition d'adhésif autocollant thermofusible qui comprend de la cire végétale et articles comprenant celle-ci
IL211180A0 (en) Multi-arm polymeric alkanoate conjugates, compositions comprising the same and uses thereof
WO2010078538A3 (fr) Supports améliorés pour la distribution de microparticules à des tissus et fluides corporels
WO2009135155A3 (fr) Bandes de vêtement comportant des compositions polymères
WO2009052171A3 (fr) Système et composition de remédiation à libération contrôlée
WO2007120855A3 (fr) Plâtre de protection
WO2011109732A3 (fr) Gels thermiques inverses et leurs utilisations
NZ597326A (en) Matrix carrier compositions, methods and uses
CA2745784A1 (fr) Procede de fabrication de microparticules a liberation prolongee
EP2380499A3 (fr) Système de canule
WO2011126839A3 (fr) Compositions et procédés pour la rétention améliorée d'une composition pharmaceutique à un site d'administration local
WO2008002691A3 (fr) Procédé de fabrication d'un système de libération de composants actifs faisant partie intégrante d'une composition comestible

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09782543

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09782543

Country of ref document: EP

Kind code of ref document: A2