WO2009141833A3 - An improved process for synthesizing highly pure atomoxetine - Google Patents
An improved process for synthesizing highly pure atomoxetine Download PDFInfo
- Publication number
- WO2009141833A3 WO2009141833A3 PCT/IN2009/000236 IN2009000236W WO2009141833A3 WO 2009141833 A3 WO2009141833 A3 WO 2009141833A3 IN 2009000236 W IN2009000236 W IN 2009000236W WO 2009141833 A3 WO2009141833 A3 WO 2009141833A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- highly pure
- improved process
- synthesizing highly
- atomoxetine
- pure atomoxetine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
- C07C209/74—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/82—Purification; Separation; Stabilisation; Use of additives
- C07C209/84—Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/08—Separation; Purification; Stabilisation; Use of additives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention relates to a process for the preparation of highly pure atomoxetine of formula (I) and pharmaceutically acceptable salts thereof Formula (I) The present invention also aims at novel processes for the preparation and purification of intermediates involved in the process of the present invention.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1002DE2008 | 2008-04-17 | ||
IN1002/DEL/2008 | 2008-04-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009141833A2 WO2009141833A2 (en) | 2009-11-26 |
WO2009141833A3 true WO2009141833A3 (en) | 2010-11-25 |
Family
ID=41340644
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2009/000236 WO2009141833A2 (en) | 2008-04-17 | 2009-04-17 | An improved process for synthesizing highly pure atomoxetine |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009141833A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015001565A2 (en) * | 2013-07-02 | 2015-01-08 | Zcl Chemicals Limited | "an improved process for the preparation of 3-aryloxy-3- phenylpropylamine and salt thereof" |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4314081A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
EP0052492A1 (en) * | 1980-11-14 | 1982-05-26 | Eli Lilly And Company | 3-Aryloxy-3-phenylpropylamines |
EP1171417B1 (en) * | 1999-04-09 | 2005-11-09 | Eli Lilly And Company | Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof |
WO2006037055A1 (en) * | 2004-09-27 | 2006-04-06 | Dr. Reddy's Laboratories Ltd. | Synthesis of atomoxetine hydrochloride |
WO2007009405A1 (en) * | 2005-07-21 | 2007-01-25 | Zentiva, A.S. | A method for the preparation of (r)-n-methyl-3-(2-methylphenoxy)-3-phenylpropylamine hydrochloride (atomoxetine) |
WO2008062473A1 (en) * | 2006-10-31 | 2008-05-29 | Cadila Healthcare Limited | Process for preparing atomoxetine hydrochloride |
-
2009
- 2009-04-17 WO PCT/IN2009/000236 patent/WO2009141833A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4314081A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
EP0052492A1 (en) * | 1980-11-14 | 1982-05-26 | Eli Lilly And Company | 3-Aryloxy-3-phenylpropylamines |
EP1171417B1 (en) * | 1999-04-09 | 2005-11-09 | Eli Lilly And Company | Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof |
WO2006037055A1 (en) * | 2004-09-27 | 2006-04-06 | Dr. Reddy's Laboratories Ltd. | Synthesis of atomoxetine hydrochloride |
WO2007009405A1 (en) * | 2005-07-21 | 2007-01-25 | Zentiva, A.S. | A method for the preparation of (r)-n-methyl-3-(2-methylphenoxy)-3-phenylpropylamine hydrochloride (atomoxetine) |
WO2008062473A1 (en) * | 2006-10-31 | 2008-05-29 | Cadila Healthcare Limited | Process for preparing atomoxetine hydrochloride |
Also Published As
Publication number | Publication date |
---|---|
WO2009141833A2 (en) | 2009-11-26 |
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