WO2009150043A1 - Dispositif de délivrance de médicament ayant deux compartiments disposés de manière fixe parallèlement l’un à l’autre - Google Patents

Dispositif de délivrance de médicament ayant deux compartiments disposés de manière fixe parallèlement l’un à l’autre Download PDF

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Publication number
WO2009150043A1
WO2009150043A1 PCT/EP2009/056409 EP2009056409W WO2009150043A1 WO 2009150043 A1 WO2009150043 A1 WO 2009150043A1 EP 2009056409 W EP2009056409 W EP 2009056409W WO 2009150043 A1 WO2009150043 A1 WO 2009150043A1
Authority
WO
WIPO (PCT)
Prior art keywords
medicament
compartment
medicament container
delivery device
actuation
Prior art date
Application number
PCT/EP2009/056409
Other languages
English (en)
Inventor
Anders Wiselblad
Original Assignee
Shl Group Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shl Group Ab filed Critical Shl Group Ab
Publication of WO2009150043A1 publication Critical patent/WO2009150043A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A61M2005/2451—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing preventing delivery before mixing is completed, e.g. by locking mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3146—Priming, e.g. purging, reducing backlash or clearance

Definitions

  • the present invention relates to a medicament delivery device and in particular an injector.
  • a large number of medicament delivery devices such as injectors have been developed during a number of years, having a number of different features that can facilitate in particular the self-administration of medicament.
  • the features include mixing, priming, penetration, injection, retraction of the injection needle and covering of the injection needle, where all or some of the features are performed automatically upon actuation. These features have been combined in many ways in different injectors.
  • a main design of the above mentioned type of injectors is a generally elongated tubular shape as well as pen-shape.
  • the advantage with this shape is that it can accommodate elongated plunger rods that act on medicament containers, where the plunger rods are acted upon by spiral springs, such that the components are placed after each other in the longitudinal direction of the injector.
  • this design also means that the injector tends to be rather long and in particular when a number of the above mentioned features are included in the injector. This can be a major drawback for the users and in particular when the injectors are used publicly and/or if the user has to carry the injector with him. Most users do not want to show others that they use such medical devices, and therefore there is a general desire that they are as small as possible.
  • Document US 5,137,516 discloses an injection device that is divided in two parts when not in use, which parts are stored in a housing, which fits into the pocket or handbag of the user.
  • the housing is opened; a syringe administrating device is pulled out and threaded onto a syringe cartridge housing containing a medicament container onto which an injection needle is attached.
  • a syringe administrating device is pulled out and threaded onto a syringe cartridge housing containing a medicament container onto which an injection needle is attached.
  • the assembled injector is withdrawn from the housing whereby a rubber septum covering the needle is removed.
  • the injector is now ready for use.
  • the housing could further include compartments for further syringe cartridge housings.
  • Document patent application No. US 2007/0219506 discloses a disassemble injection device comprising two parts connectable beside each other, where one part contains an ampoule with medicament and the other part contains a plunger rod and mechanism for bringing it forward.
  • the parts are separated from each other and the proximal end of the drive mechanism part is connected to the distal end of the ampoule part.
  • the aim of the present invention is to provide a medical delivery device that provides a very compact appearance when not in use, and provides an ergonomic grasp and simplified function when to be used.
  • a medicament delivery device comprising a housing having a first and a second elongated compartments, wherein said first compartment is arranged to store a medicament container holder arranged to hold a medicament container and to which medicament container a delivery member can be attached; and wherein said second compartment is arranged to comprise actuation means; characterised in that said compartments are fixedly arranged parallel to each other forming a large grasp surface, and in that said second compartment further comprises attachment means on its inner annular surface arranged to cooperate with corresponding attachment means arranged on the outer annular surface of said medicament container holder, such that said actuation means is capable of, upon actuation, expelling a dose of medicament from said medicament container through said delivery member after said medicament container holder is attached to said second compartment.
  • said attachment means said are bayonet fixings or threads.
  • said medicament container is a multi chamber container, and wherein a mixing of the components of the chambers is performed when the medicament container holder is threaded into said second compartment.
  • said actuation means comprises a plunger rod, a resilient means arranged compressed within the plunger rod, manually activation means and locking means for locking said plunger rod and said resilient means in a compressed state until said medicament container holder is attached to said second compartment.
  • said housing further comprises a third compartment for storing an injection needle.
  • the injector is in two parts when not ready for use, a very compact and handy device is obtained which easily can be put in a handbag for example. Further, during use, the user holds the two compartment housing, which provides a better and more comfortable grip than an ordinary tubular housing.
  • the housing is used as a part of the injector when it is to be used, thereby requiring fewer components.
  • the housing could then be arranged with different automatic functions such as injection. It is also then an advantage that the function cannot be activated until the medicament container holder is properly attached to the housing. Until then an actuation button cannot be depressed.
  • the injector could handle a multi chamber container, and in that respect the mixing is preferably performed when the two parts are properly attached to each other.
  • an injection needle is also arranged in a compartment in the housing, whereby all components needed for the function of the injection are obtained.
  • Fig. 1 shows a cross-sectional view of a medicament delivery device according to the present invention
  • Figs. 2-6 show different functional positions of the device according Fig. 1.
  • distal part/end refers to the part/end of the medicament delivery device, or the parts/ends of the members thereof, which under use of the medicament delivery device is located the furthest away from the medicament delivery site of the patient.
