WO2010023694A3 - Crystalline forms of gabapentin and process for their preparation - Google Patents

Crystalline forms of gabapentin and process for their preparation Download PDF

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Publication number
WO2010023694A3
WO2010023694A3 PCT/IN2009/000480 IN2009000480W WO2010023694A3 WO 2010023694 A3 WO2010023694 A3 WO 2010023694A3 IN 2009000480 W IN2009000480 W IN 2009000480W WO 2010023694 A3 WO2010023694 A3 WO 2010023694A3
Authority
WO
WIPO (PCT)
Prior art keywords
gabapentin
crystalline forms
preparation
relates
present
Prior art date
Application number
PCT/IN2009/000480
Other languages
French (fr)
Other versions
WO2010023694A2 (en
Inventor
Nagarajan Kuppuswamy
Rajender Pershad Gupta
Arulselvan Mariadas
Original Assignee
Hikal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hikal Ltd filed Critical Hikal Ltd
Publication of WO2010023694A2 publication Critical patent/WO2010023694A2/en
Publication of WO2010023694A3 publication Critical patent/WO2010023694A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to crystalline forms of gabapentin and processes for preparing the same. The present invention particularly relates to crystalline forms of gabapentin form II and Form IIB. The invention also relates to gabapentin form IA and form IB. The gabapentin forms IA and IB are hydrated forma that contain about 20% of water by weight which corresponds to hemipentahydrate. The present invention also relates to the process for preparing these crystalline forms of gabapentin.
PCT/IN2009/000480 2008-09-01 2009-09-01 Crystalline forms of gabapentin and process thereof WO2010023694A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2138/CHE/2008 2008-09-01
IN2138CH2008 2008-09-01

Publications (2)

Publication Number Publication Date
WO2010023694A2 WO2010023694A2 (en) 2010-03-04
WO2010023694A3 true WO2010023694A3 (en) 2010-04-22

Family

ID=41510697

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000480 WO2010023694A2 (en) 2008-09-01 2009-09-01 Crystalline forms of gabapentin and process thereof

Country Status (1)

Country Link
WO (1) WO2010023694A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104230735A (en) * 2014-08-28 2014-12-24 太仓运通生物化工有限公司 Preparation method of gabapentin
CN104402796A (en) * 2014-11-26 2015-03-11 太仓运通生物化工有限公司 Preparation method for 3,3-amylidene butyrolactam
CN112321442B (en) * 2020-11-06 2022-02-11 中国药科大学 Salt of gabapentin and 2, 6-pyridinedicarboxylic acid, preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255526B1 (en) * 1996-12-24 2001-07-03 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin
WO2003031391A1 (en) * 2001-10-09 2003-04-17 Warner-Lambert Company Llc New anhydrous crystalline forms of gabapentin
WO2004046085A1 (en) * 2002-11-20 2004-06-03 Hikal Ltd. Process for the preparation of amino methyl cyclo alkane acetic acids
WO2004093779A2 (en) * 2003-04-21 2004-11-04 Matrix Laboratories Ltd Process for the preparation of gabapentin form-ii

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255526B1 (en) * 1996-12-24 2001-07-03 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin
WO2003031391A1 (en) * 2001-10-09 2003-04-17 Warner-Lambert Company Llc New anhydrous crystalline forms of gabapentin
WO2004046085A1 (en) * 2002-11-20 2004-06-03 Hikal Ltd. Process for the preparation of amino methyl cyclo alkane acetic acids
WO2004093779A2 (en) * 2003-04-21 2004-11-04 Matrix Laboratories Ltd Process for the preparation of gabapentin form-ii

Also Published As

Publication number Publication date
WO2010023694A2 (en) 2010-03-04

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