WO2010035985A3 - Method for producing taxane derivatives - Google Patents

Method for producing taxane derivatives Download PDF

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Publication number
WO2010035985A3
WO2010035985A3 PCT/KR2009/005279 KR2009005279W WO2010035985A3 WO 2010035985 A3 WO2010035985 A3 WO 2010035985A3 KR 2009005279 W KR2009005279 W KR 2009005279W WO 2010035985 A3 WO2010035985 A3 WO 2010035985A3
Authority
WO
WIPO (PCT)
Prior art keywords
taxane derivatives
derivatives
oxazinan
present
phenyl
Prior art date
Application number
PCT/KR2009/005279
Other languages
French (fr)
Korean (ko)
Other versions
WO2010035985A2 (en
Inventor
김문성
유무희
이재걸
김용직
최준호
성시영
임홍규
차대원
손병화
류기문
Original Assignee
동아제약 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 동아제약 주식회사 filed Critical 동아제약 주식회사
Priority to JP2011528922A priority Critical patent/JP5552489B2/en
Publication of WO2010035985A2 publication Critical patent/WO2010035985A2/en
Publication of WO2010035985A3 publication Critical patent/WO2010035985A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The present invention relates to a method for producing taxane derivatives with anticancer activity. The method of the present invention produces taxane derivatives in a short time under mild conditions by employing phenyl oxazinan dione compounds which are novel compounds, as a reactant, such that the phenyl oxazinan dione compounds react to baccatin III derivatives.
PCT/KR2009/005279 2008-09-26 2009-09-17 Method for producing taxane derivatives WO2010035985A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2011528922A JP5552489B2 (en) 2008-09-26 2009-09-17 Method for producing taxane derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0094529 2008-09-26
KR1020080094529A KR101014438B1 (en) 2008-09-26 2008-09-26 The process for preparing taxane derivatives

Publications (2)

Publication Number Publication Date
WO2010035985A2 WO2010035985A2 (en) 2010-04-01
WO2010035985A3 true WO2010035985A3 (en) 2010-06-17

Family

ID=42060243

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/005279 WO2010035985A2 (en) 2008-09-26 2009-09-17 Method for producing taxane derivatives

Country Status (3)

Country Link
JP (1) JP5552489B2 (en)
KR (1) KR101014438B1 (en)
WO (1) WO2010035985A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0170430A1 (en) * 1984-07-05 1986-02-05 The Wellcome Foundation Limited Heterocyclic pharmaceutical compounds, preparation and use
US5319105A (en) * 1989-12-22 1994-06-07 Abbott Laboratories Derivatives and anologs of monoethylglycinexylidide
US5532363A (en) * 1989-11-14 1996-07-02 Florida State University Heteroaryl substituted oxazinone compounds for the preparation of taxol
WO1998017656A1 (en) * 1996-10-24 1998-04-30 Institute Armand-Frappier A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
WO1999014209A1 (en) * 1997-09-17 1999-03-25 Kabushiki Kaisha Yakult Honsha New taxane derivatives
US6911549B1 (en) * 1992-12-15 2005-06-28 Jackson B. Hester, Jr. Method of preparing a taxol derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2604337B1 (en) * 1986-09-26 1989-01-06 Stela Inox PROCESS FOR TREATING FISH BY CUTTING OUT AND DEVICE FOR CARRYING OUT THIS METHOD
FR2687150B1 (en) * 1992-02-07 1995-04-28 Rhone Poulenc Rorer Sa PROCESS FOR THE PREPARATION OF TAXANE DERIVATIVES.
US20050288520A1 (en) * 2004-06-25 2005-12-29 Phytogen Life Sciences Inc. One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0170430A1 (en) * 1984-07-05 1986-02-05 The Wellcome Foundation Limited Heterocyclic pharmaceutical compounds, preparation and use
US5532363A (en) * 1989-11-14 1996-07-02 Florida State University Heteroaryl substituted oxazinone compounds for the preparation of taxol
US5319105A (en) * 1989-12-22 1994-06-07 Abbott Laboratories Derivatives and anologs of monoethylglycinexylidide
US6911549B1 (en) * 1992-12-15 2005-06-28 Jackson B. Hester, Jr. Method of preparing a taxol derivative
WO1998017656A1 (en) * 1996-10-24 1998-04-30 Institute Armand-Frappier A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
WO1999014209A1 (en) * 1997-09-17 1999-03-25 Kabushiki Kaisha Yakult Honsha New taxane derivatives

Also Published As

Publication number Publication date
JP2012503646A (en) 2012-02-09
KR20100035261A (en) 2010-04-05
KR101014438B1 (en) 2011-02-14
JP5552489B2 (en) 2014-07-16
WO2010035985A2 (en) 2010-04-01

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