WO2009151304A3 - 에이케이에이피일이를 함유하는 조성물 및 동물 모델로서 에이케이에이피일이 돌연변이 제브라피쉬의 용도 - Google Patents

에이케이에이피일이를 함유하는 조성물 및 동물 모델로서 에이케이에이피일이 돌연변이 제브라피쉬의 용도 Download PDF

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Publication number
WO2009151304A3
WO2009151304A3 PCT/KR2009/003178 KR2009003178W WO2009151304A3 WO 2009151304 A3 WO2009151304 A3 WO 2009151304A3 KR 2009003178 W KR2009003178 W KR 2009003178W WO 2009151304 A3 WO2009151304 A3 WO 2009151304A3
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WO
WIPO (PCT)
Prior art keywords
akap12
animal model
zebrafish
circulatory
mutant zebrafish
Prior art date
Application number
PCT/KR2009/003178
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English (en)
French (fr)
Other versions
WO2009151304A2 (ko
Inventor
김규원
권혁범
Original Assignee
서울대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 서울대학교 산학협력단 filed Critical 서울대학교 산학협력단
Priority to US12/997,653 priority Critical patent/US20110162092A1/en
Publication of WO2009151304A2 publication Critical patent/WO2009151304A2/ko
Publication of WO2009151304A3 publication Critical patent/WO2009151304A3/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

본 발명은 AKAP12(A-Kinase anchoring protein 12)를 함유하는 조성물 및 동물 모델로서 AKAP12 돌연변이 제브라피쉬(zebrafish)의 용도에 관한 것으로, 보다 상세하게는 제브라피쉬 akap12 mRNA를 넉다운(knckdown)시킨 제브라피쉬는 꼬리 쪽 부위가 휘거나 짧아진 형태를 나타내고 정상적인 운동 기능을 수행하지 못하고, 뇌의 미세혈관의 형태가 일정한 형태를 나타내지 못하며, 심장의 형태가 변화하고 심장박동이 불규칙적으로 약한 박동을 하며, 뇌실, 망막, 심장 및 몸통에서 전반적으로 출혈이 관찰되는 등 다양한 순환기적 또는 발생학적 결함이 나타나며, AKAP12 주입시 순환기적 및 발생학적 결함이 치유됨을 확인함으로써 AKAP12는 이를 유효성분으로 함유하는 AKAP12의 결핍에 의해 야기되는 순환기적 또는 발생학적 결함 예방 및 치료용 조성물, 및 출혈 저해제로 이용될 수 있으며, AKAP12 결핍 돌연변이 제브라피쉬가 순환기적 또는 발생학적 결함 치료제 효과 검증 동물 모델로서 유용하게 이용될 수 있다.
PCT/KR2009/003178 2008-06-13 2009-06-12 에이케이에이피일이를 함유하는 조성물 및 동물 모델로서 에이케이에이피일이 돌연변이 제브라피쉬의 용도 WO2009151304A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/997,653 US20110162092A1 (en) 2008-06-13 2009-06-12 Composition comprised of akap12 and uses of akap12 mutant zebrafish as an animal model

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0055700 2008-06-13
KR1020080055700A KR101133289B1 (ko) 2008-06-13 2008-06-13 Ａｋａｐ１２를 함유하는 조성물 및 동물 모델로서ａｋａｐ１２ 돌연변이 제브라피쉬의 용도

Publications (2)

Publication Number Publication Date
WO2009151304A2 WO2009151304A2 (ko) 2009-12-17
WO2009151304A3 true WO2009151304A3 (ko) 2010-03-04

Family

ID=41417271

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/003178 WO2009151304A2 (ko) 2008-06-13 2009-06-12 에이케이에이피일이를 함유하는 조성물 및 동물 모델로서 에이케이에이피일이 돌연변이 제브라피쉬의 용도

Country Status (3)

Country Link
US (1) US20110162092A1 (ko)
KR (1) KR101133289B1 (ko)
WO (1) WO2009151304A2 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012115439A2 (en) * 2011-02-25 2012-08-30 Snu R&Db Foundation Composition comprising expression or activity regulators of akap12 for treating central nerve system diseases
KR101371612B1 (ko) 2011-02-25 2014-03-07 서울대학교산학협력단 Ａｋａｐ１２ 의 발현 또는 활성 조절제를 포함하는 중추신경계 질환 치료용 조성물
CN108464987B (zh) * 2018-03-22 2020-05-22 中国人民解放军第二军医大学 抑制或下调akap12基因表达的试剂在制备肿瘤放疗增敏药物中的应用
KR102548371B1 (ko) 2020-09-23 2023-06-27 강원대학교 산학협력단 제브라피쉬 치어 행동실험 및 라이브 이미징용 베드 툴
CN116548388B (zh) * 2023-06-29 2023-10-10 细胞生态海河实验室 标记造血干/祖细胞周期的转基因斑马鱼模型的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004044151A2 (en) * 2002-11-07 2004-05-27 University Of Rochester Recombinase mediated transcription

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004044151A2 (en) * 2002-11-07 2004-05-27 University Of Rochester Recombinase mediated transcription

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALKEMADE, H. ET AL.: "Differential expression of SKALP/elafin in human epidermal tumors", AM. J, PATHOL., vol. 143, no. 6, 1993, pages 1679 - 1687 *
GROVE, B. D. ET AL.: "Intracellular distribution of gravin, a PKA and PKC binding protein, in vascular endothelial cells", J. VASE. RES., vol. 38, 2001, pages 163 - 175 *
WEISER, D. C. ET AL.: "Gravin regulates mesodermal cell behavior changes required for axis elongation during zebrafish gastrulation", GENES DEV., vol. 21, 2007, pages 1559 - 1571 *
WILLOUGHBY, D. ET AL.: "An anchored PKA and PDE4 complex regulates subplasmalemmal CAMP dynamics", THE EMBO JOURNAL, vol. 25, 2006, pages 2051 - 2061 *

Also Published As

Publication number Publication date
KR101133289B1 (ko) 2012-04-05
WO2009151304A2 (ko) 2009-12-17
US20110162092A1 (en) 2011-06-30
KR20090129664A (ko) 2009-12-17

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