WO2010019725A3 - Polypeptides noeuds pour un ensemble nanostructure - Google Patents

Polypeptides noeuds pour un ensemble nanostructure Download PDF

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Publication number
WO2010019725A3
WO2010019725A3 PCT/US2009/053628 US2009053628W WO2010019725A3 WO 2010019725 A3 WO2010019725 A3 WO 2010019725A3 US 2009053628 W US2009053628 W US 2009053628W WO 2010019725 A3 WO2010019725 A3 WO 2010019725A3
Authority
WO
WIPO (PCT)
Prior art keywords
dimensional
polypeptides
node
streptavidin
nanostructure assembly
Prior art date
Application number
PCT/US2009/053628
Other languages
English (en)
Other versions
WO2010019725A8 (fr
WO2010019725A9 (fr
WO2010019725A2 (fr
Inventor
Francis R. Salemme
Mark A. Rould
Patricia C. Weber
Original Assignee
Imiplex Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imiplex Llc filed Critical Imiplex Llc
Publication of WO2010019725A2 publication Critical patent/WO2010019725A2/fr
Publication of WO2010019725A8 publication Critical patent/WO2010019725A8/fr
Publication of WO2010019725A3 publication Critical patent/WO2010019725A3/fr
Priority to US12/892,911 priority Critical patent/US9102526B2/en
Publication of WO2010019725A9 publication Critical patent/WO2010019725A9/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention porte sur des protéines synthétisées par génie génétique qui sont utilisées dans l'assemblage d'ensembles nanostructures bidimensionnels et tridimensionnels, sur la base d'une conception systématique et sur la production de structures de nœud de protéine qui peuvent être interconnectées, par exemple, par de la streptavidine ou des entretoises incorporant de la streptavidine pour produire des structures avec des dimensions et une géométrie définies. Des ensembles nanostructures ayant une utilité en tant que dispositifs fonctionnels ou en tant que réserves pour la formation de motifs de substrats ont des architectures comprenant des polygones, des polyèdres, des réseaux bidimensionnels et des réseaux tridimensionnels.
PCT/US2009/053628 2008-08-12 2009-08-13 Polypeptides nœuds pour un ensemble nanostructure WO2010019725A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/892,911 US9102526B2 (en) 2008-08-12 2010-09-28 Node polypeptides for nanostructure assembly

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13609708P 2008-08-12 2008-08-12
US61/136,097 2008-08-12
US17319809P 2009-04-27 2009-04-27
US61/173,198 2009-04-27

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US12/589,529 Continuation-In-Part US20100256342A1 (en) 2008-08-12 2009-04-27 Protein nodes for controlled nanoscale assembly

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/892,911 Continuation-In-Part US9102526B2 (en) 2008-08-12 2010-09-28 Node polypeptides for nanostructure assembly

Publications (4)

Publication Number Publication Date
WO2010019725A2 WO2010019725A2 (fr) 2010-02-18
WO2010019725A8 WO2010019725A8 (fr) 2010-04-15
WO2010019725A3 true WO2010019725A3 (fr) 2010-09-10
WO2010019725A9 WO2010019725A9 (fr) 2010-11-11

Family

ID=41669664

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/053628 WO2010019725A2 (fr) 2008-08-12 2009-08-13 Polypeptides nœuds pour un ensemble nanostructure

Country Status (1)

Country Link
WO (1) WO2010019725A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8993714B2 (en) 2007-10-26 2015-03-31 Imiplex Llc Streptavidin macromolecular adaptor and complexes thereof
US9102526B2 (en) 2008-08-12 2015-08-11 Imiplex Llc Node polypeptides for nanostructure assembly
CA2749121A1 (fr) * 2009-01-09 2010-07-15 Codexis, Inc. Polypeptides d'anhydrase carbonique et leurs utilisations
WO2010132363A1 (fr) 2009-05-11 2010-11-18 Imiplex Llc Procédé de fabrication d'une nanostructure protéique
KR101189193B1 (ko) * 2010-06-23 2012-10-09 한국과학기술연구원 저분자열충격단백질이 포함된 융합 단백질, 이에 의해 구성된 케이지 단백질 및 이의 신규한 용도
US10248758B2 (en) 2013-02-07 2019-04-02 University Of Washington Through Its Center For Commercialization Self-assembling protein nanostructures
GB201314945D0 (en) 2013-08-21 2013-10-02 Crysalin Ltd Protein crystals
US9630994B2 (en) 2014-11-03 2017-04-25 University Of Washington Polypeptides for use in self-assembling protein nanostructures
WO2018047856A1 (fr) * 2016-09-06 2018-03-15 学校法人慶應義塾 Protéine fusionnée, corps structural, agent de piégeage, méthode de piégeage, adn et vecteur
BR112019020661A2 (pt) 2017-04-04 2020-05-05 University Of Washington nanoestruturas de proteína de auto-montagem que exibem proteínas f de paramixovírus e/ou pneumovírus e seu uso
CN108444957B (zh) * 2018-02-05 2020-07-17 南京医科大学 一种基于dna-银纳米簇与聚吡咯纳米粒的转录因子检测方法
AU2019228551A1 (en) 2018-02-28 2020-10-15 University Of Washington Self-assembling nanostructure vaccines
CN109468934B (zh) * 2018-09-30 2020-09-04 重庆市智翔铺道技术工程有限公司 一种路面图案喷涂装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050130258A1 (en) * 2001-11-08 2005-06-16 Trent Jonathan D. Ordered biological nanostructures formed from chaperonin polypeptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050130258A1 (en) * 2001-11-08 2005-06-16 Trent Jonathan D. Ordered biological nanostructures formed from chaperonin polypeptides

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
"1fsz. PDB", 24 June 1997 (1997-06-24), Retrieved from the Internet <URL:http://www.pdb.org/pdb/home/home.do> [retrieved on 20100621] *
"1thj PDB", 2 April 1996 (1996-04-02), Retrieved from the Internet <URL:http://www.pdb.org/pdb/home/home.do> [retrieved on 20100621] *
"1vcg PDB", 8 March 2004 (2004-03-08), Retrieved from the Internet <URL:http:///www.pdb.org/pdb/home/home.do> [retrieved on 20100621] *
"vdh PDB", 22 March 2004 (2004-03-22), Retrieved from the Internet <URL:http://www.pdb.org/pdb/home/home.do> [retrieved on 20100621] *
LIVNAH ET AL.: "Three-dimensional structures of avidin and the avidin-biotin complex", PROC NATL ACAD SCI USA, vol. 90, June 1993 (1993-06-01), pages 5076 - 5080 *
RINGLER ET AL.: "Self-assembly of proteins into designed networks'", SCIENCE, vol. 302, 3 October 2003 (2003-10-03), pages 106 - 109 *
SALEMME: "Chapter 1:Design principles for self-assembling devices from macromolecules", BIONANOTECHNOLOGY, 2006, pages 1 - 8 *

Also Published As

Publication number Publication date
WO2010019725A8 (fr) 2010-04-15
WO2010019725A9 (fr) 2010-11-11
WO2010019725A2 (fr) 2010-02-18

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