  • proximal part/end refers to the part/end of the medicament delivery device, or the parts/ends of the members thereof, which under use of the device is located closest to the medicament delivery site of the patient.
  • the medicament delivery device shown in the drawings comprises a housing 10.
  • the housing in its turn comprises a first 12 and a second 14 elongated compartment fixedly arranged parallel to each other forming a large grasp surface, wherein said first compartment 12 is arranged to store a medicament container holder 16 arranged to hold a medicament container 18 and to which medicament container a delivery member 60, such as an injection needle, can be attached; and wherein said second compartment 14 is arranged to comprise actuation means 30.
  • the second compartment further comprises attachment means 52 on its inner annular surface arranged to cooperate with corresponding attachment means 28 arranged on the outer annular surface of said medicament container holder, such that said actuation means 30 is capable of, upon actuation, expelling a dose of medicament from said medicament container 20 through said delivery member after said medicament container holder is attached to said second compartment.
  • the medicament container 18 is a multi chamber container where one chamber 20 contains medicament in powder form and the other chamber 22 contains a diluent. The two chambers are sealed off by a first stopper 24. The end of the container is sealed off by a second stopper 26.
  • the attachment means (28, 52) comprises threads as sown in Figs. 2 and 3. Moreover, the threads 52 of the second compartment have a corresponding pitch as the threads of the container holder 16.
  • the manually activation means comprises an actuation member 46 partially surrounding a distal part of the plunger rod, and a manually actuation button 48 fixedly connected to the distal end of the actuation member 46 and protruding distally through the second compartment.
  • the actuation member is further arranged with a ledge 50 for preventing the actuation sleeve from moving axially in the distal direction.
  • the locking means comprises an actuation sleeve 34 partially surrounding the actuation member 46 and the plunger rod, and a release ring 40 surrounding the actuation sleeve.
  • the proximal end of the actuation sleeve 34 is arranged with flexible tongues 36 directed in the proximal direction, where each tongue is arranged with inwardly radially directed ledges 37. In an initial state, these ledges are positioned in a circumferential groove 38 on the plunger rod 32. The tongues and ledges are held in this position by the release ring 40.
  • the compressed spring (not shown) within the plunger rod is arranged between a proximal wall of the plunger 30 and a wall part 46 of the actuation member 46; and the actuation member is fixedly connected to the actuation sleeve 34.
  • the device is intended to function as follows. When the device is delivered to the patient/user it looks like the device of Fig. 2. Here the container holder is placed in the first compartment and held in placed by ridges 54 on the outer surface mating into corresponding recesses 55 on the inner surface of the first compartment 12.
  • the patient pushes on two diametrically placed surfaces 56, wherein the front end of the first compartment becomes slightly oval, whereby the ridges 54 can leave the recesses and the container holder 16 can be removed from the first compartment 12, Fig. 3.
  • the container holder 16 is now threaded into the second compartment due to the corresponding threads 28 and 52, Fig. 4 and 5.
  • the plunger rod 32 comes in contact with the second stopper 26 and pushes it forward.
  • the first stopper 24 is also moved, whereby passages are freed between the first and the second chamber 20, 22 and a mixing is obtained.
  • the user can now stop the threading of the container holder, Fig. 6. This may be indicated in a window 58 on the housing.
  • a delivery member, here a needle is then attached to the medicament container whereby a priming of the device is performed.
  • the distal end of the container holder 16 has now come in contact with the proximal end of the release ring 40 and has moved the ring such that it is only partly in contact with the flexible tongues of the actuation sleeve.
  • the user now penetrates the injection site with the needle, and depresses the actuation button 48.
  • the cartridge holder 16 may be screwed off and put back in the first compartment, after which the device is discarded.
  • actuation member 46 and the actuation sleeve 34 may also be manufactured as one component.
  • actuation member 46 acts on the actuation sleeve 34 and move it towards the proximal end of the device, but the flexible tongues 36 cannot be moved out of contact with the release ring 40 since the release ring is still surrounding the flexible tongues 36 and therefore the inwardly radially directed ledges 37 of the flexible tongues 36 cannot move radially outwards from the groove 38 of the plunger rod 32.
  • the delivery member it could be placed for example within a third compartment of the housing (not shown).
  • the delivery member being a needle, a safety pen needle, a nozzle or the like
  • the wording medicament container may embrace several different types of containers such as cartridges, ampoules, syringes, vials, aerosol containers, just to mention a few.
  • the present invention could also be used with other types of delivery devices such as powder or aerosol inhalers as well as nebulizers, with a delivery member as a nozzle e.g. a mouth piece or nasal piece and capable of delivering a medicament to be inhaled by the patient.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un dispositif de délivrance de médicament, qui comprend un boîtier ayant des premier (12) et deuxième (14) compartiments allongés, ledit premier compartiment (12) étant configuré pour stocker un support de récipient de médicament (16) configuré pour supporter un récipient de médicament (18), un élément de délivrance (60) pouvant être fixé à ce récipient de médicaments ; et ledit deuxième compartiment (14) étant configuré pour comprendre des moyens d’actionnement (30) ; caractérisé en ce que lesdits compartiments sont disposés de manière fixe parallèlement l’un à l’autre formant une grande surface de préhension, et en ce que ledit deuxième compartiment comprend en outre des moyens de fixation (52) sur sa surface annulaire interne configurés pour coopérer avec les éléments de fixation correspondant (28) disposés sur la surface annulaire externe dudit support de récipient de médicament, de manière à ce que lesdits moyens d’actionnement (30) soient capables, sous l’effet de l’actionnement, d’expulser une dose de médicament dudit récipient pour médicaments (20) par ledit élément de délivrance (60) après la fixation dudit support de récipient de médicament au dit deuxième compartiment.
PCT/EP2009/056409 2008-06-11 2009-05-27 Dispositif de délivrance de médicament ayant deux compartiments disposés de manière fixe parallèlement l’un à l’autre WO2009150043A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0801360 2008-06-11
SE0801360-9 2008-06-11

