WO2010005235A3 - Method for preparing optically pure lactide using an enzyme conversion reaction - Google Patents

Method for preparing optically pure lactide using an enzyme conversion reaction Download PDF

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Publication number
WO2010005235A3
WO2010005235A3 PCT/KR2009/003736 KR2009003736W WO2010005235A3 WO 2010005235 A3 WO2010005235 A3 WO 2010005235A3 KR 2009003736 W KR2009003736 W KR 2009003736W WO 2010005235 A3 WO2010005235 A3 WO 2010005235A3
Authority
WO
WIPO (PCT)
Prior art keywords
optically pure
lactide
conversion reaction
preparing optically
pure lactide
Prior art date
Application number
PCT/KR2009/003736
Other languages
French (fr)
Korean (ko)
Other versions
WO2010005235A2 (en
Inventor
김용환
조대행
김현숙
박혜정
전병욱
Original Assignee
주식회사 제이앤드제이 캐미칼
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 제이앤드제이 캐미칼 filed Critical 주식회사 제이앤드제이 캐미칼
Publication of WO2010005235A2 publication Critical patent/WO2010005235A2/en
Publication of WO2010005235A3 publication Critical patent/WO2010005235A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to a method for preparing optically pure lactide using an enzyme conversion reaction. In detail, the present invention relates to a method for preparing optically pure lactide by using an enzyme that uses, as a substrate, only one type of enantiometer from among optically impure lactic acid or alkyl lactate. The optically pure lactide prepared according to the present invention is useful in industry as the physical property of the copolymer polymerized by said lactide is far superior to the physical property of the copolymer polymerized by optically impure lactide.
PCT/KR2009/003736 2008-07-08 2009-07-08 Method for preparing optically pure lactide using an enzyme conversion reaction WO2010005235A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0065878 2008-07-08
KR1020080065878A KR101012483B1 (en) 2008-07-08 2008-07-08 Method for Synthesis of Chirally Pure Lactide and Separation of Chirally Pure Lactic Acid or Alkyl Lactate through Enzymatic Transformation

Publications (2)

Publication Number Publication Date
WO2010005235A2 WO2010005235A2 (en) 2010-01-14
WO2010005235A3 true WO2010005235A3 (en) 2010-04-01

Family

ID=41507576

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/003736 WO2010005235A2 (en) 2008-07-08 2009-07-08 Method for preparing optically pure lactide using an enzyme conversion reaction

Country Status (2)

Country Link
KR (1) KR101012483B1 (en)
WO (1) WO2010005235A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110116889A (en) 2010-04-20 2011-10-26 현대자동차주식회사 Manufacturing method of optically active d type lactic acid using by-products prepared from rice polishing process
BE1019914A3 (en) * 2011-04-26 2013-02-05 Galactic Sa PROCESS FOR SEPARATING THE TWO ISOMERS OF LACTIC ACID IN THE PRESENCE OF A IMMOBILIZED LIPASE
CN103687955B (en) 2011-07-15 2016-05-11 普拉克西卡有限公司 Separation method
KR20130041640A (en) 2011-10-17 2013-04-25 엘지전자 주식회사 Air conditioner and control method of the same
EP3112777B1 (en) 2011-10-25 2018-11-14 LG Electronics Inc. Air conditioner and operation method of the same
KR101886434B1 (en) * 2012-02-29 2018-08-07 현대자동차주식회사 A Method for Lactide Synthesis from Lactic acid
KR101459819B1 (en) 2012-04-04 2014-11-07 현대자동차주식회사 A method for lactide synthesis from lactic acid salt
KR101428340B1 (en) 2012-12-31 2014-08-07 현대자동차주식회사 A method for preparing lactide using a ionic solvent
CN106831700B (en) * 2017-03-28 2019-05-24 南京大学 A kind of method of full green sealing circulation technology production optical voidness L-/D- lactide

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100261850B1 (en) * 1992-01-24 2000-08-01 패트릭 알 그루버 Improved process for preparing polylactide
JP2002300898A (en) * 2001-01-31 2002-10-15 Shimadzu Corp Method for producing lactide from fermented lactic acid as raw material and method for producing polylactic acid
JP2002335989A (en) * 2001-05-14 2002-11-26 Ihara Chem Ind Co Ltd Method for purifying isobutyl d-lactate
WO2004013217A1 (en) * 2002-08-05 2004-02-12 Keio University Method of enzymatic depolymerization of polylactic acid and process for producing polylactic acid from depolymerization product
KR20050103691A (en) * 2004-04-27 2005-11-01 한국화학연구원 Process for preparation of alkyl s-(l)-lactate and alkyl r-(d)-o-acyllactate using lipase
US7144977B2 (en) * 1997-10-14 2006-12-05 Cargill, Incorporated Lactic acid processing; methods; arrangements; and, products

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258488A (en) 1992-01-24 1993-11-02 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
KR100592794B1 (en) 2005-01-06 2006-06-28 한국화학연구원 Method for preparation of alkyl lactate from lactide using lipase

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100261850B1 (en) * 1992-01-24 2000-08-01 패트릭 알 그루버 Improved process for preparing polylactide
US7144977B2 (en) * 1997-10-14 2006-12-05 Cargill, Incorporated Lactic acid processing; methods; arrangements; and, products
JP2002300898A (en) * 2001-01-31 2002-10-15 Shimadzu Corp Method for producing lactide from fermented lactic acid as raw material and method for producing polylactic acid
JP2002335989A (en) * 2001-05-14 2002-11-26 Ihara Chem Ind Co Ltd Method for purifying isobutyl d-lactate
WO2004013217A1 (en) * 2002-08-05 2004-02-12 Keio University Method of enzymatic depolymerization of polylactic acid and process for producing polylactic acid from depolymerization product
KR20050103691A (en) * 2004-04-27 2005-11-01 한국화학연구원 Process for preparation of alkyl s-(l)-lactate and alkyl r-(d)-o-acyllactate using lipase

Also Published As

Publication number Publication date
WO2010005235A2 (en) 2010-01-14
KR20100005820A (en) 2010-01-18
KR101012483B1 (en) 2011-02-09

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