WO2012035303A8 - A novel process for synthesis of ramelteon, and key intermediates for the synthesis of ramelteon - Google Patents

A novel process for synthesis of ramelteon, and key intermediates for the synthesis of ramelteon Download PDF

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Publication number
WO2012035303A8
WO2012035303A8 PCT/GB2011/001355 GB2011001355W WO2012035303A8 WO 2012035303 A8 WO2012035303 A8 WO 2012035303A8 GB 2011001355 W GB2011001355 W GB 2011001355W WO 2012035303 A8 WO2012035303 A8 WO 2012035303A8
Authority
WO
WIPO (PCT)
Prior art keywords
ramelteon
synthesis
novel process
key intermediates
intermediates
Prior art date
Application number
PCT/GB2011/001355
Other languages
French (fr)
Other versions
WO2012035303A2 (en
WO2012035303A3 (en
Inventor
Dharmaraj Ramachandra Rao
Rajendra Narayanrao Kankan
Maruti Ganpati Ghagare
Sandip Vasant Chikhalikar
Original Assignee
Cipla Limited
Cottrill, Emily Elizabeth Helen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Limited, Cottrill, Emily Elizabeth Helen filed Critical Cipla Limited
Publication of WO2012035303A2 publication Critical patent/WO2012035303A2/en
Publication of WO2012035303A8 publication Critical patent/WO2012035303A8/en
Publication of WO2012035303A3 publication Critical patent/WO2012035303A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems

Abstract

The present invention relates to a novel process for synthesis of ramelteon, and key intermediates for the synthesis of ramelteon.
PCT/GB2011/001355 2010-09-17 2011-09-16 A novel process for synthesis of ramelteon, and key intermediates for the synthesis of ramelteon WO2012035303A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2605/MUM/2010 2010-09-17
IN2605MU2010 2010-09-17

Publications (3)

Publication Number Publication Date
WO2012035303A2 WO2012035303A2 (en) 2012-03-22
WO2012035303A8 true WO2012035303A8 (en) 2012-06-14
WO2012035303A3 WO2012035303A3 (en) 2012-08-23

Family

ID=44677962

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2011/001355 WO2012035303A2 (en) 2010-09-17 2011-09-16 A novel process for synthesis of ramelteon, and key intermediates for the synthesis of ramelteon

Country Status (1)

Country Link
WO (1) WO2012035303A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103664849B (en) * 2012-08-31 2017-03-29 上海阳帆医药科技有限公司 Prepare the 2 (methods of 1,6,7,8 tetrahydrochysene 2H indenos [5,4 b] furan, 8 subunit ethamine
CN104119306A (en) * 2013-04-24 2014-10-29 辰欣药业股份有限公司 Preparation method for 2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine
CN104529958B (en) * 2015-01-08 2016-08-31 济川药业集团有限公司 A kind of preparation method of ramelteon
CN107325066A (en) * 2017-05-23 2017-11-07 万特制药(海南)有限公司 The method for splitting of ramelteon intermediate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0885210B2 (en) 1996-03-08 2008-06-18 Takeda Pharmaceutical Company Limited Tricylic compounds having binding affinity for melatonin receptors, their production and use
US6034239A (en) 1996-03-08 2000-03-07 Takeda Chemical Industries, Ltd. Tricyclic compounds, their production and use
TWI400220B (en) 2004-09-13 2013-07-01 Takeda Pharmaceutical Process for producing optically active amine derivatives
WO2008062468A2 (en) 2006-10-26 2008-05-29 Cadila Healthcare Limited Process for the preparation of optically pure indeno [5,4-b] furan derivatives
US20080242877A1 (en) 2007-02-26 2008-10-02 Vinod Kumar Kansal Intermediates and processes for the synthesis of Ramelteon
WO2009106966A1 (en) 2008-02-28 2009-09-03 Medichem, S.A. Process for preparing ramelteon.
US20100152468A1 (en) 2008-10-16 2010-06-17 Teva Pharmaceutical Industries Ltd. Process for the synthesis of ramelteon and its intermediates
BRPI0914068A2 (en) 2008-11-14 2015-10-13 Watson Pharma Private Ltd n- [2- (1,6,7,8-tetrahydro-2h-indeno [5,4-b] furan-8-yl)] ethylamine and ramelteon resolution process
US20120071673A1 (en) * 2009-02-12 2012-03-22 Lek Pharmaceuticals D.D. Synthesis of (s)-n-[2-(1,6,7,8-tetrahydro-2h-indeno-[5,4-b]furan-8-yl)ethyl]propionamide
EP2406242B1 (en) * 2009-03-10 2013-06-05 Industriale Chimica S.R.L. Process for the preparation of ramelteon

Also Published As

Publication number Publication date
WO2012035303A2 (en) 2012-03-22
WO2012035303A3 (en) 2012-08-23

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