Publications (1)

Publication Number Publication Date
WO2009150043A1 true WO2009150043A1 (fr) 2009-12-17

Family

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Family Applications (1)

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PCT/EP2009/056409 WO2009150043A1 (fr) 2008-06-11 2009-05-27 Dispositif de délivrance de médicament ayant deux compartiments disposés de manière fixe parallèlement l’un à l’autre

Country Status (1)

Country Link
WO (1) WO2009150043A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013048866A1 (fr) * 2011-09-30 2013-04-04 Becton Dickinson France S.A.S. Tige de piston pouvant être fixée et conditionnement associé

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518384A (en) * 1983-06-17 1985-05-21 Survival Technology, Inc. Multiple medicament cartridge clip and medicament discharging device therefor
FR2654938A1 (fr) * 1989-11-28 1991-05-31 Glaxo Group Ltd Dispositif d'administration.
WO2006047813A1 (fr) * 2004-11-05 2006-05-11 Rewall Pty Ltd Pince pour medicaments
WO2007065339A1 (fr) * 2005-12-05 2007-06-14 Zhongshan Botai Pharmaceutic Instruments Co., Ltd. Seringue automatique

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518384A (en) * 1983-06-17 1985-05-21 Survival Technology, Inc. Multiple medicament cartridge clip and medicament discharging device therefor
FR2654938A1 (fr) * 1989-11-28 1991-05-31 Glaxo Group Ltd Dispositif d'administration.
WO2006047813A1 (fr) * 2004-11-05 2006-05-11 Rewall Pty Ltd Pince pour medicaments
WO2007065339A1 (fr) * 2005-12-05 2007-06-14 Zhongshan Botai Pharmaceutic Instruments Co., Ltd. Seringue automatique

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013048866A1 (fr) * 2011-09-30 2013-04-04 Becton Dickinson France S.A.S. Tige de piston pouvant être fixée et conditionnement associé
CN103945878A (zh) * 2011-09-30 2014-07-23 贝克顿·迪金森法国公司 可连接的活塞杆及相关包装
US9333288B2 (en) 2011-09-30 2016-05-10 Becton Dickinson France, S.A.S. Attachable plunger rod and associated packaging
US10391250B2 (en) 2011-09-30 2019-08-27 Becton Dickinson France, S.A.S. Attachable plunger rod and associated packaging

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