WO2010004562A3 - Procédés et compositions permettant de détecter un cancer colorectal - Google Patents

Procédés et compositions permettant de détecter un cancer colorectal Download PDF

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Publication number
WO2010004562A3
WO2010004562A3 PCT/IL2009/000683 IL2009000683W WO2010004562A3 WO 2010004562 A3 WO2010004562 A3 WO 2010004562A3 IL 2009000683 W IL2009000683 W IL 2009000683W WO 2010004562 A3 WO2010004562 A3 WO 2010004562A3
Authority
WO
WIPO (PCT)
Prior art keywords
colorectal cancer
compositions
methods
detecting colorectal
detecting
Prior art date
Application number
PCT/IL2009/000683
Other languages
English (en)
Other versions
WO2010004562A2 (fr
Inventor
Baruch Brenner
Shlomit Gilad
Yaron Goren
Ayelet Chajut
Original Assignee
Rosetta Genomics Ltd.
Mor Research Applications Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosetta Genomics Ltd., Mor Research Applications Ltd. filed Critical Rosetta Genomics Ltd.
Publication of WO2010004562A2 publication Critical patent/WO2010004562A2/fr
Publication of WO2010004562A3 publication Critical patent/WO2010004562A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne un procédé de réalisation d’une détection précoce minimalement invasive d’un cancer colorectal et/ou de cellules précurseurs du cancer colorectal. Cette détection s’effectue au moyen de molécules de microARN associées au cancer colorectal, ainsi que de diverses molécules d’acide nucléique liées à celles-ci ou dérivées de celles-ci.
PCT/IL2009/000683 2008-07-09 2009-07-08 Procédés et compositions permettant de détecter un cancer colorectal WO2010004562A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7913608P 2008-07-09 2008-07-09
US61/079,136 2008-07-09

Publications (2)

Publication Number Publication Date
WO2010004562A2 WO2010004562A2 (fr) 2010-01-14
WO2010004562A3 true WO2010004562A3 (fr) 2010-04-01

Family

ID=41204073

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2009/000683 WO2010004562A2 (fr) 2008-07-09 2009-07-08 Procédés et compositions permettant de détecter un cancer colorectal

Country Status (1)

Country Link
WO (1) WO2010004562A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010135692A2 (fr) 2009-05-22 2010-11-25 Asuragen, Inc. Biomarqueurs miarn d'une maladie prostatique
JP5995721B2 (ja) 2009-08-28 2016-09-21 アスラジェン， インコーポレイテッド 肺疾患のｍｉＲＮＡバイオマーカー
WO2012048236A1 (fr) * 2010-10-08 2012-04-12 Baylor Research Institute Microarn (miarn) en tant que biomarqueurs pour l'identification du cancer colorectal familial et non-familial
CN103384829A (zh) * 2011-01-13 2013-11-06 财团法人工业技术研究院 预测大肠直肠癌复发的生物标记
NO3051026T3 (fr) 2011-10-21 2018-07-28
WO2016034715A2 (fr) * 2014-09-05 2016-03-10 Prestizia Methode de prediction de l'evolution clinique du cancer colorectal

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009008720A2 (fr) * 2007-07-06 2009-01-15 Koninklijke Nederlandse Akademie Van Wetenschappen Petites molécules d'arn, leurs précurseurs, les moyens et procédés permettant de les détecter et leurs utilisations pour le typage d'échantillons
WO2009025852A2 (fr) * 2007-08-22 2009-02-26 Xenomics, Inc. Procédés d'utilisation d'arnmi pour la détection de la mort cellulaire in vivo
WO2009057113A2 (fr) * 2007-10-31 2009-05-07 Rosetta Genomics Ltd. Diagnostic et pronostic de cancers spécifiques

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009008720A2 (fr) * 2007-07-06 2009-01-15 Koninklijke Nederlandse Akademie Van Wetenschappen Petites molécules d'arn, leurs précurseurs, les moyens et procédés permettant de les détecter et leurs utilisations pour le typage d'échantillons
WO2009025852A2 (fr) * 2007-08-22 2009-02-26 Xenomics, Inc. Procédés d'utilisation d'arnmi pour la détection de la mort cellulaire in vivo
WO2009057113A2 (fr) * 2007-10-31 2009-05-07 Rosetta Genomics Ltd. Diagnostic et pronostic de cancers spécifiques

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BANDRÉS E ET AL: "Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues", MOLECULAR CANCER, BIOMED CENTRAL, LONDON, GB, vol. 5, no. 1, 19 July 2006 (2006-07-19), pages 29, XP021018291, ISSN: 1476-4598 *
CHAJUT AYELET ET AL: "MicroRNA profiles in body fluids as a novel class of biomarkers.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 49, April 2008 (2008-04-01), & 99TH ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-CANCER-RESEARCH; SAN DIEGO, CA, USA; APRIL 12 -16, 2008, pages 1231, XP008107302, ISSN: 0197-016X *
CHEN XI ET AL: "Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases", CELL RESEARCH, vol. 18, no. 10, October 2008 (2008-10-01), pages 997 - 1006, XP002552942, ISSN: 1001-0602 *
LAWRIE CHARLES H ET AL: "Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma", BRITISH JOURNAL OF HAEMATOLOGY, BLACKWELL PUBLISHING LTD, vol. 141, no. 5, 1 May 2008 (2008-05-01), pages 672 - 675, XP002518103, ISSN: 1365-2141, [retrieved on 20080303] *
MITCHELL PATRICK S ET AL: "Circulating microRNAs as stable blood-based markers for cancer detection", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,, vol. 105, no. 30, 29 July 2008 (2008-07-29), pages 10513 - 10518, XP002545745 *
NAKAJIMA GO ET AL: "NON-CODING MICRORNAS HSA-LET-7G AND HSA-MIR-181B ARE ASSOCIATED WITH CHEMORESPONSE TO S-1 IN COLON CANCER", CANCER GENOMICS AND PROTEOMICS, XX, vol. 3, no. 5, 1 September 2006 (2006-09-01), pages 317 - 324, XP008075172, ISSN: 1109-6535 *
SUNG J J ET AL: "1070 Differential Expression of MicroRNAs in Plasma of Colorectal Cancer Patients: A Potential Marker for Colorectal Cancer Screening", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA, vol. 136, no. 5, 1 May 2009 (2009-05-01), pages A - 165, XP026111290, ISSN: 0016-5085, [retrieved on 20090501] *
XI Y ET AL: "Prognostic Values of microRNAs in Colorectal Cancer", BIOMARKER INSIGHTS, LIBERTAS ACADEMICA LTD, NEW ZEALAND, vol. 2, 7 February 2007 (2007-02-07), pages 113 - 121, XP002512901, ISSN: 1177-2719, Retrieved from the Internet <URL:http://www.la-press.com/prognostic-values-of-micrornas-in-colorectal- cancer-a23> [retrieved on 20060101] *

Also Published As

Publication number Publication date
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